{
    "info": {
        "nct_id": "NCT00024180",
        "official_title": "A Phase I Study of Depsipeptide in Selected Hematologic Malignancies (NSC 630176)",
        "inclusion_criteria": "Healthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "",
        "miscellaneous_criteria": "DISEASE CHARACTERISTICS:\n\n* Diagnosis of one of the following hematologic malignancies:\n\n  * Chronic lymphocytic leukemia (CLL)\n  * Small lymphocytic lymphoma (SLL) (including Waldenstrom's macroglobulinemia)\n  * Acute myeloid leukemia (AML)\n  * Acute lymphoblastic leukemia (ALL)\n* Stratum I (CLL and SLL):\n\n  * Received at least one prior therapy containing a purine analog OR\n  * Received another form of therapy (including alkylating agents) due to history of severe autoimmune disease, requirement for chronic corticosteroid, or other contraindication to purine analog therapy\n* Stratum II (AML and ALL):\n\n  * Primary refractory or relapsed leukemia within the past year that is not amenable to curative therapy\n  * OR\n  * Untreated or previously treated poor-risk leukemia defined by any of the following:\n\n    * 65 years of age and over\n    * Poor-risk candidates for aggressive chemotherapy\n    * Poor-risk cytogenetics (for AML, karyotype abnormalities other than t(8;21), inv(16), t(15;17))\n\nPATIENT CHARACTERISTICS:\n\nAge:\n\n* 18 and over\n\nPerformance status:\n\n* ECOG 0-2\n\nLife expectancy:\n\n* At least 12 weeks\n\nHematopoietic:\n\n* Stratum I only:\n\n  * No uncontrolled autoimmune hemolytic anemia\n  * No idiopathic thrombocytopenic purpura\n* Stratum II only:\n\n  * WBC no greater than 10,000/mm^3 OR\n  * WBC no greater than 40,000/mm^3 that is stable for at least 1 week (may be sustained by hydroxyurea through the first week of study)\n\nHepatic:\n\n* Bilirubin no greater than 1.5 mg/dL\n* ALT and AST no greater than 3 times upper limit of normal\n\nRenal:\n\n* Creatinine less than 2.0 mg/dL\n\nCardiovascular:\n\n* Ejection fraction at least 50% by MUGA\n* No myocardial infarction or unstable angina within the past 6 months\n* No prior unstable ventricular or supraventricular cardiac arrhythmias\n\nOther:\n\n* HIV negative\n* Not pregnant or nursing\n* Negative pregnancy test\n* Fertile patients must use effective contraception\n* No other medical or psychiatric problem that would preclude study\n* Stratum I only:\n\n  * No active infection requiring oral or IV antibiotics\n\nPRIOR CONCURRENT THERAPY:\n\nBiologic therapy:\n\n* Not specified\n\nChemotherapy:\n\n* See Disease Characteristics\n* At least 28 days since prior chemotherapy (except hydroxyurea)\n* At least 6 weeks since prior nitrosoureas\n* At least 8 weeks since prior UCN-01 (unless plasma UCN-01 level less than 1 uM)\n\nEndocrine therapy:\n\n* See Disease Characteristics\n\nRadiotherapy:\n\n* At least 28 days since prior radiotherapy\n\nSurgery:\n\n* At least 28 days since prior major surgery"
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [],
    "miscellaneous_lines": [
        {
            "identified_line": {
                "line": "DISEASE CHARACTERISTICS:",
                "criterions": [
                    {
                        "exact_snippets": "DISEASE CHARACTERISTICS",
                        "criterion": "disease characteristics",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "DISEASE CHARACTERISTICS",
                        "criterion": "disease characteristics",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Diagnosis of one of the following hematologic malignancies:",
                "criterions": [
                    {
                        "exact_snippets": "Diagnosis of one of the following hematologic malignancies",
                        "criterion": "hematologic malignancies",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Diagnosis of one of the following hematologic malignancies",
                        "criterion": "hematologic malignancies",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Chronic lymphocytic leukemia (CLL)",
                "criterions": [
                    {
                        "exact_snippets": "Chronic lymphocytic leukemia (CLL)",
                        "criterion": "chronic lymphocytic leukemia",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Chronic lymphocytic leukemia (CLL)",
                        "criterion": "chronic lymphocytic leukemia",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Small lymphocytic lymphoma (SLL) (including Waldenstrom's macroglobulinemia)",
                "criterions": [
                    {
                        "exact_snippets": "Small lymphocytic lymphoma (SLL)",
                        "criterion": "small lymphocytic lymphoma",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Waldenstrom's macroglobulinemia",
                        "criterion": "Waldenstrom's macroglobulinemia",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Small lymphocytic lymphoma (SLL)",
                        "criterion": "small lymphocytic lymphoma",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Waldenstrom's macroglobulinemia",
                        "criterion": "Waldenstrom's macroglobulinemia",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Acute myeloid leukemia (AML)",
                "criterions": [
                    {
                        "exact_snippets": "Acute myeloid leukemia (AML)",
                        "criterion": "acute myeloid leukemia",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Acute myeloid leukemia (AML)",
                        "criterion": "acute myeloid leukemia",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Acute lymphoblastic leukemia (ALL)",
                "criterions": [
                    {
                        "exact_snippets": "Acute lymphoblastic leukemia (ALL)",
                        "criterion": "Acute lymphoblastic leukemia",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Acute lymphoblastic leukemia (ALL)",
                        "criterion": "Acute lymphoblastic leukemia",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Stratum I (CLL and SLL):",
                "criterions": [
                    {
                        "exact_snippets": "Stratum I (CLL and SLL)",
                        "criterion": "disease type",
                        "requirement": {
                            "requirement_type": "specific types",
                            "expected_value": [
                                "CLL",
                                "SLL"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Stratum I (CLL and SLL)",
                        "criterion": "disease type",
                        "requirement": {
                            "requirement_type": "specific types",
                            "expected_value": [
                                "CLL",
                                "SLL"
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Received at least one prior therapy containing a purine analog OR",
                "criterions": [
                    {
                        "exact_snippets": "Received at least one prior therapy containing a purine analog",
                        "criterion": "prior therapy",
                        "requirement": {
                            "requirement_type": "content",
                            "expected_value": "purine analog"
                        }
                    },
                    {
                        "exact_snippets": "Received at least one prior therapy containing a purine analog",
                        "criterion": "prior therapy",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "therapy"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Received at least one prior therapy containing a purine analog",
                                "criterion": "prior therapy",
                                "requirement": {
                                    "requirement_type": "content",
                                    "expected_value": "purine analog"
                                }
                            },
                            {
                                "exact_snippets": "Received at least one prior therapy containing a purine analog",
                                "criterion": "prior therapy",
                                "requirement": {
                                    "requirement_type": "quantity",
                                    "expected_value": {
                                        "operator": ">=",
                                        "value": 1,
                                        "unit": "therapy"
                                    }
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Received another form of therapy (including alkylating agents) due to history of severe autoimmune disease, requirement for chronic corticosteroid, or other contraindication to purine analog therapy",
                "criterions": [
                    {
                        "exact_snippets": "Received another form of therapy (including alkylating agents)",
                        "criterion": "previous therapy",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": [
                                "another form of therapy",
                                "alkylating agents"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "history of severe autoimmune disease",
                        "criterion": "autoimmune disease",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "severe"
                        }
                    },
                    {
                        "exact_snippets": "requirement for chronic corticosteroid",
                        "criterion": "corticosteroid use",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": "chronic"
                        }
                    },
                    {
                        "exact_snippets": "contraindication to purine analog therapy",
                        "criterion": "purine analog therapy",
                        "requirement": {
                            "requirement_type": "contraindication",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "and_criteria": [
                        {
                            "and_criteria": [
                                {
                                    "and_criteria": [
                                        {
                                            "and_criteria": [
                                                {
                                                    "exact_snippets": "history of severe autoimmune disease",
                                                    "criterion": "autoimmune disease",
                                                    "requirement": {
                                                        "requirement_type": "severity",
                                                        "expected_value": "severe"
                                                    }
                                                },
                                                {
                                                    "exact_snippets": "requirement for chronic corticosteroid",
                                                    "criterion": "corticosteroid use",
                                                    "requirement": {
                                                        "requirement_type": "duration",
                                                        "expected_value": "chronic"
                                                    }
                                                }
                                            ]
                                        },
                                        {
                                            "exact_snippets": "contraindication to purine analog therapy",
                                            "criterion": "purine analog therapy",
                                            "requirement": {
                                                "requirement_type": "contraindication",
                                                "expected_value": true
                                            }
                                        }
                                    ]
                                }
                            ]
                        }
                    ]
                },
                "then_criteria": {
                    "exact_snippets": "Received another form of therapy (including alkylating agents)",
                    "criterion": "previous therapy",
                    "requirement": {
                        "requirement_type": "type",
                        "expected_value": [
                            "another form of therapy",
                            "alkylating agents"
                        ]
                    }
                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* Stratum II (AML and ALL):",
                "criterions": [
                    {
                        "exact_snippets": "Stratum II (AML and ALL)",
                        "criterion": "stratum",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": [
                                "AML",
                                "ALL"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Stratum II (AML and ALL)",
                        "criterion": "stratum",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": [
                                "AML",
                                "ALL"
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Primary refractory or relapsed leukemia within the past year that is not amenable to curative therapy",
                "criterions": [
                    {
                        "exact_snippets": "Primary refractory or relapsed leukemia",
                        "criterion": "leukemia status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": [
                                "primary refractory",
                                "relapsed"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "within the past year",
                        "criterion": "time since leukemia status",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1,
                                "unit": "year"
                            }
                        }
                    },
                    {
                        "exact_snippets": "not amenable to curative therapy",
                        "criterion": "amenability to curative therapy",
                        "requirement": {
                            "requirement_type": "amenability",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Primary refractory or relapsed leukemia",
                                "criterion": "leukemia status",
                                "requirement": {
                                    "requirement_type": "status",
                                    "expected_value": [
                                        "primary refractory",
                                        "relapsed"
                                    ]
                                }
                            },
                            {
                                "exact_snippets": "within the past year",
                                "criterion": "time since leukemia status",
                                "requirement": {
                                    "requirement_type": "time frame",
                                    "expected_value": {
                                        "operator": "<=",
                                        "value": 1,
                                        "unit": "year"
                                    }
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "not amenable to curative therapy",
                        "criterion": "amenability to curative therapy",
                        "requirement": {
                            "requirement_type": "amenability",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Untreated or previously treated poor-risk leukemia defined by any of the following:",
                "criterions": [
                    {
                        "exact_snippets": "Untreated or previously treated poor-risk leukemia",
                        "criterion": "poor-risk leukemia",
                        "requirement": {
                            "requirement_type": "treatment status",
                            "expected_value": [
                                "untreated",
                                "previously treated"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Untreated or previously treated poor-risk leukemia",
                                "criterion": "poor-risk leukemia",
                                "requirement": {
                                    "requirement_type": "treatment status",
                                    "expected_value": [
                                        "untreated",
                                        "previously treated"
                                    ]
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* 65 years of age and over",
                "criterions": [
                    {
                        "exact_snippets": "65 years of age and over",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">=",
                                "value": 65,
                                "unit": "years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "65 years of age and over",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">=",
                                "value": 65,
                                "unit": "years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Poor-risk candidates for aggressive chemotherapy",
                "criterions": [
                    {
                        "exact_snippets": "Poor-risk candidates for aggressive chemotherapy",
                        "criterion": "risk level for aggressive chemotherapy",
                        "requirement": {
                            "requirement_type": "risk level",
                            "expected_value": "poor"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Poor-risk candidates for aggressive chemotherapy",
                        "criterion": "risk level for aggressive chemotherapy",
                        "requirement": {
                            "requirement_type": "risk level",
                            "expected_value": "poor"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Poor-risk cytogenetics (for AML, karyotype abnormalities other than t(8;21), inv(16), t(15;17))",
                "criterions": [
                    {
                        "exact_snippets": "Poor-risk cytogenetics (for AML, karyotype abnormalities other than t(8;21), inv(16), t(15;17))",
                        "criterion": "cytogenetics",
                        "requirement": {
                            "requirement_type": "risk",
                            "expected_value": "poor"
                        }
                    },
                    {
                        "exact_snippets": "Poor-risk cytogenetics (for AML, karyotype abnormalities other than t(8;21), inv(16), t(15;17))",
                        "criterion": "cytogenetics",
                        "requirement": {
                            "requirement_type": "karyotype abnormalities",
                            "expected_value": {
                                "operator": "!=",
                                "value": 0,
                                "unit": "t(8;21), inv(16), t(15;17)"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Poor-risk cytogenetics (for AML, karyotype abnormalities other than t(8;21), inv(16), t(15;17))",
                        "criterion": "cytogenetics",
                        "requirement": {
                            "requirement_type": "risk",
                            "expected_value": "poor"
                        }
                    },
                    {
                        "exact_snippets": "Poor-risk cytogenetics (for AML, karyotype abnormalities other than t(8;21), inv(16), t(15;17))",
                        "criterion": "cytogenetics",
                        "requirement": {
                            "requirement_type": "karyotype abnormalities",
                            "expected_value": {
                                "operator": "!=",
                                "value": 0,
                                "unit": "t(8;21), inv(16), t(15;17)"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Age:",
                "criterions": [
                    {
                        "exact_snippets": "Age:",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Age:",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* 18 and over",
                "criterions": [
                    {
                        "exact_snippets": "18 and over",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "18 and over",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Performance status:",
                "criterions": [
                    {
                        "exact_snippets": "Performance status:",
                        "criterion": "performance status",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Performance status:",
                        "criterion": "performance status",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* ECOG 0-2",
                "criterions": [
                    {
                        "exact_snippets": "ECOG 0-2",
                        "criterion": "ECOG performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "ECOG 0-2",
                        "criterion": "ECOG performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Life expectancy:",
                "criterions": [
                    {
                        "exact_snippets": "Life expectancy",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Life expectancy",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* At least 12 weeks",
                "criterions": [
                    {
                        "exact_snippets": "At least 12 weeks",
                        "criterion": "duration",
                        "requirement": {
                            "requirement_type": "minimum duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 12,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "At least 12 weeks",
                        "criterion": "duration",
                        "requirement": {
                            "requirement_type": "minimum duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 12,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Hematopoietic:",
                "criterions": [
                    {
                        "exact_snippets": "Hematopoietic:",
                        "criterion": "hematopoietic system",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Hematopoietic:",
                        "criterion": "hematopoietic system",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Stratum I only:",
                "criterions": [
                    {
                        "exact_snippets": "Stratum I only",
                        "criterion": "stratum",
                        "requirement": {
                            "requirement_type": "specific stratum",
                            "expected_value": "I"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Stratum I only",
                        "criterion": "stratum",
                        "requirement": {
                            "requirement_type": "specific stratum",
                            "expected_value": "I"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No uncontrolled autoimmune hemolytic anemia",
                "criterions": [
                    {
                        "exact_snippets": "uncontrolled autoimmune hemolytic anemia",
                        "criterion": "autoimmune hemolytic anemia",
                        "requirement": {
                            "requirement_type": "control status",
                            "expected_value": "controlled"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "uncontrolled autoimmune hemolytic anemia",
                        "criterion": "autoimmune hemolytic anemia",
                        "requirement": {
                            "requirement_type": "control status",
                            "expected_value": "controlled"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No idiopathic thrombocytopenic purpura",
                "criterions": [
                    {
                        "exact_snippets": "No idiopathic thrombocytopenic purpura",
                        "criterion": "idiopathic thrombocytopenic purpura",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No idiopathic thrombocytopenic purpura",
                    "criterion": "idiopathic thrombocytopenic purpura",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Stratum II only:",
                "criterions": [
                    {
                        "exact_snippets": "Stratum II only",
                        "criterion": "stratum",
                        "requirement": {
                            "requirement_type": "specific stratum",
                            "expected_value": "II"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Stratum II only",
                        "criterion": "stratum",
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                            "requirement_type": "specific stratum",
                            "expected_value": "II"
                        }
                    }
                ]
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        {
            "identified_line": {
                "line": "* WBC no greater than 10,000/mm^3 OR",
                "criterions": [
                    {
                        "exact_snippets": "WBC no greater than 10,000/mm^3",
                        "criterion": "WBC",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 10000,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "WBC no greater than 10,000/mm^3",
                        "criterion": "WBC",
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                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 10000,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* WBC no greater than 40,000/mm^3 that is stable for at least 1 week (may be sustained by hydroxyurea through the first week of study)",
                "criterions": [
                    {
                        "exact_snippets": "WBC no greater than 40,000/mm^3",
                        "criterion": "WBC",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 40000,
                                "unit": "mm^3"
                            }
                        }
                    },
                    {
                        "exact_snippets": "stable for at least 1 week",
                        "criterion": "WBC stability",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": "at least 1 week"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "WBC no greater than 40,000/mm^3",
                        "criterion": "WBC",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 40000,
                                "unit": "mm^3"
                            }
                        }
                    },
                    {
                        "exact_snippets": "stable for at least 1 week",
                        "criterion": "WBC stability",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": "at least 1 week"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Hepatic:",
                "criterions": [
                    {
                        "exact_snippets": "Hepatic:",
                        "criterion": "hepatic function",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Hepatic:",
                        "criterion": "hepatic function",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Bilirubin no greater than 1.5 mg/dL",
                "criterions": [
                    {
                        "exact_snippets": "Bilirubin no greater than 1.5 mg/dL",
                        "criterion": "bilirubin level",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.5,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Bilirubin no greater than 1.5 mg/dL",
                        "criterion": "bilirubin level",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.5,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No myocardial infarction or unstable angina within the past 6 months",
                "criterions": [
                    {
                        "exact_snippets": "No myocardial infarction ... within the past 6 months",
                        "criterion": "myocardial infarction",
                        "requirement": {
                            "requirement_type": "occurrence",
                            "expected_value": {
                                "operator": "<",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    },
                    {
                        "exact_snippets": "No ... unstable angina within the past 6 months",
                        "criterion": "unstable angina",
                        "requirement": {
                            "requirement_type": "occurrence",
                            "expected_value": {
                                "operator": "<",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No myocardial infarction ... within the past 6 months",
                        "criterion": "myocardial infarction",
                        "requirement": {
                            "requirement_type": "occurrence",
                            "expected_value": {
                                "operator": "<",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    },
                    {
                        "exact_snippets": "No ... unstable angina within the past 6 months",
                        "criterion": "unstable angina",
                        "requirement": {
                            "requirement_type": "occurrence",
                            "expected_value": {
                                "operator": "<",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No prior unstable ventricular or supraventricular cardiac arrhythmias",
                "criterions": [
                    {
                        "exact_snippets": "No prior unstable ventricular or supraventricular cardiac arrhythmias",
                        "criterion": "unstable ventricular cardiac arrhythmias",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No prior unstable ventricular or supraventricular cardiac arrhythmias",
                        "criterion": "unstable supraventricular cardiac arrhythmias",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No prior unstable ventricular or supraventricular cardiac arrhythmias",
                        "criterion": "unstable ventricular cardiac arrhythmias",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No prior unstable ventricular or supraventricular cardiac arrhythmias",
                        "criterion": "unstable supraventricular cardiac arrhythmias",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* HIV negative",
                "criterions": [
                    {
                        "exact_snippets": "HIV negative",
                        "criterion": "HIV status",
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                            "requirement_type": "status",
                            "expected_value": "negative"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "HIV negative",
                        "criterion": "HIV status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "negative"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Negative pregnancy test",
                "criterions": [
                    {
                        "exact_snippets": "Negative pregnancy test",
                        "criterion": "pregnancy test",
                        "requirement": {
                            "requirement_type": "result",
                            "expected_value": "negative"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Negative pregnancy test",
                        "criterion": "pregnancy test",
                        "requirement": {
                            "requirement_type": "result",
                            "expected_value": "negative"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Fertile patients must use effective contraception",
                "criterions": [
                    {
                        "exact_snippets": "Fertile patients",
                        "criterion": "fertility",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "fertile"
                        }
                    },
                    {
                        "exact_snippets": "must use effective contraception",
                        "criterion": "contraception use",
                        "requirement": {
                            "requirement_type": "necessity",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "exact_snippets": "Fertile patients",
                    "criterion": "fertility",
                    "requirement": {
                        "requirement_type": "status",
                        "expected_value": "fertile"
                    }
                },
                "then_criteria": {
                    "exact_snippets": "must use effective contraception",
                    "criterion": "contraception use",
                    "requirement": {
                        "requirement_type": "necessity",
                        "expected_value": true
                    }
                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* No other medical or psychiatric problem that would preclude study",
                "criterions": [
                    {
                        "exact_snippets": "No other medical ... problem that would preclude study",
                        "criterion": "medical problem",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No other ... psychiatric problem that would preclude study",
                        "criterion": "psychiatric problem",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No other medical ... problem that would preclude study",
                        "criterion": "medical problem",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No other ... psychiatric problem that would preclude study",
                        "criterion": "psychiatric problem",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Stratum I only:",
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                    {
                        "exact_snippets": "Stratum I only",
                        "criterion": "stratum",
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                            "requirement_type": "specific stratum",
                            "expected_value": "I"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Stratum I only",
                        "criterion": "stratum",
                        "requirement": {
                            "requirement_type": "specific stratum",
                            "expected_value": "I"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No active infection requiring oral or IV antibiotics",
                "criterions": [
                    {
                        "exact_snippets": "No active infection",
                        "criterion": "active infection",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "requiring oral or IV antibiotics",
                        "criterion": "infection treatment",
                        "requirement": {
                            "requirement_type": "necessity",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No active infection",
                        "criterion": "active infection",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "requiring oral or IV antibiotics",
                        "criterion": "infection treatment",
                        "requirement": {
                            "requirement_type": "necessity",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "PRIOR CONCURRENT THERAPY:",
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                    {
                        "exact_snippets": "PRIOR CONCURRENT THERAPY",
                        "criterion": "prior concurrent therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "PRIOR CONCURRENT THERAPY",
                        "criterion": "prior concurrent therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Biologic therapy:",
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                    {
                        "exact_snippets": "Biologic therapy",
                        "criterion": "biologic therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Biologic therapy",
                        "criterion": "biologic therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Chemotherapy:",
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                    {
                        "exact_snippets": "Chemotherapy:",
                        "criterion": "chemotherapy",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Chemotherapy:",
                        "criterion": "chemotherapy",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* See Disease Characteristics",
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                    {
                        "exact_snippets": "Disease Characteristics",
                        "criterion": "disease characteristics",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "See Disease Characteristics"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Disease Characteristics",
                        "criterion": "disease characteristics",
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                            "requirement_type": "N/A",
                            "expected_value": "See Disease Characteristics"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* At least 28 days since prior chemotherapy (except hydroxyurea)",
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                    {
                        "exact_snippets": "At least 28 days since prior chemotherapy",
                        "criterion": "time since prior chemotherapy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 28,
                                "unit": "days"
                            }
                        }
                    },
                    {
                        "exact_snippets": "except hydroxyurea",
                        "criterion": "prior chemotherapy",
                        "requirement": {
                            "requirement_type": "exclusion",
                            "expected_value": "hydroxyurea"
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                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "At least 28 days since prior chemotherapy",
                                "criterion": "time since prior chemotherapy",
                                "requirement": {
                                    "requirement_type": "duration",
                                    "expected_value": {
                                        "operator": ">=",
                                        "value": 28,
                                        "unit": "days"
                                    }
                                }
                            },
                            {
                                "not_criteria": {
                                    "exact_snippets": "except hydroxyurea",
                                    "criterion": "prior chemotherapy",
                                    "requirement": {
                                        "requirement_type": "exclusion",
                                        "expected_value": "hydroxyurea"
                                    }
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* At least 6 weeks since prior nitrosoureas",
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                    {
                        "exact_snippets": "At least 6 weeks since prior nitrosoureas",
                        "criterion": "time since prior nitrosoureas",
                        "requirement": {
                            "requirement_type": "time since treatment",
                            "expected_value": {
                                "operator": ">=",
                                "value": 6,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "At least 6 weeks since prior nitrosoureas",
                        "criterion": "time since prior nitrosoureas",
                        "requirement": {
                            "requirement_type": "time since treatment",
                            "expected_value": {
                                "operator": ">=",
                                "value": 6,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* At least 8 weeks since prior UCN-01 (unless plasma UCN-01 level less than 1 uM)",
                "criterions": [
                    {
                        "exact_snippets": "At least 8 weeks since prior UCN-01",
                        "criterion": "time since prior UCN-01",
                        "requirement": {
                            "requirement_type": "time",
                            "expected_value": {
                                "operator": ">=",
                                "value": 8,
                                "unit": "weeks"
                            }
                        }
                    },
                    {
                        "exact_snippets": "unless plasma UCN-01 level less than 1 uM",
                        "criterion": "plasma UCN-01 level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 1,
                                "unit": "uM"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "and_criteria": [
                        {
                            "exact_snippets": "At least 8 weeks since prior UCN-01",
                            "criterion": "time since prior UCN-01",
                            "requirement": {
                                "requirement_type": "time",
                                "expected_value": {
                                    "operator": ">=",
                                    "value": 8,
                                    "unit": "weeks"
                                }
                            }
                        },
                        {
                            "not_criteria": {
                                "exact_snippets": "unless plasma UCN-01 level less than 1 uM",
                                "criterion": "plasma UCN-01 level",
                                "requirement": {
                                    "requirement_type": "level",
                                    "expected_value": {
                                        "operator": "<",
                                        "value": 1,
                                        "unit": "uM"
                                    }
                                }
                            }
                        }
                    ]
                },
                "then_criteria": null,
                "else_criteria": {
                    "exact_snippets": "unless plasma UCN-01 level less than 1 uM",
                    "criterion": "plasma UCN-01 level",
                    "requirement": {
                        "requirement_type": "level",
                        "expected_value": {
                            "operator": "<",
                            "value": 1,
                            "unit": "uM"
                        }
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "Endocrine therapy:",
                "criterions": [
                    {
                        "exact_snippets": "Endocrine therapy",
                        "criterion": "endocrine therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Endocrine therapy",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
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                ]
            }
        },
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            "identified_line": {
                "line": "* See Disease Characteristics",
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                    {
                        "exact_snippets": "Disease Characteristics",
                        "criterion": "disease characteristics",
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                            "requirement_type": "N/A",
                            "expected_value": "see referenced section"
                        }
                    }
                ]
            },
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                        "exact_snippets": "Radiotherapy",
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                                "unit": "days"
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                        "exact_snippets": "Surgery",
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                            "expected_value": true
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                    }
                ]
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                    {
                        "exact_snippets": "Surgery",
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                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* At least 28 days since prior major surgery",
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                    {
                        "exact_snippets": "At least 28 days since prior major surgery",
                        "criterion": "time since prior major surgery",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 28,
                                "unit": "days"
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                        }
                    }
                ]
            },
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                        "exact_snippets": "At least 28 days since prior major surgery",
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                                "operator": ">=",
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                                "unit": "days"
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                        }
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                ]
            }
        },
        {
            "identified_line": {
                "line": "* OR",
                "criterions": []
            },
            "logical_structure": {
                "or_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "PATIENT CHARACTERISTICS:",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "Other:",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "* Not pregnant or nursing",
                "criterions": [
                    {
                        "exact_snippets": "Not pregnant",
                        "criterion": "pregnancy status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "not ... nursing",
                        "criterion": "nursing status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
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                        "exact_snippets": "Not pregnant",
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        },
        {
            "identified_line": {
                "line": "* Not specified",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        }
    ],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": [
        {
            "identified_line": {
                "line": "* ALT and AST no greater than 3 times upper limit of normal",
                "criterions": [
                    {
                        "exact_snippets": "ALT ... no greater than 3 times upper limit of normal",
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                        "exact_snippets": "AST no greater than 3 times upper limit of normal",
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        },
        {
            "identified_line": {
                "line": "Renal:",
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                        "exact_snippets": "Renal:",
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                    }
                ]
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            "identified_line": {
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                    {
                        "exact_snippets": "Creatinine less than 2.0 mg/dL",
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                            "requirement_type": "level",
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                                "unit": "mg/dL"
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        },
        {
            "identified_line": {
                "line": "Cardiovascular:",
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                    {
                        "exact_snippets": "Cardiovascular:",
                        "criterion": "cardiovascular condition",
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                            "requirement_type": "presence",
                            "expected_value": true
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            }
        },
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            "identified_line": {
                "line": "* Ejection fraction at least 50% by MUGA",
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                    {
                        "exact_snippets": "Ejection fraction at least 50%",
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        }
    ]
}