{
    "info": {
        "nct_id": "NCT05802420",
        "official_title": "The Value of Molecular Residual Disease Monitoring Based on ctDNA in Advanced or Metastatic Pancreatic Cancer",
        "inclusion_criteria": "* patients with histologically confirmed unresectable advanced or metastatic pancreatic cancer;\n* both sexes, age ≥18 years old;\n* ECOG performance status score ≤2;\n* the expected survival time was ≥3 months.\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* a known diagnosis of pancreatic cancer other than ductal adenocarcinoma;\n* treated with any systemic antitumor treatment before first-line chemotherapy onset;\n* died or lost to follow-up within one month after the initiation of first-line chemotherpay;\n* combined with other primary malignances.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* patients with histologically confirmed unresectable advanced or metastatic pancreatic cancer;",
            "criterions": [
                {
                    "exact_snippets": "histologically confirmed",
                    "criterion": "histological confirmation",
                    "requirements": [
                        {
                            "requirement_type": "confirmation",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "unresectable",
                    "criterion": "resectability of pancreatic cancer",
                    "requirements": [
                        {
                            "requirement_type": "resectability",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "advanced or metastatic pancreatic cancer",
                    "criterion": "stage of pancreatic cancer",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": [
                                "advanced",
                                "metastatic"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* both sexes, age ≥18 years old;",
            "criterions": [
                {
                    "exact_snippets": "both sexes",
                    "criterion": "sex",
                    "requirements": [
                        {
                            "requirement_type": "allowed",
                            "expected_value": [
                                "male",
                                "female"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "age ≥18 years old",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* ECOG performance status score ≤2;",
            "criterions": [
                {
                    "exact_snippets": "ECOG performance status score ≤2",
                    "criterion": "ECOG performance status score",
                    "requirements": [
                        {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2,
                                "unit": "N/A"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* the expected survival time was ≥3 months.",
            "criterions": [
                {
                    "exact_snippets": "expected survival time was ≥3 months",
                    "criterion": "expected survival time",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* a known diagnosis of pancreatic cancer other than ductal adenocarcinoma;",
            "criterions": [
                {
                    "exact_snippets": "a known diagnosis of pancreatic cancer other than ductal adenocarcinoma",
                    "criterion": "pancreatic cancer diagnosis",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": "other than ductal adenocarcinoma"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* treated with any systemic antitumor treatment before first-line chemotherapy onset;",
            "criterions": [
                {
                    "exact_snippets": "treated with any systemic antitumor treatment before first-line chemotherapy onset",
                    "criterion": "prior systemic antitumor treatment",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* combined with other primary malignances.",
            "criterions": [
                {
                    "exact_snippets": "combined with other primary malignances",
                    "criterion": "primary malignancies",
                    "requirements": [
                        {
                            "requirement_type": "combination",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [
        {
            "line": "* died or lost to follow-up within one month after the initiation of first-line chemotherpay;",
            "criterions": [
                {
                    "exact_snippets": "died ... within one month after the initiation of first-line chemotherapy",
                    "criterion": "mortality",
                    "requirements": [
                        {
                            "requirement_type": "time frame",
                            "expected_value": "within one month after the initiation of first-line chemotherapy"
                        }
                    ]
                },
                {
                    "exact_snippets": "lost to follow-up within one month after the initiation of first-line chemotherapy",
                    "criterion": "follow-up status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "lost"
                        },
                        {
                            "requirement_type": "time frame",
                            "expected_value": "within one month after the initiation of first-line chemotherapy"
                        }
                    ]
                }
            ]
        }
    ],
    "failed_miscellaneous": []
}