{
    "info": {
        "nct_id": "NCT00361231",
        "official_title": "Phase II Study of Gemcitabine, Oxaliplatin in Combination With Bevacizumab (Avastin) in Unresectable or Metastatic Biliary Tract and Gallbladder Cancer",
        "inclusion_criteria": "* Histologically confirmed, locally unresectable or metastatic biliary tract or gallbladder adenocarcinoma. Patients must have at least one measurable lesion outside prior radiation field.\n* Zero to one prior chemotherapy for biliary tract or gallbladder cancer\n* Age > 18 years\n* ECOG performance status 0-2\n* Life expectancy > 12 weeks\n* Adequate organ and bone marrow function\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Chemotherapy within past 3 weeks of initiation of therapy\n* Pregnant or lactating women\n* Clinically apparent central nervous system metastases or carcinomatous meningitis\n* Biliary obstruction with inadequate drainage and total bilirubin > 2.5 mg/dL\n* Concurrent malignancy of any site, except limited basal cell carcinoma or squamous cell carcinoma of the skin or carcinoma in situ of the cervix\n* Uncontrolled serious medical or psychiatric illness\n* Pre-existing peripheral neuropathy of grade 2 or greater severity according to the Common Terminology Criteria of the NCI (version 3.0)\n* Current, recent (within 4 weeks of the first infusion of this study), or planned participation in an experimental drug study\n* Blood pressure of > 150/100 mmHg\n* Unstable angina\n* NYHA Grade II or greater congestive heart failure\n* History of myocardial infarction or stroke within 6 months\n* Clinically significant peripheral vascular disease\n* Evidence of bleeding diathesis or coagulopathy\n* Major surgical procedure, open biopsy, or significant traumatic injury with 28 days prior to Day 1, anticipation of need for major surgical procedure during the course of the study\n* History of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within 6 months prior to day 1\n* Serious, non-healing wound, ulcer, or bone fracture",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Histologically confirmed, locally unresectable or metastatic biliary tract or gallbladder adenocarcinoma. Patients must have at least one measurable lesion outside prior radiation field.",
                "criterions": [
                    {
                        "exact_snippets": "Histologically confirmed, locally unresectable or metastatic biliary tract or gallbladder adenocarcinoma",
                        "criterion": "biliary tract or gallbladder adenocarcinoma",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": "histologically confirmed"
                        }
                    },
                    {
                        "exact_snippets": "Histologically confirmed, locally unresectable or metastatic biliary tract or gallbladder adenocarcinoma",
                        "criterion": "biliary tract or gallbladder adenocarcinoma",
                        "requirement": {
                            "requirement_type": "resectability",
                            "expected_value": "locally unresectable"
                        }
                    },
                    {
                        "exact_snippets": "Histologically confirmed, locally unresectable or metastatic biliary tract or gallbladder adenocarcinoma",
                        "criterion": "biliary tract or gallbladder adenocarcinoma",
                        "requirement": {
                            "requirement_type": "metastasis",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Patients must have at least one measurable lesion outside prior radiation field",
                        "criterion": "measurable lesion",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "lesion"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Patients must have at least one measurable lesion outside prior radiation field",
                        "criterion": "measurable lesion",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": "outside prior radiation field"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "or_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "Histologically confirmed, locally unresectable or metastatic biliary tract or gallbladder adenocarcinoma",
                                        "criterion": "biliary tract or gallbladder adenocarcinoma",
                                        "requirement": {
                                            "requirement_type": "confirmation",
                                            "expected_value": "histologically confirmed"
                                        }
                                    },
                                    {
                                        "exact_snippets": "Histologically confirmed, locally unresectable or metastatic biliary tract or gallbladder adenocarcinoma",
                                        "criterion": "biliary tract or gallbladder adenocarcinoma",
                                        "requirement": {
                                            "requirement_type": "resectability",
                                            "expected_value": "locally unresectable"
                                        }
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "Histologically confirmed, locally unresectable or metastatic biliary tract or gallbladder adenocarcinoma",
                                "criterion": "biliary tract or gallbladder adenocarcinoma",
                                "requirement": {
                                    "requirement_type": "metastasis",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Patients must have at least one measurable lesion outside prior radiation field",
                                "criterion": "measurable lesion",
                                "requirement": {
                                    "requirement_type": "quantity",
                                    "expected_value": {
                                        "operator": ">=",
                                        "value": 1,
                                        "unit": "lesion"
                                    }
                                }
                            },
                            {
                                "exact_snippets": "Patients must have at least one measurable lesion outside prior radiation field",
                                "criterion": "measurable lesion",
                                "requirement": {
                                    "requirement_type": "location",
                                    "expected_value": "outside prior radiation field"
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Age > 18 years",
                "criterions": [
                    {
                        "exact_snippets": "Age > 18 years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Age > 18 years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* ECOG performance status 0-2",
                "criterions": [
                    {
                        "exact_snippets": "ECOG performance status 0-2",
                        "criterion": "ECOG performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "ECOG performance status 0-2",
                        "criterion": "ECOG performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Life expectancy > 12 weeks",
                "criterions": [
                    {
                        "exact_snippets": "Life expectancy > 12 weeks",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">",
                                "value": 12,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Life expectancy > 12 weeks",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">",
                                "value": 12,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Adequate organ and bone marrow function",
                "criterions": [
                    {
                        "exact_snippets": "Adequate organ ... function",
                        "criterion": "organ function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Adequate ... bone marrow function",
                        "criterion": "bone marrow function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Adequate organ ... function",
                        "criterion": "organ function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Adequate ... bone marrow function",
                        "criterion": "bone marrow function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Chemotherapy within past 3 weeks of initiation of therapy",
                "criterions": [
                    {
                        "exact_snippets": "Chemotherapy within past 3 weeks",
                        "criterion": "chemotherapy",
                        "requirement": {
                            "requirement_type": "time since last treatment",
                            "expected_value": {
                                "operator": "<=",
                                "value": 3,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Chemotherapy within past 3 weeks",
                        "criterion": "chemotherapy",
                        "requirement": {
                            "requirement_type": "time since last treatment",
                            "expected_value": {
                                "operator": "<=",
                                "value": 3,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Clinically apparent central nervous system metastases or carcinomatous meningitis",
                "criterions": [
                    {
                        "exact_snippets": "Clinically apparent central nervous system metastases",
                        "criterion": "central nervous system metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "carcinomatous meningitis",
                        "criterion": "carcinomatous meningitis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Clinically apparent central nervous system metastases",
                        "criterion": "central nervous system metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "carcinomatous meningitis",
                        "criterion": "carcinomatous meningitis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Biliary obstruction with inadequate drainage and total bilirubin > 2.5 mg/dL",
                "criterions": [
                    {
                        "exact_snippets": "Biliary obstruction with inadequate drainage",
                        "criterion": "biliary obstruction",
                        "requirement": {
                            "requirement_type": "drainage adequacy",
                            "expected_value": "inadequate"
                        }
                    },
                    {
                        "exact_snippets": "total bilirubin > 2.5 mg/dL",
                        "criterion": "total bilirubin",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">",
                                "value": 2.5,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Biliary obstruction with inadequate drainage",
                                "criterion": "biliary obstruction",
                                "requirement": {
                                    "requirement_type": "drainage adequacy",
                                    "expected_value": "inadequate"
                                }
                            },
                            {
                                "exact_snippets": "total bilirubin > 2.5 mg/dL",
                                "criterion": "total bilirubin",
                                "requirement": {
                                    "requirement_type": "level",
                                    "expected_value": {
                                        "operator": ">",
                                        "value": 2.5,
                                        "unit": "mg/dL"
                                    }
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Concurrent malignancy of any site, except limited basal cell carcinoma or squamous cell carcinoma of the skin or carcinoma in situ of the cervix",
                "criterions": [
                    {
                        "exact_snippets": "Concurrent malignancy of any site",
                        "criterion": "concurrent malignancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "except limited basal cell carcinoma",
                        "criterion": "basal cell carcinoma",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "limited"
                        }
                    },
                    {
                        "exact_snippets": "except ... squamous cell carcinoma of the skin",
                        "criterion": "squamous cell carcinoma of the skin",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "except ... carcinoma in situ of the cervix",
                        "criterion": "carcinoma in situ of the cervix",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "not_criteria": {
                            "and_criteria": [
                                {
                                    "exact_snippets": "Concurrent malignancy of any site",
                                    "criterion": "concurrent malignancy",
                                    "requirement": {
                                        "requirement_type": "presence",
                                        "expected_value": false
                                    }
                                },
                                {
                                    "not_criteria": {
                                        "exact_snippets": "except limited basal cell carcinoma",
                                        "criterion": "basal cell carcinoma",
                                        "requirement": {
                                            "requirement_type": "severity",
                                            "expected_value": "limited"
                                        }
                                    }
                                },
                                {
                                    "not_criteria": {
                                        "exact_snippets": "except ... squamous cell carcinoma of the skin",
                                        "criterion": "squamous cell carcinoma of the skin",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    }
                                },
                                {
                                    "not_criteria": {
                                        "exact_snippets": "except ... carcinoma in situ of the cervix",
                                        "criterion": "carcinoma in situ of the cervix",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    }
                                }
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Uncontrolled serious medical or psychiatric illness",
                "criterions": [
                    {
                        "exact_snippets": "Uncontrolled serious medical ... illness",
                        "criterion": "serious medical illness",
                        "requirement": {
                            "requirement_type": "control status",
                            "expected_value": "uncontrolled"
                        }
                    },
                    {
                        "exact_snippets": "Uncontrolled serious ... psychiatric illness",
                        "criterion": "serious psychiatric illness",
                        "requirement": {
                            "requirement_type": "control status",
                            "expected_value": "uncontrolled"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Uncontrolled serious medical ... illness",
                        "criterion": "serious medical illness",
                        "requirement": {
                            "requirement_type": "control status",
                            "expected_value": "uncontrolled"
                        }
                    },
                    {
                        "exact_snippets": "Uncontrolled serious ... psychiatric illness",
                        "criterion": "serious psychiatric illness",
                        "requirement": {
                            "requirement_type": "control status",
                            "expected_value": "uncontrolled"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Pre-existing peripheral neuropathy of grade 2 or greater severity according to the Common Terminology Criteria of the NCI (version 3.0)",
                "criterions": [
                    {
                        "exact_snippets": "Pre-existing peripheral neuropathy of grade 2 or greater severity",
                        "criterion": "peripheral neuropathy",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2,
                                "unit": "grade"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Pre-existing peripheral neuropathy of grade 2 or greater severity",
                        "criterion": "peripheral neuropathy",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2,
                                "unit": "grade"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Current, recent (within 4 weeks of the first infusion of this study), or planned participation in an experimental drug study",
                "criterions": [
                    {
                        "exact_snippets": "Current, recent (within 4 weeks of the first infusion of this study), or planned participation in an experimental drug study",
                        "criterion": "participation in an experimental drug study",
                        "requirement": {
                            "requirement_type": "timeframe",
                            "expected_value": "current"
                        }
                    },
                    {
                        "exact_snippets": "Current, recent (within 4 weeks of the first infusion of this study), or planned participation in an experimental drug study",
                        "criterion": "participation in an experimental drug study",
                        "requirement": {
                            "requirement_type": "timeframe",
                            "expected_value": "recent (within 4 weeks of the first infusion of this study)"
                        }
                    },
                    {
                        "exact_snippets": "Current, recent (within 4 weeks of the first infusion of this study), or planned participation in an experimental drug study",
                        "criterion": "participation in an experimental drug study",
                        "requirement": {
                            "requirement_type": "timeframe",
                            "expected_value": "planned"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Current, recent (within 4 weeks of the first infusion of this study), or planned participation in an experimental drug study",
                        "criterion": "participation in an experimental drug study",
                        "requirement": {
                            "requirement_type": "timeframe",
                            "expected_value": "current"
                        }
                    },
                    {
                        "exact_snippets": "Current, recent (within 4 weeks of the first infusion of this study), or planned participation in an experimental drug study",
                        "criterion": "participation in an experimental drug study",
                        "requirement": {
                            "requirement_type": "timeframe",
                            "expected_value": "recent (within 4 weeks of the first infusion of this study)"
                        }
                    },
                    {
                        "exact_snippets": "Current, recent (within 4 weeks of the first infusion of this study), or planned participation in an experimental drug study",
                        "criterion": "participation in an experimental drug study",
                        "requirement": {
                            "requirement_type": "timeframe",
                            "expected_value": "planned"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Blood pressure of > 150/100 mmHg",
                "criterions": [
                    {
                        "exact_snippets": "Blood pressure of > 150/100 mmHg",
                        "criterion": "blood pressure",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 150,
                                "unit": "mmHg"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Blood pressure of > 150/100 mmHg",
                        "criterion": "blood pressure",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 150,
                                "unit": "mmHg"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Blood pressure of > 150/100 mmHg",
                        "criterion": "blood pressure",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 100,
                                "unit": "mmHg"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Unstable angina",
                "criterions": [
                    {
                        "exact_snippets": "Unstable angina",
                        "criterion": "unstable angina",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Unstable angina",
                    "criterion": "unstable angina",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* NYHA Grade II or greater congestive heart failure",
                "criterions": [
                    {
                        "exact_snippets": "NYHA Grade II or greater congestive heart failure",
                        "criterion": "congestive heart failure",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2,
                                "unit": "NYHA Grade"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "NYHA Grade II or greater congestive heart failure",
                        "criterion": "congestive heart failure",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2,
                                "unit": "NYHA Grade"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* History of myocardial infarction or stroke within 6 months",
                "criterions": [
                    {
                        "exact_snippets": "History of myocardial infarction",
                        "criterion": "myocardial infarction",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "History of myocardial infarction",
                        "criterion": "myocardial infarction",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 6,
                                        "unit": "months"
                                    }
                                ]
                            }
                        }
                    },
                    {
                        "exact_snippets": "History of ... stroke within 6 months",
                        "criterion": "stroke",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "History of ... stroke within 6 months",
                        "criterion": "stroke",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 6,
                                        "unit": "months"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "History of myocardial infarction",
                                "criterion": "myocardial infarction",
                                "requirement": {
                                    "requirement_type": "history",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "History of myocardial infarction",
                                "criterion": "myocardial infarction",
                                "requirement": {
                                    "requirement_type": "time frame",
                                    "expected_value": {
                                        "comparisons": [
                                            {
                                                "operator": "<=",
                                                "value": 6,
                                                "unit": "months"
                                            }
                                        ]
                                    }
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "History of ... stroke within 6 months",
                                "criterion": "stroke",
                                "requirement": {
                                    "requirement_type": "history",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "History of ... stroke within 6 months",
                                "criterion": "stroke",
                                "requirement": {
                                    "requirement_type": "time frame",
                                    "expected_value": {
                                        "comparisons": [
                                            {
                                                "operator": "<=",
                                                "value": 6,
                                                "unit": "months"
                                            }
                                        ]
                                    }
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Clinically significant peripheral vascular disease",
                "criterions": [
                    {
                        "exact_snippets": "Clinically significant peripheral vascular disease",
                        "criterion": "peripheral vascular disease",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "clinically significant"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Clinically significant peripheral vascular disease",
                        "criterion": "peripheral vascular disease",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "clinically significant"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Evidence of bleeding diathesis or coagulopathy",
                "criterions": [
                    {
                        "exact_snippets": "Evidence of bleeding diathesis",
                        "criterion": "bleeding diathesis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Evidence of ... coagulopathy",
                        "criterion": "coagulopathy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Evidence of bleeding diathesis",
                        "criterion": "bleeding diathesis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Evidence of ... coagulopathy",
                        "criterion": "coagulopathy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Major surgical procedure, open biopsy, or significant traumatic injury with 28 days prior to Day 1, anticipation of need for major surgical procedure during the course of the study",
                "criterions": [
                    {
                        "exact_snippets": "Major surgical procedure, open biopsy, or significant traumatic injury with 28 days prior to Day 1",
                        "criterion": "recent major surgical procedure, open biopsy, or significant traumatic injury",
                        "requirement": {
                            "requirement_type": "time since occurrence",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 28,
                                        "unit": "days"
                                    }
                                ]
                            }
                        }
                    },
                    {
                        "exact_snippets": "anticipation of need for major surgical procedure during the course of the study",
                        "criterion": "anticipated need for major surgical procedure",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Major surgical procedure, open biopsy, or significant traumatic injury with 28 days prior to Day 1",
                                "criterion": "recent major surgical procedure, open biopsy, or significant traumatic injury",
                                "requirement": {
                                    "requirement_type": "time since occurrence",
                                    "expected_value": {
                                        "comparisons": [
                                            {
                                                "operator": "<=",
                                                "value": 28,
                                                "unit": "days"
                                            }
                                        ]
                                    }
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "anticipation of need for major surgical procedure during the course of the study",
                        "criterion": "anticipated need for major surgical procedure",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* History of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within 6 months prior to day 1",
                "criterions": [
                    {
                        "exact_snippets": "History of abdominal fistula",
                        "criterion": "abdominal fistula",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "History of abdominal fistula",
                        "criterion": "abdominal fistula",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 6,
                                        "unit": "months"
                                    }
                                ]
                            }
                        }
                    },
                    {
                        "exact_snippets": "History of ... gastrointestinal perforation",
                        "criterion": "gastrointestinal perforation",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "History of ... gastrointestinal perforation",
                        "criterion": "gastrointestinal perforation",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 6,
                                        "unit": "months"
                                    }
                                ]
                            }
                        }
                    },
                    {
                        "exact_snippets": "History of ... intra-abdominal abscess",
                        "criterion": "intra-abdominal abscess",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "History of ... intra-abdominal abscess",
                        "criterion": "intra-abdominal abscess",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 6,
                                        "unit": "months"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "History of abdominal fistula",
                                        "criterion": "abdominal fistula",
                                        "requirement": {
                                            "requirement_type": "history",
                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "History of abdominal fistula",
                                        "criterion": "abdominal fistula",
                                        "requirement": {
                                            "requirement_type": "time frame",
                                            "expected_value": {
                                                "comparisons": [
                                                    {
                                                        "operator": "<=",
                                                        "value": 6,
                                                        "unit": "months"
                                                    }
                                                ]
                                            }
                                        }
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "History of ... gastrointestinal perforation",
                                        "criterion": "gastrointestinal perforation",
                                        "requirement": {
                                            "requirement_type": "history",
                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "History of ... gastrointestinal perforation",
                                        "criterion": "gastrointestinal perforation",
                                        "requirement": {
                                            "requirement_type": "time frame",
                                            "expected_value": {
                                                "comparisons": [
                                                    {
                                                        "operator": "<=",
                                                        "value": 6,
                                                        "unit": "months"
                                                    }
                                                ]
                                            }
                                        }
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "History of ... intra-abdominal abscess",
                                "criterion": "intra-abdominal abscess",
                                "requirement": {
                                    "requirement_type": "history",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "History of ... intra-abdominal abscess",
                                "criterion": "intra-abdominal abscess",
                                "requirement": {
                                    "requirement_type": "time frame",
                                    "expected_value": {
                                        "comparisons": [
                                            {
                                                "operator": "<=",
                                                "value": 6,
                                                "unit": "months"
                                            }
                                        ]
                                    }
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Serious, non-healing wound, ulcer, or bone fracture",
                "criterions": [
                    {
                        "exact_snippets": "Serious, non-healing wound",
                        "criterion": "wound",
                        "requirement": {
                            "requirement_type": "healing status",
                            "expected_value": "non-healing"
                        }
                    },
                    {
                        "exact_snippets": "Serious, non-healing wound",
                        "criterion": "wound",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "serious"
                        }
                    },
                    {
                        "exact_snippets": "Serious, non-healing ... ulcer",
                        "criterion": "ulcer",
                        "requirement": {
                            "requirement_type": "healing status",
                            "expected_value": "non-healing"
                        }
                    },
                    {
                        "exact_snippets": "Serious, non-healing ... ulcer",
                        "criterion": "ulcer",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "serious"
                        }
                    },
                    {
                        "exact_snippets": "Serious, non-healing ... bone fracture",
                        "criterion": "bone fracture",
                        "requirement": {
                            "requirement_type": "healing status",
                            "expected_value": "non-healing"
                        }
                    },
                    {
                        "exact_snippets": "Serious, non-healing ... bone fracture",
                        "criterion": "bone fracture",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "serious"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Serious, non-healing wound",
                                "criterion": "wound",
                                "requirement": {
                                    "requirement_type": "healing status",
                                    "expected_value": "non-healing"
                                }
                            },
                            {
                                "exact_snippets": "Serious, non-healing wound",
                                "criterion": "wound",
                                "requirement": {
                                    "requirement_type": "severity",
                                    "expected_value": "serious"
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Serious, non-healing ... ulcer",
                                "criterion": "ulcer",
                                "requirement": {
                                    "requirement_type": "healing status",
                                    "expected_value": "non-healing"
                                }
                            },
                            {
                                "exact_snippets": "Serious, non-healing ... ulcer",
                                "criterion": "ulcer",
                                "requirement": {
                                    "requirement_type": "severity",
                                    "expected_value": "serious"
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Serious, non-healing ... bone fracture",
                                "criterion": "bone fracture",
                                "requirement": {
                                    "requirement_type": "healing status",
                                    "expected_value": "non-healing"
                                }
                            },
                            {
                                "exact_snippets": "Serious, non-healing ... bone fracture",
                                "criterion": "bone fracture",
                                "requirement": {
                                    "requirement_type": "severity",
                                    "expected_value": "serious"
                                }
                            }
                        ]
                    }
                ]
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "identified_line": {
                "line": "* Zero to one prior chemotherapy for biliary tract or gallbladder cancer",
                "criterions": [
                    {
                        "exact_snippets": "Zero to one prior chemotherapy",
                        "criterion": "prior chemotherapy",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 1,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    },
                    {
                        "exact_snippets": "biliary tract or gallbladder cancer",
                        "criterion": "cancer type",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": [
                                "biliary tract",
                                "gallbladder"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Zero to one prior chemotherapy",
                                "criterion": "prior chemotherapy",
                                "requirement": {
                                    "requirement_type": "quantity",
                                    "expected_value": {
                                        "comparisons": [
                                            {
                                                "operator": ">=",
                                                "value": 0,
                                                "unit": "N/A"
                                            },
                                            {
                                                "operator": "<=",
                                                "value": 1,
                                                "unit": "N/A"
                                            }
                                        ]
                                    }
                                }
                            },
                            {
                                "or_criteria": [
                                    {
                                        "exact_snippets": "biliary tract or gallbladder cancer",
                                        "criterion": "cancer type",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": "biliary tract"
                                        }
                                    },
                                    {
                                        "exact_snippets": "biliary tract or gallbladder cancer",
                                        "criterion": "cancer type",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": "gallbladder"
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        }
    ],
    "failed_exclusion": [
        {
            "identified_line": {
                "line": "* Pregnant or lactating women",
                "criterions": [
                    {
                        "exact_snippets": "Pregnant",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "lactating women",
                        "criterion": "lactation",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Pregnant",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "lactating women",
                        "criterion": "lactation",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        }
    ],
    "failed_miscellaneous": []
}