{
    "info": {
        "nct_id": "NCT06464380",
        "official_title": "Anti Cancer Potential of Saffron in Hepatocellular Carcinoma",
        "inclusion_criteria": "* Adult male and female patients above 18 years\n* Patients with end-stage HCC not candidate for curative, loco regional treatment and /or systemic chemotherapy\n* Patients with available baseline laboratory parameters and contrast- enhancing images after given written consent for research participation.\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Patients who are candidate for curative and/or loco-regional or combination treatment for HCC\n* Patients with concomitant malignancies other than HCC",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Adult male and female patients above 18 years",
            "criterions": [
                {
                    "exact_snippets": "Adult male and female patients",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": [
                                "male",
                                "female"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "above 18 years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum age",
                            "expected_value": {
                                "operator": ">",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Patients with end-stage HCC not candidate for curative, loco regional treatment and /or systemic chemotherapy",
            "criterions": [
                {
                    "exact_snippets": "end-stage HCC",
                    "criterion": "HCC stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": "end-stage"
                        }
                    ]
                },
                {
                    "exact_snippets": "not candidate for curative, loco regional treatment",
                    "criterion": "treatment candidacy",
                    "requirements": [
                        {
                            "requirement_type": "candidacy",
                            "expected_value": [
                                "curative treatment",
                                "loco regional treatment"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "not candidate for ... systemic chemotherapy",
                    "criterion": "chemotherapy candidacy",
                    "requirements": [
                        {
                            "requirement_type": "candidacy",
                            "expected_value": "systemic chemotherapy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Patients who are candidate for curative and/or loco-regional or combination treatment for HCC",
            "criterions": [
                {
                    "exact_snippets": "Patients who are candidate for curative and/or loco-regional or combination treatment for HCC",
                    "criterion": "treatment candidacy",
                    "requirements": [
                        {
                            "requirement_type": "treatment type",
                            "expected_value": [
                                "curative",
                                "loco-regional",
                                "combination"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "HCC",
                    "criterion": "condition",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Patients with concomitant malignancies other than HCC",
            "criterions": [
                {
                    "exact_snippets": "concomitant malignancies other than HCC",
                    "criterion": "concomitant malignancies",
                    "requirements": [
                        {
                            "requirement_type": "exclusion",
                            "expected_value": "HCC"
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "line": "* Patients with available baseline laboratory parameters and contrast- enhancing images after given written consent for research participation.",
            "criterions": [
                {
                    "exact_snippets": "available baseline laboratory parameters",
                    "criterion": "baseline laboratory parameters",
                    "requirements": [
                        {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "contrast-enhancing images",
                    "criterion": "contrast-enhancing images",
                    "requirements": [
                        {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "given written consent for research participation",
                    "criterion": "written consent for research participation",
                    "requirements": [
                        {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}