{
    "info": {
        "nct_id": "NCT00101348",
        "official_title": "A Phase I, and Biologic Correlative Study of Erlotinib, in Combination With Cetuximab and Bevacizumab in Patients With Metastatic Renal Cell Carcinoma",
        "inclusion_criteria": "* One of the following histologically confirmed diagnoses:\n\n  * Renal cell cancer\n\n    * Clear cell histology\n    * Metastatic or unresectable disease AND meets 1 of the following criteria:\n\n      * Recurrent disease\n      * Refractory to interleukin-2 (IL-2)- or interferon-based therapy\n      * Previously untreated AND not a candidate for IL-2-based therapy\n  * Colorectal, head and neck, pancreatic, or non-small cell lung cancer\n\n    * Metastatic or unresectable disease\n    * Progression after prior standard treatment\n* No evidence of CNS disease, including the following (part 2 only):\n\n  * Primary brain tumor\n  * Brain metastases\n* Paraffin embedded tumor blocks available\n* Performance status - ECOG 0-2\n* Performance status - Karnofsky 60-100%\n* More than 12 weeks\n* Absolute neutrophil count ≥ 1,500 mm^3\n* Platelet count ≥ 100,000 mm^3\n* Bilirubin ≤ 1.5 mg/dL\n* AST and ALT ≤ 2.5 times upper limit of normal (ULN) (5 times ULN if liver metastasis is present)\n* PTT and INR ≤ 1.5, unless receiving full-dose warfarin (part 2 only)\n* Creatinine ≤ 1.5 times ULN\n* Creatinine clearance ≥ 60 mL/min\n* Calcium < 10 mg/dL (hypocalcemic agents allowed)\n* No proteinuria*\n* Protein < 1 g on 24-hour urine collection*\n* No unstable angina pectoris\n* No cardiac arrhythmia\n* No symptomatic congestive heart failure\n* None of the following are allowed for part 2:\n\n  * Myocardial infarction within the past 6 months\n  * New York Heart Association class II-IV heart disease\n  * Serious cardiac arrhythmia requiring medication\n  * Peripheral vascular disease ≥ grade II\n  * Recent history of cerebrovascular accident\n  * Uncontrolled hypertension (blood pressure ≥ 150/85 mm Hg despite medication)\n  * Other clinically significant cardiovascular disease\n* No gastrointestinal (GI) tract disease resulting in an inability to take oral medication\n* No GI tract disease resulting in a requirement for IV alimentation\n* No active peptic ulcer disease\n* No history of allergic reaction attributed to compounds of similar chemical or biologic composition to study drugs\n* No known hypersensitivity to Chinese hamster ovary cell products or other recombinant human antibodies (part 2 only)\n* No ongoing or active infection\n* No active infection requiring parenteral antibiotics (part 2 only)\n* Not pregnant or nursing\n* Negative pregnancy test\n* Fertile patients must use effective contraception during and for 2 months after study treatment\n* No significant traumatic injury within the past 28 days (part 2 only)\n* No history of abnormalities of the cornea (e.g., dry eye syndrome, Sjögren's syndrome, or congenital abnormality [e.g., Fuch's dystrophy])\n* No other malignancy within the past 3 years except nonmelanoma skin cancer or carcinoma in situ of the breast or cervix\n* No psychiatric illness or social situation that would preclude study compliance\n* No serious or non-healing wound ulcer or bone fracture (part 2 only)\n* No other uncontrolled illness\n* See Disease Characteristics\n* More than 4 weeks since prior immunotherapy\n* No prior cetuximab\n* No prior bevacizumab\n* Concurrent epoetin alfa or darbepoetin alfa allowed\n* More than 4 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin)\n* More than 4 weeks since prior radiotherapy\n* No prior surgical procedures affecting absorption\n* Prior nephrectomy or resection of metastatic lesions allowed provided patient has fully recovered\n* More than 7 days since prior core biopsy*\n* More than 28 days since prior major surgery or open biopsy*\n* No concurrent major surgery*\n* Recovered from all prior therapy\n* No prior erlotinib\n* Concurrent bisphosphonates allowed\n* Concurrent full-dose anticoagulants allowed provided the following criteria are met (part 2 only):\n\n  * In-range INR (usually between 2 and 3) AND on a stable dose of warfarin or low molecular weight heparin\n  * No active bleeding\n  * No pathological conditions that carry a high risk of bleeding (e.g., tumor involving major vessels or varices)\n* No other concurrent investigational agents\n* No concurrent combination antiretroviral therapy for HIV-positive patients\n* No other concurrent anticancer therapy\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* One of the following histologically confirmed diagnoses:",
                "criterions": [
                    {
                        "exact_snippets": "One of the following histologically confirmed diagnoses",
                        "criterion": "histologically confirmed diagnosis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "or_criteria": [
                            {
                                "exact_snippets": "One of the following histologically confirmed diagnoses",
                                "criterion": "histologically confirmed diagnosis",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Renal cell cancer",
                "criterions": [
                    {
                        "exact_snippets": "Renal cell cancer",
                        "criterion": "renal cell cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Renal cell cancer",
                        "criterion": "renal cell cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Clear cell histology",
                "criterions": [
                    {
                        "exact_snippets": "Clear cell histology",
                        "criterion": "histology",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "clear cell"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Clear cell histology",
                        "criterion": "histology",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "clear cell"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Metastatic or unresectable disease AND meets 1 of the following criteria:",
                "criterions": [
                    {
                        "exact_snippets": "Metastatic or unresectable disease",
                        "criterion": "disease status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": [
                                "metastatic",
                                "unresectable"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Metastatic or unresectable disease",
                        "criterion": "disease status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": [
                                "metastatic",
                                "unresectable"
                            ]
                        }
                    },
                    {
                        "or_criteria": [
                            {
                                "exact_snippets": "meets 1 of the following criteria",
                                "criterion": "additional criteria",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Recurrent disease",
                "criterions": [
                    {
                        "exact_snippets": "Recurrent disease",
                        "criterion": "disease recurrence",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Recurrent disease",
                        "criterion": "disease recurrence",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Previously untreated AND not a candidate for IL-2-based therapy",
                "criterions": [
                    {
                        "exact_snippets": "Previously untreated",
                        "criterion": "treatment history",
                        "requirement": {
                            "requirement_type": "treatment status",
                            "expected_value": "untreated"
                        }
                    },
                    {
                        "exact_snippets": "not a candidate for IL-2-based therapy",
                        "criterion": "IL-2-based therapy candidacy",
                        "requirement": {
                            "requirement_type": "candidacy",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Previously untreated",
                        "criterion": "treatment history",
                        "requirement": {
                            "requirement_type": "treatment status",
                            "expected_value": "untreated"
                        }
                    },
                    {
                        "exact_snippets": "not a candidate for IL-2-based therapy",
                        "criterion": "IL-2-based therapy candidacy",
                        "requirement": {
                            "requirement_type": "candidacy",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Colorectal, head and neck, pancreatic, or non-small cell lung cancer",
                "criterions": [
                    {
                        "exact_snippets": "Colorectal",
                        "criterion": "cancer type",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": "colorectal"
                        }
                    },
                    {
                        "exact_snippets": "head and neck",
                        "criterion": "cancer type",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": "head and neck"
                        }
                    },
                    {
                        "exact_snippets": "pancreatic",
                        "criterion": "cancer type",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": "pancreatic"
                        }
                    },
                    {
                        "exact_snippets": "non-small cell lung",
                        "criterion": "cancer type",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": "non-small cell lung"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Colorectal",
                        "criterion": "cancer type",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": "colorectal"
                        }
                    },
                    {
                        "exact_snippets": "head and neck",
                        "criterion": "cancer type",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": "head and neck"
                        }
                    },
                    {
                        "exact_snippets": "pancreatic",
                        "criterion": "cancer type",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": "pancreatic"
                        }
                    },
                    {
                        "exact_snippets": "non-small cell lung",
                        "criterion": "cancer type",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": "non-small cell lung"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Metastatic or unresectable disease",
                "criterions": [
                    {
                        "exact_snippets": "Metastatic",
                        "criterion": "disease state",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": "metastatic"
                        }
                    },
                    {
                        "exact_snippets": "unresectable disease",
                        "criterion": "disease state",
                        "requirement": {
                            "requirement_type": "resectability",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Metastatic",
                        "criterion": "disease state",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": "metastatic"
                        }
                    },
                    {
                        "exact_snippets": "unresectable disease",
                        "criterion": "disease state",
                        "requirement": {
                            "requirement_type": "resectability",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Progression after prior standard treatment",
                "criterions": [
                    {
                        "exact_snippets": "Progression after prior standard treatment",
                        "criterion": "progression",
                        "requirement": {
                            "requirement_type": "after prior standard treatment",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Progression after prior standard treatment",
                        "criterion": "progression",
                        "requirement": {
                            "requirement_type": "after prior standard treatment",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No evidence of CNS disease, including the following (part 2 only):",
                "criterions": [
                    {
                        "exact_snippets": "No evidence of CNS disease",
                        "criterion": "CNS disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No evidence of CNS disease",
                        "criterion": "CNS disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Primary brain tumor",
                "criterions": [
                    {
                        "exact_snippets": "Primary brain tumor",
                        "criterion": "primary brain tumor",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Primary brain tumor",
                        "criterion": "primary brain tumor",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Brain metastases",
                "criterions": [
                    {
                        "exact_snippets": "Brain metastases",
                        "criterion": "brain metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Brain metastases",
                        "criterion": "brain metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Paraffin embedded tumor blocks available",
                "criterions": [
                    {
                        "exact_snippets": "Paraffin embedded tumor blocks available",
                        "criterion": "paraffin embedded tumor blocks",
                        "requirement": {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Paraffin embedded tumor blocks available",
                        "criterion": "paraffin embedded tumor blocks",
                        "requirement": {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Performance status - ECOG 0-2",
                "criterions": [
                    {
                        "exact_snippets": "Performance status - ECOG 0-2",
                        "criterion": "performance status",
                        "requirement": {
                            "requirement_type": "scale",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "ECOG"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "ECOG"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Performance status - ECOG 0-2",
                        "criterion": "performance status",
                        "requirement": {
                            "requirement_type": "scale",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "ECOG"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "ECOG"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Performance status - Karnofsky 60-100%",
                "criterions": [
                    {
                        "exact_snippets": "Performance status - Karnofsky 60-100%",
                        "criterion": "performance status",
                        "requirement": {
                            "requirement_type": "Karnofsky score",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 60,
                                        "unit": "%"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 100,
                                        "unit": "%"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Performance status - Karnofsky 60-100%",
                        "criterion": "performance status",
                        "requirement": {
                            "requirement_type": "Karnofsky score",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 60,
                                        "unit": "%"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 100,
                                        "unit": "%"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* More than 12 weeks",
                "criterions": [
                    {
                        "exact_snippets": "More than 12 weeks",
                        "criterion": "duration",
                        "requirement": {
                            "requirement_type": "length",
                            "expected_value": {
                                "operator": ">",
                                "value": 12,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "More than 12 weeks",
                        "criterion": "duration",
                        "requirement": {
                            "requirement_type": "length",
                            "expected_value": {
                                "operator": ">",
                                "value": 12,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Absolute neutrophil count ≥ 1,500 mm^3",
                "criterions": [
                    {
                        "exact_snippets": "Absolute neutrophil count ≥ 1,500 mm^3",
                        "criterion": "absolute neutrophil count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1500,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Absolute neutrophil count ≥ 1,500 mm^3",
                        "criterion": "absolute neutrophil count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1500,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Platelet count ≥ 100,000 mm^3",
                "criterions": [
                    {
                        "exact_snippets": "Platelet count ≥ 100,000 mm^3",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 100000,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Platelet count ≥ 100,000 mm^3",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 100000,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Bilirubin ≤ 1.5 mg/dL",
                "criterions": [
                    {
                        "exact_snippets": "Bilirubin ≤ 1.5 mg/dL",
                        "criterion": "bilirubin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.5,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Bilirubin ≤ 1.5 mg/dL",
                        "criterion": "bilirubin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.5,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* AST and ALT ≤ 2.5 times upper limit of normal (ULN) (5 times ULN if liver metastasis is present)",
                "criterions": [
                    {
                        "exact_snippets": "AST and ALT ≤ 2.5 times upper limit of normal (ULN)",
                        "criterion": "AST and ALT levels",
                        "requirement": {
                            "requirement_type": "comparison",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2.5,
                                "unit": "times ULN"
                            }
                        }
                    },
                    {
                        "exact_snippets": "AST and ALT ... (5 times ULN if liver metastasis is present)",
                        "criterion": "AST and ALT levels with liver metastasis",
                        "requirement": {
                            "requirement_type": "comparison",
                            "expected_value": {
                                "operator": "<=",
                                "value": 5,
                                "unit": "times ULN"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "exact_snippets": "liver metastasis",
                    "criterion": "liver metastasis",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                },
                "then_criteria": {
                    "exact_snippets": "AST and ALT ... (5 times ULN if liver metastasis is present)",
                    "criterion": "AST and ALT levels with liver metastasis",
                    "requirement": {
                        "requirement_type": "comparison",
                        "expected_value": {
                            "operator": "<=",
                            "value": 5,
                            "unit": "times ULN"
                        }
                    }
                },
                "else_criteria": {
                    "exact_snippets": "AST and ALT ≤ 2.5 times upper limit of normal (ULN)",
                    "criterion": "AST and ALT levels",
                    "requirement": {
                        "requirement_type": "comparison",
                        "expected_value": {
                            "operator": "<=",
                            "value": 2.5,
                            "unit": "times ULN"
                        }
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Creatinine ≤ 1.5 times ULN",
                "criterions": [
                    {
                        "exact_snippets": "Creatinine ≤ 1.5 times ULN",
                        "criterion": "creatinine level",
                        "requirement": {
                            "requirement_type": "comparison",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.5,
                                "unit": "times ULN"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Creatinine ≤ 1.5 times ULN",
                        "criterion": "creatinine level",
                        "requirement": {
                            "requirement_type": "comparison",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.5,
                                "unit": "times ULN"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Creatinine clearance ≥ 60 mL/min",
                "criterions": [
                    {
                        "exact_snippets": "Creatinine clearance ≥ 60 mL/min",
                        "criterion": "creatinine clearance",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">=",
                                "value": 60,
                                "unit": "mL/min"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Creatinine clearance ≥ 60 mL/min",
                        "criterion": "creatinine clearance",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">=",
                                "value": 60,
                                "unit": "mL/min"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Calcium < 10 mg/dL (hypocalcemic agents allowed)",
                "criterions": [
                    {
                        "exact_snippets": "Calcium < 10 mg/dL",
                        "criterion": "calcium level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 10,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Calcium < 10 mg/dL",
                        "criterion": "calcium level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 10,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No proteinuria*",
                "criterions": [
                    {
                        "exact_snippets": "No proteinuria",
                        "criterion": "proteinuria",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No proteinuria",
                        "criterion": "proteinuria",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Protein < 1 g on 24-hour urine collection*",
                "criterions": [
                    {
                        "exact_snippets": "Protein < 1 g on 24-hour urine collection",
                        "criterion": "protein in urine",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<",
                                "value": 1,
                                "unit": "g"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Protein < 1 g on 24-hour urine collection",
                        "criterion": "protein in urine",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<",
                                "value": 1,
                                "unit": "g"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No unstable angina pectoris",
                "criterions": [
                    {
                        "exact_snippets": "No unstable angina pectoris",
                        "criterion": "unstable angina pectoris",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No unstable angina pectoris",
                        "criterion": "unstable angina pectoris",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No cardiac arrhythmia",
                "criterions": [
                    {
                        "exact_snippets": "No cardiac arrhythmia",
                        "criterion": "cardiac arrhythmia",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No cardiac arrhythmia",
                        "criterion": "cardiac arrhythmia",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No symptomatic congestive heart failure",
                "criterions": [
                    {
                        "exact_snippets": "No symptomatic congestive heart failure",
                        "criterion": "symptomatic congestive heart failure",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No symptomatic congestive heart failure",
                    "criterion": "symptomatic congestive heart failure",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* None of the following are allowed for part 2:",
                "criterions": [
                    {
                        "exact_snippets": "None of the following are allowed for part 2",
                        "criterion": "part 2 eligibility",
                        "requirement": {
                            "requirement_type": "eligibility",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "None of the following are allowed for part 2",
                    "criterion": "part 2 eligibility",
                    "requirement": {
                        "requirement_type": "eligibility",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Myocardial infarction within the past 6 months",
                "criterions": [
                    {
                        "exact_snippets": "Myocardial infarction within the past 6 months",
                        "criterion": "myocardial infarction",
                        "requirement": {
                            "requirement_type": "time since event",
                            "expected_value": {
                                "operator": "<=",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Myocardial infarction within the past 6 months",
                        "criterion": "myocardial infarction",
                        "requirement": {
                            "requirement_type": "time since event",
                            "expected_value": {
                                "operator": "<=",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* New York Heart Association class II-IV heart disease",
                "criterions": [
                    {
                        "exact_snippets": "New York Heart Association class II-IV heart disease",
                        "criterion": "New York Heart Association heart disease class",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 2,
                                        "unit": "class"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 4,
                                        "unit": "class"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "New York Heart Association class II-IV heart disease",
                        "criterion": "New York Heart Association heart disease class",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 2,
                                        "unit": "class"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 4,
                                        "unit": "class"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Serious cardiac arrhythmia requiring medication",
                "criterions": [
                    {
                        "exact_snippets": "Serious cardiac arrhythmia requiring medication",
                        "criterion": "cardiac arrhythmia",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "serious"
                        }
                    },
                    {
                        "exact_snippets": "Serious cardiac arrhythmia requiring medication",
                        "criterion": "cardiac arrhythmia",
                        "requirement": {
                            "requirement_type": "treatment",
                            "expected_value": "medication"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Serious cardiac arrhythmia requiring medication",
                        "criterion": "cardiac arrhythmia",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "serious"
                        }
                    },
                    {
                        "exact_snippets": "Serious cardiac arrhythmia requiring medication",
                        "criterion": "cardiac arrhythmia",
                        "requirement": {
                            "requirement_type": "treatment",
                            "expected_value": "medication"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Peripheral vascular disease ≥ grade II",
                "criterions": [
                    {
                        "exact_snippets": "Peripheral vascular disease ≥ grade II",
                        "criterion": "peripheral vascular disease",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2,
                                "unit": "grade"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Peripheral vascular disease ≥ grade II",
                        "criterion": "peripheral vascular disease",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2,
                                "unit": "grade"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Recent history of cerebrovascular accident",
                "criterions": [
                    {
                        "exact_snippets": "Recent history of cerebrovascular accident",
                        "criterion": "cerebrovascular accident",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": "recent"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Recent history of cerebrovascular accident",
                        "criterion": "cerebrovascular accident",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": "recent"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Uncontrolled hypertension (blood pressure ≥ 150/85 mm Hg despite medication)",
                "criterions": [
                    {
                        "exact_snippets": "Uncontrolled hypertension",
                        "criterion": "hypertension",
                        "requirement": {
                            "requirement_type": "control",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "blood pressure ≥ 150/85 mm Hg despite medication",
                        "criterion": "blood pressure",
                        "requirement": {
                            "requirement_type": "measurement",
                            "expected_value": {
                                "operator": ">=",
                                "value": 150,
                                "unit": "mm Hg"
                            }
                        }
                    },
                    {
                        "exact_snippets": "blood pressure ≥ 150/85 mm Hg despite medication",
                        "criterion": "blood pressure",
                        "requirement": {
                            "requirement_type": "measurement",
                            "expected_value": {
                                "operator": ">=",
                                "value": 85,
                                "unit": "mm Hg"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Uncontrolled hypertension",
                                "criterion": "hypertension",
                                "requirement": {
                                    "requirement_type": "control",
                                    "expected_value": false
                                }
                            },
                            {
                                "or_criteria": [
                                    {
                                        "exact_snippets": "blood pressure ≥ 150/85 mm Hg despite medication",
                                        "criterion": "blood pressure",
                                        "requirement": {
                                            "requirement_type": "measurement",
                                            "expected_value": {
                                                "operator": ">=",
                                                "value": 150,
                                                "unit": "mm Hg"
                                            }
                                        }
                                    },
                                    {
                                        "exact_snippets": "blood pressure ≥ 150/85 mm Hg despite medication",
                                        "criterion": "blood pressure",
                                        "requirement": {
                                            "requirement_type": "measurement",
                                            "expected_value": {
                                                "operator": ">=",
                                                "value": 85,
                                                "unit": "mm Hg"
                                            }
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Other clinically significant cardiovascular disease",
                "criterions": [
                    {
                        "exact_snippets": "clinically significant cardiovascular disease",
                        "criterion": "cardiovascular disease",
                        "requirement": {
                            "requirement_type": "significance",
                            "expected_value": "clinically significant"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "clinically significant cardiovascular disease",
                        "criterion": "cardiovascular disease",
                        "requirement": {
                            "requirement_type": "significance",
                            "expected_value": "clinically significant"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No gastrointestinal (GI) tract disease resulting in an inability to take oral medication",
                "criterions": [
                    {
                        "exact_snippets": "No gastrointestinal (GI) tract disease resulting in an inability to take oral medication",
                        "criterion": "gastrointestinal (GI) tract disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No gastrointestinal (GI) tract disease resulting in an inability to take oral medication",
                        "criterion": "gastrointestinal (GI) tract disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No GI tract disease resulting in a requirement for IV alimentation",
                "criterions": [
                    {
                        "exact_snippets": "No GI tract disease resulting in a requirement for IV alimentation",
                        "criterion": "GI tract disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No GI tract disease resulting in a requirement for IV alimentation",
                        "criterion": "requirement for IV alimentation",
                        "requirement": {
                            "requirement_type": "necessity",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No GI tract disease resulting in a requirement for IV alimentation",
                        "criterion": "GI tract disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No GI tract disease resulting in a requirement for IV alimentation",
                        "criterion": "requirement for IV alimentation",
                        "requirement": {
                            "requirement_type": "necessity",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No active peptic ulcer disease",
                "criterions": [
                    {
                        "exact_snippets": "No active peptic ulcer disease",
                        "criterion": "peptic ulcer disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No active peptic ulcer disease",
                        "criterion": "peptic ulcer disease",
                        "requirement": {
                            "requirement_type": "activity",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No active peptic ulcer disease",
                        "criterion": "peptic ulcer disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No active peptic ulcer disease",
                        "criterion": "peptic ulcer disease",
                        "requirement": {
                            "requirement_type": "activity",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No history of allergic reaction attributed to compounds of similar chemical or biologic composition to study drugs",
                "criterions": [
                    {
                        "exact_snippets": "No history of allergic reaction attributed to compounds of similar chemical or biologic composition to study drugs",
                        "criterion": "allergic reaction history",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No history of allergic reaction attributed to compounds of similar chemical or biologic composition to study drugs",
                        "criterion": "allergic reaction history",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No known hypersensitivity to Chinese hamster ovary cell products or other recombinant human antibodies (part 2 only)",
                "criterions": [
                    {
                        "exact_snippets": "No known hypersensitivity to Chinese hamster ovary cell products",
                        "criterion": "hypersensitivity to Chinese hamster ovary cell products",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No known hypersensitivity to ... other recombinant human antibodies",
                        "criterion": "hypersensitivity to recombinant human antibodies",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "No known hypersensitivity to Chinese hamster ovary cell products",
                                "criterion": "hypersensitivity to Chinese hamster ovary cell products",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": false
                                }
                            },
                            {
                                "exact_snippets": "No known hypersensitivity to ... other recombinant human antibodies",
                                "criterion": "hypersensitivity to recombinant human antibodies",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": false
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No ongoing or active infection",
                "criterions": [
                    {
                        "exact_snippets": "No ongoing or active infection",
                        "criterion": "infection",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No ongoing or active infection",
                        "criterion": "infection",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No active infection requiring parenteral antibiotics (part 2 only)",
                "criterions": [
                    {
                        "exact_snippets": "No active infection",
                        "criterion": "active infection",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "requiring parenteral antibiotics",
                        "criterion": "parenteral antibiotics",
                        "requirement": {
                            "requirement_type": "requirement",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "No active infection",
                                "criterion": "active infection",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": false
                                }
                            },
                            {
                                "exact_snippets": "requiring parenteral antibiotics",
                                "criterion": "parenteral antibiotics",
                                "requirement": {
                                    "requirement_type": "requirement",
                                    "expected_value": false
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Negative pregnancy test",
                "criterions": [
                    {
                        "exact_snippets": "Negative pregnancy test",
                        "criterion": "pregnancy test",
                        "requirement": {
                            "requirement_type": "result",
                            "expected_value": "negative"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Negative pregnancy test",
                        "criterion": "pregnancy test",
                        "requirement": {
                            "requirement_type": "result",
                            "expected_value": "negative"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Fertile patients must use effective contraception during and for 2 months after study treatment",
                "criterions": [
                    {
                        "exact_snippets": "Fertile patients",
                        "criterion": "fertility",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "fertile"
                        }
                    },
                    {
                        "exact_snippets": "must use effective contraception",
                        "criterion": "contraception use",
                        "requirement": {
                            "requirement_type": "necessity",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "during and for 2 months after study treatment",
                        "criterion": "contraception duration",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": "during and for 2 months after study treatment"
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "exact_snippets": "Fertile patients",
                    "criterion": "fertility",
                    "requirement": {
                        "requirement_type": "status",
                        "expected_value": "fertile"
                    }
                },
                "then_criteria": {
                    "and_criteria": [
                        {
                            "exact_snippets": "must use effective contraception",
                            "criterion": "contraception use",
                            "requirement": {
                                "requirement_type": "necessity",
                                "expected_value": true
                            }
                        },
                        {
                            "exact_snippets": "during and for 2 months after study treatment",
                            "criterion": "contraception duration",
                            "requirement": {
                                "requirement_type": "duration",
                                "expected_value": "during and for 2 months after study treatment"
                            }
                        }
                    ]
                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* No significant traumatic injury within the past 28 days (part 2 only)",
                "criterions": [
                    {
                        "exact_snippets": "No significant traumatic injury within the past 28 days",
                        "criterion": "significant traumatic injury",
                        "requirement": {
                            "requirement_type": "time since occurrence",
                            "expected_value": {
                                "operator": "<",
                                "value": 28,
                                "unit": "days"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "No significant traumatic injury within the past 28 days",
                                "criterion": "significant traumatic injury",
                                "requirement": {
                                    "requirement_type": "time since occurrence",
                                    "expected_value": {
                                        "operator": "<",
                                        "value": 28,
                                        "unit": "days"
                                    }
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No history of abnormalities of the cornea (e.g., dry eye syndrome, Sjögren's syndrome, or congenital abnormality [e.g., Fuch's dystrophy])",
                "criterions": [
                    {
                        "exact_snippets": "No history of abnormalities of the cornea",
                        "criterion": "abnormalities of the cornea",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "dry eye syndrome",
                        "criterion": "dry eye syndrome",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "Sjögren's syndrome",
                        "criterion": "Sjögren's syndrome",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "congenital abnormality",
                        "criterion": "congenital abnormality of the cornea",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "Fuch's dystrophy",
                        "criterion": "Fuch's dystrophy",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "not_criteria": {
                            "or_criteria": [
                                {
                                    "and_criteria": [
                                        {
                                            "exact_snippets": "dry eye syndrome",
                                            "criterion": "dry eye syndrome",
                                            "requirement": {
                                                "requirement_type": "history",
                                                "expected_value": false
                                            }
                                        },
                                        {
                                            "exact_snippets": "Sjögren's syndrome",
                                            "criterion": "Sjögren's syndrome",
                                            "requirement": {
                                                "requirement_type": "history",
                                                "expected_value": false
                                            }
                                        },
                                        {
                                            "exact_snippets": "congenital abnormality",
                                            "criterion": "congenital abnormality of the cornea",
                                            "requirement": {
                                                "requirement_type": "history",
                                                "expected_value": false
                                            }
                                        },
                                        {
                                            "exact_snippets": "Fuch's dystrophy",
                                            "criterion": "Fuch's dystrophy",
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                                                "requirement_type": "history",
                                                "expected_value": false
                                            }
                                        }
                                    ]
                                }
                            ]
                        }
                    },
                    {
                        "exact_snippets": "No history of abnormalities of the cornea",
                        "criterion": "abnormalities of the cornea",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No other malignancy within the past 3 years except nonmelanoma skin cancer or carcinoma in situ of the breast or cervix",
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                    {
                        "exact_snippets": "No other malignancy within the past 3 years",
                        "criterion": "other malignancy",
                        "requirement": {
                            "requirement_type": "time frame",
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                                "operator": "<",
                                "value": 3,
                                "unit": "years"
                            }
                        }
                    },
                    {
                        "exact_snippets": "No other malignancy within the past 3 years",
                        "criterion": "other malignancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "except nonmelanoma skin cancer",
                        "criterion": "nonmelanoma skin cancer",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "except ... carcinoma in situ of the breast",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "except ... carcinoma in situ of the ... cervix",
                        "criterion": "carcinoma in situ of the cervix",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
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                        {
                            "and_criteria": [
                                {
                                    "exact_snippets": "No other malignancy within the past 3 years",
                                    "criterion": "other malignancy",
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                                        "requirement_type": "time frame",
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                                            "operator": "<",
                                            "value": 3,
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                                        }
                                    }
                                },
                                {
                                    "exact_snippets": "No other malignancy within the past 3 years",
                                    "criterion": "other malignancy",
                                    "requirement": {
                                        "requirement_type": "presence",
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                                    }
                                }
                            ]
                        },
                        {
                            "not_criteria": {
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                                    {
                                        "exact_snippets": "except nonmelanoma skin cancer",
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                                        }
                                    },
                                    {
                                        "exact_snippets": "except ... carcinoma in situ of the breast",
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                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "except ... carcinoma in situ of the ... cervix",
                                        "criterion": "carcinoma in situ of the cervix",
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                                            "requirement_type": "presence",
                                            "expected_value": true
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                                    }
                                ]
                            }
                        }
                    ]
                },
                "then_criteria": null,
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* No psychiatric illness or social situation that would preclude study compliance",
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                    {
                        "exact_snippets": "No psychiatric illness",
                        "criterion": "psychiatric illness",
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                            "requirement_type": "presence",
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                    },
                    {
                        "exact_snippets": "No ... social situation that would preclude study compliance",
                        "criterion": "social situation",
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                            "requirement_type": "impact on study compliance",
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                        }
                    }
                ]
            },
            "logical_structure": {
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                    {
                        "exact_snippets": "No psychiatric illness",
                        "criterion": "psychiatric illness",
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                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No ... social situation that would preclude study compliance",
                        "criterion": "social situation",
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                            "requirement_type": "impact on study compliance",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No serious or non-healing wound ulcer or bone fracture (part 2 only)",
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                    {
                        "exact_snippets": "No serious or non-healing wound",
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                            "requirement_type": "severity",
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                    {
                        "exact_snippets": "No serious or non-healing wound",
                        "criterion": "wound",
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                            "requirement_type": "healing status",
                            "expected_value": "healing"
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                    {
                        "exact_snippets": "No serious or non-healing ... ulcer",
                        "criterion": "ulcer",
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                            "requirement_type": "severity",
                            "expected_value": "not serious"
                        }
                    },
                    {
                        "exact_snippets": "No serious or non-healing ... ulcer",
                        "criterion": "ulcer",
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                            "requirement_type": "healing status",
                            "expected_value": "healing"
                        }
                    },
                    {
                        "exact_snippets": "No serious or non-healing ... bone fracture",
                        "criterion": "bone fracture",
                        "requirement": {
                            "requirement_type": "severity",
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                    },
                    {
                        "exact_snippets": "No serious or non-healing ... bone fracture",
                        "criterion": "bone fracture",
                        "requirement": {
                            "requirement_type": "healing status",
                            "expected_value": "healing"
                        }
                    }
                ]
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                                "and_criteria": [
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                                            "expected_value": "not serious"
                                        }
                                    },
                                    {
                                        "exact_snippets": "No serious or non-healing wound",
                                        "criterion": "wound",
                                        "requirement": {
                                            "requirement_type": "healing status",
                                            "expected_value": "healing"
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                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "No serious or non-healing ... ulcer",
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                                        "exact_snippets": "No serious or non-healing ... ulcer",
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                                            "requirement_type": "healing status",
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                                ]
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                                "and_criteria": [
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                                        "exact_snippets": "No serious or non-healing ... bone fracture",
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                                    {
                                        "exact_snippets": "No serious or non-healing ... bone fracture",
                                        "criterion": "bone fracture",
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                                            "requirement_type": "healing status",
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        {
            "identified_line": {
                "line": "* No other uncontrolled illness",
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                            "requirement_type": "presence",
                            "expected_value": false
                        }
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                        "exact_snippets": "No other uncontrolled illness",
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                            "expected_value": false
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                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* See Disease Characteristics",
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                    {
                        "exact_snippets": "Disease Characteristics",
                        "criterion": "disease characteristics",
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                            "requirement_type": "N/A",
                            "expected_value": "See Disease Characteristics"
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                    }
                ]
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                        "exact_snippets": "Disease Characteristics",
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                ]
            }
        },
        {
            "identified_line": {
                "line": "* More than 4 weeks since prior immunotherapy",
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                    {
                        "exact_snippets": "More than 4 weeks since prior immunotherapy",
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                            "requirement_type": "time elapsed",
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                                "operator": ">",
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                                "unit": "weeks"
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            "logical_structure": {
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                        "exact_snippets": "More than 4 weeks since prior immunotherapy",
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                            "requirement_type": "time elapsed",
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                                "operator": ">",
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                                "unit": "weeks"
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                ]
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        },
        {
            "identified_line": {
                "line": "* No prior cetuximab",
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                        "exact_snippets": "No prior cetuximab",
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                            "requirement_type": "presence",
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            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No prior cetuximab",
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                        "requirement_type": "presence",
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        {
            "identified_line": {
                "line": "* No prior bevacizumab",
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                    {
                        "exact_snippets": "No prior bevacizumab",
                        "criterion": "prior bevacizumab",
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                            "requirement_type": "presence",
                            "expected_value": false
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            "logical_structure": {
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                    "exact_snippets": "No prior bevacizumab",
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        },
        {
            "identified_line": {
                "line": "* Concurrent epoetin alfa or darbepoetin alfa allowed",
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                    {
                        "exact_snippets": "Concurrent epoetin alfa or darbepoetin alfa allowed",
                        "criterion": "epoetin alfa or darbepoetin alfa",
                        "requirement": {
                            "requirement_type": "concurrent use",
                            "expected_value": true
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            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Concurrent epoetin alfa or darbepoetin alfa allowed",
                        "criterion": "epoetin alfa or darbepoetin alfa",
                        "requirement": {
                            "requirement_type": "concurrent use",
                            "expected_value": true
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                    }
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        },
        {
            "identified_line": {
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                    {
                        "exact_snippets": "More than 4 weeks since prior chemotherapy",
                        "criterion": "prior chemotherapy",
                        "requirement": {
                            "requirement_type": "time since last treatment",
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                                "operator": ">",
                                "value": 4,
                                "unit": "weeks"
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                    {
                        "exact_snippets": "6 weeks for nitrosoureas or mitomycin",
                        "criterion": "prior nitrosoureas or mitomycin",
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                            "requirement_type": "time since last treatment",
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                                "operator": ">",
                                "value": 6,
                                "unit": "weeks"
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                ]
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                    {
                        "or_criteria": [
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                                "and_criteria": [
                                    {
                                        "exact_snippets": "More than 4 weeks since prior chemotherapy",
                                        "criterion": "prior chemotherapy",
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                                            "requirement_type": "time since last treatment",
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                                                "operator": ">",
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                                                "unit": "weeks"
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                                        }
                                    },
                                    {
                                        "not_criteria": {
                                            "exact_snippets": "6 weeks for nitrosoureas or mitomycin",
                                            "criterion": "prior nitrosoureas or mitomycin",
                                            "requirement": {
                                                "requirement_type": "time since last treatment",
                                                "expected_value": {
                                                    "operator": ">",
                                                    "value": 6,
                                                    "unit": "weeks"
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                            {
                                "and_criteria": [
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                                        "exact_snippets": "6 weeks for nitrosoureas or mitomycin",
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                                            "requirement_type": "time since last treatment",
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                                                "operator": ">",
                                                "value": 6,
                                                "unit": "weeks"
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                                        }
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        },
        {
            "identified_line": {
                "line": "* More than 4 weeks since prior radiotherapy",
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                    {
                        "exact_snippets": "More than 4 weeks since prior radiotherapy",
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                            "requirement_type": "time since",
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                                "operator": ">",
                                "value": 4,
                                "unit": "weeks"
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                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "More than 4 weeks since prior radiotherapy",
                        "criterion": "time since prior radiotherapy",
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                            "requirement_type": "time since",
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                                "operator": ">",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No prior surgical procedures affecting absorption",
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                    {
                        "exact_snippets": "No prior surgical procedures affecting absorption",
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                            "requirement_type": "effect on absorption",
                            "expected_value": false
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                    }
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            "logical_structure": {
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                    {
                        "exact_snippets": "No prior surgical procedures affecting absorption",
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                            "requirement_type": "effect on absorption",
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                    }
                ]
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        },
        {
            "identified_line": {
                "line": "* Prior nephrectomy or resection of metastatic lesions allowed provided patient has fully recovered",
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                    {
                        "exact_snippets": "provided patient has fully recovered",
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                            "requirement_type": "recovery status",
                            "expected_value": "fully recovered"
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            "logical_structure": {
                "condition": {
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                    "exact_snippets": "provided patient has fully recovered",
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            }
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            "identified_line": {
                "line": "* More than 7 days since prior core biopsy*",
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                        "exact_snippets": "More than 7 days since prior core biopsy",
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                            "requirement_type": "time elapsed",
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                                "operator": ">",
                                "value": 7,
                                "unit": "days"
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            "logical_structure": {
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                        "exact_snippets": "More than 7 days since prior core biopsy",
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                            "requirement_type": "time elapsed",
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                                "operator": ">",
                                "value": 7,
                                "unit": "days"
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                ]
            }
        },
        {
            "identified_line": {
                "line": "* More than 28 days since prior major surgery or open biopsy*",
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                    {
                        "exact_snippets": "More than 28 days since prior major surgery",
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                            "requirement_type": "time since",
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                                "operator": ">",
                                "value": 28,
                                "unit": "days"
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                    },
                    {
                        "exact_snippets": "More than 28 days since prior ... open biopsy",
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                            "requirement_type": "time since",
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                                "operator": ">",
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                                "unit": "days"
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                    }
                ]
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            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "More than 28 days since prior major surgery",
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                            "requirement_type": "time since",
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                                "operator": ">",
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                                "unit": "days"
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                    },
                    {
                        "exact_snippets": "More than 28 days since prior ... open biopsy",
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                            "requirement_type": "time since",
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                                "operator": ">",
                                "value": 28,
                                "unit": "days"
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                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No concurrent major surgery*",
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                        "exact_snippets": "No concurrent major surgery",
                        "criterion": "major surgery",
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                            "requirement_type": "concurrency",
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                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No concurrent major surgery",
                        "criterion": "major surgery",
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                            "requirement_type": "concurrency",
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                    }
                ]
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        },
        {
            "identified_line": {
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                        "exact_snippets": "Recovered from all prior therapy",
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                            "requirement_type": "status",
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                ]
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            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Recovered from all prior therapy",
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                            "requirement_type": "status",
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                ]
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        },
        {
            "identified_line": {
                "line": "* Concurrent bisphosphonates allowed",
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                    {
                        "exact_snippets": "Concurrent bisphosphonates allowed",
                        "criterion": "concurrent bisphosphonates",
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                            "requirement_type": "allowance",
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            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Concurrent bisphosphonates allowed",
                        "criterion": "concurrent bisphosphonates",
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                            "requirement_type": "allowance",
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                ]
            }
        },
        {
            "identified_line": {
                "line": "* Concurrent full-dose anticoagulants allowed provided the following criteria are met (part 2 only):",
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                    {
                        "exact_snippets": "Concurrent full-dose anticoagulants allowed",
                        "criterion": "concurrent full-dose anticoagulants",
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                            "requirement_type": "allowance",
                            "expected_value": true
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            "logical_structure": {
                "and_criteria": [
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                        "exact_snippets": "Concurrent full-dose anticoagulants allowed",
                        "criterion": "concurrent full-dose anticoagulants",
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                            "requirement_type": "allowance",
                            "expected_value": true
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                ]
            }
        },
        {
            "identified_line": {
                "line": "* In-range INR (usually between 2 and 3) AND on a stable dose of warfarin or low molecular weight heparin",
                "criterions": [
                    {
                        "exact_snippets": "In-range INR (usually between 2 and 3)",
                        "criterion": "INR",
                        "requirement": {
                            "requirement_type": "range",
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                                    {
                                        "operator": ">=",
                                        "value": 2,
                                        "unit": "N/A"
                                    },
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                                    }
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                        "exact_snippets": "on a stable dose of warfarin",
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                    {
                        "exact_snippets": "on a stable dose of ... low molecular weight heparin",
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                    {
                        "and_criteria": [
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                                "exact_snippets": "on a stable dose of warfarin",
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                                    "requirement_type": "stability",
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                            },
                            {
                                "exact_snippets": "on a stable dose of ... low molecular weight heparin",
                                "criterion": "low molecular weight heparin dose",
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                                    "requirement_type": "stability",
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                                }
                            }
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                    {
                        "exact_snippets": "In-range INR (usually between 2 and 3)",
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                                    {
                                        "operator": ">=",
                                        "value": 2,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 3,
                                        "unit": "N/A"
                                    }
                                ]
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                ]
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        },
        {
            "identified_line": {
                "line": "* No active bleeding",
                "criterions": [
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                        "exact_snippets": "No active bleeding",
                        "criterion": "active bleeding",
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                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
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                        "exact_snippets": "No active bleeding",
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                        }
                    }
                ]
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        },
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            "identified_line": {
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                "criterions": [
                    {
                        "exact_snippets": "No pathological conditions that carry a high risk of bleeding",
                        "criterion": "pathological conditions",
                        "requirement": {
                            "requirement_type": "risk of bleeding",
                            "expected_value": "low"
                        }
                    },
                    {
                        "exact_snippets": "tumor involving major vessels",
                        "criterion": "tumor",
                        "requirement": {
                            "requirement_type": "involvement of major vessels",
                            "expected_value": false
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                    },
                    {
                        "exact_snippets": "varices",
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                                    "exact_snippets": "No pathological conditions that carry a high risk of bleeding",
                                    "criterion": "pathological conditions",
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                                        "requirement_type": "risk of bleeding",
                                        "expected_value": "low"
                                    }
                                },
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                                            "exact_snippets": "tumor involving major vessels",
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                                            "requirement": {
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                                        {
                                            "exact_snippets": "varices",
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                                            }
                                        }
                                    ]
                                }
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No other concurrent investigational agents",
                "criterions": [
                    {
                        "exact_snippets": "No other concurrent investigational agents",
                        "criterion": "concurrent investigational agents",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
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        {
            "identified_line": {
                "line": "* No concurrent combination antiretroviral therapy for HIV-positive patients",
                "criterions": [
                    {
                        "exact_snippets": "No concurrent combination antiretroviral therapy for HIV-positive patients",
                        "criterion": "combination antiretroviral therapy",
                        "requirement": {
                            "requirement_type": "concurrency",
                            "expected_value": false
                        }
                    }
                ]
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            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No concurrent combination antiretroviral therapy for HIV-positive patients",
                        "criterion": "combination antiretroviral therapy",
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                            "requirement_type": "concurrency",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No other concurrent anticancer therapy",
                "criterions": [
                    {
                        "exact_snippets": "No other concurrent anticancer therapy",
                        "criterion": "concurrent anticancer therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No other concurrent anticancer therapy",
                        "criterion": "concurrent anticancer therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Not pregnant or nursing",
                "criterions": [
                    {
                        "exact_snippets": "Not pregnant",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "not ... nursing",
                        "criterion": "nursing",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Not pregnant",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "not ... nursing",
                        "criterion": "nursing",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "identified_line": {
                "line": "* Refractory to interleukin-2 (IL-2)- or interferon-based therapy",
                "criterions": [
                    {
                        "exact_snippets": "Refractory to interleukin-2 (IL-2)- or interferon-based therapy",
                        "criterion": "refractory to therapy",
                        "requirement": {
                            "requirement_type": "therapy type",
                            "expected_value": [
                                "interleukin-2 (IL-2)",
                                "interferon"
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                        }
                    }
                ]
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            "logical_structure": {
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                        "exact_snippets": "Refractory to interleukin-2 (IL-2)- or interferon-based therapy",
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                        "requirement": {
                            "requirement_type": "therapy type",
                            "expected_value": "interleukin-2 (IL-2)"
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                    {
                        "exact_snippets": "Refractory to interleukin-2 (IL-2)- or interferon-based therapy",
                        "criterion": "refractory to therapy",
                        "requirement": {
                            "requirement_type": "therapy type",
                            "expected_value": "interferon"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* PTT and INR ≤ 1.5, unless receiving full-dose warfarin (part 2 only)",
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                        "exact_snippets": "PTT ... ≤ 1.5",
                        "criterion": "PTT",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
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                                "value": 1.5,
                                "unit": "N/A"
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                    },
                    {
                        "exact_snippets": "INR ≤ 1.5",
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                            "requirement_type": "value",
                            "expected_value": {
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                                "unit": "N/A"
                            }
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                    },
                    {
                        "exact_snippets": "unless receiving full-dose warfarin (part 2 only)",
                        "criterion": "warfarin treatment",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
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                            "and_criteria": [
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                                    "exact_snippets": "PTT ... \u0014 1.5",
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                                    "requirement": {
                                        "requirement_type": "value",
                                        "expected_value": {
                                            "operator": "<=",
                                            "value": 1.5,
                                            "unit": "N/A"
                                        }
                                    }
                                },
                                {
                                    "exact_snippets": "INR \u0014 1.5",
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                                        "requirement_type": "value",
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                                            "value": 1.5,
                                            "unit": "N/A"
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                "line": "* No prior erlotinib",
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                        "exact_snippets": "No prior erlotinib",
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        }
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    "failed_exclusion": [],
    "failed_miscellaneous": []
}