{
    "info": {
        "nct_id": "NCT00001272",
        "official_title": "A Phase I Study of Taxol, Cisplatin, Cyclophosphamide and Granulocyte Colony-Stimulating Factor (G-CSF) in Previously Nontreated Ovarian Cancer Patients",
        "inclusion_criteria": "Healthy volunteers allowed\nMust be FEMALE",
        "exclusion_criteria": "",
        "miscellaneous_criteria": "All patients must have biopsy proven ovarian cancer as determined by evaluation in the Laboratory of Pathology, NCI.\n\nGerm cell and borderline histologies are specifically excluded.\n\nPatients must have FIGO stage III and IV disease, or FIGO Stage IIC disease with poorly differentiated histology, and will undergo attempted surgical debulking prior to the initiation of chemotherapy.\n\nPrior chemotherapy or radiation therapy will make a patient ineligible.\n\nPerformance status: less than or equal to ECOG 2.\n\nPatients must have the following end organ function:\n\nNo brain involvement.\n\nNo history of myocardial infarction, cardiac arrhythmias requiring\n\ntherapy, right bundle branch block with left anterior hemiblock, and left bundle branch block.\n\nRenal function: creatinine clearance greater than or equal to 60 cc/min; patients with ureteral obstruction must have this corrected prior to starting therapy.\n\nHepatic function: normal coagulation parameters, serum transaminases within 3 times upper limit of normal.\n\nNeurologic function: no preexisting dysfunction greater than grade 1 (exclusive of mild vibratory delay).\n\nNo recent history of active GI bleeding.\n\nHematologic parameters prior to starting cycle 1 of therapy: total granulocyte count greater than 2000 and platelet count greater than 100,000.\n\nPatients may not have had prior history of invasive malignancy with the exception of nonmelanoma skin cancer curatively treated.\n\nPatients must be able to give written informed consent and express a willingness to meet all of the expected requirements of the protocol.\n\nPatients must be able to begin therapy within 8 weeks of staging laparotomy and should have a central venous catheter placed for infusion of chemotherapy.\n\nAll patients must be registered by calling the Orkand Corporation at 402-1732 between the hours of 8:30 AM and 5:00 PM; eligibility criteria will be queried."
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must be FEMALE",
                "criterions": [
                    {
                        "exact_snippets": "Must be FEMALE",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Must be FEMALE",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [],
    "miscellaneous_lines": [
        {
            "identified_line": {
                "line": "All patients must have biopsy proven ovarian cancer as determined by evaluation in the Laboratory of Pathology, NCI.",
                "criterions": [
                    {
                        "exact_snippets": "biopsy proven ovarian cancer",
                        "criterion": "ovarian cancer",
                        "requirement": {
                            "requirement_type": "confirmation method",
                            "expected_value": "biopsy proven"
                        }
                    },
                    {
                        "exact_snippets": "evaluation in the Laboratory of Pathology, NCI",
                        "criterion": "evaluation location",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": "Laboratory of Pathology, NCI"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "biopsy proven ovarian cancer",
                        "criterion": "ovarian cancer",
                        "requirement": {
                            "requirement_type": "confirmation method",
                            "expected_value": "biopsy proven"
                        }
                    },
                    {
                        "exact_snippets": "evaluation in the Laboratory of Pathology, NCI",
                        "criterion": "evaluation location",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": "Laboratory of Pathology, NCI"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Germ cell and borderline histologies are specifically excluded.",
                "criterions": [
                    {
                        "exact_snippets": "Germ cell ... are specifically excluded.",
                        "criterion": "germ cell histology",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "borderline histologies are specifically excluded.",
                        "criterion": "borderline histology",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Germ cell ... are specifically excluded.",
                        "criterion": "germ cell histology",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "borderline histologies are specifically excluded.",
                        "criterion": "borderline histology",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Performance status: less than or equal to ECOG 2.",
                "criterions": [
                    {
                        "exact_snippets": "Performance status: less than or equal to ECOG 2.",
                        "criterion": "performance status",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2,
                                "unit": "ECOG"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Performance status: less than or equal to ECOG 2.",
                        "criterion": "performance status",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2,
                                "unit": "ECOG"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Patients must have the following end organ function:",
                "criterions": [
                    {
                        "exact_snippets": "end organ function",
                        "criterion": "end organ function",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "end organ function",
                        "criterion": "end organ function",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "No brain involvement.",
                "criterions": [
                    {
                        "exact_snippets": "No brain involvement.",
                        "criterion": "brain involvement",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No brain involvement.",
                        "criterion": "brain involvement",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "No history of myocardial infarction, cardiac arrhythmias requiring",
                "criterions": [
                    {
                        "exact_snippets": "No history of myocardial infarction",
                        "criterion": "myocardial infarction",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "cardiac arrhythmias requiring",
                        "criterion": "cardiac arrhythmias",
                        "requirement": {
                            "requirement_type": "treatment",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No history of myocardial infarction",
                        "criterion": "myocardial infarction",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "cardiac arrhythmias requiring",
                        "criterion": "cardiac arrhythmias",
                        "requirement": {
                            "requirement_type": "treatment",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "therapy, right bundle branch block with left anterior hemiblock, and left bundle branch block.",
                "criterions": [
                    {
                        "exact_snippets": "right bundle branch block",
                        "criterion": "right bundle branch block",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "left anterior hemiblock",
                        "criterion": "left anterior hemiblock",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "left bundle branch block",
                        "criterion": "left bundle branch block",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "right bundle branch block",
                                        "criterion": "right bundle branch block",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "left anterior hemiblock",
                                        "criterion": "left anterior hemiblock",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "left bundle branch block",
                                "criterion": "left bundle branch block",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Hepatic function: normal coagulation parameters, serum transaminases within 3 times upper limit of normal.",
                "criterions": [
                    {
                        "exact_snippets": "Hepatic function: normal coagulation parameters",
                        "criterion": "hepatic function",
                        "requirement": {
                            "requirement_type": "coagulation parameters",
                            "expected_value": "normal"
                        }
                    },
                    {
                        "exact_snippets": "serum transaminases within 3 times upper limit of normal",
                        "criterion": "serum transaminases",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 3,
                                "unit": "times upper limit of normal"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Hepatic function: normal coagulation parameters",
                        "criterion": "hepatic function",
                        "requirement": {
                            "requirement_type": "coagulation parameters",
                            "expected_value": "normal"
                        }
                    },
                    {
                        "exact_snippets": "serum transaminases within 3 times upper limit of normal",
                        "criterion": "serum transaminases",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 3,
                                "unit": "times upper limit of normal"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Neurologic function: no preexisting dysfunction greater than grade 1 (exclusive of mild vibratory delay).",
                "criterions": [
                    {
                        "exact_snippets": "Neurologic function: no preexisting dysfunction greater than grade 1",
                        "criterion": "neurologic function",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1,
                                "unit": "grade"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Neurologic function: no preexisting dysfunction greater than grade 1",
                        "criterion": "neurologic function",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1,
                                "unit": "grade"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "No recent history of active GI bleeding.",
                "criterions": [
                    {
                        "exact_snippets": "No recent history of active GI bleeding.",
                        "criterion": "active GI bleeding",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No recent history of active GI bleeding.",
                        "criterion": "active GI bleeding",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Hematologic parameters prior to starting cycle 1 of therapy: total granulocyte count greater than 2000 and platelet count greater than 100,000.",
                "criterions": [
                    {
                        "exact_snippets": "total granulocyte count greater than 2000",
                        "criterion": "total granulocyte count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 2000,
                                "unit": "N/A"
                            }
                        }
                    },
                    {
                        "exact_snippets": "platelet count greater than 100,000",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 100000,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "total granulocyte count greater than 2000",
                        "criterion": "total granulocyte count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 2000,
                                "unit": "N/A"
                            }
                        }
                    },
                    {
                        "exact_snippets": "platelet count greater than 100,000",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 100000,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Patients must be able to give written informed consent and express a willingness to meet all of the expected requirements of the protocol.",
                "criterions": [
                    {
                        "exact_snippets": "able to give written informed consent",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "express a willingness to meet all of the expected requirements of the protocol",
                        "criterion": "willingness to meet protocol requirements",
                        "requirement": {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "able to give written informed consent",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "express a willingness to meet all of the expected requirements of the protocol",
                        "criterion": "willingness to meet protocol requirements",
                        "requirement": {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Patients must be able to begin therapy within 8 weeks of staging laparotomy and should have a central venous catheter placed for infusion of chemotherapy.",
                "criterions": [
                    {
                        "exact_snippets": "able to begin therapy within 8 weeks of staging laparotomy",
                        "criterion": "therapy initiation time",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "operator": "<=",
                                "value": 8,
                                "unit": "weeks"
                            }
                        }
                    },
                    {
                        "exact_snippets": "central venous catheter placed for infusion of chemotherapy",
                        "criterion": "central venous catheter",
                        "requirement": {
                            "requirement_type": "placement",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "able to begin therapy within 8 weeks of staging laparotomy",
                        "criterion": "therapy initiation time",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "operator": "<=",
                                "value": 8,
                                "unit": "weeks"
                            }
                        }
                    },
                    {
                        "exact_snippets": "central venous catheter placed for infusion of chemotherapy",
                        "criterion": "central venous catheter",
                        "requirement": {
                            "requirement_type": "placement",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "All patients must be registered by calling the Orkand Corporation at 402-1732 between the hours of 8:30 AM and 5:00 PM; eligibility criteria will be queried.",
                "criterions": [
                    {
                        "exact_snippets": "All patients must be registered by calling the Orkand Corporation at 402-1732 between the hours of 8:30 AM and 5:00 PM",
                        "criterion": "registration",
                        "requirement": {
                            "requirement_type": "method",
                            "expected_value": "calling"
                        }
                    },
                    {
                        "exact_snippets": "All patients must be registered by calling the Orkand Corporation at 402-1732 between the hours of 8:30 AM and 5:00 PM",
                        "criterion": "registration",
                        "requirement": {
                            "requirement_type": "contact",
                            "expected_value": "Orkand Corporation at 402-1732"
                        }
                    },
                    {
                        "exact_snippets": "All patients must be registered by calling the Orkand Corporation at 402-1732 between the hours of 8:30 AM and 5:00 PM",
                        "criterion": "registration",
                        "requirement": {
                            "requirement_type": "time",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 8.5,
                                        "unit": "hours"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 17,
                                        "unit": "hours"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "All patients must be registered by calling the Orkand Corporation at 402-1732 between the hours of 8:30 AM and 5:00 PM",
                                        "criterion": "registration",
                                        "requirement": {
                                            "requirement_type": "method",
                                            "expected_value": "calling"
                                        }
                                    },
                                    {
                                        "exact_snippets": "All patients must be registered by calling the Orkand Corporation at 402-1732 between the hours of 8:30 AM and 5:00 PM",
                                        "criterion": "registration",
                                        "requirement": {
                                            "requirement_type": "contact",
                                            "expected_value": "Orkand Corporation at 402-1732"
                                        }
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "All patients must be registered by calling the Orkand Corporation at 402-1732 between the hours of 8:30 AM and 5:00 PM",
                                "criterion": "registration",
                                "requirement": {
                                    "requirement_type": "time",
                                    "expected_value": {
                                        "comparisons": [
                                            {
                                                "operator": ">=",
                                                "value": 8.5,
                                                "unit": "hours"
                                            },
                                            {
                                                "operator": "<=",
                                                "value": 17,
                                                "unit": "hours"
                                            }
                                        ]
                                    }
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Prior chemotherapy or radiation therapy will make a patient ineligible.",
                "criterions": [
                    {
                        "exact_snippets": "Prior chemotherapy",
                        "criterion": "prior chemotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "prior ... radiation therapy",
                        "criterion": "prior radiation therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Prior chemotherapy",
                        "criterion": "prior chemotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "prior ... radiation therapy",
                        "criterion": "prior radiation therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        }
    ],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": [
        {
            "identified_line": {
                "line": "Patients must have FIGO stage III and IV disease, or FIGO Stage IIC disease with poorly differentiated histology, and will undergo attempted surgical debulking prior to the initiation of chemotherapy.",
                "criterions": [
                    {
                        "exact_snippets": "FIGO stage III and IV disease",
                        "criterion": "FIGO stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": [
                                "III",
                                "IV"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "FIGO Stage IIC disease with poorly differentiated histology",
                        "criterion": "FIGO stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": "IIC"
                        }
                    },
                    {
                        "exact_snippets": "FIGO Stage IIC disease with poorly differentiated histology",
                        "criterion": "FIGO stage",
                        "requirement": {
                            "requirement_type": "histology differentiation",
                            "expected_value": "poorly differentiated"
                        }
                    },
                    {
                        "exact_snippets": "will undergo attempted surgical debulking",
                        "criterion": "surgical debulking",
                        "requirement": {
                            "requirement_type": "procedure",
                            "expected_value": "attempted"
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "Renal function: creatinine clearance greater than or equal to 60 cc/min; patients with ureteral obstruction must have this corrected prior to starting therapy.",
                "criterions": [
                    {
                        "exact_snippets": "Renal function: creatinine clearance greater than or equal to 60 cc/min",
                        "criterion": "creatinine clearance",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 60,
                                "unit": "cc/min"
                            }
                        }
                    },
                    {
                        "exact_snippets": "patients with ureteral obstruction must have this corrected prior to starting therapy",
                        "criterion": "ureteral obstruction",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "exact_snippets": "ureteral obstruction must have this corrected prior to starting therapy",
                    "criterion": "ureteral obstruction",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": false
                    }
                },
                "then_criteria": {
                    "and_criteria": [
                        {
                            "exact_snippets": "Renal function: creatinine clearance greater than or equal to 60 cc/min",
                            "criterion": "creatinine clearance",
                            "requirement": {
                                "requirement_type": "quantity",
                                "expected_value": {
                                    "operator": ">=",
                                    "value": 60,
                                    "unit": "cc/min"
                                }
                            }
                        },
                        {
                            "exact_snippets": "patients with ureteral obstruction must have this corrected prior to starting therapy",
                            "criterion": "ureteral obstruction",
                            "requirement": {
                                "requirement_type": "presence",
                                "expected_value": false
                            }
                        }
                    ]
                },
                "else_criteria": {
                    "exact_snippets": "Renal function: creatinine clearance greater than or equal to 60 cc/min",
                    "criterion": "creatinine clearance",
                    "requirement": {
                        "requirement_type": "quantity",
                        "expected_value": {
                            "operator": ">=",
                            "value": 60,
                            "unit": "cc/min"
                        }
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "Patients may not have had prior history of invasive malignancy with the exception of nonmelanoma skin cancer curatively treated.",
                "criterions": [
                    {
                        "exact_snippets": "prior history of invasive malignancy",
                        "criterion": "prior history of invasive malignancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "nonmelanoma skin cancer curatively treated",
                        "criterion": "nonmelanoma skin cancer",
                        "requirement": {
                            "requirement_type": "treatment status",
                            "expected_value": "curatively treated"
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "not_criteria": {
                        "and_criteria": [
                            {
                                "exact_snippets": "prior history of invasive malignancy",
                                "criterion": "prior history of invasive malignancy",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "nonmelanoma skin cancer curatively treated",
                                "criterion": "nonmelanoma skin cancer",
                                "requirement": {
                                    "requirement_type": "treatment status",
                                    "expected_value": "curatively treated"
                                }
                            }
                        ]
                    }
                },
                "then_criteria": null,
                "else_criteria": {
                    "exact_snippets": "prior history of invasive malignancy",
                    "criterion": "prior history of invasive malignancy",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": false
                    }
                }
            }
        }
    ]
}