{
    "info": {
        "nct_id": "NCT00254891",
        "official_title": "International, Randomized, Open-Label, Phase 3 Trial of Paclitaxel/Carboplatin Plus PF-3512676 Versus Paclitaxel/Carboplatin Alone as First-Line Treatment of Patients With Advanced Non-Small Cell Lung Cancer",
        "inclusion_criteria": "* Advanced Non-Small-Cell Lung Cancer (NSCLC) stage IIIB with pleural effusion or stage IV\n* No prior systemic treatment for Non-Small-Cell Lung Cancer (NSCLC)with chemotherapy, immunotherapy, biologic response modifiers or other investigational drugs\n* Eastern Cooperative Oncology Performance Status (ECOG PS) 0 or 1\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Small cell or carcinoid lung cancer\n* Known Central Nervous System (CNS) metastasis\n* Pre-existing auto-immune or antibody mediated diseases",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Advanced Non-Small-Cell Lung Cancer (NSCLC) stage IIIB with pleural effusion or stage IV",
                "criterions": [
                    {
                        "exact_snippets": "Advanced Non-Small-Cell Lung Cancer (NSCLC)",
                        "criterion": "Non-Small-Cell Lung Cancer (NSCLC)",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": "advanced"
                        }
                    },
                    {
                        "exact_snippets": "stage IIIB with pleural effusion",
                        "criterion": "NSCLC stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": "IIIB"
                        }
                    },
                    {
                        "exact_snippets": "stage IIIB with pleural effusion",
                        "criterion": "NSCLC stage",
                        "requirement": {
                            "requirement_type": "condition",
                            "expected_value": "pleural effusion"
                        }
                    },
                    {
                        "exact_snippets": "stage IV",
                        "criterion": "NSCLC stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": "IV"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Advanced Non-Small-Cell Lung Cancer (NSCLC)",
                                "criterion": "Non-Small-Cell Lung Cancer (NSCLC)",
                                "requirement": {
                                    "requirement_type": "stage",
                                    "expected_value": "advanced"
                                }
                            },
                            {
                                "or_criteria": [
                                    {
                                        "and_criteria": [
                                            {
                                                "exact_snippets": "stage IIIB with pleural effusion",
                                                "criterion": "NSCLC stage",
                                                "requirement": {
                                                    "requirement_type": "stage",
                                                    "expected_value": "IIIB"
                                                }
                                            },
                                            {
                                                "exact_snippets": "stage IIIB with pleural effusion",
                                                "criterion": "NSCLC stage",
                                                "requirement": {
                                                    "requirement_type": "condition",
                                                    "expected_value": "pleural effusion"
                                                }
                                            }
                                        ]
                                    },
                                    {
                                        "exact_snippets": "stage IV",
                                        "criterion": "NSCLC stage",
                                        "requirement": {
                                            "requirement_type": "stage",
                                            "expected_value": "IV"
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No prior systemic treatment for Non-Small-Cell Lung Cancer (NSCLC)with chemotherapy, immunotherapy, biologic response modifiers or other investigational drugs",
                "criterions": [
                    {
                        "exact_snippets": "No prior systemic treatment for Non-Small-Cell Lung Cancer (NSCLC) with chemotherapy",
                        "criterion": "prior systemic treatment with chemotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No prior systemic treatment for Non-Small-Cell Lung Cancer (NSCLC) with ... immunotherapy",
                        "criterion": "prior systemic treatment with immunotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No prior systemic treatment for Non-Small-Cell Lung Cancer (NSCLC) with ... biologic response modifiers",
                        "criterion": "prior systemic treatment with biologic response modifiers",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No prior systemic treatment for Non-Small-Cell Lung Cancer (NSCLC) with ... other investigational drugs",
                        "criterion": "prior systemic treatment with other investigational drugs",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No prior systemic treatment for Non-Small-Cell Lung Cancer (NSCLC) with chemotherapy",
                        "criterion": "prior systemic treatment with chemotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No prior systemic treatment for Non-Small-Cell Lung Cancer (NSCLC) with ... immunotherapy",
                        "criterion": "prior systemic treatment with immunotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No prior systemic treatment for Non-Small-Cell Lung Cancer (NSCLC) with ... biologic response modifiers",
                        "criterion": "prior systemic treatment with biologic response modifiers",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No prior systemic treatment for Non-Small-Cell Lung Cancer (NSCLC) with ... other investigational drugs",
                        "criterion": "prior systemic treatment with other investigational drugs",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Small cell or carcinoid lung cancer",
                "criterions": [
                    {
                        "exact_snippets": "Small cell ... lung cancer",
                        "criterion": "small cell lung cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "carcinoid lung cancer",
                        "criterion": "carcinoid lung cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Small cell ... lung cancer",
                        "criterion": "small cell lung cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "carcinoid lung cancer",
                        "criterion": "carcinoid lung cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Known Central Nervous System (CNS) metastasis",
                "criterions": [
                    {
                        "exact_snippets": "Known Central Nervous System (CNS) metastasis",
                        "criterion": "Central Nervous System (CNS) metastasis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Known Central Nervous System (CNS) metastasis",
                    "criterion": "Central Nervous System (CNS) metastasis",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Pre-existing auto-immune or antibody mediated diseases",
                "criterions": [
                    {
                        "exact_snippets": "Pre-existing auto-immune or antibody mediated diseases",
                        "criterion": "auto-immune diseases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "Pre-existing auto-immune or antibody mediated diseases",
                        "criterion": "antibody mediated diseases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Pre-existing auto-immune or antibody mediated diseases",
                        "criterion": "auto-immune diseases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "Pre-existing auto-immune or antibody mediated diseases",
                        "criterion": "antibody mediated diseases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "identified_line": {
                "line": "* Eastern Cooperative Oncology Performance Status (ECOG PS) 0 or 1",
                "criterions": [
                    {
                        "exact_snippets": "Eastern Cooperative Oncology Performance Status (ECOG PS) 0 or 1",
                        "criterion": "Eastern Cooperative Oncology Performance Status (ECOG PS)",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": [
                                "0",
                                "1"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Eastern Cooperative Oncology Performance Status (ECOG PS) 0 or 1",
                        "criterion": "Eastern Cooperative Oncology Performance Status (ECOG PS)",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": "0"
                        }
                    },
                    {
                        "exact_snippets": "Eastern Cooperative Oncology Performance Status (ECOG PS) 0 or 1",
                        "criterion": "Eastern Cooperative Oncology Performance Status (ECOG PS)",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": "1"
                        }
                    }
                ]
            }
        }
    ],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}