{
    "info": {
        "nct_id": "NCT06427460",
        "official_title": "Central-boost Ablative Radiation Therapy for Large Tumors or Tumors Adjacent to Organs at Risk",
        "inclusion_criteria": "* Aged 18-75 years.\n* Pathologically confirmed lung, liver, pancreas or retroperitoneal malignant tumor.\n* Oligometastasis in the case of metastatic tumor\n* the shortest diameter ≥2cm or the distance from the tumor to the organs at risk less than 5mm\n* ECOG of 0 to 1 point\n* No abnormality in blood routine test, liver and kidney function test and coagulation test (White blood cell count ≥4.0×10^9/L, neutrophil count ≥2.0×10^9, hemoglobin level ≥100g/L, platelet count ≥100×10^9/L, ALT and AST level < 2.5 times the upper limit of normal, total bilirubin and creatinine level within the normal, international normalized ratio <2)\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 75 Years",
        "exclusion_criteria": "* History of radiotherapy for the lesion\n* History of tumor within 5 years\n* ECOG ≥2 points\n* Significant abnormality in blood routine test, liver and kidney function test and coagulation test\n* Active inflammatory bowel disease in the case of pancreas or retroperitoneal tumor\n* Gastrointestinal bleeding or perforation within 6 months in the case of pancreas or retroperitoneal tumor\n* Infections required antibiotics\n* Heart or respiratory insufficiency\n* Pregnant or breastfeeding women",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Aged 18-75 years.",
            "criterions": [
                {
                    "exact_snippets": "Aged 18-75 years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 75,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Pathologically confirmed lung, liver, pancreas or retroperitoneal malignant tumor.",
            "criterions": [
                {
                    "exact_snippets": "Pathologically confirmed lung ... malignant tumor.",
                    "criterion": "lung malignant tumor",
                    "requirements": [
                        {
                            "requirement_type": "confirmation",
                            "expected_value": "pathologically confirmed"
                        }
                    ]
                },
                {
                    "exact_snippets": "Pathologically confirmed ... liver ... malignant tumor.",
                    "criterion": "liver malignant tumor",
                    "requirements": [
                        {
                            "requirement_type": "confirmation",
                            "expected_value": "pathologically confirmed"
                        }
                    ]
                },
                {
                    "exact_snippets": "Pathologically confirmed ... pancreas ... malignant tumor.",
                    "criterion": "pancreas malignant tumor",
                    "requirements": [
                        {
                            "requirement_type": "confirmation",
                            "expected_value": "pathologically confirmed"
                        }
                    ]
                },
                {
                    "exact_snippets": "Pathologically confirmed ... retroperitoneal malignant tumor.",
                    "criterion": "retroperitoneal malignant tumor",
                    "requirements": [
                        {
                            "requirement_type": "confirmation",
                            "expected_value": "pathologically confirmed"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Oligometastasis in the case of metastatic tumor",
            "criterions": [
                {
                    "exact_snippets": "Oligometastasis in the case of metastatic tumor",
                    "criterion": "oligometastasis",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* the shortest diameter ≥2cm or the distance from the tumor to the organs at risk less than 5mm",
            "criterions": [
                {
                    "exact_snippets": "shortest diameter ≥2cm",
                    "criterion": "tumor size",
                    "requirements": [
                        {
                            "requirement_type": "shortest diameter",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2,
                                "unit": "cm"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "distance from the tumor to the organs at risk less than 5mm",
                    "criterion": "distance from tumor to organs at risk",
                    "requirements": [
                        {
                            "requirement_type": "distance",
                            "expected_value": {
                                "operator": "<",
                                "value": 5,
                                "unit": "mm"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* ECOG of 0 to 1 point",
            "criterions": [
                {
                    "exact_snippets": "ECOG of 0 to 1 point",
                    "criterion": "ECOG performance status",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "point"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 1,
                                        "unit": "point"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* No abnormality in blood routine test, liver and kidney function test and coagulation test (White blood cell count ≥4.0×10^9/L, neutrophil count ≥2.0×10^9, hemoglobin level ≥100g/L, platelet count ≥100×10^9/L, ALT and AST level < 2.5 times the upper limit of normal, total bilirubin and creatinine level within the normal, international normalized ratio <2)",
            "criterions": [
                {
                    "exact_snippets": "No abnormality in blood routine test",
                    "criterion": "blood routine test",
                    "requirements": [
                        {
                            "requirement_type": "abnormality",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "White blood cell count ≥4.0×10^9/L",
                    "criterion": "white blood cell count",
                    "requirements": [
                        {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 4.0,
                                "unit": "×10^9/L"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "neutrophil count ≥2.0×10^9",
                    "criterion": "neutrophil count",
                    "requirements": [
                        {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2.0,
                                "unit": "×10^9"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "hemoglobin level ≥100g/L",
                    "criterion": "hemoglobin level",
                    "requirements": [
                        {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 100,
                                "unit": "g/L"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "platelet count ≥100×10^9/L",
                    "criterion": "platelet count",
                    "requirements": [
                        {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 100,
                                "unit": "×10^9/L"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "ALT and AST level < 2.5 times the upper limit of normal",
                    "criterion": "ALT and AST level",
                    "requirements": [
                        {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<",
                                "value": 2.5,
                                "unit": "times the upper limit of normal"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "total bilirubin and creatinine level within the normal",
                    "criterion": "total bilirubin and creatinine level",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": "within the normal"
                        }
                    ]
                },
                {
                    "exact_snippets": "international normalized ratio <2",
                    "criterion": "international normalized ratio",
                    "requirements": [
                        {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<",
                                "value": 2,
                                "unit": ""
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 75 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 75 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 75,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* History of radiotherapy for the lesion",
            "criterions": [
                {
                    "exact_snippets": "History of radiotherapy for the lesion",
                    "criterion": "radiotherapy history",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* History of tumor within 5 years",
            "criterions": [
                {
                    "exact_snippets": "History of tumor within 5 years",
                    "criterion": "tumor history",
                    "requirements": [
                        {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "operator": "<=",
                                "value": 5,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* ECOG ≥2 points",
            "criterions": [
                {
                    "exact_snippets": "ECOG ≥2 points",
                    "criterion": "ECOG",
                    "requirements": [
                        {
                            "requirement_type": "score",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2,
                                "unit": "points"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Significant abnormality in blood routine test, liver and kidney function test and coagulation test",
            "criterions": [
                {
                    "exact_snippets": "Significant abnormality in blood routine test",
                    "criterion": "blood routine test",
                    "requirements": [
                        {
                            "requirement_type": "abnormality",
                            "expected_value": "significant"
                        }
                    ]
                },
                {
                    "exact_snippets": "Significant abnormality in ... liver ... function test",
                    "criterion": "liver function test",
                    "requirements": [
                        {
                            "requirement_type": "abnormality",
                            "expected_value": "significant"
                        }
                    ]
                },
                {
                    "exact_snippets": "Significant abnormality in ... kidney function test",
                    "criterion": "kidney function test",
                    "requirements": [
                        {
                            "requirement_type": "abnormality",
                            "expected_value": "significant"
                        }
                    ]
                },
                {
                    "exact_snippets": "Significant abnormality in ... coagulation test",
                    "criterion": "coagulation test",
                    "requirements": [
                        {
                            "requirement_type": "abnormality",
                            "expected_value": "significant"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Active inflammatory bowel disease in the case of pancreas or retroperitoneal tumor",
            "criterions": [
                {
                    "exact_snippets": "Active inflammatory bowel disease",
                    "criterion": "inflammatory bowel disease",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "pancreas or retroperitoneal tumor",
                    "criterion": "tumor location",
                    "requirements": [
                        {
                            "requirement_type": "location",
                            "expected_value": [
                                "pancreas",
                                "retroperitoneal"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Gastrointestinal bleeding or perforation within 6 months in the case of pancreas or retroperitoneal tumor",
            "criterions": [
                {
                    "exact_snippets": "Gastrointestinal bleeding or perforation within 6 months",
                    "criterion": "gastrointestinal bleeding or perforation",
                    "requirements": [
                        {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "operator": "<=",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "pancreas or retroperitoneal tumor",
                    "criterion": "tumor location",
                    "requirements": [
                        {
                            "requirement_type": "location",
                            "expected_value": [
                                "pancreas",
                                "retroperitoneal"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Infections required antibiotics",
            "criterions": [
                {
                    "exact_snippets": "Infections required antibiotics",
                    "criterion": "infections",
                    "requirements": [
                        {
                            "requirement_type": "treatment",
                            "expected_value": "antibiotics"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Heart or respiratory insufficiency",
            "criterions": [
                {
                    "exact_snippets": "Heart ... insufficiency",
                    "criterion": "heart insufficiency",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "respiratory insufficiency",
                    "criterion": "respiratory insufficiency",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Pregnant or breastfeeding women",
            "criterions": [
                {
                    "exact_snippets": "Pregnant",
                    "criterion": "pregnancy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "breastfeeding",
                    "criterion": "breastfeeding",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}