{
    "info": {
        "nct_id": "NCT05553873",
        "official_title": "Evaluation of Inflammatory Markers in ph Negative Myeloproliferative Neoplasms: Impact on Outcome and Response to Therapy. Multicenter Retro-prospective Observational Study. The INFLA-ME (INFLAmmation in Myeloproliferative Disease) Study.",
        "inclusion_criteria": "* Age ≥ 18 years at the time of diagnosis of MPN Ph negative\n* Diagnosis of PV, ET, PMF or post PV and post ET MF, according to current WHO or IWG-MRT criteria (diagnosis since 2000)\n* Obtaining informed consent\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 99 Years",
        "exclusion_criteria": "* Life expectancy of less than 6 months\n* Accelerated phase myelofibrosis or MPN with signs of leukemic evolution",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Age ≥ 18 years at the time of diagnosis of MPN Ph negative",
            "criterions": [
                {
                    "exact_snippets": "Age ≥ 18 years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum age",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "diagnosis of MPN Ph negative",
                    "criterion": "MPN Ph negative diagnosis",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Diagnosis of PV, ET, PMF or post PV and post ET MF, according to current WHO or IWG-MRT criteria (diagnosis since 2000)",
            "criterions": [
                {
                    "exact_snippets": "Diagnosis of PV",
                    "criterion": "diagnosis",
                    "requirements": [
                        {
                            "requirement_type": "condition",
                            "expected_value": "PV"
                        }
                    ]
                },
                {
                    "exact_snippets": "Diagnosis of ... ET",
                    "criterion": "diagnosis",
                    "requirements": [
                        {
                            "requirement_type": "condition",
                            "expected_value": "ET"
                        }
                    ]
                },
                {
                    "exact_snippets": "Diagnosis of ... PMF",
                    "criterion": "diagnosis",
                    "requirements": [
                        {
                            "requirement_type": "condition",
                            "expected_value": "PMF"
                        }
                    ]
                },
                {
                    "exact_snippets": "Diagnosis of ... post PV ... MF",
                    "criterion": "diagnosis",
                    "requirements": [
                        {
                            "requirement_type": "condition",
                            "expected_value": "post PV MF"
                        }
                    ]
                },
                {
                    "exact_snippets": "Diagnosis of ... post ET MF",
                    "criterion": "diagnosis",
                    "requirements": [
                        {
                            "requirement_type": "condition",
                            "expected_value": "post ET MF"
                        }
                    ]
                },
                {
                    "exact_snippets": "according to current WHO or IWG-MRT criteria",
                    "criterion": "diagnostic criteria",
                    "requirements": [
                        {
                            "requirement_type": "standard",
                            "expected_value": [
                                "current WHO",
                                "IWG-MRT"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "diagnosis since 2000",
                    "criterion": "diagnosis date",
                    "requirements": [
                        {
                            "requirement_type": "year",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2000,
                                "unit": "year"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Obtaining informed consent",
            "criterions": [
                {
                    "exact_snippets": "Obtaining informed consent",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "obtaining",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 99 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 99 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 99,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Life expectancy of less than 6 months",
            "criterions": [
                {
                    "exact_snippets": "Life expectancy of less than 6 months",
                    "criterion": "life expectancy",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": "<",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Accelerated phase myelofibrosis or MPN with signs of leukemic evolution",
            "criterions": [
                {
                    "exact_snippets": "Accelerated phase myelofibrosis",
                    "criterion": "myelofibrosis",
                    "requirements": [
                        {
                            "requirement_type": "phase",
                            "expected_value": "accelerated"
                        }
                    ]
                },
                {
                    "exact_snippets": "MPN with signs of leukemic evolution",
                    "criterion": "MPN",
                    "requirements": [
                        {
                            "requirement_type": "signs of leukemic evolution",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}