{
    "info": {
        "nct_id": "NCT00006366",
        "official_title": "Randomized Phase II Trial of Preoperative Combined Modality Chemoradiation for Distal Rectal Cancer",
        "inclusion_criteria": "Healthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "",
        "miscellaneous_criteria": "DISEASE CHARACTERISTICS:\n\n* Histologically confirmed adenocarcinoma of the distal rectum\n\n  * Located 0-9 cm from the dentate line (3-12 cm from the anal verge)\n\n    * No extension of malignant disease into the anal canal\n* Lesions may be mobile stage T3 by endorectal ultrasound OR fixed, defined as clinical stage T4, by palpation\n* No evidence of distant metastases\n\nPATIENT CHARACTERISTICS:\n\nAge:\n\n* Over 18\n\nPerformance status:\n\n* Zubrod 0-1\n\nLife expectancy:\n\n* Not specified\n\nHematopoietic:\n\n* WBC (white blood cell count) greater than 4,000/mm^3\n* Platelet count greater than 130,000/mm^3\n\nHepatic:\n\n* Bilirubin no greater than 1.5 times upper limit of normal\n* Alkaline phosphatase, SGOT (serum glutamic oxaloacetic transaminase), and LDH (lactate dehydrogenase) normal\n\nRenal:\n\n* Creatinine normal\n\nOther:\n\n* Not pregnant or nursing\n* Fertile patients must use effective contraception\n* No other invasive malignancy within the past 5 years except:\n\n  * Inactive nonmelanomatous skin cancer\n  * Carcinoma in situ of the cervix\n  * Synchronous colonic cancer if tumor is Tis or T1 and has been completely resected\n* No other serious medical illnesses\n\nPRIOR CONCURRENT THERAPY:\n\nBiologic therapy:\n\n* Not specified\n\nChemotherapy:\n\n* No prior chemotherapy\n\nEndocrine therapy:\n\n* Not specified\n\nRadiotherapy:\n\n* No prior radiotherapy to pelvis\n\nSurgery:\n\n* Not specified\n\nOther:\n\n* No concurrent antiepileptic drugs"
    },
    "inclusion_lines": [
        {
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                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
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                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
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                    {
                        "exact_snippets": "minimum age of 18 Years",
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                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
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                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [],
    "miscellaneous_lines": [
        {
            "identified_line": {
                "line": "DISEASE CHARACTERISTICS:",
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                    {
                        "exact_snippets": "DISEASE CHARACTERISTICS",
                        "criterion": "disease characteristics",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "DISEASE CHARACTERISTICS",
                        "criterion": "disease characteristics",
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                        }
                    }
                ]
            }
        },
        {
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                "line": "* Histologically confirmed adenocarcinoma of the distal rectum",
                "criterions": [
                    {
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                            "requirement_type": "confirmation method",
                            "expected_value": "histologically"
                        }
                    },
                    {
                        "exact_snippets": "adenocarcinoma of the distal rectum",
                        "criterion": "location of adenocarcinoma",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": "distal rectum"
                        }
                    }
                ]
            },
            "logical_structure": {
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                    {
                        "exact_snippets": "Histologically confirmed adenocarcinoma",
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                            "requirement_type": "confirmation method",
                            "expected_value": "histologically"
                        }
                    },
                    {
                        "exact_snippets": "adenocarcinoma of the distal rectum",
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                            "expected_value": "distal rectum"
                        }
                    }
                ]
            }
        },
        {
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                "line": "* Located 0-9 cm from the dentate line (3-12 cm from the anal verge)",
                "criterions": [
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                        "exact_snippets": "Located 0-9 cm from the dentate line",
                        "criterion": "tumor location from dentate line",
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                            "requirement_type": "distance",
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                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "cm"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 9,
                                        "unit": "cm"
                                    }
                                ]
                            }
                        }
                    },
                    {
                        "exact_snippets": "(3-12 cm from the anal verge)",
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                        "requirement": {
                            "requirement_type": "distance",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 3,
                                        "unit": "cm"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 12,
                                        "unit": "cm"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
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                        "exact_snippets": "Located 0-9 cm from the dentate line",
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                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "cm"
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                                        "unit": "cm"
                                    }
                                ]
                            }
                        }
                    },
                    {
                        "exact_snippets": "(3-12 cm from the anal verge)",
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                            "expected_value": {
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                                    {
                                        "operator": ">=",
                                        "value": 3,
                                        "unit": "cm"
                                    },
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                                        "operator": "<=",
                                        "value": 12,
                                        "unit": "cm"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No extension of malignant disease into the anal canal",
                "criterions": [
                    {
                        "exact_snippets": "No extension of malignant disease into the anal canal",
                        "criterion": "extension of malignant disease into the anal canal",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No extension of malignant disease into the anal canal",
                    "criterion": "extension of malignant disease into the anal canal",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Lesions may be mobile stage T3 by endorectal ultrasound OR fixed, defined as clinical stage T4, by palpation",
                "criterions": [
                    {
                        "exact_snippets": "Lesions may be mobile stage T3 by endorectal ultrasound",
                        "criterion": "lesion mobility",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": "T3"
                        }
                    },
                    {
                        "exact_snippets": "Lesions may be mobile stage T3 by endorectal ultrasound",
                        "criterion": "lesion mobility",
                        "requirement": {
                            "requirement_type": "detection method",
                            "expected_value": "endorectal ultrasound"
                        }
                    },
                    {
                        "exact_snippets": "fixed, defined as clinical stage T4, by palpation",
                        "criterion": "lesion fixation",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": "T4"
                        }
                    },
                    {
                        "exact_snippets": "fixed, defined as clinical stage T4, by palpation",
                        "criterion": "lesion fixation",
                        "requirement": {
                            "requirement_type": "detection method",
                            "expected_value": "palpation"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Lesions may be mobile stage T3 by endorectal ultrasound",
                                "criterion": "lesion mobility",
                                "requirement": {
                                    "requirement_type": "stage",
                                    "expected_value": "T3"
                                }
                            },
                            {
                                "exact_snippets": "Lesions may be mobile stage T3 by endorectal ultrasound",
                                "criterion": "lesion mobility",
                                "requirement": {
                                    "requirement_type": "detection method",
                                    "expected_value": "endorectal ultrasound"
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "fixed, defined as clinical stage T4, by palpation",
                                "criterion": "lesion fixation",
                                "requirement": {
                                    "requirement_type": "stage",
                                    "expected_value": "T4"
                                }
                            },
                            {
                                "exact_snippets": "fixed, defined as clinical stage T4, by palpation",
                                "criterion": "lesion fixation",
                                "requirement": {
                                    "requirement_type": "detection method",
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                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No evidence of distant metastases",
                "criterions": [
                    {
                        "exact_snippets": "No evidence of distant metastases",
                        "criterion": "distant metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No evidence of distant metastases",
                        "criterion": "distant metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Age:",
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                    {
                        "exact_snippets": "Age:",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Age:",
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                        "requirement": {
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                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Over 18",
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                    {
                        "exact_snippets": "Over 18",
                        "criterion": "age",
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                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Over 18",
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                            "requirement_type": "value",
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                                "operator": ">",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Performance status:",
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                        "exact_snippets": "Performance status:",
                        "criterion": "performance status",
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                        }
                    }
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            "logical_structure": {
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                        "exact_snippets": "Performance status:",
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                            "requirement_type": "N/A",
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                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Zubrod 0-1",
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                    {
                        "exact_snippets": "Zubrod 0-1",
                        "criterion": "Zubrod performance status",
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                            "requirement_type": "range",
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                                        "operator": ">=",
                                        "value": 0,
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                                        "unit": "N/A"
                                    }
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                            }
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                    {
                        "exact_snippets": "Zubrod 0-1",
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                            "requirement_type": "range",
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                                        "operator": ">=",
                                        "value": 0,
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                                    },
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                                        "operator": "<=",
                                        "value": 1,
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        },
        {
            "identified_line": {
                "line": "Life expectancy:",
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                        "exact_snippets": "Life expectancy",
                        "criterion": "life expectancy",
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                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Life expectancy",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Hematopoietic:",
                "criterions": [
                    {
                        "exact_snippets": "Hematopoietic",
                        "criterion": "hematopoietic system",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
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            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Hematopoietic",
                        "criterion": "hematopoietic system",
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                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* WBC (white blood cell count) greater than 4,000/mm^3",
                "criterions": [
                    {
                        "exact_snippets": "WBC (white blood cell count) greater than 4,000/mm^3",
                        "criterion": "white blood cell count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 4000,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "WBC (white blood cell count) greater than 4,000/mm^3",
                        "criterion": "white blood cell count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 4000,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Bilirubin no greater than 1.5 times upper limit of normal",
                "criterions": [
                    {
                        "exact_snippets": "Bilirubin no greater than 1.5 times upper limit of normal",
                        "criterion": "bilirubin level",
                        "requirement": {
                            "requirement_type": "comparison",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.5,
                                "unit": "times upper limit of normal"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Bilirubin no greater than 1.5 times upper limit of normal",
                        "criterion": "bilirubin level",
                        "requirement": {
                            "requirement_type": "comparison",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.5,
                                "unit": "times upper limit of normal"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Alkaline phosphatase, SGOT (serum glutamic oxaloacetic transaminase), and LDH (lactate dehydrogenase) normal",
                "criterions": [
                    {
                        "exact_snippets": "Alkaline phosphatase ... normal",
                        "criterion": "alkaline phosphatase",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": "normal"
                        }
                    },
                    {
                        "exact_snippets": "SGOT (serum glutamic oxaloacetic transaminase) ... normal",
                        "criterion": "SGOT (serum glutamic oxaloacetic transaminase)",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": "normal"
                        }
                    },
                    {
                        "exact_snippets": "LDH (lactate dehydrogenase) ... normal",
                        "criterion": "LDH (lactate dehydrogenase)",
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                            "requirement_type": "level",
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                        }
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                ]
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            "logical_structure": {
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                        "exact_snippets": "Alkaline phosphatase ... normal",
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                        }
                    },
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                        "exact_snippets": "SGOT (serum glutamic oxaloacetic transaminase) ... normal",
                        "criterion": "SGOT (serum glutamic oxaloacetic transaminase)",
                        "requirement": {
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                        }
                    },
                    {
                        "exact_snippets": "LDH (lactate dehydrogenase) ... normal",
                        "criterion": "LDH (lactate dehydrogenase)",
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                            "requirement_type": "level",
                            "expected_value": "normal"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Renal:",
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                    {
                        "exact_snippets": "Renal:",
                        "criterion": "renal function",
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                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Renal:",
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                            "expected_value": "N/A"
                        }
                    }
                ]
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        },
        {
            "identified_line": {
                "line": "* Creatinine normal",
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                        "exact_snippets": "Creatinine normal",
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                ]
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                        "exact_snippets": "Creatinine normal",
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                ]
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        },
        {
            "identified_line": {
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                    {
                        "exact_snippets": "Fertile patients",
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                            "requirement_type": "status",
                            "expected_value": "fertile"
                        }
                    },
                    {
                        "exact_snippets": "must use effective contraception",
                        "criterion": "contraception use",
                        "requirement": {
                            "requirement_type": "necessity",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "exact_snippets": "Fertile patients",
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                        "requirement_type": "status",
                        "expected_value": "fertile"
                    }
                },
                "then_criteria": {
                    "exact_snippets": "must use effective contraception",
                    "criterion": "contraception use",
                    "requirement": {
                        "requirement_type": "necessity",
                        "expected_value": true
                    }
                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* No other invasive malignancy within the past 5 years except:",
                "criterions": [
                    {
                        "exact_snippets": "No other invasive malignancy within the past 5 years",
                        "criterion": "invasive malignancy",
                        "requirement": {
                            "requirement_type": "time since last occurrence",
                            "expected_value": {
                                "operator": "<",
                                "value": 5,
                                "unit": "years"
                            }
                        }
                    },
                    {
                        "exact_snippets": "No other invasive malignancy within the past 5 years",
                        "criterion": "invasive malignancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No other invasive malignancy within the past 5 years",
                        "criterion": "invasive malignancy",
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                            "requirement_type": "time since last occurrence",
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                            }
                        }
                    },
                    {
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                        "criterion": "invasive malignancy",
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                            "requirement_type": "presence",
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                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Inactive nonmelanomatous skin cancer",
                "criterions": [
                    {
                        "exact_snippets": "Inactive nonmelanomatous skin cancer",
                        "criterion": "nonmelanomatous skin cancer",
                        "requirement": {
                            "requirement_type": "activity status",
                            "expected_value": "inactive"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Inactive nonmelanomatous skin cancer",
                        "criterion": "nonmelanomatous skin cancer",
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                            "requirement_type": "activity status",
                            "expected_value": "inactive"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Carcinoma in situ of the cervix",
                "criterions": [
                    {
                        "exact_snippets": "Carcinoma in situ of the cervix",
                        "criterion": "carcinoma in situ",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": "cervix"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Carcinoma in situ of the cervix",
                        "criterion": "carcinoma in situ",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": "cervix"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Synchronous colonic cancer if tumor is Tis or T1 and has been completely resected",
                "criterions": [
                    {
                        "exact_snippets": "Synchronous colonic cancer",
                        "criterion": "synchronous colonic cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "tumor is Tis or T1",
                        "criterion": "tumor stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": [
                                "Tis",
                                "T1"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "has been completely resected",
                        "criterion": "tumor resection",
                        "requirement": {
                            "requirement_type": "completeness",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "and_criteria": [
                        {
                            "exact_snippets": "Synchronous colonic cancer",
                            "criterion": "synchronous colonic cancer",
                            "requirement": {
                                "requirement_type": "presence",
                                "expected_value": true
                            }
                        },
                        {
                            "exact_snippets": "tumor is Tis or T1",
                            "criterion": "tumor stage",
                            "requirement": {
                                "requirement_type": "stage",
                                "expected_value": [
                                    "Tis",
                                    "T1"
                                ]
                            }
                        }
                    ]
                },
                "then_criteria": {
                    "exact_snippets": "has been completely resected",
                    "criterion": "tumor resection",
                    "requirement": {
                        "requirement_type": "completeness",
                        "expected_value": true
                    }
                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* No other serious medical illnesses",
                "criterions": [
                    {
                        "exact_snippets": "No other serious medical illnesses",
                        "criterion": "serious medical illnesses",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No other serious medical illnesses",
                    "criterion": "serious medical illnesses",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "PRIOR CONCURRENT THERAPY:",
                "criterions": [
                    {
                        "exact_snippets": "PRIOR CONCURRENT THERAPY",
                        "criterion": "prior concurrent therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "PRIOR CONCURRENT THERAPY",
                        "criterion": "prior concurrent therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Biologic therapy:",
                "criterions": [
                    {
                        "exact_snippets": "Biologic therapy",
                        "criterion": "biologic therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Biologic therapy",
                        "criterion": "biologic therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Chemotherapy:",
                "criterions": [
                    {
                        "exact_snippets": "Chemotherapy",
                        "criterion": "chemotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Chemotherapy",
                        "criterion": "chemotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No prior chemotherapy",
                "criterions": [
                    {
                        "exact_snippets": "No prior chemotherapy",
                        "criterion": "prior chemotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No prior chemotherapy",
                        "criterion": "prior chemotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Endocrine therapy:",
                "criterions": [
                    {
                        "exact_snippets": "Endocrine therapy",
                        "criterion": "endocrine therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Endocrine therapy",
                        "criterion": "endocrine therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Radiotherapy:",
                "criterions": [
                    {
                        "exact_snippets": "Radiotherapy",
                        "criterion": "radiotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Radiotherapy",
                        "criterion": "radiotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No prior radiotherapy to pelvis",
                "criterions": [
                    {
                        "exact_snippets": "No prior radiotherapy to pelvis",
                        "criterion": "prior radiotherapy to pelvis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No prior radiotherapy to pelvis",
                    "criterion": "prior radiotherapy to pelvis",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "Surgery:",
                "criterions": [
                    {
                        "exact_snippets": "Surgery",
                        "criterion": "surgery",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Surgery",
                        "criterion": "surgery",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "PATIENT CHARACTERISTICS:",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "* Not specified",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "Other:",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "* Not pregnant or nursing",
                "criterions": [
                    {
                        "exact_snippets": "Not pregnant",
                        "criterion": "pregnancy status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "not ... nursing",
                        "criterion": "nursing status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Not pregnant",
                        "criterion": "pregnancy status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "not ... nursing",
                        "criterion": "nursing status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Not specified",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "* Not specified",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "* Not specified",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "Other:",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        }
    ],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": [
        {
            "identified_line": {
                "line": "* Platelet count greater than 130,000/mm^3",
                "criterions": [
                    {
                        "exact_snippets": "Platelet count greater than 130,000/mm^3",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 130000,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "Hepatic:",
                "criterions": [
                    {
                        "exact_snippets": "Hepatic:",
                        "criterion": "hepatic function",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* No concurrent antiepileptic drugs",
                "criterions": [
                    {
                        "exact_snippets": "No concurrent antiepileptic drugs",
                        "criterion": "antiepileptic drugs",
                        "requirement": {
                            "requirement_type": "concurrent use",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No concurrent antiepileptic drugs",
                    "criterion": "antiepileptic drugs",
                    "requirement": {
                        "requirement_type": "concurrent use",
                        "expected_value": true
                    }
                }
            }
        }
    ]
}