{
    "info": {
        "nct_id": "NCT00002620",
        "official_title": "EFFECT OF DIBROMODULCITOL PLUS BCNU ON FREE INTERVAL AND SURVIVAL OF PATIENTS WITH SUPRATENTORIAL MALIGNANT BRAIN GLIOMAS, A PHASE III TYPE STUDY",
        "inclusion_criteria": "Healthy volunteers allowed\nMust have minimum age of 16 Years",
        "exclusion_criteria": "",
        "miscellaneous_criteria": "DISEASE CHARACTERISTICS: Histologically confirmed anaplastic astrocytoma Standard maximum resection or stereotactic biopsy required within 4 weeks prior to therapy\n\nPATIENT CHARACTERISTICS: Age: Over 16 Performance status: ECOG/ZUBROD/WHO 0-2 Life expectancy: At least 8 weeks Hematopoietic: WBC greater than 4,000 Platelets greater than 100,000 Hematocrit greater than 30% Hepatic: Bilirubin less than 2 mg/dl Renal: Creatinine less than 1.5 mg/dl Creatinine clearance greater than 70 ml/min BUN less than 40 mg/dl Other: No major medical illness\n\nPRIOR CONCURRENT THERAPY: No anticancer drugs between surgery and protocol treatment No steroids after 10 days following surgery (may be resumed occasionally during radiotherapy)"
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 16 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 16 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 16,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 16 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 16,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [],
    "miscellaneous_lines": [
        {
            "identified_line": {
                "line": "PRIOR CONCURRENT THERAPY: No anticancer drugs between surgery and protocol treatment No steroids after 10 days following surgery (may be resumed occasionally during radiotherapy)",
                "criterions": [
                    {
                        "exact_snippets": "No anticancer drugs between surgery and protocol treatment",
                        "criterion": "anticancer drugs",
                        "requirement": {
                            "requirement_type": "usage",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No steroids after 10 days following surgery",
                        "criterion": "steroids",
                        "requirement": {
                            "requirement_type": "usage",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No anticancer drugs between surgery and protocol treatment",
                        "criterion": "anticancer drugs",
                        "requirement": {
                            "requirement_type": "usage",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No steroids after 10 days following surgery",
                        "criterion": "steroids",
                        "requirement": {
                            "requirement_type": "usage",
                            "expected_value": false
                        }
                    }
                ]
            }
        }
    ],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": [
        {
            "identified_line": {
                "line": "DISEASE CHARACTERISTICS: Histologically confirmed anaplastic astrocytoma Standard maximum resection or stereotactic biopsy required within 4 weeks prior to therapy",
                "criterions": [
                    {
                        "exact_snippets": "Histologically confirmed anaplastic astrocytoma",
                        "criterion": "anaplastic astrocytoma",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": "histologically confirmed"
                        }
                    },
                    {
                        "exact_snippets": "Standard maximum resection or stereotactic biopsy required within 4 weeks prior to therapy",
                        "criterion": "surgical procedure",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": [
                                "standard maximum resection",
                                "stereotactic biopsy"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "Standard maximum resection or stereotactic biopsy required within 4 weeks prior to therapy",
                        "criterion": "surgical procedure",
                        "requirement": {
                            "requirement_type": "timing",
                            "expected_value": "within 4 weeks prior to therapy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "PATIENT CHARACTERISTICS: Age: Over 16 Performance status: ECOG/ZUBROD/WHO 0-2 Life expectancy: At least 8 weeks Hematopoietic: WBC greater than 4,000 Platelets greater than 100,000 Hematocrit greater than 30% Hepatic: Bilirubin less than 2 mg/dl Renal: Creatinine less than 1.5 mg/dl Creatinine clearance greater than 70 ml/min BUN less than 40 mg/dl Other: No major medical illness",
                "criterions": [
                    {
                        "exact_snippets": "Age: Over 16",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum age",
                            "expected_value": {
                                "operator": ">",
                                "value": 16,
                                "unit": "years"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Performance status: ECOG/ZUBROD/WHO 0-2",
                        "criterion": "performance status",
                        "requirement": {
                            "requirement_type": "scale",
                            "expected_value": [
                                "ECOG",
                                "ZUBROD",
                                "WHO"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "Performance status: ECOG/ZUBROD/WHO 0-2",
                        "criterion": "performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    },
                    {
                        "exact_snippets": "Life expectancy: At least 8 weeks",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "minimum duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 8,
                                "unit": "weeks"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Hematopoietic: WBC greater than 4,000",
                        "criterion": "white blood cell count",
                        "requirement": {
                            "requirement_type": "minimum count",
                            "expected_value": {
                                "operator": ">",
                                "value": 4000,
                                "unit": "N/A"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Platelets greater than 100,000",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "minimum count",
                            "expected_value": {
                                "operator": ">",
                                "value": 100000,
                                "unit": "N/A"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Hematocrit greater than 30%",
                        "criterion": "hematocrit",
                        "requirement": {
                            "requirement_type": "minimum percentage",
                            "expected_value": {
                                "operator": ">",
                                "value": 30,
                                "unit": "%"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Hepatic: Bilirubin less than 2 mg/dl",
                        "criterion": "bilirubin level",
                        "requirement": {
                            "requirement_type": "maximum level",
                            "expected_value": {
                                "operator": "<",
                                "value": 2,
                                "unit": "mg/dl"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Renal: Creatinine less than 1.5 mg/dl",
                        "criterion": "creatinine level",
                        "requirement": {
                            "requirement_type": "maximum level",
                            "expected_value": {
                                "operator": "<",
                                "value": 1.5,
                                "unit": "mg/dl"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Creatinine clearance greater than 70 ml/min",
                        "criterion": "creatinine clearance",
                        "requirement": {
                            "requirement_type": "minimum clearance",
                            "expected_value": {
                                "operator": ">",
                                "value": 70,
                                "unit": "ml/min"
                            }
                        }
                    },
                    {
                        "exact_snippets": "BUN less than 40 mg/dl",
                        "criterion": "blood urea nitrogen level",
                        "requirement": {
                            "requirement_type": "maximum level",
                            "expected_value": {
                                "operator": "<",
                                "value": 40,
                                "unit": "mg/dl"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Other: No major medical illness",
                        "criterion": "major medical illness",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        }
    ]
}