{
    "info": {
        "nct_id": "NCT00118131",
        "official_title": "Phase II Study of Weekly Docetaxel Together With Weekly Cisplatin in Chemotherapy-Naive Patients With Stage IV or Select Stage IIIB (Malignant Effusion) Non-Small Cell Lung Cancer",
        "inclusion_criteria": "Healthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 120 Years",
        "exclusion_criteria": "",
        "miscellaneous_criteria": "DISEASE CHARACTERISTICS:\n\n* Histologically or cytologically confirmed non-small cell lung cancer, meeting 1 of the following stage criteria:\n\n  * Stage IIIB disease with malignant pericardial or malignant pleural effusions, as indicated by 1 of the following:\n\n    * Positive cytology\n    * Exudative effusion AND lactic dehydrogenase (LDH) > 200 IU with effusion/serum LDH ratio ≥ 0.6\n  * Stage IV disease\n* Measurable disease, defined as ≥ 1 unidimensionally measurable lesion > 20 mm by conventional techniques OR > 10 mm by spiral CT scan\n* Brain metastases allowed provided they have been irradiated AND are radiographically stable for ≥ 28 days after the completion of radiotherapy\n\nPATIENT CHARACTERISTICS:\n\nAge\n\n* 18 and over\n\nPerformance status\n\n* ECOG 0-1\n\nLife expectancy\n\n* At least 12 weeks\n\nHematopoietic\n\n* Absolute neutrophil count ≥ 1,500/mm^3\n* Platelet count ≥ 100,000/mm^3\n* Hemoglobin ≥ 8.0 g/dL\n\nHepatic\n\n* AST and ALT normal\n* Bilirubin normal\n\nRenal\n\n* Creatinine clearance ≥ 50 mL/min\n\nImmunologic\n\n* No known HIV positivity\n* No history of severe hypersensitivity reaction to docetaxel or other drugs formulated with polysorbate 80\n* No clinically significant active infection\n\nOther\n\n* Not pregnant or nursing\n* Fertile patients must use effective contraception before, during, and for 4 weeks after completion of study treatment\n* No other primary malignancy within the past 5 years except adequately treated nonmelanoma skin cancer or carcinoma in situ of the cervix\n* No other serious systemic disorder that would preclude study participation\n* No other condition that would preclude study compliance\n\nPRIOR CONCURRENT THERAPY:\n\nBiologic therapy\n\n* Prior antibody-based therapy that targets growth factor pathways (e.g., epidermal growth factor receptor [EGFR]) allowed provided there is disease progression during therapy and patient has recovered\n* No concurrent immunotherapy\n* No concurrent prophylactic colony-stimulating factors\n* No concurrent interleukin-11\n\nChemotherapy\n\n* No prior cytotoxic chemotherapy\n* No other concurrent chemotherapy\n\nEndocrine therapy\n\n* No concurrent hormonal therapy for the malignancy\n\nRadiotherapy\n\n* See Disease Characteristics\n* More than 28 days since prior radiotherapy and recovered\n* No prior radiotherapy to ≥ 25% of the bone marrow\n* No prior radiotherapy to sites of measurable disease unless there is documented tumor progression after completion of radiotherapy\n* No concurrent radiotherapy\n\nSurgery\n\n* No concurrent surgery for the malignancy\n\nOther\n\n* More than 3 weeks since prior investigational drugs\n* Prior oral small molecule drug therapy that targets growth factor pathways (e.g., EGFR) allowed provided there is disease progression during therapy and patient has recovered\n* No other concurrent investigational or commercial agents or therapies for the malignancy"
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
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                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
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                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have maximum age of 120 Years",
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                        "exact_snippets": "maximum age of 120 Years",
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                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 120,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "maximum age of 120 Years",
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                            "expected_value": {
                                "operator": "<=",
                                "value": 120,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [],
    "miscellaneous_lines": [
        {
            "identified_line": {
                "line": "* Histologically or cytologically confirmed non-small cell lung cancer, meeting 1 of the following stage criteria:",
                "criterions": [
                    {
                        "exact_snippets": "Histologically or cytologically confirmed non-small cell lung cancer",
                        "criterion": "non-small cell lung cancer",
                        "requirement": {
                            "requirement_type": "confirmation method",
                            "expected_value": [
                                "histologically",
                                "cytologically"
                            ]
                        }
                    }
                ]
            },
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                        "exact_snippets": "Histologically or cytologically confirmed non-small cell lung cancer",
                        "criterion": "non-small cell lung cancer",
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                            "requirement_type": "confirmation method",
                            "expected_value": [
                                "histologically",
                                "cytologically"
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Stage IIIB disease with malignant pericardial or malignant pleural effusions, as indicated by 1 of the following:",
                "criterions": [
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                        "criterion": "disease stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": "IIIB"
                        }
                    },
                    {
                        "exact_snippets": "malignant pericardial ... effusions",
                        "criterion": "pericardial effusions",
                        "requirement": {
                            "requirement_type": "malignancy",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "malignant ... pleural effusions",
                        "criterion": "pleural effusions",
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                            "expected_value": true
                        }
                    }
                ]
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                            "expected_value": "IIIB"
                        }
                    },
                    {
                        "or_criteria": [
                            {
                                "exact_snippets": "malignant pericardial ... effusions",
                                "criterion": "pericardial effusions",
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                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "malignant ... pleural effusions",
                                "criterion": "pleural effusions",
                                "requirement": {
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                                    "expected_value": true
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Positive cytology",
                "criterions": [
                    {
                        "exact_snippets": "Positive cytology",
                        "criterion": "cytology",
                        "requirement": {
                            "requirement_type": "result",
                            "expected_value": "positive"
                        }
                    }
                ]
            },
            "logical_structure": {
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                        "exact_snippets": "Positive cytology",
                        "criterion": "cytology",
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                            "expected_value": "positive"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Exudative effusion AND lactic dehydrogenase (LDH) > 200 IU with effusion/serum LDH ratio ≥ 0.6",
                "criterions": [
                    {
                        "exact_snippets": "Exudative effusion",
                        "criterion": "exudative effusion",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "lactic dehydrogenase (LDH) > 200 IU",
                        "criterion": "lactic dehydrogenase (LDH)",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">",
                                "value": 200,
                                "unit": "IU"
                            }
                        }
                    },
                    {
                        "exact_snippets": "effusion/serum LDH ratio ≥ 0.6",
                        "criterion": "effusion/serum LDH ratio",
                        "requirement": {
                            "requirement_type": "ratio",
                            "expected_value": {
                                "operator": ">=",
                                "value": 0.6,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Exudative effusion",
                        "criterion": "exudative effusion",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "lactic dehydrogenase (LDH) > 200 IU",
                        "criterion": "lactic dehydrogenase (LDH)",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">",
                                "value": 200,
                                "unit": "IU"
                            }
                        }
                    },
                    {
                        "exact_snippets": "effusion/serum LDH ratio ≥ 0.6",
                        "criterion": "effusion/serum LDH ratio",
                        "requirement": {
                            "requirement_type": "ratio",
                            "expected_value": {
                                "operator": ">=",
                                "value": 0.6,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Stage IV disease",
                "criterions": [
                    {
                        "exact_snippets": "Stage IV disease",
                        "criterion": "disease stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": "IV"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Stage IV disease",
                        "criterion": "disease stage",
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                            "requirement_type": "stage",
                            "expected_value": "IV"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Measurable disease, defined as ≥ 1 unidimensionally measurable lesion > 20 mm by conventional techniques OR > 10 mm by spiral CT scan",
                "criterions": [
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                        "exact_snippets": "Measurable disease, defined as ≥ 1 unidimensionally measurable lesion > 20 mm by conventional techniques",
                        "criterion": "unidimensionally measurable lesion",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "N/A"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Measurable disease, defined as ≥ 1 unidimensionally measurable lesion > 20 mm by conventional techniques",
                        "criterion": "unidimensionally measurable lesion",
                        "requirement": {
                            "requirement_type": "size",
                            "expected_value": {
                                "operator": ">",
                                "value": 20,
                                "unit": "mm"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Measurable disease, defined as ... > 10 mm by spiral CT scan",
                        "criterion": "unidimensionally measurable lesion",
                        "requirement": {
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                                "value": 1,
                                "unit": "N/A"
                            }
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                                "unit": "mm"
                            }
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                ]
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                "or_criteria": [
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                        "and_criteria": [
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                                "exact_snippets": "Measurable disease, defined as ≥ 1 unidimensionally measurable lesion > 20 mm by conventional techniques",
                                "criterion": "unidimensionally measurable lesion",
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                                        "value": 1,
                                        "unit": "N/A"
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                            {
                                "exact_snippets": "Measurable disease, defined as ≥ 1 unidimensionally measurable lesion > 20 mm by conventional techniques",
                                "criterion": "unidimensionally measurable lesion",
                                "requirement": {
                                    "requirement_type": "size",
                                    "expected_value": {
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                    {
                        "and_criteria": [
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                                "exact_snippets": "Measurable disease, defined as ... > 10 mm by spiral CT scan",
                                "criterion": "unidimensionally measurable lesion",
                                "requirement": {
                                    "requirement_type": "quantity",
                                    "expected_value": {
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                                        "value": 1,
                                        "unit": "N/A"
                                    }
                                }
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                            {
                                "exact_snippets": "Measurable disease, defined as ... > 10 mm by spiral CT scan",
                                "criterion": "unidimensionally measurable lesion",
                                "requirement": {
                                    "requirement_type": "size",
                                    "expected_value": {
                                        "operator": ">",
                                        "value": 10,
                                        "unit": "mm"
                                    }
                                }
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                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Brain metastases allowed provided they have been irradiated AND are radiographically stable for ≥ 28 days after the completion of radiotherapy",
                "criterions": [
                    {
                        "exact_snippets": "Brain metastases allowed provided they have been irradiated",
                        "criterion": "brain metastases",
                        "requirement": {
                            "requirement_type": "irradiation",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Brain metastases ... are radiographically stable for ≥ 28 days after the completion of radiotherapy",
                        "criterion": "brain metastases",
                        "requirement": {
                            "requirement_type": "stability",
                            "expected_value": {
                                "operator": ">=",
                                "value": 28,
                                "unit": "days"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Brain metastases allowed provided they have been irradiated",
                        "criterion": "brain metastases",
                        "requirement": {
                            "requirement_type": "irradiation",
                            "expected_value": true
                        }
                    },
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                        "exact_snippets": "Brain metastases ... are radiographically stable for ≥ 28 days after the completion of radiotherapy",
                        "criterion": "brain metastases",
                        "requirement": {
                            "requirement_type": "stability",
                            "expected_value": {
                                "operator": ">=",
                                "value": 28,
                                "unit": "days"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Age",
                "criterions": [
                    {
                        "exact_snippets": "Age",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Age",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* 18 and over",
                "criterions": [
                    {
                        "exact_snippets": "18 and over",
                        "criterion": "age",
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                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
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            "logical_structure": {
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                        "exact_snippets": "18 and over",
                        "criterion": "age",
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                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Performance status",
                "criterions": [
                    {
                        "exact_snippets": "Performance status",
                        "criterion": "performance status",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
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            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Performance status",
                        "criterion": "performance status",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* ECOG 0-1",
                "criterions": [
                    {
                        "exact_snippets": "ECOG 0-1",
                        "criterion": "ECOG performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 1,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
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                        "exact_snippets": "ECOG 0-1",
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                            "requirement_type": "range",
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                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 1,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Life expectancy",
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                    {
                        "exact_snippets": "Life expectancy",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Life expectancy",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* At least 12 weeks",
                "criterions": [
                    {
                        "exact_snippets": "At least 12 weeks",
                        "criterion": "duration",
                        "requirement": {
                            "requirement_type": "minimum duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 12,
                                "unit": "weeks"
                            }
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                ]
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            "logical_structure": {
                "and_criteria": [
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                        "exact_snippets": "At least 12 weeks",
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                            "requirement_type": "minimum duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 12,
                                "unit": "weeks"
                            }
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                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Hematopoietic",
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                    {
                        "exact_snippets": "Hematopoietic",
                        "criterion": "hematopoietic system",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
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            "logical_structure": {
                "and_criteria": [
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                        "exact_snippets": "Hematopoietic",
                        "criterion": "hematopoietic system",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Absolute neutrophil count ≥ 1,500/mm^3",
                "criterions": [
                    {
                        "exact_snippets": "Absolute neutrophil count ≥ 1,500/mm^3",
                        "criterion": "absolute neutrophil count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1500,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
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            "logical_structure": {
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                        "exact_snippets": "Absolute neutrophil count ≥ 1,500/mm^3",
                        "criterion": "absolute neutrophil count",
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                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
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                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Platelet count ≥ 100,000/mm^3",
                "criterions": [
                    {
                        "exact_snippets": "Platelet count ≥ 100,000/mm^3",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 100000,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
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                        "exact_snippets": "Platelet count ≥ 100,000/mm^3",
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                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 100000,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Hemoglobin ≥ 8.0 g/dL",
                "criterions": [
                    {
                        "exact_snippets": "Hemoglobin ≥ 8.0 g/dL",
                        "criterion": "hemoglobin",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">=",
                                "value": 8.0,
                                "unit": "g/dL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Hemoglobin ≥ 8.0 g/dL",
                        "criterion": "hemoglobin",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">=",
                                "value": 8.0,
                                "unit": "g/dL"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Hepatic",
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                    {
                        "exact_snippets": "Hepatic",
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                    {
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        {
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                "line": "Renal",
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        },
        {
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                        "exact_snippets": "Immunologic",
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                ]
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                    {
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                    {
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                ]
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                        "exact_snippets": "PRIOR CONCURRENT THERAPY",
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                        "exact_snippets": "Surgery",
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                "line": "* More than 3 weeks since prior investigational drugs",
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                        "exact_snippets": "More than 3 weeks since prior investigational drugs",
                        "criterion": "time since prior investigational drugs",
                        "requirement": {
                            "requirement_type": "time elapsed",
                            "expected_value": {
                                "operator": ">",
                                "value": 3,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "More than 3 weeks since prior investigational drugs",
                        "criterion": "time since prior investigational drugs",
                        "requirement": {
                            "requirement_type": "time elapsed",
                            "expected_value": {
                                "operator": ">",
                                "value": 3,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No other concurrent investigational or commercial agents or therapies for the malignancy",
                "criterions": [
                    {
                        "exact_snippets": "No other concurrent investigational or commercial agents or therapies for the malignancy",
                        "criterion": "concurrent investigational or commercial agents or therapies",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No other concurrent investigational or commercial agents or therapies for the malignancy",
                    "criterion": "concurrent investigational or commercial agents or therapies",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "DISEASE CHARACTERISTICS:",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "PATIENT CHARACTERISTICS:",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "Other",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "* Not pregnant or nursing",
                "criterions": [
                    {
                        "exact_snippets": "Not pregnant",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "not ... nursing",
                        "criterion": "nursing",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Not pregnant",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "not ... nursing",
                        "criterion": "nursing",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Other",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        }
    ],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": [
        {
            "identified_line": {
                "line": "* No known HIV positivity",
                "criterions": [
                    {
                        "exact_snippets": "No known HIV positivity",
                        "criterion": "HIV status",
                        "requirement": {
                            "requirement_type": "positivity",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No known HIV positivity",
                    "criterion": "HIV status",
                    "requirement": {
                        "requirement_type": "positivity",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* No concurrent immunotherapy",
                "criterions": [
                    {
                        "exact_snippets": "No concurrent immunotherapy",
                        "criterion": "immunotherapy",
                        "requirement": {
                            "requirement_type": "concurrent use",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No concurrent immunotherapy",
                    "criterion": "immunotherapy",
                    "requirement": {
                        "requirement_type": "concurrent use",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* No concurrent prophylactic colony-stimulating factors",
                "criterions": [
                    {
                        "exact_snippets": "No concurrent prophylactic colony-stimulating factors",
                        "criterion": "prophylactic colony-stimulating factors",
                        "requirement": {
                            "requirement_type": "concurrent use",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No concurrent prophylactic colony-stimulating factors",
                    "criterion": "prophylactic colony-stimulating factors",
                    "requirement": {
                        "requirement_type": "concurrent use",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* No concurrent interleukin-11",
                "criterions": [
                    {
                        "exact_snippets": "No concurrent interleukin-11",
                        "criterion": "interleukin-11",
                        "requirement": {
                            "requirement_type": "concurrent use",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No concurrent interleukin-11",
                    "criterion": "interleukin-11",
                    "requirement": {
                        "requirement_type": "concurrent use",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* No prior cytotoxic chemotherapy",
                "criterions": [
                    {
                        "exact_snippets": "No prior cytotoxic chemotherapy",
                        "criterion": "prior cytotoxic chemotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No prior cytotoxic chemotherapy",
                    "criterion": "prior cytotoxic chemotherapy",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* No concurrent hormonal therapy for the malignancy",
                "criterions": [
                    {
                        "exact_snippets": "No concurrent hormonal therapy for the malignancy",
                        "criterion": "hormonal therapy",
                        "requirement": {
                            "requirement_type": "concurrency",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No concurrent hormonal therapy for the malignancy",
                    "criterion": "hormonal therapy",
                    "requirement": {
                        "requirement_type": "concurrency",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* No concurrent surgery for the malignancy",
                "criterions": [
                    {
                        "exact_snippets": "No concurrent surgery for the malignancy",
                        "criterion": "concurrent surgery for the malignancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No concurrent surgery for the malignancy",
                    "criterion": "concurrent surgery for the malignancy",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Prior oral small molecule drug therapy that targets growth factor pathways (e.g., EGFR) allowed provided there is disease progression during therapy and patient has recovered",
                "criterions": [
                    {
                        "exact_snippets": "Prior oral small molecule drug therapy that targets growth factor pathways (e.g., EGFR)",
                        "criterion": "prior oral small molecule drug therapy",
                        "requirement": {
                            "requirement_type": "target",
                            "expected_value": "growth factor pathways (e.g., EGFR)"
                        }
                    },
                    {
                        "exact_snippets": "Prior oral small molecule drug therapy that targets growth factor pathways (e.g., EGFR)",
                        "criterion": "prior oral small molecule drug therapy",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "allowed"
                        }
                    },
                    {
                        "exact_snippets": "disease progression during therapy",
                        "criterion": "disease progression",
                        "requirement": {
                            "requirement_type": "timing",
                            "expected_value": "during therapy"
                        }
                    },
                    {
                        "exact_snippets": "patient has recovered",
                        "criterion": "recovery",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        }
    ]
}