{
    "info": {
        "nct_id": "NCT06706973",
        "official_title": "Profiling and Targeting Epigenetic Marks to Improve Diagnosis and Therapeutic Approaches in Head and Neck Cancer",
        "inclusion_criteria": "• Age: Adults aged ≥ 18 years diagnosed with HNC\n\n* Sex: Both male and female\n* Human papilloma virus (HPV) test: Both positive and negative.\n* Tumor: primary tumors, treatment naïve, squamous cell carcinoma\n* Cancer stage: I-IV\n* Anatomic location: oral cavity, larynx, oropharynx\n* Tumor fragments not required for diagnostics\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Previous radiotherapy, chemotherapy or immunotherapy for HNC\n* Unable to provide written informed consent",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "• Age: Adults aged ≥ 18 years diagnosed with HNC",
            "criterions": [
                {
                    "exact_snippets": "Age: Adults aged ≥ 18 years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "age",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "diagnosed with HNC",
                    "criterion": "HNC diagnosis",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Sex: Both male and female",
            "criterions": [
                {
                    "exact_snippets": "Sex: Both male and female",
                    "criterion": "sex",
                    "requirements": [
                        {
                            "requirement_type": "allowed_values",
                            "expected_value": [
                                "male",
                                "female"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Human papilloma virus (HPV) test: Both positive and negative.",
            "criterions": [
                {
                    "exact_snippets": "Human papilloma virus (HPV) test",
                    "criterion": "HPV test",
                    "requirements": [
                        {
                            "requirement_type": "result",
                            "expected_value": [
                                "positive",
                                "negative"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Tumor: primary tumors, treatment naïve, squamous cell carcinoma",
            "criterions": [
                {
                    "exact_snippets": "Tumor: primary tumors",
                    "criterion": "tumor type",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": "primary"
                        }
                    ]
                },
                {
                    "exact_snippets": "treatment naïve",
                    "criterion": "treatment history",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "naïve"
                        }
                    ]
                },
                {
                    "exact_snippets": "squamous cell carcinoma",
                    "criterion": "tumor histology",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": "squamous cell carcinoma"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Cancer stage: I-IV",
            "criterions": [
                {
                    "exact_snippets": "Cancer stage: I-IV",
                    "criterion": "cancer stage",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 1,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 4,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Anatomic location: oral cavity, larynx, oropharynx",
            "criterions": [
                {
                    "exact_snippets": "Anatomic location: oral cavity, larynx, oropharynx",
                    "criterion": "anatomic location",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": [
                                "oral cavity",
                                "larynx",
                                "oropharynx"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Tumor fragments not required for diagnostics",
            "criterions": [
                {
                    "exact_snippets": "Tumor fragments not required for diagnostics",
                    "criterion": "tumor fragments",
                    "requirements": [
                        {
                            "requirement_type": "requirement for diagnostics",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Previous radiotherapy, chemotherapy or immunotherapy for HNC",
            "criterions": [
                {
                    "exact_snippets": "Previous radiotherapy ... for HNC",
                    "criterion": "previous radiotherapy for HNC",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "Previous ... chemotherapy ... for HNC",
                    "criterion": "previous chemotherapy for HNC",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "Previous ... immunotherapy for HNC",
                    "criterion": "previous immunotherapy for HNC",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Unable to provide written informed consent",
            "criterions": [
                {
                    "exact_snippets": "Unable to provide written informed consent",
                    "criterion": "written informed consent",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": false
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}