{
    "info": {
        "nct_id": "NCT06697782",
        "official_title": "Clinical Study of Aprepitant and Ondansetron Monotherapy or Combination in the Treatment of Postoperative Nausea and Vomiting in Thyroid Carcinoma",
        "inclusion_criteria": "1. Patients aged 18-80 years;\n2. Voluntary enrollment in the study and signing the informed consent form;\n3. Diagnosed with thyroid cancer and needing surgical treatment;\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 80 Years",
        "exclusion_criteria": "1. Patient has depression, history of chronic pain, insulin-dependent diabetes mellitus I or II, history of severe vomiting;\n2. history of prior thyroid or neck surgery;\n3. Cases in which surgery requiring sternotomy is anticipated;\n4. History of long-term hormone use, period of immunosuppressive therapy;\n5. pre-operative voice changes or laryngoscopic confirmation of vocal cord paralysis;\n6. Pregnant or breastfeeding patients;\n7. Patients who are allergic to any of the study medications;\n8. Patients who have received any sedative, hypnotic, anxiolytic, opioid, steroid or other antiemetic medication within 24 hours prior to the procedure;\n9. Patients taking or planning to take a combination of drugs such as rifampicin, carbamazepine, phenytoin or other drugs that strongly induce CYP3A4 activity;\n10. patients with other malignant tumors;\n11. Patients with hypothyroidism;\n12. Participating or planning to participate in other clinical studies.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "1. Patients aged 18-80 years;",
            "criterions": [
                {
                    "exact_snippets": "Patients aged 18-80 years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 80,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. Voluntary enrollment in the study and signing the informed consent form;",
            "criterions": [
                {
                    "exact_snippets": "Voluntary enrollment in the study",
                    "criterion": "enrollment",
                    "requirements": [
                        {
                            "requirement_type": "voluntary",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "signing the informed consent form",
                    "criterion": "informed consent form",
                    "requirements": [
                        {
                            "requirement_type": "signed",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "3. Diagnosed with thyroid cancer and needing surgical treatment;",
            "criterions": [
                {
                    "exact_snippets": "Diagnosed with thyroid cancer",
                    "criterion": "thyroid cancer",
                    "requirements": [
                        {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "needing surgical treatment",
                    "criterion": "surgical treatment",
                    "requirements": [
                        {
                            "requirement_type": "necessity",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 80 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 80 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 80,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "1. Patient has depression, history of chronic pain, insulin-dependent diabetes mellitus I or II, history of severe vomiting;",
            "criterions": [
                {
                    "exact_snippets": "Patient has depression",
                    "criterion": "depression",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "history of chronic pain",
                    "criterion": "chronic pain",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "insulin-dependent diabetes mellitus I or II",
                    "criterion": "insulin-dependent diabetes mellitus",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": [
                                "I",
                                "II"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "history of severe vomiting",
                    "criterion": "severe vomiting",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. history of prior thyroid or neck surgery;",
            "criterions": [
                {
                    "exact_snippets": "history of prior thyroid or neck surgery",
                    "criterion": "prior thyroid or neck surgery",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "3. Cases in which surgery requiring sternotomy is anticipated;",
            "criterions": [
                {
                    "exact_snippets": "surgery requiring sternotomy is anticipated",
                    "criterion": "surgery requiring sternotomy",
                    "requirements": [
                        {
                            "requirement_type": "anticipation",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "4. History of long-term hormone use, period of immunosuppressive therapy;",
            "criterions": [
                {
                    "exact_snippets": "History of long-term hormone use",
                    "criterion": "long-term hormone use",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "period of immunosuppressive therapy",
                    "criterion": "immunosuppressive therapy",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "5. pre-operative voice changes or laryngoscopic confirmation of vocal cord paralysis;",
            "criterions": [
                {
                    "exact_snippets": "pre-operative voice changes",
                    "criterion": "voice changes",
                    "requirements": [
                        {
                            "requirement_type": "timing",
                            "expected_value": "pre-operative"
                        }
                    ]
                },
                {
                    "exact_snippets": "laryngoscopic confirmation of vocal cord paralysis",
                    "criterion": "vocal cord paralysis",
                    "requirements": [
                        {
                            "requirement_type": "confirmation method",
                            "expected_value": "laryngoscopic"
                        }
                    ]
                }
            ]
        },
        {
            "line": "6. Pregnant or breastfeeding patients;",
            "criterions": [
                {
                    "exact_snippets": "Pregnant",
                    "criterion": "pregnancy status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "breastfeeding",
                    "criterion": "breastfeeding status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "7. Patients who are allergic to any of the study medications;",
            "criterions": [
                {
                    "exact_snippets": "Patients who are allergic to any of the study medications",
                    "criterion": "allergy to study medications",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "8. Patients who have received any sedative, hypnotic, anxiolytic, opioid, steroid or other antiemetic medication within 24 hours prior to the procedure;",
            "criterions": [
                {
                    "exact_snippets": "Patients who have received any sedative, hypnotic, anxiolytic, opioid, steroid or other antiemetic medication within 24 hours prior to the procedure",
                    "criterion": "medication use",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": [
                                "sedative",
                                "hypnotic",
                                "anxiolytic",
                                "opioid",
                                "steroid",
                                "antiemetic"
                            ]
                        },
                        {
                            "requirement_type": "time frame",
                            "expected_value": "within 24 hours prior to the procedure"
                        }
                    ]
                }
            ]
        },
        {
            "line": "9. Patients taking or planning to take a combination of drugs such as rifampicin, carbamazepine, phenytoin or other drugs that strongly induce CYP3A4 activity;",
            "criterions": [
                {
                    "exact_snippets": "Patients taking or planning to take a combination of drugs such as rifampicin, carbamazepine, phenytoin or other drugs that strongly induce CYP3A4 activity",
                    "criterion": "CYP3A4-inducing drugs",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "10. patients with other malignant tumors;",
            "criterions": [
                {
                    "exact_snippets": "patients with other malignant tumors",
                    "criterion": "malignant tumors",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "11. Patients with hypothyroidism;",
            "criterions": [
                {
                    "exact_snippets": "Patients with hypothyroidism",
                    "criterion": "hypothyroidism",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "12. Participating or planning to participate in other clinical studies.",
            "criterions": [
                {
                    "exact_snippets": "Participating or planning to participate in other clinical studies.",
                    "criterion": "participation in other clinical studies",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": [
                                "participating",
                                "planning to participate"
                            ]
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}