{
    "info": {
        "nct_id": "NCT00053391",
        "official_title": "Vaccination Of HLA-A1 And/Or -A2+ Stage III or IV Melanoma Patients With Tumor Peptide - Loaded Autologous Dendritic Cells That Are Generated In The Absence Or Presence Of CD40 Ligand",
        "inclusion_criteria": "Healthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "",
        "miscellaneous_criteria": "DISEASE CHARACTERISTICS:\n\n* Histologically confirmed stage III or IV cutaneous malignant melanoma\n* HLA-A1 and/or HLA-A2 expression by serologic HLA typing\n\n  * HLA-A2.1 subtype must be confirmed by polymerase chain reaction on genomic DNA obtained from peripheral blood mononuclear cells\n* No active CNS metastases by CT scan or MRI\n\nPATIENT CHARACTERISTICS:\n\nAge\n\n* Over 18\n\nPerformance status\n\n* Karnofsky 60-100%\n\nLife expectancy\n\n* At least 4 months\n\nHematopoietic\n\n* WBC greater than 2,500/mm^3\n* Neutrophil count greater than 1,000/mm^3\n* Lymphocyte count greater than 700/mm^3\n* Platelet count greater than 75,000/mm^3\n* Hemoglobin greater than 9 g/dL\n* No bleeding disorders\n\nHepatic\n\n* Bilirubin less than 2.0 mg/dL\n* Hepatitis B surface antigen negative\n* Hepatitis C antibody negative\n\nRenal\n\n* Creatinine less than 2.5 mg/dL\n\nCardiovascular\n\n* No clinically significant heart disease\n\nPulmonary\n\n* No clinically significant respiratory disease\n\nImmunologic\n\n* No active systemic infection\n* No immunodeficiency disease\n\n  * No evidence of HIV-1, HIV-2, or human T-cell lymphotropic virus-1\n* No active autoimmune disease including (but not limited to):\n\n  * Lupus erythematosus\n  * Autoimmune thyroiditis or uveitis\n  * Multiple sclerosis\n  * Inflammatory bowel disease\n\nOther\n\n* Stable medical condition\n* Not pregnant or nursing\n* Negative pregnancy test\n* Fertile patients must use effective contraception during and for at least 1 month after study participation\n* No organic brain syndrome or psychiatric illness that would preclude study compliance\n* No other concurrent active malignancy\n* No other concurrent serious illness that would preclude study treatment\n* No contraindication to leukapheresis\n\nPRIOR CONCURRENT THERAPY:\n\nBiologic therapy\n\n* More than 4 weeks since prior immunotherapy\n* No other concurrent immunotherapy\n\nChemotherapy\n\n* More than 4 weeks since prior systemic chemotherapy (6 weeks for nitrosoureas)\n* No concurrent chemotherapy\n\nEndocrine therapy\n\n* No concurrent corticosteroids\n\nRadiotherapy\n\n* More than 4 weeks since prior radiotherapy\n* No prior radiotherapy to the spleen\n* Concurrent palliative radiotherapy allowed\n\nSurgery\n\n* Recovered from prior surgery\n* No prior splenectomy\n* No prior organ allograft\n* Concurrent surgery on selected metastases (e.g., because of pain or local complications such as compression) allowed\n\nOther\n\n* No other concurrent investigational drugs\n* No concurrent participation in another clinical trial"
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [],
    "miscellaneous_lines": [
        {
            "identified_line": {
                "line": "DISEASE CHARACTERISTICS:",
                "criterions": [
                    {
                        "exact_snippets": "DISEASE CHARACTERISTICS",
                        "criterion": "disease characteristics",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "DISEASE CHARACTERISTICS",
                        "criterion": "disease characteristics",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Histologically confirmed stage III or IV cutaneous malignant melanoma",
                "criterions": [
                    {
                        "exact_snippets": "Histologically confirmed",
                        "criterion": "histological confirmation",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "stage III or IV",
                        "criterion": "cancer stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": [
                                "III",
                                "IV"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "cutaneous malignant melanoma",
                        "criterion": "cancer type",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "cutaneous malignant melanoma"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Histologically confirmed",
                        "criterion": "histological confirmation",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "stage III or IV",
                        "criterion": "cancer stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": [
                                "III",
                                "IV"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "cutaneous malignant melanoma",
                        "criterion": "cancer type",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "cutaneous malignant melanoma"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* HLA-A1 and/or HLA-A2 expression by serologic HLA typing",
                "criterions": [
                    {
                        "exact_snippets": "HLA-A1",
                        "criterion": "HLA-A1 expression",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "HLA-A2",
                        "criterion": "HLA-A2 expression",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "HLA-A1",
                                "criterion": "HLA-A1 expression",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "HLA-A2",
                                "criterion": "HLA-A2 expression",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* HLA-A2.1 subtype must be confirmed by polymerase chain reaction on genomic DNA obtained from peripheral blood mononuclear cells",
                "criterions": [
                    {
                        "exact_snippets": "HLA-A2.1 subtype must be confirmed",
                        "criterion": "HLA-A2.1 subtype",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "polymerase chain reaction on genomic DNA obtained from peripheral blood mononuclear cells",
                        "criterion": "method of confirmation",
                        "requirement": {
                            "requirement_type": "method",
                            "expected_value": "polymerase chain reaction on genomic DNA obtained from peripheral blood mononuclear cells"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "HLA-A2.1 subtype must be confirmed",
                        "criterion": "HLA-A2.1 subtype",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "polymerase chain reaction on genomic DNA obtained from peripheral blood mononuclear cells",
                        "criterion": "method of confirmation",
                        "requirement": {
                            "requirement_type": "method",
                            "expected_value": "polymerase chain reaction on genomic DNA obtained from peripheral blood mononuclear cells"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No active CNS metastases by CT scan or MRI",
                "criterions": [
                    {
                        "exact_snippets": "No active CNS metastases by CT scan or MRI",
                        "criterion": "CNS metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No active CNS metastases by CT scan or MRI",
                        "criterion": "CNS metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Age",
                "criterions": [
                    {
                        "exact_snippets": "Age",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Age",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Over 18",
                "criterions": [
                    {
                        "exact_snippets": "Over 18",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Over 18",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Performance status",
                "criterions": [
                    {
                        "exact_snippets": "Performance status",
                        "criterion": "performance status",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Performance status",
                        "criterion": "performance status",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Karnofsky 60-100%",
                "criterions": [
                    {
                        "exact_snippets": "Karnofsky 60-100%",
                        "criterion": "Karnofsky performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 60,
                                        "unit": "%"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 100,
                                        "unit": "%"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Karnofsky 60-100%",
                        "criterion": "Karnofsky performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 60,
                                        "unit": "%"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 100,
                                        "unit": "%"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Life expectancy",
                "criterions": [
                    {
                        "exact_snippets": "Life expectancy",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Life expectancy",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* At least 4 months",
                "criterions": [
                    {
                        "exact_snippets": "At least 4 months",
                        "criterion": "time period",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 4,
                                "unit": "months"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "At least 4 months",
                        "criterion": "time period",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 4,
                                "unit": "months"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Hematopoietic",
                "criterions": [
                    {
                        "exact_snippets": "Hematopoietic",
                        "criterion": "hematopoietic",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Hematopoietic",
                        "criterion": "hematopoietic",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* WBC greater than 2,500/mm^3",
                "criterions": [
                    {
                        "exact_snippets": "WBC greater than 2,500/mm^3",
                        "criterion": "WBC",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 2500,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "WBC greater than 2,500/mm^3",
                        "criterion": "WBC",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 2500,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Neutrophil count greater than 1,000/mm^3",
                "criterions": [
                    {
                        "exact_snippets": "Neutrophil count greater than 1,000/mm^3",
                        "criterion": "neutrophil count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 1000,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Neutrophil count greater than 1,000/mm^3",
                        "criterion": "neutrophil count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 1000,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Lymphocyte count greater than 700/mm^3",
                "criterions": [
                    {
                        "exact_snippets": "Lymphocyte count greater than 700/mm^3",
                        "criterion": "lymphocyte count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 700,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Lymphocyte count greater than 700/mm^3",
                        "criterion": "lymphocyte count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 700,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Platelet count greater than 75,000/mm^3",
                "criterions": [
                    {
                        "exact_snippets": "Platelet count greater than 75,000/mm^3",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 75000,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Platelet count greater than 75,000/mm^3",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 75000,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Hemoglobin greater than 9 g/dL",
                "criterions": [
                    {
                        "exact_snippets": "Hemoglobin greater than 9 g/dL",
                        "criterion": "hemoglobin",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">",
                                "value": 9,
                                "unit": "g/dL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Hemoglobin greater than 9 g/dL",
                        "criterion": "hemoglobin",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">",
                                "value": 9,
                                "unit": "g/dL"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Hepatic",
                "criterions": [
                    {
                        "exact_snippets": "Hepatic",
                        "criterion": "hepatic function",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Hepatic",
                        "criterion": "hepatic function",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Bilirubin less than 2.0 mg/dL",
                "criterions": [
                    {
                        "exact_snippets": "Bilirubin less than 2.0 mg/dL",
                        "criterion": "bilirubin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 2.0,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Bilirubin less than 2.0 mg/dL",
                        "criterion": "bilirubin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 2.0,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Hepatitis B surface antigen negative",
                "criterions": [
                    {
                        "exact_snippets": "Hepatitis B surface antigen negative",
                        "criterion": "Hepatitis B surface antigen",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Hepatitis B surface antigen negative",
                        "criterion": "Hepatitis B surface antigen",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Renal",
                "criterions": [
                    {
                        "exact_snippets": "Renal",
                        "criterion": "renal function",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Renal",
                        "criterion": "renal function",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Creatinine less than 2.5 mg/dL",
                "criterions": [
                    {
                        "exact_snippets": "Creatinine less than 2.5 mg/dL",
                        "criterion": "creatinine level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 2.5,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Creatinine less than 2.5 mg/dL",
                        "criterion": "creatinine level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 2.5,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Cardiovascular",
                "criterions": [
                    {
                        "exact_snippets": "Cardiovascular",
                        "criterion": "cardiovascular condition",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Cardiovascular",
                        "criterion": "cardiovascular condition",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No clinically significant heart disease",
                "criterions": [
                    {
                        "exact_snippets": "clinically significant heart disease",
                        "criterion": "heart disease",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "not clinically significant"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "clinically significant heart disease",
                        "criterion": "heart disease",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "not clinically significant"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Pulmonary",
                "criterions": [
                    {
                        "exact_snippets": "Pulmonary",
                        "criterion": "pulmonary",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Pulmonary",
                        "criterion": "pulmonary",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No clinically significant respiratory disease",
                "criterions": [
                    {
                        "exact_snippets": "clinically significant respiratory disease",
                        "criterion": "respiratory disease",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "not clinically significant"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "clinically significant respiratory disease",
                        "criterion": "respiratory disease",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "not clinically significant"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Immunologic",
                "criterions": [
                    {
                        "exact_snippets": "Immunologic",
                        "criterion": "immunologic",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Immunologic",
                        "criterion": "immunologic",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No evidence of HIV-1, HIV-2, or human T-cell lymphotropic virus-1",
                "criterions": [
                    {
                        "exact_snippets": "No evidence of HIV-1",
                        "criterion": "HIV-1",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No evidence of ... HIV-2",
                        "criterion": "HIV-2",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No evidence of ... human T-cell lymphotropic virus-1",
                        "criterion": "human T-cell lymphotropic virus-1",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No evidence of HIV-1",
                        "criterion": "HIV-1",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No evidence of ... HIV-2",
                        "criterion": "HIV-2",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No evidence of ... human T-cell lymphotropic virus-1",
                        "criterion": "human T-cell lymphotropic virus-1",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No active autoimmune disease including (but not limited to):",
                "criterions": [
                    {
                        "exact_snippets": "No active autoimmune disease",
                        "criterion": "active autoimmune disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No active autoimmune disease",
                        "criterion": "active autoimmune disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Negative pregnancy test",
                "criterions": [
                    {
                        "exact_snippets": "Negative pregnancy test",
                        "criterion": "pregnancy test",
                        "requirement": {
                            "requirement_type": "result",
                            "expected_value": "negative"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Negative pregnancy test",
                        "criterion": "pregnancy test",
                        "requirement": {
                            "requirement_type": "result",
                            "expected_value": "negative"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Fertile patients must use effective contraception during and for at least 1 month after study participation",
                "criterions": [
                    {
                        "exact_snippets": "Fertile patients",
                        "criterion": "fertility",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "fertile"
                        }
                    },
                    {
                        "exact_snippets": "must use effective contraception",
                        "criterion": "contraception use",
                        "requirement": {
                            "requirement_type": "necessity",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "during and for at least 1 month after study participation",
                        "criterion": "contraception duration",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": "during and for at least 1 month after study participation"
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "exact_snippets": "Fertile patients",
                    "criterion": "fertility",
                    "requirement": {
                        "requirement_type": "status",
                        "expected_value": "fertile"
                    }
                },
                "then_criteria": {
                    "and_criteria": [
                        {
                            "exact_snippets": "must use effective contraception",
                            "criterion": "contraception use",
                            "requirement": {
                                "requirement_type": "necessity",
                                "expected_value": true
                            }
                        },
                        {
                            "exact_snippets": "during and for at least 1 month after study participation",
                            "criterion": "contraception duration",
                            "requirement": {
                                "requirement_type": "duration",
                                "expected_value": "during and for at least 1 month after study participation"
                            }
                        }
                    ]
                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* No organic brain syndrome or psychiatric illness that would preclude study compliance",
                "criterions": [
                    {
                        "exact_snippets": "No organic brain syndrome",
                        "criterion": "organic brain syndrome",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No ... psychiatric illness that would preclude study compliance",
                        "criterion": "psychiatric illness",
                        "requirement": {
                            "requirement_type": "impact on study compliance",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No organic brain syndrome",
                        "criterion": "organic brain syndrome",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No ... psychiatric illness that would preclude study compliance",
                        "criterion": "psychiatric illness",
                        "requirement": {
                            "requirement_type": "impact on study compliance",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No other concurrent active malignancy",
                "criterions": [
                    {
                        "exact_snippets": "No other concurrent active malignancy",
                        "criterion": "concurrent active malignancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No other concurrent active malignancy",
                    "criterion": "concurrent active malignancy",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* No other concurrent serious illness that would preclude study treatment",
                "criterions": [
                    {
                        "exact_snippets": "No other concurrent serious illness",
                        "criterion": "concurrent serious illness",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No other concurrent serious illness",
                        "criterion": "concurrent serious illness",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "PRIOR CONCURRENT THERAPY:",
                "criterions": [
                    {
                        "exact_snippets": "PRIOR CONCURRENT THERAPY",
                        "criterion": "prior concurrent therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "PRIOR CONCURRENT THERAPY",
                        "criterion": "prior concurrent therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Biologic therapy",
                "criterions": [
                    {
                        "exact_snippets": "Biologic therapy",
                        "criterion": "biologic therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Biologic therapy",
                        "criterion": "biologic therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* More than 4 weeks since prior immunotherapy",
                "criterions": [
                    {
                        "exact_snippets": "More than 4 weeks since prior immunotherapy",
                        "criterion": "time since prior immunotherapy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "More than 4 weeks since prior immunotherapy",
                        "criterion": "time since prior immunotherapy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No other concurrent immunotherapy",
                "criterions": [
                    {
                        "exact_snippets": "No other concurrent immunotherapy",
                        "criterion": "concurrent immunotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No other concurrent immunotherapy",
                    "criterion": "concurrent immunotherapy",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "Chemotherapy",
                "criterions": [
                    {
                        "exact_snippets": "Chemotherapy",
                        "criterion": "chemotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Chemotherapy",
                        "criterion": "chemotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* More than 4 weeks since prior systemic chemotherapy (6 weeks for nitrosoureas)",
                "criterions": [
                    {
                        "exact_snippets": "More than 4 weeks since prior systemic chemotherapy",
                        "criterion": "time since prior systemic chemotherapy",
                        "requirement": {
                            "requirement_type": "time since treatment",
                            "expected_value": {
                                "operator": ">",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    },
                    {
                        "exact_snippets": "6 weeks for nitrosoureas",
                        "criterion": "time since prior nitrosoureas chemotherapy",
                        "requirement": {
                            "requirement_type": "time since treatment",
                            "expected_value": {
                                "operator": ">",
                                "value": 6,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "More than 4 weeks since prior systemic chemotherapy",
                                "criterion": "time since prior systemic chemotherapy",
                                "requirement": {
                                    "requirement_type": "time since treatment",
                                    "expected_value": {
                                        "operator": ">",
                                        "value": 4,
                                        "unit": "weeks"
                                    }
                                }
                            },
                            {
                                "not_criteria": {
                                    "exact_snippets": "6 weeks for nitrosoureas",
                                    "criterion": "time since prior nitrosoureas chemotherapy",
                                    "requirement": {
                                        "requirement_type": "time since treatment",
                                        "expected_value": {
                                            "operator": ">",
                                            "value": 6,
                                            "unit": "weeks"
                                        }
                                    }
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "6 weeks for nitrosoureas",
                        "criterion": "time since prior nitrosoureas chemotherapy",
                        "requirement": {
                            "requirement_type": "time since treatment",
                            "expected_value": {
                                "operator": ">",
                                "value": 6,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No concurrent chemotherapy",
                "criterions": [
                    {
                        "exact_snippets": "No concurrent chemotherapy",
                        "criterion": "concurrent chemotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No concurrent chemotherapy",
                        "criterion": "concurrent chemotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Endocrine therapy",
                "criterions": [
                    {
                        "exact_snippets": "Endocrine therapy",
                        "criterion": "endocrine therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Endocrine therapy",
                        "criterion": "endocrine therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Radiotherapy",
                "criterions": [
                    {
                        "exact_snippets": "Radiotherapy",
                        "criterion": "radiotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Radiotherapy",
                        "criterion": "radiotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* More than 4 weeks since prior radiotherapy",
                "criterions": [
                    {
                        "exact_snippets": "More than 4 weeks since prior radiotherapy",
                        "criterion": "time since prior radiotherapy",
                        "requirement": {
                            "requirement_type": "time elapsed",
                            "expected_value": {
                                "operator": ">",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "More than 4 weeks since prior radiotherapy",
                        "criterion": "time since prior radiotherapy",
                        "requirement": {
                            "requirement_type": "time elapsed",
                            "expected_value": {
                                "operator": ">",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Concurrent palliative radiotherapy allowed",
                "criterions": [
                    {
                        "exact_snippets": "Concurrent palliative radiotherapy allowed",
                        "criterion": "palliative radiotherapy",
                        "requirement": {
                            "requirement_type": "concurrency",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Concurrent palliative radiotherapy allowed",
                        "criterion": "palliative radiotherapy",
                        "requirement": {
                            "requirement_type": "concurrency",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Surgery",
                "criterions": [
                    {
                        "exact_snippets": "Surgery",
                        "criterion": "surgery",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Surgery",
                        "criterion": "surgery",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Recovered from prior surgery",
                "criterions": [
                    {
                        "exact_snippets": "Recovered from prior surgery",
                        "criterion": "recovery from prior surgery",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "recovered"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Recovered from prior surgery",
                        "criterion": "recovery from prior surgery",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "recovered"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No prior splenectomy",
                "criterions": [
                    {
                        "exact_snippets": "No prior splenectomy",
                        "criterion": "splenectomy",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No prior splenectomy",
                        "criterion": "splenectomy",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No prior organ allograft",
                "criterions": [
                    {
                        "exact_snippets": "No prior organ allograft",
                        "criterion": "organ allograft",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No prior organ allograft",
                    "criterion": "organ allograft",
                    "requirement": {
                        "requirement_type": "history",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Concurrent surgery on selected metastases (e.g., because of pain or local complications such as compression) allowed",
                "criterions": [
                    {
                        "exact_snippets": "Concurrent surgery on selected metastases ... allowed",
                        "criterion": "concurrent surgery on selected metastases",
                        "requirement": {
                            "requirement_type": "allowance",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "pain",
                        "criterion": "pain",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "local complications such as compression",
                        "criterion": "local complications",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "or_criteria": [
                        {
                            "exact_snippets": "pain",
                            "criterion": "pain",
                            "requirement": {
                                "requirement_type": "presence",
                                "expected_value": true
                            }
                        },
                        {
                            "exact_snippets": "local complications such as compression",
                            "criterion": "local complications",
                            "requirement": {
                                "requirement_type": "presence",
                                "expected_value": true
                            }
                        }
                    ]
                },
                "then_criteria": {
                    "exact_snippets": "Concurrent surgery on selected metastases ... allowed",
                    "criterion": "concurrent surgery on selected metastases",
                    "requirement": {
                        "requirement_type": "allowance",
                        "expected_value": true
                    }
                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* No other concurrent investigational drugs",
                "criterions": [
                    {
                        "exact_snippets": "No other concurrent investigational drugs",
                        "criterion": "concurrent investigational drugs",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No other concurrent investigational drugs",
                    "criterion": "concurrent investigational drugs",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* No concurrent participation in another clinical trial",
                "criterions": [
                    {
                        "exact_snippets": "No concurrent participation in another clinical trial",
                        "criterion": "concurrent participation in another clinical trial",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No concurrent participation in another clinical trial",
                        "criterion": "concurrent participation in another clinical trial",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "PATIENT CHARACTERISTICS:",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "Other",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "* Not pregnant or nursing",
                "criterions": [
                    {
                        "exact_snippets": "Not pregnant",
                        "criterion": "pregnancy status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "not ... nursing",
                        "criterion": "nursing status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Not pregnant",
                        "criterion": "pregnancy status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "not ... nursing",
                        "criterion": "nursing status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Other",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        }
    ],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": [
        {
            "identified_line": {
                "line": "* No bleeding disorders",
                "criterions": [
                    {
                        "exact_snippets": "No bleeding disorders",
                        "criterion": "bleeding disorders",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No bleeding disorders",
                    "criterion": "bleeding disorders",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Hepatitis C antibody negative",
                "criterions": [
                    {
                        "exact_snippets": "Hepatitis C antibody negative",
                        "criterion": "Hepatitis C antibody",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Hepatitis C antibody negative",
                    "criterion": "Hepatitis C antibody",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* No active systemic infection",
                "criterions": [
                    {
                        "exact_snippets": "No active systemic infection",
                        "criterion": "systemic infection",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No active systemic infection",
                    "criterion": "systemic infection",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* No immunodeficiency disease",
                "criterions": [
                    {
                        "exact_snippets": "No immunodeficiency disease",
                        "criterion": "immunodeficiency disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No immunodeficiency disease",
                    "criterion": "immunodeficiency disease",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Lupus erythematosus",
                "criterions": [
                    {
                        "exact_snippets": "Lupus erythematosus",
                        "criterion": "Lupus erythematosus",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* Autoimmune thyroiditis or uveitis",
                "criterions": [
                    {
                        "exact_snippets": "Autoimmune thyroiditis",
                        "criterion": "autoimmune thyroiditis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "uveitis",
                        "criterion": "uveitis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* Multiple sclerosis",
                "criterions": [
                    {
                        "exact_snippets": "Multiple sclerosis",
                        "criterion": "multiple sclerosis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* Inflammatory bowel disease",
                "criterions": [
                    {
                        "exact_snippets": "Inflammatory bowel disease",
                        "criterion": "inflammatory bowel disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* Stable medical condition",
                "criterions": [
                    {
                        "exact_snippets": "Stable medical condition",
                        "criterion": "medical condition",
                        "requirement": {
                            "requirement_type": "stability",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* No contraindication to leukapheresis",
                "criterions": [
                    {
                        "exact_snippets": "No contraindication to leukapheresis",
                        "criterion": "leukapheresis contraindication",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No contraindication to leukapheresis",
                    "criterion": "leukapheresis contraindication",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* No concurrent corticosteroids",
                "criterions": [
                    {
                        "exact_snippets": "No concurrent corticosteroids",
                        "criterion": "corticosteroids",
                        "requirement": {
                            "requirement_type": "concurrent use",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No concurrent corticosteroids",
                    "criterion": "corticosteroids",
                    "requirement": {
                        "requirement_type": "concurrent use",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* No prior radiotherapy to the spleen",
                "criterions": [
                    {
                        "exact_snippets": "No prior radiotherapy to the spleen",
                        "criterion": "radiotherapy to the spleen",
                        "requirement": {
                            "requirement_type": "prior treatment",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No prior radiotherapy to the spleen",
                    "criterion": "radiotherapy to the spleen",
                    "requirement": {
                        "requirement_type": "prior treatment",
                        "expected_value": true
                    }
                }
            }
        }
    ]
}