{
    "info": {
        "nct_id": "NCT05257876",
        "official_title": "An Evidence-based Breathing Exercise Intervention Protocol for Chronic Pain Management in Breast Cancer Survivors: A Preliminary Randomized Controlled Trial",
        "inclusion_criteria": "1. female breast cancer survivors ≥18 years age;\n2. has a confirmed diagnosis of breast cancer at stage I, II or IIIa;\n3. has been experiencing pain since cancer diagnosis constantly or intermittently for ≥3 months, with the average pain intensity in the last seven days on a numerical scale ≥4/10 (\"0\" indicates no pain and \"10\" indicates the worst pain);\n4. has completed active anticancer treatment (such as chemotherapy, radiotherapy, surgery) for at least three months;\n5. agrees to participate in the research and is willing to give informed consent;\n6. can read and understand Mandarin Chinese.\nHealthy volunteers allowed\nMust be FEMALE\nMust have minimum age of 18 Years",
        "exclusion_criteria": "1. extremely weak and unable to perform the breathing exercises;\n2. mentally incapable (i.e., unable to follow the study instructions);\n3. has scheduled pain management interventions, such as having a procedure or operation;\n4. receiving other pain relief treatments, such as acupuncture, yoga, qigong, exercise program, etc.;\n5. has any pre-existing chronic pain conditions before cancer diagnosis, such as arthritis, rheumatoid arthritis, chronic low back pain, migraines, trigeminal neuralgia, fibromyalgia, joint dysfunction, Complex Regional Pain Syndrome, endometriosis, etc.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "1. female breast cancer survivors ≥18 years age;",
            "criterions": [
                {
                    "exact_snippets": "female breast cancer survivors",
                    "criterion": "breast cancer survivor",
                    "requirements": [
                        {
                            "requirement_type": "gender",
                            "expected_value": "female"
                        }
                    ]
                },
                {
                    "exact_snippets": "≥18 years age",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "N/A",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. has a confirmed diagnosis of breast cancer at stage I, II or IIIa;",
            "criterions": [
                {
                    "exact_snippets": "confirmed diagnosis of breast cancer",
                    "criterion": "breast cancer diagnosis",
                    "requirements": [
                        {
                            "requirement_type": "confirmation",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "stage I, II or IIIa",
                    "criterion": "breast cancer stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": [
                                "I",
                                "II",
                                "IIIa"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "3. has been experiencing pain since cancer diagnosis constantly or intermittently for ≥3 months, with the average pain intensity in the last seven days on a numerical scale ≥4/10 (\"0\" indicates no pain and \"10\" indicates the worst pain);",
            "criterions": [
                {
                    "exact_snippets": "has been experiencing pain since cancer diagnosis",
                    "criterion": "pain since cancer diagnosis",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 3,
                                        "unit": "months"
                                    }
                                ]
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "average pain intensity in the last seven days on a numerical scale ≥4/10",
                    "criterion": "average pain intensity",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 4,
                                "unit": "/10"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "4. has completed active anticancer treatment (such as chemotherapy, radiotherapy, surgery) for at least three months;",
            "criterions": [
                {
                    "exact_snippets": "has completed active anticancer treatment (such as chemotherapy, radiotherapy, surgery)",
                    "criterion": "completion of active anticancer treatment",
                    "requirements": [
                        {
                            "requirement_type": "time since completion",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "5. agrees to participate in the research and is willing to give informed consent;",
            "criterions": [
                {
                    "exact_snippets": "agrees to participate in the research",
                    "criterion": "participation agreement",
                    "requirements": [
                        {
                            "requirement_type": "agreement",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "willing to give informed consent",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "6. can read and understand Mandarin Chinese.",
            "criterions": [
                {
                    "exact_snippets": "can read and understand Mandarin Chinese",
                    "criterion": "Mandarin Chinese language proficiency",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": [
                                "read",
                                "understand"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must be FEMALE",
            "criterions": [
                {
                    "exact_snippets": "Must be FEMALE",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "1. extremely weak and unable to perform the breathing exercises;",
            "criterions": [
                {
                    "exact_snippets": "extremely weak",
                    "criterion": "physical strength",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": "extremely weak"
                        }
                    ]
                },
                {
                    "exact_snippets": "unable to perform the breathing exercises",
                    "criterion": "ability to perform breathing exercises",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. mentally incapable (i.e., unable to follow the study instructions);",
            "criterions": [
                {
                    "exact_snippets": "mentally incapable (i.e., unable to follow the study instructions)",
                    "criterion": "mental capability",
                    "requirements": [
                        {
                            "requirement_type": "capability",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "3. has scheduled pain management interventions, such as having a procedure or operation;",
            "criterions": [
                {
                    "exact_snippets": "scheduled pain management interventions",
                    "criterion": "pain management interventions",
                    "requirements": [
                        {
                            "requirement_type": "scheduled",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "having a procedure or operation",
                    "criterion": "procedure or operation",
                    "requirements": [
                        {
                            "requirement_type": "scheduled",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "4. receiving other pain relief treatments, such as acupuncture, yoga, qigong, exercise program, etc.;",
            "criterions": [
                {
                    "exact_snippets": "receiving other pain relief treatments, such as acupuncture, yoga, qigong, exercise program, etc.",
                    "criterion": "other pain relief treatments",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "5. has any pre-existing chronic pain conditions before cancer diagnosis, such as arthritis, rheumatoid arthritis, chronic low back pain, migraines, trigeminal neuralgia, fibromyalgia, joint dysfunction, Complex Regional Pain Syndrome, endometriosis, etc.",
            "criterions": [
                {
                    "exact_snippets": "pre-existing chronic pain conditions before cancer diagnosis",
                    "criterion": "pre-existing chronic pain conditions",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "arthritis",
                    "criterion": "arthritis",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "rheumatoid arthritis",
                    "criterion": "rheumatoid arthritis",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "chronic low back pain",
                    "criterion": "chronic low back pain",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "migraines",
                    "criterion": "migraines",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "trigeminal neuralgia",
                    "criterion": "trigeminal neuralgia",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "fibromyalgia",
                    "criterion": "fibromyalgia",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "joint dysfunction",
                    "criterion": "joint dysfunction",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "Complex Regional Pain Syndrome",
                    "criterion": "Complex Regional Pain Syndrome",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "endometriosis",
                    "criterion": "endometriosis",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}