{
    "info": {
        "nct_id": "NCT00096382",
        "official_title": "Treatment of Patients With Metastatic Melanoma Using a Transplant of Autologous Lymphocytes Reactive With Tumor Following a Myeloablative Lymphocyte Depleting Regimen of Chemotherapy, Total Body Irradiation and Reconstitution With CD34+ Cells",
        "inclusion_criteria": "Healthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "",
        "miscellaneous_criteria": "DISEASE CHARACTERISTICS:\n\n* Diagnosis of metastatic melanoma\n* Measurable disease\n* Resected or stable brain metastases are allowed\n\nPATIENT CHARACTERISTICS:\n\nAge\n\n* 18 and over\n\nPerformance status\n\n* Eastern Cooperative Oncology Group (ECOG) 0-1\n\nLife expectancy\n\n* At least 3 months\n\nHematopoietic\n\n* See Immunologic\n* Absolute neutrophil count > 1,000/mm^3 (without support of filgrastim [G-CSF])\n* Platelet count > 100,000/mm^3\n* Hemoglobin ≥ 8 g/dL (transfusion allowed)\n* No coagulation disorders\n\nHepatic\n\n* Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) < 3 times upper limit of normal\n* Bilirubin ≤ 2 mg/dL (< 3 mg/dL in patients with Gilbert's syndrome)\n* No hepatitis B or C\n\nRenal\n\n* Creatinine ≤ 1.6 mg/dL\n\nCardiovascular\n\n* Left ventricular ejection fraction (LVEF) ≥ 45% by cardiac stress test*\n* No active major cardiovascular illness as evidenced by stress thallium or other comparable test\n* No myocardial infarction\n* No cardiac arrhythmias NOTE: *For patients ≥ 50 years of age receiving high-dose interleukin-2 (IL-2) OR patients with a history of electrocardiogram (EKG) abnormalities, symptoms of cardiac ischemia, or arrhythmias\n\nPulmonary\n\n* Forced expiratory volume 1 (FEV_1) ≥ 60% of predicted by pulmonary function test in patients with prolonged history of cigarette smoking or symptoms of respiratory dysfunction*\n* No active major respiratory illness\n* No obstructive or restrictive pulmonary disease NOTE: *For patients receiving high-dose IL-2 only\n\nImmunologic\n\n* No active major immunologic illness\n* No active systemic infections\n* No primary or secondary immunodeficiency\n\n  * Fully recovered immune competence after prior chemotherapy or radiotherapy as evidenced by both of the following:\n\n    * Absolute neutrophil count > 1,000/mm^3\n    * No opportunistic infections\n* Human Immunodeficiency virus (HIV) negative\n* Epstein-Barr virus positive\n\nOther\n\n* Not pregnant or nursing\n* Fertile patients must use effective contraception during and for 4 months after study treatment\n\nPRIOR CONCURRENT THERAPY:\n\nBiologic therapy\n\n* See Disease Characteristics\n\nChemotherapy\n\n* At least 6 weeks since prior nitrosourea therapy\n* No prior cyclophosphamide and fludarabine as part of a preparative regimen on National Cancer Institute (NCI) Surgery Branch adoptive cell therapy studies unless sufficient numbers of CD34+ stem cells (more than 2 x10^6/kg patient weight) have been obtained prior to the administration of chemotherapy\n\nEndocrine therapy\n\n* No concurrent systemic steroid therapy\n\nRadiotherapy\n\n* Not specified\n\nSurgery\n\n* See Disease Characteristics\n* Prior minor surgery within the past 3 weeks allowed if recovered\n\nOther\n\n* Recovered from all prior therapy\n* At least 30 days since prior systemic therapy\n* No other concurrent experimental agents"
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [],
    "miscellaneous_lines": [
        {
            "identified_line": {
                "line": "* Diagnosis of metastatic melanoma",
                "criterions": [
                    {
                        "exact_snippets": "Diagnosis of metastatic melanoma",
                        "criterion": "metastatic melanoma",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Diagnosis of metastatic melanoma",
                        "criterion": "metastatic melanoma",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Measurable disease",
                "criterions": [
                    {
                        "exact_snippets": "Measurable disease",
                        "criterion": "disease",
                        "requirement": {
                            "requirement_type": "measurability",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Measurable disease",
                        "criterion": "disease",
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                            "requirement_type": "measurability",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Resected or stable brain metastases are allowed",
                "criterions": [
                    {
                        "exact_snippets": "Resected ... brain metastases are allowed",
                        "criterion": "brain metastases",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "resected"
                        }
                    },
                    {
                        "exact_snippets": "stable brain metastases are allowed",
                        "criterion": "brain metastases",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "stable"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
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                        "criterion": "brain metastases",
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                            "requirement_type": "status",
                            "expected_value": "resected"
                        }
                    },
                    {
                        "exact_snippets": "stable brain metastases are allowed",
                        "criterion": "brain metastases",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "stable"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Age",
                "criterions": [
                    {
                        "exact_snippets": "Age",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Age",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* 18 and over",
                "criterions": [
                    {
                        "exact_snippets": "18 and over",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "18 and over",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Performance status",
                "criterions": [
                    {
                        "exact_snippets": "Performance status",
                        "criterion": "performance status",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Performance status",
                        "criterion": "performance status",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Eastern Cooperative Oncology Group (ECOG) 0-1",
                "criterions": [
                    {
                        "exact_snippets": "Eastern Cooperative Oncology Group (ECOG) 0-1",
                        "criterion": "ECOG performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 1,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Eastern Cooperative Oncology Group (ECOG) 0-1",
                        "criterion": "ECOG performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 1,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Life expectancy",
                "criterions": [
                    {
                        "exact_snippets": "Life expectancy",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Life expectancy",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* At least 3 months",
                "criterions": [
                    {
                        "exact_snippets": "At least 3 months",
                        "criterion": "time since a specific event",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "At least 3 months",
                        "criterion": "time since a specific event",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Hematopoietic",
                "criterions": [
                    {
                        "exact_snippets": "Hematopoietic",
                        "criterion": "hematopoietic",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Hematopoietic",
                        "criterion": "hematopoietic",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* See Immunologic",
                "criterions": [
                    {
                        "exact_snippets": "See Immunologic",
                        "criterion": "immunologic condition",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "See Immunologic"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "See Immunologic",
                        "criterion": "immunologic condition",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "See Immunologic"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Absolute neutrophil count > 1,000/mm^3 (without support of filgrastim [G-CSF])",
                "criterions": [
                    {
                        "exact_snippets": "Absolute neutrophil count > 1,000/mm^3 (without support of filgrastim [G-CSF])",
                        "criterion": "absolute neutrophil count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 1000,
                                "unit": "mm^3"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Absolute neutrophil count > 1,000/mm^3 (without support of filgrastim [G-CSF])",
                        "criterion": "absolute neutrophil count",
                        "requirement": {
                            "requirement_type": "support",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Absolute neutrophil count > 1,000/mm^3 (without support of filgrastim [G-CSF])",
                                "criterion": "absolute neutrophil count",
                                "requirement": {
                                    "requirement_type": "quantity",
                                    "expected_value": {
                                        "operator": ">",
                                        "value": 1000,
                                        "unit": "mm^3"
                                    }
                                }
                            },
                            {
                                "exact_snippets": "Absolute neutrophil count > 1,000/mm^3 (without support of filgrastim [G-CSF])",
                                "criterion": "absolute neutrophil count",
                                "requirement": {
                                    "requirement_type": "support",
                                    "expected_value": false
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Platelet count > 100,000/mm^3",
                "criterions": [
                    {
                        "exact_snippets": "Platelet count > 100,000/mm^3",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 100000,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Platelet count > 100,000/mm^3",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 100000,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Hemoglobin ≥ 8 g/dL (transfusion allowed)",
                "criterions": [
                    {
                        "exact_snippets": "Hemoglobin ≥ 8 g/dL",
                        "criterion": "hemoglobin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">=",
                                "value": 8,
                                "unit": "g/dL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Hemoglobin ≥ 8 g/dL",
                        "criterion": "hemoglobin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">=",
                                "value": 8,
                                "unit": "g/dL"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No coagulation disorders",
                "criterions": [
                    {
                        "exact_snippets": "No coagulation disorders",
                        "criterion": "coagulation disorders",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No coagulation disorders",
                    "criterion": "coagulation disorders",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "Hepatic",
                "criterions": [
                    {
                        "exact_snippets": "Hepatic",
                        "criterion": "hepatic function",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Hepatic",
                        "criterion": "hepatic function",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) < 3 times upper limit of normal",
                "criterions": [
                    {
                        "exact_snippets": "Alanine aminotransferase (ALT) ... < 3 times upper limit of normal",
                        "criterion": "Alanine aminotransferase (ALT)",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 3,
                                "unit": "times upper limit of normal"
                            }
                        }
                    },
                    {
                        "exact_snippets": "aspartate aminotransferase (AST) < 3 times upper limit of normal",
                        "criterion": "aspartate aminotransferase (AST)",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 3,
                                "unit": "times upper limit of normal"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Alanine aminotransferase (ALT) ... < 3 times upper limit of normal",
                        "criterion": "Alanine aminotransferase (ALT)",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 3,
                                "unit": "times upper limit of normal"
                            }
                        }
                    },
                    {
                        "exact_snippets": "aspartate aminotransferase (AST) < 3 times upper limit of normal",
                        "criterion": "aspartate aminotransferase (AST)",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 3,
                                "unit": "times upper limit of normal"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Bilirubin ≤ 2 mg/dL (< 3 mg/dL in patients with Gilbert's syndrome)",
                "criterions": [
                    {
                        "exact_snippets": "Bilirubin ≤ 2 mg/dL",
                        "criterion": "bilirubin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2,
                                "unit": "mg/dL"
                            }
                        }
                    },
                    {
                        "exact_snippets": "< 3 mg/dL in patients with Gilbert's syndrome",
                        "criterion": "bilirubin level in patients with Gilbert's syndrome",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 3,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "exact_snippets": "< 3 mg/dL in patients with Gilbert's syndrome",
                    "criterion": "bilirubin level in patients with Gilbert's syndrome",
                    "requirement": {
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                        "expected_value": {
                            "operator": "<",
                            "value": 3,
                            "unit": "mg/dL"
                        }
                    }
                },
                "then_criteria": null,
                "else_criteria": {
                    "exact_snippets": "Bilirubin ≤ 2 mg/dL",
                    "criterion": "bilirubin level",
                    "requirement": {
                        "requirement_type": "level",
                        "expected_value": {
                            "operator": "<=",
                            "value": 2,
                            "unit": "mg/dL"
                        }
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* No hepatitis B or C",
                "criterions": [
                    {
                        "exact_snippets": "No hepatitis B",
                        "criterion": "hepatitis B",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No ... C",
                        "criterion": "hepatitis C",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No hepatitis B",
                        "criterion": "hepatitis B",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No ... C",
                        "criterion": "hepatitis C",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Renal",
                "criterions": [
                    {
                        "exact_snippets": "Renal",
                        "criterion": "renal function",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Renal",
                        "criterion": "renal function",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Cardiovascular",
                "criterions": [
                    {
                        "exact_snippets": "Cardiovascular",
                        "criterion": "cardiovascular condition",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Cardiovascular",
                        "criterion": "cardiovascular condition",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Left ventricular ejection fraction (LVEF) ≥ 45% by cardiac stress test*",
                "criterions": [
                    {
                        "exact_snippets": "Left ventricular ejection fraction (LVEF) ≥ 45%",
                        "criterion": "left ventricular ejection fraction (LVEF)",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">=",
                                "value": 45,
                                "unit": "%"
                            }
                        }
                    },
                    {
                        "exact_snippets": "cardiac stress test",
                        "criterion": "cardiac stress test",
                        "requirement": {
                            "requirement_type": "method",
                            "expected_value": "cardiac stress test"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Left ventricular ejection fraction (LVEF) ≥ 45%",
                        "criterion": "left ventricular ejection fraction (LVEF)",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">=",
                                "value": 45,
                                "unit": "%"
                            }
                        }
                    },
                    {
                        "exact_snippets": "cardiac stress test",
                        "criterion": "cardiac stress test",
                        "requirement": {
                            "requirement_type": "method",
                            "expected_value": "cardiac stress test"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No active major cardiovascular illness as evidenced by stress thallium or other comparable test",
                "criterions": [
                    {
                        "exact_snippets": "No active major cardiovascular illness",
                        "criterion": "major cardiovascular illness",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "evidenced by stress thallium or other comparable test",
                        "criterion": "stress thallium or other comparable test",
                        "requirement": {
                            "requirement_type": "evidence",
                            "expected_value": "absence of major cardiovascular illness"
                        }
                    }
                ]
            },
            "logical_structure": {
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                    {
                        "exact_snippets": "No active major cardiovascular illness",
                        "criterion": "major cardiovascular illness",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "evidenced by stress thallium or other comparable test",
                        "criterion": "stress thallium or other comparable test",
                        "requirement": {
                            "requirement_type": "evidence",
                            "expected_value": "absence of major cardiovascular illness"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No cardiac arrhythmias NOTE: *For patients ≥ 50 years of age receiving high-dose interleukin-2 (IL-2) OR patients with a history of electrocardiogram (EKG) abnormalities, symptoms of cardiac ischemia, or arrhythmias",
                "criterions": [
                    {
                        "exact_snippets": "No cardiac arrhythmias",
                        "criterion": "cardiac arrhythmias",
                        "requirement": {
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                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "patients ≥ 50 years of age",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "comparison",
                            "expected_value": {
                                "operator": ">=",
                                "value": 50,
                                "unit": "years"
                            }
                        }
                    },
                    {
                        "exact_snippets": "receiving high-dose interleukin-2 (IL-2)",
                        "criterion": "interleukin-2 (IL-2) dosage",
                        "requirement": {
                            "requirement_type": "dosage",
                            "expected_value": "high-dose"
                        }
                    },
                    {
                        "exact_snippets": "history of electrocardiogram (EKG) abnormalities",
                        "criterion": "electrocardiogram (EKG) abnormalities",
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                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "symptoms of cardiac ischemia",
                        "criterion": "cardiac ischemia",
                        "requirement": {
                            "requirement_type": "symptoms",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "arrhythmias",
                        "criterion": "arrhythmias",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "not_criteria": {
                            "exact_snippets": "No cardiac arrhythmias",
                            "criterion": "cardiac arrhythmias",
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                            }
                        }
                    },
                    {
                        "or_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "patients ≥ 50 years of age",
                                        "criterion": "age",
                                        "requirement": {
                                            "requirement_type": "comparison",
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                                                "operator": ">=",
                                                "value": 50,
                                                "unit": "years"
                                            }
                                        }
                                    },
                                    {
                                        "exact_snippets": "receiving high-dose interleukin-2 (IL-2)",
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                                            "expected_value": "high-dose"
                                        }
                                    }
                                ]
                            },
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                                "criterion": "electrocardiogram (EKG) abnormalities",
                                "requirement": {
                                    "requirement_type": "history",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "symptoms of cardiac ischemia",
                                "criterion": "cardiac ischemia",
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                                    "requirement_type": "symptoms",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "arrhythmias",
                                "criterion": "arrhythmias",
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                                    "requirement_type": "history",
                                    "expected_value": true
                                }
                            }
                        ]
                    }
                ]
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        },
        {
            "identified_line": {
                "line": "Pulmonary",
                "criterions": [
                    {
                        "exact_snippets": "Pulmonary",
                        "criterion": "pulmonary condition",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
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                        "exact_snippets": "Pulmonary",
                        "criterion": "pulmonary condition",
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                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Forced expiratory volume 1 (FEV_1) ≥ 60% of predicted by pulmonary function test in patients with prolonged history of cigarette smoking or symptoms of respiratory dysfunction*",
                "criterions": [
                    {
                        "exact_snippets": "Forced expiratory volume 1 (FEV_1) ≥ 60% of predicted by pulmonary function test",
                        "criterion": "forced expiratory volume 1 (FEV_1)",
                        "requirement": {
                            "requirement_type": "comparison",
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                                "operator": ">=",
                                "value": 60,
                                "unit": "% of predicted"
                            }
                        }
                    },
                    {
                        "exact_snippets": "patients with prolonged history of cigarette smoking",
                        "criterion": "history of cigarette smoking",
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                    },
                    {
                        "exact_snippets": "symptoms of respiratory dysfunction",
                        "criterion": "respiratory dysfunction",
                        "requirement": {
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                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
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                        {
                            "exact_snippets": "patients with prolonged history of cigarette smoking",
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                            }
                        },
                        {
                            "exact_snippets": "symptoms of respiratory dysfunction",
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                                "requirement_type": "symptoms",
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                            }
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                    "exact_snippets": "Forced expiratory volume 1 (FEV_1) ≥ 60% of predicted by pulmonary function test",
                    "criterion": "forced expiratory volume 1 (FEV_1)",
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                            "operator": ">=",
                            "value": 60,
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                "else_criteria": null
            }
        },
        {
            "identified_line": {
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                        "exact_snippets": "No active major respiratory illness",
                        "criterion": "major respiratory illness",
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                            "requirement_type": "presence",
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                        }
                    },
                    {
                        "exact_snippets": "No active major respiratory illness",
                        "criterion": "major respiratory illness",
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                            "requirement_type": "activity",
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                        }
                    }
                ]
            },
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                        "criterion": "major respiratory illness",
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                            "requirement_type": "presence",
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                        }
                    },
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                        "exact_snippets": "No active major respiratory illness",
                        "criterion": "major respiratory illness",
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                    }
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            }
        },
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            "identified_line": {
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                ]
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                            }
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                },
                "else_criteria": null
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        },
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            "identified_line": {
                "line": "Immunologic",
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                    {
                        "exact_snippets": "Immunologic",
                        "criterion": "immunologic",
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                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
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                        "exact_snippets": "Immunologic",
                        "criterion": "immunologic",
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                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
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                        "exact_snippets": "No active major immunologic illness",
                        "criterion": "major immunologic illness",
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                            "expected_value": false
                        }
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                        "exact_snippets": "No active major immunologic illness",
                        "criterion": "major immunologic illness",
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                            "requirement_type": "activity",
                            "expected_value": false
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                        "exact_snippets": "No active major immunologic illness",
                        "criterion": "major immunologic illness",
                        "requirement": {
                            "requirement_type": "activity",
                            "expected_value": false
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                    }
                ]
            }
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            "identified_line": {
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                        "exact_snippets": "No primary or secondary immunodeficiency",
                        "criterion": "primary immunodeficiency",
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                        "exact_snippets": "No primary or secondary immunodeficiency",
                        "criterion": "secondary immunodeficiency",
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                            "expected_value": false
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                    }
                ]
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                        "exact_snippets": "No primary or secondary immunodeficiency",
                        "criterion": "secondary immunodeficiency",
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                    }
                ]
            }
        },
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            "identified_line": {
                "line": "* Fully recovered immune competence after prior chemotherapy or radiotherapy as evidenced by both of the following:",
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                    {
                        "exact_snippets": "Fully recovered immune competence after prior chemotherapy or radiotherapy",
                        "criterion": "immune competence",
                        "requirement": {
                            "requirement_type": "recovery",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
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                        "exact_snippets": "Fully recovered immune competence after prior chemotherapy or radiotherapy",
                        "criterion": "immune competence",
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                            "requirement_type": "recovery",
                            "expected_value": true
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                    }
                ]
            }
        },
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            "identified_line": {
                "line": "* Absolute neutrophil count > 1,000/mm^3",
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                    {
                        "exact_snippets": "Absolute neutrophil count > 1,000/mm^3",
                        "criterion": "absolute neutrophil count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 1000,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
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            "logical_structure": {
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                        "exact_snippets": "Absolute neutrophil count > 1,000/mm^3",
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                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 1000,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Human Immunodeficiency virus (HIV) negative",
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                    {
                        "exact_snippets": "Human Immunodeficiency virus (HIV) negative",
                        "criterion": "HIV status",
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                            "requirement_type": "status",
                            "expected_value": "negative"
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                    }
                ]
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            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Human Immunodeficiency virus (HIV) negative",
                        "criterion": "HIV status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "negative"
                        }
                    }
                ]
            }
        },
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            "identified_line": {
                "line": "* Epstein-Barr virus positive",
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                    {
                        "exact_snippets": "Epstein-Barr virus positive",
                        "criterion": "Epstein-Barr virus",
                        "requirement": {
                            "requirement_type": "presence",
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                    }
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                        "criterion": "Epstein-Barr virus",
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                            "requirement_type": "presence",
                            "expected_value": "positive"
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                ]
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        },
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            "identified_line": {
                "line": "* Fertile patients must use effective contraception during and for 4 months after study treatment",
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                        "exact_snippets": "Fertile patients",
                        "criterion": "fertility",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
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                    {
                        "exact_snippets": "must use effective contraception during and for 4 months after study treatment",
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                            "expected_value": "during and for 4 months after study treatment"
                        }
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                ]
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                    "exact_snippets": "Fertile patients",
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                "then_criteria": {
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                        "requirement_type": "duration",
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            "identified_line": {
                "line": "PRIOR CONCURRENT THERAPY:",
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                        "exact_snippets": "PRIOR CONCURRENT THERAPY",
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                            "requirement_type": "presence",
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                ]
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                    {
                        "exact_snippets": "PRIOR CONCURRENT THERAPY",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
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                        "exact_snippets": "Biologic therapy",
                        "criterion": "biologic therapy",
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                            "requirement_type": "presence",
                            "expected_value": true
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                        "exact_snippets": "Biologic therapy",
                        "criterion": "biologic therapy",
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            "identified_line": {
                "line": "* See Disease Characteristics",
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                        "exact_snippets": "Disease Characteristics",
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                        }
                    }
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            },
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                        "exact_snippets": "At least 6 weeks since prior nitrosourea therapy",
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                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 6,
                                "unit": "weeks"
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                        "exact_snippets": "At least 6 weeks since prior nitrosourea therapy",
                        "criterion": "time since prior nitrosourea therapy",
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                                "operator": ">=",
                                "value": 6,
                                "unit": "weeks"
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        },
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            "identified_line": {
                "line": "* No prior cyclophosphamide and fludarabine as part of a preparative regimen on National Cancer Institute (NCI) Surgery Branch adoptive cell therapy studies unless sufficient numbers of CD34+ stem cells (more than 2 x10^6/kg patient weight) have been obtained prior to the administration of chemotherapy",
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                            "requirement_type": "quantity",
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                                "unit": "x10^6/kg patient weight"
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                        }
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                            "exact_snippets": "No prior cyclophosphamide and fludarabine as part of a preparative regimen on National Cancer Institute (NCI) Surgery Branch adoptive cell therapy studies",
                            "criterion": "prior cyclophosphamide and fludarabine",
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                            "exact_snippets": "sufficient numbers of CD34+ stem cells (more than 2 x10^6/kg patient weight) have been obtained prior to the administration of chemotherapy",
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                                    "value": 2,
                                    "unit": "x10^6/kg patient weight"
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                        }
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                "then_criteria": null,
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                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "Endocrine therapy",
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                        "exact_snippets": "Endocrine therapy",
                        "criterion": "endocrine therapy",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
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                        "exact_snippets": "Endocrine therapy",
                        "criterion": "endocrine therapy",
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                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Radiotherapy",
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                    {
                        "exact_snippets": "Radiotherapy",
                        "criterion": "radiotherapy",
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                            "requirement_type": "presence",
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                    }
                ]
            },
            "logical_structure": {
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                    {
                        "exact_snippets": "Radiotherapy",
                        "criterion": "radiotherapy",
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            }
        },
        {
            "identified_line": {
                "line": "Surgery",
                "criterions": [
                    {
                        "exact_snippets": "Surgery",
                        "criterion": "surgery",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Surgery",
                        "criterion": "surgery",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* See Disease Characteristics",
                "criterions": [
                    {
                        "exact_snippets": "Disease Characteristics",
                        "criterion": "disease characteristics",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "see disease characteristics section"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Disease Characteristics",
                        "criterion": "disease characteristics",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "see disease characteristics section"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Prior minor surgery within the past 3 weeks allowed if recovered",
                "criterions": [
                    {
                        "exact_snippets": "Prior minor surgery within the past 3 weeks",
                        "criterion": "prior minor surgery",
                        "requirement": {
                            "requirement_type": "time since surgery",
                            "expected_value": {
                                "operator": "<=",
                                "value": 3,
                                "unit": "weeks"
                            }
                        }
                    },
                    {
                        "exact_snippets": "if recovered",
                        "criterion": "recovery from surgery",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "recovered"
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "and_criteria": [
                        {
                            "exact_snippets": "Prior minor surgery within the past 3 weeks",
                            "criterion": "prior minor surgery",
                            "requirement": {
                                "requirement_type": "time since surgery",
                                "expected_value": {
                                    "operator": "<=",
                                    "value": 3,
                                    "unit": "weeks"
                                }
                            }
                        },
                        {
                            "exact_snippets": "if recovered",
                            "criterion": "recovery from surgery",
                            "requirement": {
                                "requirement_type": "status",
                                "expected_value": "recovered"
                            }
                        }
                    ]
                },
                "then_criteria": null,
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* Recovered from all prior therapy",
                "criterions": [
                    {
                        "exact_snippets": "Recovered from all prior therapy",
                        "criterion": "recovery from prior therapy",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "recovered"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Recovered from all prior therapy",
                        "criterion": "recovery from prior therapy",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "recovered"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* At least 30 days since prior systemic therapy",
                "criterions": [
                    {
                        "exact_snippets": "At least 30 days since prior systemic therapy",
                        "criterion": "time since prior systemic therapy",
                        "requirement": {
                            "requirement_type": "time since",
                            "expected_value": {
                                "operator": ">=",
                                "value": 30,
                                "unit": "days"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "At least 30 days since prior systemic therapy",
                        "criterion": "time since prior systemic therapy",
                        "requirement": {
                            "requirement_type": "time since",
                            "expected_value": {
                                "operator": ">=",
                                "value": 30,
                                "unit": "days"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "DISEASE CHARACTERISTICS:",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "PATIENT CHARACTERISTICS:",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "Other",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "* Not pregnant or nursing",
                "criterions": [
                    {
                        "exact_snippets": "Not pregnant",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "not ... nursing",
                        "criterion": "nursing",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Not pregnant",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "not ... nursing",
                        "criterion": "nursing",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Not specified",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "Other",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        }
    ],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": [
        {
            "identified_line": {
                "line": "* Creatinine ≤ 1.6 mg/dL",
                "criterions": [
                    {
                        "exact_snippets": "Creatinine ≤ 1.6 mg/dL",
                        "criterion": "creatinine level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.6,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Creatinine \u0010 1.6 mg/dL",
                        "criterion": "creatinine level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.6,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No myocardial infarction",
                "criterions": [
                    {
                        "exact_snippets": "No myocardial infarction",
                        "criterion": "myocardial infarction",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No myocardial infarction",
                    "criterion": "myocardial infarction",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* No active systemic infections",
                "criterions": [
                    {
                        "exact_snippets": "No active systemic infections",
                        "criterion": "systemic infections",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No active systemic infections",
                    "criterion": "systemic infections",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* No opportunistic infections",
                "criterions": [
                    {
                        "exact_snippets": "No opportunistic infections",
                        "criterion": "opportunistic infections",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No opportunistic infections",
                    "criterion": "opportunistic infections",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* No concurrent systemic steroid therapy",
                "criterions": [
                    {
                        "exact_snippets": "No concurrent systemic steroid therapy",
                        "criterion": "systemic steroid therapy",
                        "requirement": {
                            "requirement_type": "concurrent use",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No concurrent systemic steroid therapy",
                    "criterion": "systemic steroid therapy",
                    "requirement": {
                        "requirement_type": "concurrent use",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* No other concurrent experimental agents",
                "criterions": [
                    {
                        "exact_snippets": "No other concurrent experimental agents",
                        "criterion": "concurrent experimental agents",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No other concurrent experimental agents",
                    "criterion": "concurrent experimental agents",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        }
    ]
}