{
    "info": {
        "nct_id": "NCT00003462",
        "official_title": "Phase I Study of Intrathecal Spartaject-Busulfan in Patients With Neoplastic Meningitis",
        "inclusion_criteria": "Healthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "",
        "miscellaneous_criteria": "DISEASE CHARACTERISTICS:\n\n* Histologically confirmed neoplasm that is metastatic in the cerebrospinal fluid or leptomeningeal/subarachnoid space\n\n  * Cytologic diagnosis of malignancy in the cerebrospinal fluid or neuroimaging evidence of leptomeningeal tumor by MRI\n* Must have a recurrent or refractory leptomeningeal tumor\n\n  * Leptomeningeal tumors of leukemia, lymphoma, and all germ cell tumors must have also failed initial treatment or be recurrent\n* No evidence of obstructive hydrocephalus or complete block of the spinal cerebrospinal fluid pathways on prestudy technetium Tc 99m albumin or indium In 111 DTPA flow study\n\nPATIENT CHARACTERISTICS:\n\nAge:\n\n* 18 and over\n\nPerformance status:\n\n* Karnofsky 60-100%\n\nLife expectancy:\n\n* At least 8 weeks\n\nHematopoietic:\n\n* Absolute neutrophil count greater than 1,500/mm^3\n* Platelet count greater than 100,000/mm^3\n\nHepatic:\n\n* Bilirubin less than 2.5 mg/dL\n* SGOT or SGPT less than 1.5 times normal\n\nRenal:\n\n* BUN less than 30 mg/dL\n* Creatinine less than 1.5 mg/dL\n* Calcium within normal limits\n\nNeurological:\n\n* Neurological examination stable\n* No rapidly progressing or deteriorating neurological deficits\n\nOther:\n\n* No active infectious process\n* Magnesium, phosphorus, potassium, chloride, and bicarbonate normal\n* Not pregnant or nursing\n* Fertile patients must use effective contraception\n\nPRIOR CONCURRENT THERAPY:\n\nBiologic therapy:\n\n* At least 4 weeks since prior immunotherapy\n\nChemotherapy:\n\n* At least 6 weeks since prior nitrosoureas or mitomycin\n* At least 4 weeks since any other prior chemotherapy\n* At least 3 weeks since prior intrathecal chemotherapy\n* No other concurrent intrathecal chemotherapy\n\nEndocrine therapy:\n\n* For patients on corticosteroids:\n\n  * Must be on a stable dose of corticosteroids for at least 1 week\n\nRadiotherapy:\n\n* At least 3 weeks since prior radiotherapy to the CNS\n* At least 4 weeks since any other prior radiotherapy\n* No concurrent radiotherapy to the CNS\n\nSurgery:\n\n* At least 3 weeks since prior surgery\n\nOther:\n\n* No concurrent medication that may interfere with study results (e.g., immunosuppressive agents other than corticosteroids)"
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [],
    "miscellaneous_lines": [
        {
            "identified_line": {
                "line": "DISEASE CHARACTERISTICS:",
                "criterions": [
                    {
                        "exact_snippets": "DISEASE CHARACTERISTICS",
                        "criterion": "disease characteristics",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "DISEASE CHARACTERISTICS",
                        "criterion": "disease characteristics",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Histologically confirmed neoplasm that is metastatic in the cerebrospinal fluid or leptomeningeal/subarachnoid space",
                "criterions": [
                    {
                        "exact_snippets": "Histologically confirmed neoplasm",
                        "criterion": "neoplasm",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": "histologically"
                        }
                    },
                    {
                        "exact_snippets": "metastatic in the cerebrospinal fluid",
                        "criterion": "metastatic neoplasm in cerebrospinal fluid",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "metastatic in the ... leptomeningeal/subarachnoid space",
                        "criterion": "metastatic neoplasm in leptomeningeal/subarachnoid space",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
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                        "and_criteria": [
                            {
                                "exact_snippets": "Histologically confirmed neoplasm",
                                "criterion": "neoplasm",
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                                    "requirement_type": "confirmation",
                                    "expected_value": "histologically"
                                }
                            },
                            {
                                "exact_snippets": "metastatic in the cerebrospinal fluid",
                                "criterion": "metastatic neoplasm in cerebrospinal fluid",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "metastatic in the ... leptomeningeal/subarachnoid space",
                        "criterion": "metastatic neoplasm in leptomeningeal/subarachnoid space",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Cytologic diagnosis of malignancy in the cerebrospinal fluid or neuroimaging evidence of leptomeningeal tumor by MRI",
                "criterions": [
                    {
                        "exact_snippets": "Cytologic diagnosis of malignancy in the cerebrospinal fluid",
                        "criterion": "malignancy in the cerebrospinal fluid",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": "cytologic"
                        }
                    },
                    {
                        "exact_snippets": "neuroimaging evidence of leptomeningeal tumor by MRI",
                        "criterion": "leptomeningeal tumor",
                        "requirement": {
                            "requirement_type": "evidence",
                            "expected_value": "neuroimaging"
                        }
                    },
                    {
                        "exact_snippets": "neuroimaging evidence of leptomeningeal tumor by MRI",
                        "criterion": "leptomeningeal tumor",
                        "requirement": {
                            "requirement_type": "method",
                            "expected_value": "MRI"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Cytologic diagnosis of malignancy in the cerebrospinal fluid",
                                "criterion": "malignancy in the cerebrospinal fluid",
                                "requirement": {
                                    "requirement_type": "diagnosis",
                                    "expected_value": "cytologic"
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "neuroimaging evidence of leptomeningeal tumor by MRI",
                                "criterion": "leptomeningeal tumor",
                                "requirement": {
                                    "requirement_type": "evidence",
                                    "expected_value": "neuroimaging"
                                }
                            },
                            {
                                "exact_snippets": "neuroimaging evidence of leptomeningeal tumor by MRI",
                                "criterion": "leptomeningeal tumor",
                                "requirement": {
                                    "requirement_type": "method",
                                    "expected_value": "MRI"
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Leptomeningeal tumors of leukemia, lymphoma, and all germ cell tumors must have also failed initial treatment or be recurrent",
                "criterions": [
                    {
                        "exact_snippets": "Leptomeningeal tumors of leukemia, lymphoma, and all germ cell tumors",
                        "criterion": "leptomeningeal tumors",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": [
                                "leukemia",
                                "lymphoma",
                                "germ cell tumors"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "must have also failed initial treatment",
                        "criterion": "treatment response",
                        "requirement": {
                            "requirement_type": "response",
                            "expected_value": "failed initial treatment"
                        }
                    },
                    {
                        "exact_snippets": "be recurrent",
                        "criterion": "tumor status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "recurrent"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "Leptomeningeal tumors of leukemia, lymphoma, and all germ cell tumors",
                                        "criterion": "leptomeningeal tumors",
                                        "requirement": {
                                            "requirement_type": "type",
                                            "expected_value": [
                                                "leukemia",
                                                "lymphoma",
                                                "germ cell tumors"
                                            ]
                                        }
                                    },
                                    {
                                        "exact_snippets": "must have also failed initial treatment",
                                        "criterion": "treatment response",
                                        "requirement": {
                                            "requirement_type": "response",
                                            "expected_value": "failed initial treatment"
                                        }
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "be recurrent",
                                "criterion": "tumor status",
                                "requirement": {
                                    "requirement_type": "status",
                                    "expected_value": "recurrent"
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No evidence of obstructive hydrocephalus or complete block of the spinal cerebrospinal fluid pathways on prestudy technetium Tc 99m albumin or indium In 111 DTPA flow study",
                "criterions": [
                    {
                        "exact_snippets": "No evidence of obstructive hydrocephalus",
                        "criterion": "obstructive hydrocephalus",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No evidence of ... complete block of the spinal cerebrospinal fluid pathways",
                        "criterion": "complete block of the spinal cerebrospinal fluid pathways",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No evidence of obstructive hydrocephalus",
                        "criterion": "obstructive hydrocephalus",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No evidence of ... complete block of the spinal cerebrospinal fluid pathways",
                        "criterion": "complete block of the spinal cerebrospinal fluid pathways",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Age:",
                "criterions": [
                    {
                        "exact_snippets": "Age:",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Age:",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* 18 and over",
                "criterions": [
                    {
                        "exact_snippets": "18 and over",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "18 and over",
                        "criterion": "age",
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                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Performance status:",
                "criterions": [
                    {
                        "exact_snippets": "Performance status:",
                        "criterion": "performance status",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Performance status:",
                        "criterion": "performance status",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Karnofsky 60-100%",
                "criterions": [
                    {
                        "exact_snippets": "Karnofsky 60-100%",
                        "criterion": "Karnofsky performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 60,
                                        "unit": "%"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 100,
                                        "unit": "%"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Karnofsky 60-100%",
                        "criterion": "Karnofsky performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 60,
                                        "unit": "%"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 100,
                                        "unit": "%"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Life expectancy:",
                "criterions": [
                    {
                        "exact_snippets": "Life expectancy",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Life expectancy",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* At least 8 weeks",
                "criterions": [
                    {
                        "exact_snippets": "At least 8 weeks",
                        "criterion": "duration",
                        "requirement": {
                            "requirement_type": "minimum duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 8,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "At least 8 weeks",
                        "criterion": "duration",
                        "requirement": {
                            "requirement_type": "minimum duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 8,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Hematopoietic:",
                "criterions": [
                    {
                        "exact_snippets": "Hematopoietic",
                        "criterion": "hematopoietic system",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Hematopoietic",
                        "criterion": "hematopoietic system",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Absolute neutrophil count greater than 1,500/mm^3",
                "criterions": [
                    {
                        "exact_snippets": "Absolute neutrophil count greater than 1,500/mm^3",
                        "criterion": "absolute neutrophil count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 1500,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Absolute neutrophil count greater than 1,500/mm^3",
                        "criterion": "absolute neutrophil count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 1500,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Platelet count greater than 100,000/mm^3",
                "criterions": [
                    {
                        "exact_snippets": "Platelet count greater than 100,000/mm^3",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 100000,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Platelet count greater than 100,000/mm^3",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 100000,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Hepatic:",
                "criterions": [
                    {
                        "exact_snippets": "Hepatic",
                        "criterion": "hepatic function",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Hepatic",
                        "criterion": "hepatic function",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Bilirubin less than 2.5 mg/dL",
                "criterions": [
                    {
                        "exact_snippets": "Bilirubin less than 2.5 mg/dL",
                        "criterion": "bilirubin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 2.5,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Bilirubin less than 2.5 mg/dL",
                        "criterion": "bilirubin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 2.5,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* SGOT or SGPT less than 1.5 times normal",
                "criterions": [
                    {
                        "exact_snippets": "SGOT ... less than 1.5 times normal",
                        "criterion": "SGOT",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 1.5,
                                "unit": "times normal"
                            }
                        }
                    },
                    {
                        "exact_snippets": "SGPT less than 1.5 times normal",
                        "criterion": "SGPT",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 1.5,
                                "unit": "times normal"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "SGOT ... less than 1.5 times normal",
                        "criterion": "SGOT",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 1.5,
                                "unit": "times normal"
                            }
                        }
                    },
                    {
                        "exact_snippets": "SGPT less than 1.5 times normal",
                        "criterion": "SGPT",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 1.5,
                                "unit": "times normal"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Renal:",
                "criterions": [
                    {
                        "exact_snippets": "Renal:",
                        "criterion": "renal function",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Renal:",
                        "criterion": "renal function",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* BUN less than 30 mg/dL",
                "criterions": [
                    {
                        "exact_snippets": "BUN less than 30 mg/dL",
                        "criterion": "BUN",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 30,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "BUN less than 30 mg/dL",
                        "criterion": "BUN",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 30,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Creatinine less than 1.5 mg/dL",
                "criterions": [
                    {
                        "exact_snippets": "Creatinine less than 1.5 mg/dL",
                        "criterion": "creatinine level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 1.5,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Creatinine less than 1.5 mg/dL",
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                            "requirement_type": "level",
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        {
            "identified_line": {
                "line": "* Calcium within normal limits",
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                        "exact_snippets": "Calcium within normal limits",
                        "criterion": "calcium level",
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                            "requirement_type": "range",
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                ]
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                    {
                        "exact_snippets": "Calcium within normal limits",
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                            "requirement_type": "range",
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        {
            "identified_line": {
                "line": "Neurological:",
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                    {
                        "exact_snippets": "Neurological",
                        "criterion": "neurological condition",
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                            "requirement_type": "presence",
                            "expected_value": true
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                    }
                ]
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            "logical_structure": {
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                    {
                        "exact_snippets": "Neurological",
                        "criterion": "neurological condition",
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                            "requirement_type": "presence",
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                ]
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            "identified_line": {
                "line": "* Neurological examination stable",
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                        "exact_snippets": "Neurological examination stable",
                        "criterion": "neurological examination",
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                            "requirement_type": "stability",
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                        "exact_snippets": "Neurological examination stable",
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                            "requirement_type": "stability",
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        {
            "identified_line": {
                "line": "* No rapidly progressing or deteriorating neurological deficits",
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                    {
                        "exact_snippets": "No rapidly progressing or deteriorating neurological deficits",
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                            "requirement_type": "progression",
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                    {
                        "exact_snippets": "No rapidly progressing or deteriorating neurological deficits",
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                            "requirement_type": "deterioration",
                            "expected_value": "not deteriorating"
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                    }
                ]
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                    {
                        "exact_snippets": "No rapidly progressing or deteriorating neurological deficits",
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                            "requirement_type": "progression",
                            "expected_value": "not rapidly progressing"
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                    },
                    {
                        "exact_snippets": "No rapidly progressing or deteriorating neurological deficits",
                        "criterion": "neurological deficits",
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                            "requirement_type": "deterioration",
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        {
            "identified_line": {
                "line": "* No active infectious process",
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                        "exact_snippets": "No active infectious process",
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                            "requirement_type": "presence",
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                "not_criteria": {
                    "exact_snippets": "No active infectious process",
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                        "requirement_type": "presence",
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        {
            "identified_line": {
                "line": "* Magnesium, phosphorus, potassium, chloride, and bicarbonate normal",
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                    {
                        "exact_snippets": "Magnesium ... normal",
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                    {
                        "exact_snippets": "phosphorus ... normal",
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                            "requirement_type": "level",
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                    {
                        "exact_snippets": "potassium ... normal",
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                            "requirement_type": "level",
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                        "exact_snippets": "chloride ... normal",
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                        "exact_snippets": "bicarbonate normal",
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                        "exact_snippets": "Magnesium ... normal",
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                            "requirement_type": "level",
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                        "exact_snippets": "phosphorus ... normal",
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                    {
                        "exact_snippets": "potassium ... normal",
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                    {
                        "exact_snippets": "chloride ... normal",
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                            "requirement_type": "level",
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                    {
                        "exact_snippets": "bicarbonate normal",
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                            "requirement_type": "level",
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                            "requirement_type": "status",
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                    {
                        "exact_snippets": "must use effective contraception",
                        "criterion": "contraception use",
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                            "requirement_type": "necessity",
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            "logical_structure": {
                "condition": {
                    "exact_snippets": "Fertile patients",
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                        "requirement_type": "status",
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                    "exact_snippets": "must use effective contraception",
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                        "requirement_type": "necessity",
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                "else_criteria": null
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            "identified_line": {
                "line": "PRIOR CONCURRENT THERAPY:",
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                    {
                        "exact_snippets": "PRIOR CONCURRENT THERAPY",
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                            "requirement_type": "presence",
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            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "PRIOR CONCURRENT THERAPY",
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                            "requirement_type": "presence",
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            "identified_line": {
                "line": "Biologic therapy:",
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                        "exact_snippets": "Biologic therapy",
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                        "exact_snippets": "Biologic therapy",
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                        "exact_snippets": "At least 4 weeks since prior immunotherapy",
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                            "requirement_type": "duration",
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                                "operator": ">=",
                                "value": 4,
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                        "exact_snippets": "At least 4 weeks since prior immunotherapy",
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                            "requirement_type": "duration",
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                        "exact_snippets": "Chemotherapy",
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            "logical_structure": {
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                    {
                        "exact_snippets": "Chemotherapy",
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                        "exact_snippets": "At least 6 weeks since prior nitrosoureas",
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                            "requirement_type": "duration",
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                                "value": 6,
                                "unit": "weeks"
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                    {
                        "exact_snippets": "At least 6 weeks since prior ... mitomycin",
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                            "requirement_type": "duration",
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                                "value": 6,
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                        "exact_snippets": "At least 6 weeks since prior nitrosoureas",
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                    {
                        "exact_snippets": "At least 6 weeks since prior ... mitomycin",
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                                "operator": ">=",
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                            "requirement_type": "duration",
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                                "unit": "weeks"
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            "logical_structure": {
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                        "exact_snippets": "At least 4 weeks since any other prior chemotherapy",
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                            "requirement_type": "duration",
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                                "unit": "weeks"
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                        "exact_snippets": "At least 3 weeks since prior radiotherapy to the CNS",
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                            "requirement_type": "time since treatment",
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                                "operator": ">=",
                                "value": 3,
                                "unit": "weeks"
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            "logical_structure": {
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                    {
                        "exact_snippets": "At least 3 weeks since prior radiotherapy to the CNS",
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                            "requirement_type": "time since treatment",
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            "identified_line": {
                "line": "* At least 4 weeks since any other prior radiotherapy",
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                    {
                        "exact_snippets": "At least 4 weeks since any other prior radiotherapy",
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                            "requirement_type": "duration",
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                                "operator": ">=",
                                "value": 4,
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            "logical_structure": {
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                        "exact_snippets": "At least 4 weeks since any other prior radiotherapy",
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                            "requirement_type": "duration",
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                                "unit": "weeks"
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            "identified_line": {
                "line": "Surgery:",
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                        "exact_snippets": "Surgery:",
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            "logical_structure": {
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                    {
                        "exact_snippets": "Surgery:",
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            "identified_line": {
                "line": "* At least 3 weeks since prior surgery",
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                        "exact_snippets": "At least 3 weeks since prior surgery",
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                            "requirement_type": "time elapsed",
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                                "operator": ">=",
                                "value": 3,
                                "unit": "weeks"
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                    }
                ]
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            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "At least 3 weeks since prior surgery",
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                            "requirement_type": "time elapsed",
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                                "operator": ">=",
                                "value": 3,
                                "unit": "weeks"
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        },
        {
            "identified_line": {
                "line": "* No concurrent medication that may interfere with study results (e.g., immunosuppressive agents other than corticosteroids)",
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                    {
                        "exact_snippets": "No concurrent medication that may interfere with study results (e.g., immunosuppressive agents other than corticosteroids)",
                        "criterion": "concurrent medication",
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                            "requirement_type": "interference with study results",
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                ]
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                    "exact_snippets": "No concurrent medication that may interfere with study results (e.g., immunosuppressive agents other than corticosteroids)",
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                        "requirement_type": "interference with study results",
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        {
            "identified_line": {
                "line": "PATIENT CHARACTERISTICS:",
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                "and_criteria": []
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            "identified_line": {
                "line": "Other:",
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                    {
                        "exact_snippets": "Tissue from tumor must be available",
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                            "requirement_type": "availability",
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                    {
                        "exact_snippets": "Tissue from tumor ... > 2 cm in diameter.",
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                            "requirement_type": "size",
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                                "operator": ">",
                                "value": 2,
                                "unit": "cm"
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                        "exact_snippets": "Tissue from tumor must be available",
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                            "requirement_type": "availability",
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                        "exact_snippets": "Tissue from tumor ... > 2 cm in diameter.",
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                            "requirement_type": "size",
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                                "operator": ">",
                                "value": 2,
                                "unit": "cm"
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        },
        {
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                        "exact_snippets": "Not pregnant",
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                            "requirement_type": "status",
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                    {
                        "exact_snippets": "not ... nursing",
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                            "requirement_type": "status",
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            "logical_structure": {
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                        "exact_snippets": "Not pregnant",
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                            "requirement_type": "status",
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                        "exact_snippets": "not ... nursing",
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                ]
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        },
        {
            "identified_line": {
                "line": "* At least 3 weeks since prior intrathecal chemotherapy",
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                    {
                        "exact_snippets": "at least 3 weeks since prior intrathecal chemotherapy",
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                            "requirement_type": "time since prior treatment",
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                                "operator": ">=",
                                "value": 3,
                                "unit": "weeks"
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            "logical_structure": {
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                                "operator": ">=",
                                "value": 3,
                                "unit": "weeks"
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        },
        {
            "identified_line": {
                "line": "Other:",
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            },
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                "and_criteria": []
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        }
    ],
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    "failed_exclusion": [],
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        {
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                    {
                        "exact_snippets": "recurrent or refractory leptomeningeal tumor",
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                                "recurrent",
                                "refractory"
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                    {
                        "exact_snippets": "recurrent or refractory leptomeningeal tumor",
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                        "exact_snippets": "recurrent or refractory leptomeningeal tumor",
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                ]
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        },
        {
            "identified_line": {
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                        "exact_snippets": "No other concurrent intrathecal chemotherapy",
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                ]
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            "logical_structure": {
                "exact_snippets": "failed",
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                    "requirement_type": "failed",
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            "identified_line": {
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                        "exact_snippets": "Endocrine therapy",
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            "logical_structure": {
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                    "requirement_type": "failed",
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        },
        {
            "identified_line": {
                "line": "* For patients on corticosteroids:",
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                    {
                        "exact_snippets": "patients on corticosteroids",
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                            "requirement_type": "presence",
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            "logical_structure": {
                "exact_snippets": "failed",
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                    "requirement_type": "failed",
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        },
        {
            "identified_line": {
                "line": "* Must be on a stable dose of corticosteroids for at least 1 week",
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                    {
                        "exact_snippets": "Must be on a stable dose of corticosteroids for at least 1 week",
                        "criterion": "corticosteroids",
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                            "requirement_type": "dose stability",
                            "expected_value": true
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                    {
                        "exact_snippets": "Must be on a stable dose of corticosteroids for at least 1 week",
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                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "week"
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                ]
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            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "Radiotherapy:",
                "criterions": [
                    {
                        "exact_snippets": "Radiotherapy",
                        "criterion": "radiotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* No concurrent radiotherapy to the CNS",
                "criterions": [
                    {
                        "exact_snippets": "No concurrent radiotherapy to the CNS",
                        "criterion": "concurrent radiotherapy to the CNS",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No concurrent radiotherapy to the CNS",
                    "criterion": "concurrent radiotherapy to the CNS",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        }
    ]
}