{
    "info": {
        "nct_id": "NCT05405673",
        "official_title": "A Prospective Cross-sectional Multi-center Study to Assess the Diagnostic Accuracy of a Panel of Bacterial Gene Markers (M3) for Colorectal Advanced Neoplasia",
        "inclusion_criteria": "1. They require elective colonoscopy for colorectal cancer screening or polyp surveillance, or investigation of symptoms (e.g. anemia, change of bowel habit, abdominal pain);\n2. Aged ≥18 years old;\n3. Written informed consent obtained.\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "1. Contraindications to colonoscopy (e.g. perforation, intestinal obstruction, unstable cardiopulmonary status);\n2. Contraindication to polyp resection (e.g. active gastrointestinal bleeding, uninterrupted anticoagulation or dual antiplatelets);\n3. Known colorectal cancer or adenoma for staged procedure;\n4. Previous colonic resection;\n5. Personal history of colorectal cancer;\n6. Personal history of polyposis syndrome;\n7. Personal history of inflammatory bowel disease;\n8. Known pregnancy or lactation;\n9. Advanced comorbid conditions (defined as American Society of Anesthesiologists grade 4 or above);",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "1. They require elective colonoscopy for colorectal cancer screening or polyp surveillance, or investigation of symptoms (e.g. anemia, change of bowel habit, abdominal pain);",
            "criterions": [
                {
                    "exact_snippets": "elective colonoscopy for colorectal cancer screening",
                    "criterion": "elective colonoscopy",
                    "requirements": [
                        {
                            "requirement_type": "purpose",
                            "expected_value": "colorectal cancer screening"
                        }
                    ]
                },
                {
                    "exact_snippets": "elective colonoscopy for ... polyp surveillance",
                    "criterion": "elective colonoscopy",
                    "requirements": [
                        {
                            "requirement_type": "purpose",
                            "expected_value": "polyp surveillance"
                        }
                    ]
                },
                {
                    "exact_snippets": "elective colonoscopy for ... investigation of symptoms",
                    "criterion": "elective colonoscopy",
                    "requirements": [
                        {
                            "requirement_type": "purpose",
                            "expected_value": "investigation of symptoms"
                        }
                    ]
                },
                {
                    "exact_snippets": "symptoms (e.g. anemia",
                    "criterion": "symptoms",
                    "requirements": [
                        {
                            "requirement_type": "examples",
                            "expected_value": [
                                "anemia"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "symptoms ... change of bowel habit",
                    "criterion": "symptoms",
                    "requirements": [
                        {
                            "requirement_type": "examples",
                            "expected_value": [
                                "change of bowel habit"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "symptoms ... abdominal pain",
                    "criterion": "symptoms",
                    "requirements": [
                        {
                            "requirement_type": "examples",
                            "expected_value": [
                                "abdominal pain"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. Aged ≥18 years old;",
            "criterions": [
                {
                    "exact_snippets": "Aged ≥18 years old",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "N/A",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "3. Written informed consent obtained.",
            "criterions": [
                {
                    "exact_snippets": "Written informed consent obtained",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "obtained",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "1. Contraindications to colonoscopy (e.g. perforation, intestinal obstruction, unstable cardiopulmonary status);",
            "criterions": [
                {
                    "exact_snippets": "Contraindications to colonoscopy (e.g. perforation",
                    "criterion": "perforation",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "Contraindications to colonoscopy (e.g. ... intestinal obstruction",
                    "criterion": "intestinal obstruction",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "Contraindications to colonoscopy (e.g. ... unstable cardiopulmonary status",
                    "criterion": "unstable cardiopulmonary status",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. Contraindication to polyp resection (e.g. active gastrointestinal bleeding, uninterrupted anticoagulation or dual antiplatelets);",
            "criterions": [
                {
                    "exact_snippets": "Contraindication to polyp resection",
                    "criterion": "contraindication to polyp resection",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "active gastrointestinal bleeding",
                    "criterion": "active gastrointestinal bleeding",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "uninterrupted anticoagulation",
                    "criterion": "uninterrupted anticoagulation",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "dual antiplatelets",
                    "criterion": "dual antiplatelets",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "3. Known colorectal cancer or adenoma for staged procedure;",
            "criterions": [
                {
                    "exact_snippets": "Known colorectal cancer",
                    "criterion": "colorectal cancer",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "adenoma for staged procedure",
                    "criterion": "adenoma",
                    "requirements": [
                        {
                            "requirement_type": "procedure stage",
                            "expected_value": "staged"
                        }
                    ]
                }
            ]
        },
        {
            "line": "4. Previous colonic resection;",
            "criterions": [
                {
                    "exact_snippets": "Previous colonic resection",
                    "criterion": "colonic resection",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "5. Personal history of colorectal cancer;",
            "criterions": [
                {
                    "exact_snippets": "Personal history of colorectal cancer",
                    "criterion": "personal history of colorectal cancer",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "6. Personal history of polyposis syndrome;",
            "criterions": [
                {
                    "exact_snippets": "Personal history of polyposis syndrome",
                    "criterion": "polyposis syndrome",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "7. Personal history of inflammatory bowel disease;",
            "criterions": [
                {
                    "exact_snippets": "Personal history of inflammatory bowel disease",
                    "criterion": "inflammatory bowel disease",
                    "requirements": [
                        {
                            "requirement_type": "personal history",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "8. Known pregnancy or lactation;",
            "criterions": [
                {
                    "exact_snippets": "Known pregnancy",
                    "criterion": "pregnancy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "lactation",
                    "criterion": "lactation",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "9. Advanced comorbid conditions (defined as American Society of Anesthesiologists grade 4 or above);",
            "criterions": [
                {
                    "exact_snippets": "Advanced comorbid conditions (defined as American Society of Anesthesiologists grade 4 or above)",
                    "criterion": "comorbid conditions",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 4,
                                "unit": "ASA grade"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}