{
    "info": {
        "nct_id": "NCT06844357",
        "official_title": "A Multi-center, Randomized, Controlled, Open-label Phase II/III Clinical Trial to Investigate Whether Transarterial Tirapazamine Injection Followed by Transarterial Embolization (TATE) is Superior to Traditional Transarterial Chemoembolization (TACE) in Patients with Intermediate-Stage Hepatocellular Carcinoma (HCC)",
        "inclusion_criteria": "* Patients diagnosed with primary hepatocellular carcinoma according to AASLD criteria.\n* No evidence of extrahepatic metastasis, regional lymph node involvement, or vascular tumor thrombus.\n* Patients must be eligible for TAE or TACE treatment.\n* ECOG ≤ 1.\n* Child-Pugh score ≤ 7.\n* Adequate bone marrow, liver, and kidney function is required.\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* History of liver transplantation.\n* Previous radioemblization or radiotherapy for liver tumors.\n* severe cardiovascular or renal diseases, active systemic infections.\n* Clinically significant hypoxia (oxygen saturation < 92% without oxygen supplementation)",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Patients diagnosed with primary hepatocellular carcinoma according to AASLD criteria.",
            "criterions": [
                {
                    "exact_snippets": "diagnosed with primary hepatocellular carcinoma",
                    "criterion": "primary hepatocellular carcinoma",
                    "requirements": [
                        {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "according to AASLD criteria",
                    "criterion": "AASLD criteria",
                    "requirements": [
                        {
                            "requirement_type": "compliance",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* No evidence of extrahepatic metastasis, regional lymph node involvement, or vascular tumor thrombus.",
            "criterions": [
                {
                    "exact_snippets": "No evidence of extrahepatic metastasis",
                    "criterion": "extrahepatic metastasis",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "No evidence of ... regional lymph node involvement",
                    "criterion": "regional lymph node involvement",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "No evidence of ... vascular tumor thrombus",
                    "criterion": "vascular tumor thrombus",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Patients must be eligible for TAE or TACE treatment.",
            "criterions": [
                {
                    "exact_snippets": "eligible for TAE or TACE treatment",
                    "criterion": "TAE or TACE treatment eligibility",
                    "requirements": [
                        {
                            "requirement_type": "eligibility",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* ECOG ≤ 1.",
            "criterions": [
                {
                    "exact_snippets": "ECOG ≤ 1",
                    "criterion": "ECOG performance status",
                    "requirements": [
                        {
                            "requirement_type": "performance status",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1,
                                "unit": "N/A"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Child-Pugh score ≤ 7.",
            "criterions": [
                {
                    "exact_snippets": "Child-Pugh score ≤ 7",
                    "criterion": "Child-Pugh score",
                    "requirements": [
                        {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": "<=",
                                "value": 7,
                                "unit": "N/A"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Adequate bone marrow, liver, and kidney function is required.",
            "criterions": [
                {
                    "exact_snippets": "Adequate bone marrow ... function is required.",
                    "criterion": "bone marrow function",
                    "requirements": [
                        {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "Adequate ... liver ... function is required.",
                    "criterion": "liver function",
                    "requirements": [
                        {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "Adequate ... kidney function is required.",
                    "criterion": "kidney function",
                    "requirements": [
                        {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* History of liver transplantation.",
            "criterions": [
                {
                    "exact_snippets": "History of liver transplantation",
                    "criterion": "liver transplantation",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Previous radioemblization or radiotherapy for liver tumors.",
            "criterions": [
                {
                    "exact_snippets": "Previous radioemblization ... for liver tumors.",
                    "criterion": "radioemblization for liver tumors",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "Previous ... radiotherapy for liver tumors.",
                    "criterion": "radiotherapy for liver tumors",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* severe cardiovascular or renal diseases, active systemic infections.",
            "criterions": [
                {
                    "exact_snippets": "severe cardiovascular ... diseases",
                    "criterion": "cardiovascular diseases",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": "severe"
                        }
                    ]
                },
                {
                    "exact_snippets": "severe ... renal diseases",
                    "criterion": "renal diseases",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": "severe"
                        }
                    ]
                },
                {
                    "exact_snippets": "active systemic infections",
                    "criterion": "systemic infections",
                    "requirements": [
                        {
                            "requirement_type": "activity",
                            "expected_value": "active"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Clinically significant hypoxia (oxygen saturation < 92% without oxygen supplementation)",
            "criterions": [
                {
                    "exact_snippets": "Clinically significant hypoxia (oxygen saturation < 92% without oxygen supplementation)",
                    "criterion": "oxygen saturation",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": "clinically significant"
                        },
                        {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 92,
                                "unit": "%"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}