{
    "info": {
        "nct_id": "NCT06796348",
        "official_title": "Multi-center, 1:1 Randomized, Stratified, Parallel-group, Non-inferiority Clinical Trial of Small Thyroid Cancers Treated with Hemithyroidectomy or Radiofrequency Ablation.",
        "inclusion_criteria": "* Single tumor in the thyroid gland with a FNAB suspecious of cancer or diagnostic of cancer (category V or VI in the Bethesda system)\n* tumor size of less than 2 cm in all dimensions.\nHealthy volunteers allowed\nMust have minimum age of 30 Years",
        "exclusion_criteria": "* suspicion of disseminated disease because of PET-positive lymph nodes ; suspect lymph-nodes by ultrasonography (US); or signs of capsular invasion of the tumor OR\n* tumor not eligible for RFA treatment because of high-risk location; previous thyroid surgery; concomitant hyperparathyroidism (ionized calcium > 1.32 mmol/L and PTH > 6 pmol//L ) OR\n* if the patient is pregnant OR\n* If the patient is unable to give informed consent.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Single tumor in the thyroid gland with a FNAB suspecious of cancer or diagnostic of cancer (category V or VI in the Bethesda system)",
            "criterions": [
                {
                    "exact_snippets": "Single tumor in the thyroid gland",
                    "criterion": "tumor in the thyroid gland",
                    "requirements": [
                        {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "=",
                                "value": 1,
                                "unit": "tumor"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "FNAB suspecious of cancer",
                    "criterion": "FNAB result",
                    "requirements": [
                        {
                            "requirement_type": "suspicion of cancer",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "FNAB ... diagnostic of cancer (category V or VI in the Bethesda system)",
                    "criterion": "FNAB result",
                    "requirements": [
                        {
                            "requirement_type": "diagnostic category",
                            "expected_value": [
                                "V",
                                "VI"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* tumor size of less than 2 cm in all dimensions.",
            "criterions": [
                {
                    "exact_snippets": "tumor size of less than 2 cm in all dimensions",
                    "criterion": "tumor size",
                    "requirements": [
                        {
                            "requirement_type": "size",
                            "expected_value": {
                                "operator": "<",
                                "value": 2,
                                "unit": "cm"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 30 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 30 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 30,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* suspicion of disseminated disease because of PET-positive lymph nodes ; suspect lymph-nodes by ultrasonography (US); or signs of capsular invasion of the tumor OR",
            "criterions": [
                {
                    "exact_snippets": "suspicion of disseminated disease because of PET-positive lymph nodes",
                    "criterion": "disseminated disease",
                    "requirements": [
                        {
                            "requirement_type": "suspicion",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "suspect lymph-nodes by ultrasonography (US)",
                    "criterion": "lymph nodes",
                    "requirements": [
                        {
                            "requirement_type": "suspicion",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "signs of capsular invasion of the tumor",
                    "criterion": "capsular invasion of the tumor",
                    "requirements": [
                        {
                            "requirement_type": "signs",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* tumor not eligible for RFA treatment because of high-risk location; previous thyroid surgery; concomitant hyperparathyroidism (ionized calcium > 1.32 mmol/L and PTH > 6 pmol//L ) OR",
            "criterions": [
                {
                    "exact_snippets": "tumor not eligible for RFA treatment because of high-risk location",
                    "criterion": "tumor location",
                    "requirements": [
                        {
                            "requirement_type": "risk",
                            "expected_value": "high-risk"
                        }
                    ]
                },
                {
                    "exact_snippets": "previous thyroid surgery",
                    "criterion": "thyroid surgery",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "concomitant hyperparathyroidism (ionized calcium > 1.32 mmol/L and PTH > 6 pmol//L )",
                    "criterion": "hyperparathyroidism",
                    "requirements": [
                        {
                            "requirement_type": "concomitance",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "ionized calcium > 1.32 mmol/L",
                    "criterion": "ionized calcium",
                    "requirements": [
                        {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">",
                                "value": 1.32,
                                "unit": "mmol/L"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "PTH > 6 pmol//L",
                    "criterion": "PTH",
                    "requirements": [
                        {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">",
                                "value": 6,
                                "unit": "pmol/L"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* if the patient is pregnant OR",
            "criterions": [
                {
                    "exact_snippets": "if the patient is pregnant",
                    "criterion": "pregnancy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* If the patient is unable to give informed consent.",
            "criterions": [
                {
                    "exact_snippets": "unable to give informed consent",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}