{
    "info": {
        "nct_id": "NCT00227773",
        "official_title": "Phase II Study of Vatalanib and Octreotide in Patients With Progressive Low-Grade Neuroendocrine Tumors",
        "inclusion_criteria": "Healthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 120 Years",
        "exclusion_criteria": "",
        "miscellaneous_criteria": "DISEASE CHARACTERISTICS:\n\n* Histologically confirmed low-grade neuroendocrine tumors\n* The following tumor types are excluded:\n* Small cell lung cancer\n* Medullary thyroid cancer\n* Paraganglioma\n* Pheochromocytoma\n* Measurable disease\n* Radiographic evidence of disease progression after completion of any prior systemic therapy, chemoembolization, bland embolization, or observation within the past year, defined as either of the following:\n* Appearance of a new lesion\n* At least 20% increase in the longest diameter (LD) of any previously documented lesion or an increase in the sum of the LDs of multiple lesions in the aggregate of 20%\n\nPATIENT CHARACTERISTICS:\n\nAge\n\n* 18 and over\n\nPerformance status\n\n* ECOG 0-2\n\nLife expectancy\n\n* Not specified\n\nHematopoietic\n\n* Absolute neutrophil count ≥ 1,000/mm^3\n* Platelet count ≥ 75,000/mm^3\n* Hemoglobin ≥ 8.0 g/dL\n\nHepatic\n\n* Bilirubin ≤ 2.0 times upper limit of normal (ULN)\n* AST ≤ 3 times ULN (5 times ULN if liver metastases are present)\n\nRenal\n\n* Creatinine ≤ 1.5 times ULN\n* Meets 1 of the following criteria:\n* Urine protein negative by dipstick\n* Urine protein:creatinine ratio < 1.0\n* Urine protein < 1 g by 24-hour urine collection\n\nGastrointestinal\n\n* Must be able to swallow tablets\n* No ulcerative disease\n* No uncontrolled nausea, vomiting, or diarrhea\n* No bowel obstruction\n* No other gastrointestinal tract disease resulting in an inability to take oral medication\n\nOther\n\n* Not pregnant or nursing\n* Negative pregnancy test\n* Fertile patients must use effective contraception\n* Must be able to receive a contrast-enhanced CT scan\n* No known history of allergic reaction to vatalanib or its derivatives or octreotide injections\n\nPRIOR CONCURRENT THERAPY:\n\nBiologic therapy\n\n* Not specified\n\nChemotherapy\n\n* At least 4 weeks since prior chemotherapy\n* No more than 1 prior systemic chemotherapy regimen\n* Chemoembolization is not considered systemic chemotherapy\n* No concurrent chemotherapy\n\nEndocrine therapy\n\n* Not specified\n\nRadiotherapy\n\n* At least 3 weeks since prior radiotherapy\n* No concurrent radiotherapy\n\nSurgery\n\n* At least 4 weeks since prior major surgery\n\nOther\n\n* At least 4 weeks since other prior systemic therapy\n* At least 4 weeks since prior local liver therapy\n* No prior anti-vascular endothelial growth factor agents\n* No concurrent grapefruit or grapefruit juice\n* No concurrent therapeutic warfarin or similar oral anticoagulants that are metabolized by the cytochrome P450 system\n* Concurrent heparin allowed"
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have maximum age of 120 Years",
                "criterions": [
                    {
                        "exact_snippets": "maximum age of 120 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 120,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "maximum age of 120 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 120,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [],
    "miscellaneous_lines": [
        {
            "identified_line": {
                "line": "DISEASE CHARACTERISTICS:",
                "criterions": [
                    {
                        "exact_snippets": "DISEASE CHARACTERISTICS",
                        "criterion": "disease characteristics",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "DISEASE CHARACTERISTICS",
                        "criterion": "disease characteristics",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Histologically confirmed low-grade neuroendocrine tumors",
                "criterions": [
                    {
                        "exact_snippets": "Histologically confirmed low-grade neuroendocrine tumors",
                        "criterion": "neuroendocrine tumors",
                        "requirement": {
                            "requirement_type": "grade",
                            "expected_value": "low"
                        }
                    },
                    {
                        "exact_snippets": "Histologically confirmed low-grade neuroendocrine tumors",
                        "criterion": "neuroendocrine tumors",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": "histologically"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Histologically confirmed low-grade neuroendocrine tumors",
                        "criterion": "neuroendocrine tumors",
                        "requirement": {
                            "requirement_type": "grade",
                            "expected_value": "low"
                        }
                    },
                    {
                        "exact_snippets": "Histologically confirmed low-grade neuroendocrine tumors",
                        "criterion": "neuroendocrine tumors",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": "histologically"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* The following tumor types are excluded:",
                "criterions": [
                    {
                        "exact_snippets": "The following tumor types are excluded",
                        "criterion": "tumor types",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "The following tumor types are excluded",
                    "criterion": "tumor types",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Small cell lung cancer",
                "criterions": [
                    {
                        "exact_snippets": "Small cell lung cancer",
                        "criterion": "small cell lung cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Small cell lung cancer",
                        "criterion": "small cell lung cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Medullary thyroid cancer",
                "criterions": [
                    {
                        "exact_snippets": "Medullary thyroid cancer",
                        "criterion": "medullary thyroid cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Medullary thyroid cancer",
                        "criterion": "medullary thyroid cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Paraganglioma",
                "criterions": [
                    {
                        "exact_snippets": "Paraganglioma",
                        "criterion": "paraganglioma",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Paraganglioma",
                        "criterion": "paraganglioma",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Pheochromocytoma",
                "criterions": [
                    {
                        "exact_snippets": "Pheochromocytoma",
                        "criterion": "pheochromocytoma",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Pheochromocytoma",
                        "criterion": "pheochromocytoma",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Measurable disease",
                "criterions": [
                    {
                        "exact_snippets": "Measurable disease",
                        "criterion": "disease",
                        "requirement": {
                            "requirement_type": "measurability",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Measurable disease",
                        "criterion": "disease",
                        "requirement": {
                            "requirement_type": "measurability",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Radiographic evidence of disease progression after completion of any prior systemic therapy, chemoembolization, bland embolization, or observation within the past year, defined as either of the following:",
                "criterions": [
                    {
                        "exact_snippets": "Radiographic evidence of disease progression after completion of any prior systemic therapy",
                        "criterion": "disease progression after systemic therapy",
                        "requirement": {
                            "requirement_type": "evidence",
                            "expected_value": "radiographic"
                        }
                    },
                    {
                        "exact_snippets": "Radiographic evidence of disease progression after completion of any prior ... chemoembolization",
                        "criterion": "disease progression after chemoembolization",
                        "requirement": {
                            "requirement_type": "evidence",
                            "expected_value": "radiographic"
                        }
                    },
                    {
                        "exact_snippets": "Radiographic evidence of disease progression after completion of any prior ... bland embolization",
                        "criterion": "disease progression after bland embolization",
                        "requirement": {
                            "requirement_type": "evidence",
                            "expected_value": "radiographic"
                        }
                    },
                    {
                        "exact_snippets": "Radiographic evidence of disease progression after completion of any prior ... observation within the past year",
                        "criterion": "disease progression after observation",
                        "requirement": {
                            "requirement_type": "evidence",
                            "expected_value": "radiographic"
                        }
                    },
                    {
                        "exact_snippets": "Radiographic evidence of disease progression after completion of any prior ... observation within the past year",
                        "criterion": "disease progression after observation",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": "within the past year"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "or_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "Radiographic evidence of disease progression after completion of any prior systemic therapy",
                                        "criterion": "disease progression after systemic therapy",
                                        "requirement": {
                                            "requirement_type": "evidence",
                                            "expected_value": "radiographic"
                                        }
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "Radiographic evidence of disease progression after completion of any prior ... chemoembolization",
                                        "criterion": "disease progression after chemoembolization",
                                        "requirement": {
                                            "requirement_type": "evidence",
                                            "expected_value": "radiographic"
                                        }
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "Radiographic evidence of disease progression after completion of any prior ... bland embolization",
                                        "criterion": "disease progression after bland embolization",
                                        "requirement": {
                                            "requirement_type": "evidence",
                                            "expected_value": "radiographic"
                                        }
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "Radiographic evidence of disease progression after completion of any prior ... observation within the past year",
                                        "criterion": "disease progression after observation",
                                        "requirement": {
                                            "requirement_type": "evidence",
                                            "expected_value": "radiographic"
                                        }
                                    },
                                    {
                                        "exact_snippets": "Radiographic evidence of disease progression after completion of any prior ... observation within the past year",
                                        "criterion": "disease progression after observation",
                                        "requirement": {
                                            "requirement_type": "time frame",
                                            "expected_value": "within the past year"
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Appearance of a new lesion",
                "criterions": [
                    {
                        "exact_snippets": "Appearance of a new lesion",
                        "criterion": "new lesion",
                        "requirement": {
                            "requirement_type": "appearance",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Appearance of a new lesion",
                        "criterion": "new lesion",
                        "requirement": {
                            "requirement_type": "appearance",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* At least 20% increase in the longest diameter (LD) of any previously documented lesion or an increase in the sum of the LDs of multiple lesions in the aggregate of 20%",
                "criterions": [
                    {
                        "exact_snippets": "At least 20% increase in the longest diameter (LD) of any previously documented lesion",
                        "criterion": "increase in longest diameter of any previously documented lesion",
                        "requirement": {
                            "requirement_type": "percentage increase",
                            "expected_value": {
                                "operator": ">=",
                                "value": 20,
                                "unit": "%"
                            }
                        }
                    },
                    {
                        "exact_snippets": "an increase in the sum of the LDs of multiple lesions in the aggregate of 20%",
                        "criterion": "increase in the sum of the longest diameters of multiple lesions",
                        "requirement": {
                            "requirement_type": "percentage increase",
                            "expected_value": {
                                "operator": ">=",
                                "value": 20,
                                "unit": "%"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "At least 20% increase in the longest diameter (LD) of any previously documented lesion",
                        "criterion": "increase in longest diameter of any previously documented lesion",
                        "requirement": {
                            "requirement_type": "percentage increase",
                            "expected_value": {
                                "operator": ">=",
                                "value": 20,
                                "unit": "%"
                            }
                        }
                    },
                    {
                        "exact_snippets": "an increase in the sum of the LDs of multiple lesions in the aggregate of 20%",
                        "criterion": "increase in the sum of the longest diameters of multiple lesions",
                        "requirement": {
                            "requirement_type": "percentage increase",
                            "expected_value": {
                                "operator": ">=",
                                "value": 20,
                                "unit": "%"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Age",
                "criterions": [
                    {
                        "exact_snippets": "Age",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Age",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* 18 and over",
                "criterions": [
                    {
                        "exact_snippets": "18 and over",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "18 and over",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Performance status",
                "criterions": [
                    {
                        "exact_snippets": "Performance status",
                        "criterion": "performance status",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Performance status",
                        "criterion": "performance status",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* ECOG 0-2",
                "criterions": [
                    {
                        "exact_snippets": "ECOG 0-2",
                        "criterion": "ECOG performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "ECOG 0-2",
                        "criterion": "ECOG performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Life expectancy",
                "criterions": [
                    {
                        "exact_snippets": "Life expectancy",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Life expectancy",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Hematopoietic",
                "criterions": [
                    {
                        "exact_snippets": "Hematopoietic",
                        "criterion": "hematopoietic system",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Hematopoietic",
                        "criterion": "hematopoietic system",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Absolute neutrophil count ≥ 1,000/mm^3",
                "criterions": [
                    {
                        "exact_snippets": "Absolute neutrophil count ≥ 1,000/mm^3",
                        "criterion": "absolute neutrophil count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1000,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Absolute neutrophil count ≥ 1,000/mm^3",
                        "criterion": "absolute neutrophil count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1000,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Platelet count ≥ 75,000/mm^3",
                "criterions": [
                    {
                        "exact_snippets": "Platelet count ≥ 75,000/mm^3",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 75000,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Platelet count ≥ 75,000/mm^3",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 75000,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Hemoglobin ≥ 8.0 g/dL",
                "criterions": [
                    {
                        "exact_snippets": "Hemoglobin ≥ 8.0 g/dL",
                        "criterion": "hemoglobin",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">=",
                                "value": 8.0,
                                "unit": "g/dL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Hemoglobin ≥ 8.0 g/dL",
                        "criterion": "hemoglobin",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">=",
                                "value": 8.0,
                                "unit": "g/dL"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Hepatic",
                "criterions": [
                    {
                        "exact_snippets": "Hepatic",
                        "criterion": "hepatic function",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Hepatic",
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                            "requirement_type": "presence",
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                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* AST ≤ 3 times ULN (5 times ULN if liver metastases are present)",
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                    {
                        "exact_snippets": "AST ≤ 3 times ULN (5 times ULN if liver metastases are present)",
                        "criterion": "AST level",
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                            "requirement_type": "quantity",
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                                    {
                                        "operator": "<=",
                                        "value": 3,
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                    {
                        "exact_snippets": "AST ≤ 3 times ULN (5 times ULN if liver metastases are present)",
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                                        "operator": "<=",
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                    {
                        "exact_snippets": "AST ≤ 3 times ULN (5 times ULN if liver metastases are present)",
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                            "requirement_type": "condition",
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                    }
                ]
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                "condition": {
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                        "requirement_type": "condition",
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                                {
                                    "operator": "<=",
                                    "value": 5,
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                        }
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                },
                "else_criteria": {
                    "exact_snippets": "AST ≤ 3 times ULN (5 times ULN if liver metastases are present)",
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                "line": "Renal",
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                    {
                        "exact_snippets": "Renal",
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                "and_criteria": [
                    {
                        "exact_snippets": "Renal",
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                ]
            }
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        {
            "identified_line": {
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                                "value": 1,
                                "unit": "criteria"
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                    {
                        "exact_snippets": "Meets 1 of the following criteria",
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            "identified_line": {
                "line": "* Urine protein negative by dipstick",
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                        "exact_snippets": "Urine protein negative by dipstick",
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                        "exact_snippets": "Urine protein negative by dipstick",
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                "line": "* Urine protein:creatinine ratio < 1.0",
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                                "value": 1.0,
                                "unit": "N/A"
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                    {
                        "exact_snippets": "Urine protein:creatinine ratio < 1.0",
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                            "requirement_type": "value",
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        {
            "identified_line": {
                "line": "* Urine protein < 1 g by 24-hour urine collection",
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                        "exact_snippets": "Urine protein < 1 g by 24-hour urine collection",
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                                "operator": "<",
                                "value": 1,
                                "unit": "g"
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                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Urine protein < 1 g by 24-hour urine collection",
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                                "operator": "<",
                                "value": 1,
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            "identified_line": {
                "line": "Gastrointestinal",
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                    {
                        "exact_snippets": "Gastrointestinal",
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                    }
                ]
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                    {
                        "exact_snippets": "Gastrointestinal",
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        {
            "identified_line": {
                "line": "* Must be able to swallow tablets",
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                        "exact_snippets": "Must be able to swallow tablets",
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                            "requirement_type": "ability",
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            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Must be able to swallow tablets",
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                            "requirement_type": "ability",
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        {
            "identified_line": {
                "line": "* No uncontrolled nausea, vomiting, or diarrhea",
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                        "exact_snippets": "uncontrolled nausea",
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                        "exact_snippets": "uncontrolled ... vomiting",
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                            "requirement_type": "control",
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                    {
                        "exact_snippets": "uncontrolled ... diarrhea",
                        "criterion": "diarrhea",
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                                    "exact_snippets": "uncontrolled ... vomiting",
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                                    "exact_snippets": "uncontrolled ... diarrhea",
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                                        "requirement_type": "control",
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        {
            "identified_line": {
                "line": "* Negative pregnancy test",
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                        "exact_snippets": "Negative pregnancy test",
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                        "exact_snippets": "Negative pregnancy test",
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        {
            "identified_line": {
                "line": "* Fertile patients must use effective contraception",
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                    {
                        "exact_snippets": "Fertile patients",
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                            "requirement_type": "status",
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                    {
                        "exact_snippets": "must use effective contraception",
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                            "requirement_type": "necessity",
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            "logical_structure": {
                "condition": {
                    "exact_snippets": "Fertile patients",
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            "identified_line": {
                "line": "* Must be able to receive a contrast-enhanced CT scan",
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                        "exact_snippets": "Must be able to receive a contrast-enhanced CT scan",
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            "logical_structure": {
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                        "exact_snippets": "Must be able to receive a contrast-enhanced CT scan",
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            "identified_line": {
                "line": "* No known history of allergic reaction to vatalanib or its derivatives or octreotide injections",
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                        "exact_snippets": "No known history of allergic reaction to vatalanib",
                        "criterion": "allergic reaction to vatalanib",
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                            "requirement_type": "presence",
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                    {
                        "exact_snippets": "No known history of allergic reaction to ... octreotide injections",
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                        "exact_snippets": "No known history of allergic reaction to vatalanib",
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                        "exact_snippets": "No known history of allergic reaction to ... octreotide injections",
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        {
            "identified_line": {
                "line": "PRIOR CONCURRENT THERAPY:",
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                        "exact_snippets": "PRIOR CONCURRENT THERAPY",
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            "logical_structure": {
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                        "exact_snippets": "PRIOR CONCURRENT THERAPY",
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        {
            "identified_line": {
                "line": "Biologic therapy",
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                        "exact_snippets": "Biologic therapy",
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                        "exact_snippets": "Biologic therapy",
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                        "exact_snippets": "Chemotherapy",
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                                "unit": "weeks"
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            "identified_line": {
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                            "requirement_type": "quantity",
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                                "value": 1,
                                "unit": "N/A"
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                        "exact_snippets": "No more than 1 prior systemic chemotherapy regimen",
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        {
            "identified_line": {
                "line": "* Chemoembolization is not considered systemic chemotherapy",
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                        "exact_snippets": "Chemoembolization is not considered systemic chemotherapy",
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                        "exact_snippets": "Chemoembolization is not considered systemic chemotherapy",
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            "identified_line": {
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                        "exact_snippets": "Endocrine therapy",
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        {
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            "logical_structure": {
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                        "exact_snippets": "Radiotherapy",
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        {
            "identified_line": {
                "line": "* At least 3 weeks since prior radiotherapy",
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                        "exact_snippets": "At least 3 weeks since prior radiotherapy",
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                            "requirement_type": "duration",
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                                "operator": ">=",
                                "value": 3,
                                "unit": "weeks"
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                ]
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            "logical_structure": {
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                        "exact_snippets": "At least 3 weeks since prior radiotherapy",
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                            "requirement_type": "duration",
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                                "operator": ">=",
                                "value": 3,
                                "unit": "weeks"
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                ]
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        {
            "identified_line": {
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            "logical_structure": {
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                        "exact_snippets": "Surgery",
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                ]
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        },
        {
            "identified_line": {
                "line": "* At least 4 weeks since prior major surgery",
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                    {
                        "exact_snippets": "At least 4 weeks since prior major surgery",
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                            "requirement_type": "time elapsed",
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                                "operator": ">=",
                                "value": 4,
                                "unit": "weeks"
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                ]
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            "logical_structure": {
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                        "exact_snippets": "At least 4 weeks since prior major surgery",
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                            "requirement_type": "time elapsed",
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                                "operator": ">=",
                                "value": 4,
                                "unit": "weeks"
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                ]
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        },
        {
            "identified_line": {
                "line": "* At least 4 weeks since other prior systemic therapy",
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                    {
                        "exact_snippets": "At least 4 weeks since other prior systemic therapy",
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                            "requirement_type": "duration",
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                                "operator": ">=",
                                "value": 4,
                                "unit": "weeks"
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            "logical_structure": {
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                        "exact_snippets": "At least 4 weeks since other prior systemic therapy",
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                            "requirement_type": "duration",
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                                "operator": ">=",
                                "value": 4,
                                "unit": "weeks"
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        },
        {
            "identified_line": {
                "line": "* At least 4 weeks since prior local liver therapy",
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                    {
                        "exact_snippets": "At least 4 weeks since prior local liver therapy",
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                            "requirement_type": "time since",
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                                "operator": ">=",
                                "value": 4,
                                "unit": "weeks"
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                ]
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            "logical_structure": {
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                        "exact_snippets": "At least 4 weeks since prior local liver therapy",
                        "criterion": "time since prior local liver therapy",
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                            "requirement_type": "time since",
                            "expected_value": {
                                "operator": ">=",
                                "value": 4,
                                "unit": "weeks"
                            }
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                ]
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        },
        {
            "identified_line": {
                "line": "* No concurrent grapefruit or grapefruit juice",
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                    {
                        "exact_snippets": "No concurrent grapefruit or grapefruit juice",
                        "criterion": "grapefruit consumption",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No concurrent grapefruit or grapefruit juice",
                        "criterion": "grapefruit consumption",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No concurrent therapeutic warfarin or similar oral anticoagulants that are metabolized by the cytochrome P450 system",
                "criterions": [
                    {
                        "exact_snippets": "No concurrent therapeutic warfarin or similar oral anticoagulants",
                        "criterion": "concurrent therapeutic warfarin or similar oral anticoagulants",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "anticoagulants that are metabolized by the cytochrome P450 system",
                        "criterion": "anticoagulants metabolized by the cytochrome P450 system",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "No concurrent therapeutic warfarin or similar oral anticoagulants",
                                "criterion": "concurrent therapeutic warfarin or similar oral anticoagulants",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": false
                                }
                            },
                            {
                                "exact_snippets": "anticoagulants that are metabolized by the cytochrome P450 system",
                                "criterion": "anticoagulants metabolized by the cytochrome P450 system",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": false
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Concurrent heparin allowed",
                "criterions": [
                    {
                        "exact_snippets": "Concurrent heparin allowed",
                        "criterion": "heparin use",
                        "requirement": {
                            "requirement_type": "concurrent use",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Concurrent heparin allowed",
                        "criterion": "heparin use",
                        "requirement": {
                            "requirement_type": "concurrent use",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "PATIENT CHARACTERISTICS:",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "* Not specified",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "Other",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "* Not pregnant or nursing",
                "criterions": [
                    {
                        "exact_snippets": "Not pregnant",
                        "criterion": "pregnancy status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "not ... nursing",
                        "criterion": "nursing status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Not pregnant",
                        "criterion": "pregnancy status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "not ... nursing",
                        "criterion": "nursing status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Not specified",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "* Not specified",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "Other",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        }
    ],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": [
        {
            "identified_line": {
                "line": "* Bilirubin ≤ 2.0 times upper limit of normal (ULN)",
                "criterions": [
                    {
                        "exact_snippets": "Bilirubin ≤ 2.0 times upper limit of normal (ULN)",
                        "criterion": "bilirubin level",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2.0,
                                "unit": "times ULN"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Bilirubin \u0010 2.0 times upper limit of normal (ULN)",
                        "criterion": "bilirubin level",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2.0,
                                "unit": "times ULN"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Creatinine ≤ 1.5 times ULN",
                "criterions": [
                    {
                        "exact_snippets": "Creatinine ≤ 1.5 times ULN",
                        "criterion": "creatinine level",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.5,
                                "unit": "times ULN"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Creatinine \u0010.5 times ULN",
                        "criterion": "creatinine level",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.5,
                                "unit": "times ULN"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No ulcerative disease",
                "criterions": [
                    {
                        "exact_snippets": "No ulcerative disease",
                        "criterion": "ulcerative disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No ulcerative disease",
                    "criterion": "ulcerative disease",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* No bowel obstruction",
                "criterions": [
                    {
                        "exact_snippets": "No bowel obstruction",
                        "criterion": "bowel obstruction",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No bowel obstruction",
                    "criterion": "bowel obstruction",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* No other gastrointestinal tract disease resulting in an inability to take oral medication",
                "criterions": [
                    {
                        "exact_snippets": "No other gastrointestinal tract disease resulting in an inability to take oral medication",
                        "criterion": "gastrointestinal tract disease",
                        "requirement": {
                            "requirement_type": "resulting in an inability to take oral medication",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No other gastrointestinal tract disease resulting in an inability to take oral medication",
                    "criterion": "gastrointestinal tract disease",
                    "requirement": {
                        "requirement_type": "resulting in an inability to take oral medication",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* No concurrent radiotherapy",
                "criterions": [
                    {
                        "exact_snippets": "No concurrent radiotherapy",
                        "criterion": "concurrent radiotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No concurrent radiotherapy",
                    "criterion": "concurrent radiotherapy",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* No prior anti-vascular endothelial growth factor agents",
                "criterions": [
                    {
                        "exact_snippets": "No prior anti-vascular endothelial growth factor agents",
                        "criterion": "prior anti-vascular endothelial growth factor agents",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No prior anti-vascular endothelial growth factor agents",
                    "criterion": "prior anti-vascular endothelial growth factor agents",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        }
    ]
}