{
    "info": {
        "nct_id": "NCT05018182",
        "official_title": "To Observe the Pathological Remission Rate and Safety of FOLFOXIRI for Neoadjuvant Treatment of High-risk Locally Advanced Colorectal Cancer With a Single-arm, Open, Prospective Phase II Exploratory Clinical Study",
        "inclusion_criteria": "* Age: 18-75 years old; Sex: Male or female;\n* WHO performance status of 0, 1 or 2\n* Histologically proven colorectal carcinoma (defined as cancer that is located >10 cm from the anal verge by endoscopy)\n* Unequivocal radiological evidence of locally advanced cancer based on thin slice spiral CT [defined as T4a/b or (and) N2 / fused lymph nodes or (and) positive extramural vascular invasion (EMVI +) or (and) circumferential resection margin (CRM) ≤ 2mm].\n* No distant metastases (distant organ or (and) distant lymph node metastases) assessed by CT scan or other radiographic examination.\n* For patients with T4b, R0 resection was expected to be achieved, including the necessary combined organ resection，by MDT discussion.\n* No history of 5-Fu and platinum drug allergy.\n* Adequate bone marrow function: Hb>9g/dl; PLT >100 x 10^9/l; WBC >3.5 x 10^9/l and ANC ≥1.5x10^9/l.\n* Adequate hepatobiliary function: ASAT (aspartate aminotransferase) and ALAT (alanine aminotransferase) of 2.5 x ULN (upper limits of normal) or less, Alkaline phosphatase of 2.5 x ULN or less, total bilirubin 1.5 x upper normal level or less.\n* Adequate renal biochemistry: GFR >50 ml/min calculated by the Wright or Cockroft formula or EDTA clearance >70 ml/min.\n* For female and of childbearing potential, patient must have a negative pregnancy test ≤72hours prior to initiating study treatment and agree to avoid pregnancy during and for 6 months after study treatment. For male with a partner of childbearing potential, patient must agree to use adequate, medically approved, contraceptive precautions during and for 90 days after the last dose of study treatment\n* Patient able and willing to provide written informed consent for the study.\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 70 Years",
        "exclusion_criteria": "* Patients with lynch syndrome\n* Rectal cancer located 10 cm or less from the anal verge.\n* Any patient for whom radiotherapy is advised by the MDT.\n* Patient with evidence of distant metastases or peritoneal nodules (M1).\n* Severe intestinal complications on initial clinical or imaging assessment: perforation, obstruction, uncontrollable bleeding.\n* Another serious medical condition judged to compromise ability to tolerate neoadjuvant therapy and/or surgery.\n* Pre-existing or concurrent other malignancies (including concurrent colon cancer), except for cured basal cell carcinoma of the skin and carcinoma in situ of the cervix.\n* Pregnant or breastfeeding women.\n* Patients with severe cardiovascular disease and diabetes mellitus that cannot be easily controlled.\n* Persons with mental disorders.\n* Patients with severe infections.\n* Patients on thrombolytic/anticoagulant therapy, bleeding quality or coagulation disorders; or aneurysms, strokes, transient ischemic attacks, arteriovenous malformations in the past year.\n* Previous history of renal disease with urine protein on urinalysis or clinically significant renal function abnormalities.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Age: 18-75 years old; Sex: Male or female;",
            "criterions": [
                {
                    "exact_snippets": "Age: 18-75 years old",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 75,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "Sex: Male or female",
                    "criterion": "sex",
                    "requirements": [
                        {
                            "requirement_type": "allowed values",
                            "expected_value": [
                                "male",
                                "female"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* WHO performance status of 0, 1 or 2",
            "criterions": [
                {
                    "exact_snippets": "WHO performance status of 0, 1 or 2",
                    "criterion": "WHO performance status",
                    "requirements": [
                        {
                            "requirement_type": "value",
                            "expected_value": [
                                "0",
                                "1",
                                "2"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Histologically proven colorectal carcinoma (defined as cancer that is located >10 cm from the anal verge by endoscopy)",
            "criterions": [
                {
                    "exact_snippets": "Histologically proven colorectal carcinoma",
                    "criterion": "colorectal carcinoma",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "cancer that is located >10 cm from the anal verge",
                    "criterion": "cancer location from anal verge",
                    "requirements": [
                        {
                            "requirement_type": "distance",
                            "expected_value": {
                                "operator": ">",
                                "value": 10,
                                "unit": "cm"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Unequivocal radiological evidence of locally advanced cancer based on thin slice spiral CT [defined as T4a/b or (and) N2 / fused lymph nodes or (and) positive extramural vascular invasion (EMVI +) or (and) circumferential resection margin (CRM) ≤ 2mm].",
            "criterions": [
                {
                    "exact_snippets": "Unequivocal radiological evidence of locally advanced cancer based on thin slice spiral CT",
                    "criterion": "radiological evidence of locally advanced cancer",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "T4a/b",
                    "criterion": "tumor stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": [
                                "T4a",
                                "T4b"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "N2",
                    "criterion": "lymph node involvement",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": "N2"
                        }
                    ]
                },
                {
                    "exact_snippets": "fused lymph nodes",
                    "criterion": "fused lymph nodes",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "positive extramural vascular invasion (EMVI +)",
                    "criterion": "extramural vascular invasion",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "positive"
                        }
                    ]
                },
                {
                    "exact_snippets": "circumferential resection margin (CRM) ≤ 2mm",
                    "criterion": "circumferential resection margin",
                    "requirements": [
                        {
                            "requirement_type": "size",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2,
                                "unit": "mm"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* No distant metastases (distant organ or (and) distant lymph node metastases) assessed by CT scan or other radiographic examination.",
            "criterions": [
                {
                    "exact_snippets": "No distant metastases (distant organ or (and) distant lymph node metastases)",
                    "criterion": "distant metastases",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "assessed by CT scan or other radiographic examination",
                    "criterion": "assessment method for metastases",
                    "requirements": [
                        {
                            "requirement_type": "method",
                            "expected_value": [
                                "CT scan",
                                "other radiographic examination"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* For patients with T4b, R0 resection was expected to be achieved, including the necessary combined organ resection，by MDT discussion.",
            "criterions": [
                {
                    "exact_snippets": "patients with T4b",
                    "criterion": "cancer stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": "T4b"
                        }
                    ]
                },
                {
                    "exact_snippets": "R0 resection was expected to be achieved",
                    "criterion": "R0 resection",
                    "requirements": [
                        {
                            "requirement_type": "expectation",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "combined organ resection",
                    "criterion": "combined organ resection",
                    "requirements": [
                        {
                            "requirement_type": "necessity",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "MDT discussion",
                    "criterion": "MDT discussion",
                    "requirements": [
                        {
                            "requirement_type": "involvement",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* No history of 5-Fu and platinum drug allergy.",
            "criterions": [
                {
                    "exact_snippets": "No history of 5-Fu and platinum drug allergy.",
                    "criterion": "5-Fu allergy",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "No history of 5-Fu and platinum drug allergy.",
                    "criterion": "platinum drug allergy",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Adequate bone marrow function: Hb>9g/dl; PLT >100 x 10^9/l; WBC >3.5 x 10^9/l and ANC ≥1.5x10^9/l.",
            "criterions": [
                {
                    "exact_snippets": "Adequate bone marrow function: Hb>9g/dl",
                    "criterion": "hemoglobin level",
                    "requirements": [
                        {
                            "requirement_type": "adequacy",
                            "expected_value": {
                                "operator": ">",
                                "value": 9,
                                "unit": "g/dl"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "Adequate bone marrow function: ... PLT >100 x 10^9/l",
                    "criterion": "platelet count",
                    "requirements": [
                        {
                            "requirement_type": "adequacy",
                            "expected_value": {
                                "operator": ">",
                                "value": 100,
                                "unit": "x 10^9/l"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "Adequate bone marrow function: ... WBC >3.5 x 10^9/l",
                    "criterion": "white blood cell count",
                    "requirements": [
                        {
                            "requirement_type": "adequacy",
                            "expected_value": {
                                "operator": ">",
                                "value": 3.5,
                                "unit": "x 10^9/l"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "Adequate bone marrow function: ... ANC ≥1.5x10^9/l",
                    "criterion": "absolute neutrophil count",
                    "requirements": [
                        {
                            "requirement_type": "adequacy",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1.5,
                                "unit": "x 10^9/l"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Adequate hepatobiliary function: ASAT (aspartate aminotransferase) and ALAT (alanine aminotransferase) of 2.5 x ULN (upper limits of normal) or less, Alkaline phosphatase of 2.5 x ULN or less, total bilirubin 1.5 x upper normal level or less.",
            "criterions": [
                {
                    "exact_snippets": "ASAT (aspartate aminotransferase) ... 2.5 x ULN or less",
                    "criterion": "ASAT (aspartate aminotransferase)",
                    "requirements": [
                        {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2.5,
                                "unit": "x ULN"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "ALAT (alanine aminotransferase) ... 2.5 x ULN or less",
                    "criterion": "ALAT (alanine aminotransferase)",
                    "requirements": [
                        {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2.5,
                                "unit": "x ULN"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "Alkaline phosphatase ... 2.5 x ULN or less",
                    "criterion": "Alkaline phosphatase",
                    "requirements": [
                        {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2.5,
                                "unit": "x ULN"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "total bilirubin 1.5 x upper normal level or less",
                    "criterion": "total bilirubin",
                    "requirements": [
                        {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.5,
                                "unit": "x upper normal level"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Adequate renal biochemistry: GFR >50 ml/min calculated by the Wright or Cockroft formula or EDTA clearance >70 ml/min.",
            "criterions": [
                {
                    "exact_snippets": "Adequate renal biochemistry: GFR >50 ml/min",
                    "criterion": "GFR",
                    "requirements": [
                        {
                            "requirement_type": "adequacy",
                            "expected_value": {
                                "operator": ">",
                                "value": 50,
                                "unit": "ml/min"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "Adequate renal biochemistry: ... EDTA clearance >70 ml/min",
                    "criterion": "EDTA clearance",
                    "requirements": [
                        {
                            "requirement_type": "adequacy",
                            "expected_value": {
                                "operator": ">",
                                "value": 70,
                                "unit": "ml/min"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* For female and of childbearing potential, patient must have a negative pregnancy test ≤72hours prior to initiating study treatment and agree to avoid pregnancy during and for 6 months after study treatment. For male with a partner of childbearing potential, patient must agree to use adequate, medically approved, contraceptive precautions during and for 90 days after the last dose of study treatment",
            "criterions": [
                {
                    "exact_snippets": "female and of childbearing potential",
                    "criterion": "gender and childbearing potential",
                    "requirements": [
                        {
                            "requirement_type": "gender",
                            "expected_value": "female"
                        },
                        {
                            "requirement_type": "childbearing potential",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "negative pregnancy test ≤72hours prior to initiating study treatment",
                    "criterion": "pregnancy test result",
                    "requirements": [
                        {
                            "requirement_type": "result",
                            "expected_value": "negative"
                        },
                        {
                            "requirement_type": "timing",
                            "expected_value": {
                                "operator": "<=",
                                "value": 72,
                                "unit": "hours"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "agree to avoid pregnancy during and for 6 months after study treatment",
                    "criterion": "pregnancy avoidance",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": "during and for 6 months after study treatment"
                        }
                    ]
                },
                {
                    "exact_snippets": "male with a partner of childbearing potential",
                    "criterion": "gender and partner's childbearing potential",
                    "requirements": [
                        {
                            "requirement_type": "gender",
                            "expected_value": "male"
                        },
                        {
                            "requirement_type": "partner's childbearing potential",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "agree to use adequate, medically approved, contraceptive precautions during and for 90 days after the last dose of study treatment",
                    "criterion": "contraceptive use",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": "during and for 90 days after the last dose of study treatment"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Patient able and willing to provide written informed consent for the study.",
            "criterions": [
                {
                    "exact_snippets": "Patient able and willing to provide written informed consent",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 70 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 70 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 70,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Patients with lynch syndrome",
            "criterions": [
                {
                    "exact_snippets": "Patients with lynch syndrome",
                    "criterion": "lynch syndrome",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Rectal cancer located 10 cm or less from the anal verge.",
            "criterions": [
                {
                    "exact_snippets": "Rectal cancer",
                    "criterion": "rectal cancer",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "located 10 cm or less from the anal verge",
                    "criterion": "location of rectal cancer",
                    "requirements": [
                        {
                            "requirement_type": "distance from anal verge",
                            "expected_value": {
                                "operator": "<=",
                                "value": 10,
                                "unit": "cm"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Any patient for whom radiotherapy is advised by the MDT.",
            "criterions": [
                {
                    "exact_snippets": "radiotherapy is advised by the MDT",
                    "criterion": "radiotherapy recommendation",
                    "requirements": [
                        {
                            "requirement_type": "recommendation",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Patient with evidence of distant metastases or peritoneal nodules (M1).",
            "criterions": [
                {
                    "exact_snippets": "evidence of distant metastases",
                    "criterion": "distant metastases",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "evidence of ... peritoneal nodules",
                    "criterion": "peritoneal nodules",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Severe intestinal complications on initial clinical or imaging assessment: perforation, obstruction, uncontrollable bleeding.",
            "criterions": [
                {
                    "exact_snippets": "Severe intestinal complications ... perforation",
                    "criterion": "intestinal perforation",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": "severe"
                        }
                    ]
                },
                {
                    "exact_snippets": "Severe intestinal complications ... obstruction",
                    "criterion": "intestinal obstruction",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": "severe"
                        }
                    ]
                },
                {
                    "exact_snippets": "Severe intestinal complications ... uncontrollable bleeding",
                    "criterion": "intestinal bleeding",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": "severe"
                        },
                        {
                            "requirement_type": "control",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Another serious medical condition judged to compromise ability to tolerate neoadjuvant therapy and/or surgery.",
            "criterions": [
                {
                    "exact_snippets": "Another serious medical condition judged to compromise ability to tolerate neoadjuvant therapy and/or surgery.",
                    "criterion": "serious medical condition",
                    "requirements": [
                        {
                            "requirement_type": "impact on treatment tolerance",
                            "expected_value": "compromise ability to tolerate neoadjuvant therapy and/or surgery"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Pre-existing or concurrent other malignancies (including concurrent colon cancer), except for cured basal cell carcinoma of the skin and carcinoma in situ of the cervix.",
            "criterions": [
                {
                    "exact_snippets": "Pre-existing or concurrent other malignancies",
                    "criterion": "other malignancies",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "concurrent colon cancer",
                    "criterion": "colon cancer",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "cured basal cell carcinoma of the skin",
                    "criterion": "basal cell carcinoma of the skin",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "cured"
                        }
                    ]
                },
                {
                    "exact_snippets": "carcinoma in situ of the cervix",
                    "criterion": "carcinoma in situ of the cervix",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Pregnant or breastfeeding women.",
            "criterions": [
                {
                    "exact_snippets": "Pregnant",
                    "criterion": "pregnancy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "breastfeeding",
                    "criterion": "breastfeeding",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Patients with severe cardiovascular disease and diabetes mellitus that cannot be easily controlled.",
            "criterions": [
                {
                    "exact_snippets": "severe cardiovascular disease",
                    "criterion": "cardiovascular disease",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": "severe"
                        }
                    ]
                },
                {
                    "exact_snippets": "diabetes mellitus that cannot be easily controlled",
                    "criterion": "diabetes mellitus",
                    "requirements": [
                        {
                            "requirement_type": "control",
                            "expected_value": "cannot be easily controlled"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Persons with mental disorders.",
            "criterions": [
                {
                    "exact_snippets": "Persons with mental disorders.",
                    "criterion": "mental disorders",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Patients with severe infections.",
            "criterions": [
                {
                    "exact_snippets": "severe infections",
                    "criterion": "infections",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": "severe"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Patients on thrombolytic/anticoagulant therapy, bleeding quality or coagulation disorders; or aneurysms, strokes, transient ischemic attacks, arteriovenous malformations in the past year.",
            "criterions": [
                {
                    "exact_snippets": "Patients on thrombolytic/anticoagulant therapy",
                    "criterion": "thrombolytic/anticoagulant therapy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "bleeding quality or coagulation disorders",
                    "criterion": "bleeding quality or coagulation disorders",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "aneurysms",
                    "criterion": "aneurysms",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "strokes",
                    "criterion": "strokes",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "transient ischemic attacks",
                    "criterion": "transient ischemic attacks",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "arteriovenous malformations in the past year",
                    "criterion": "arteriovenous malformations",
                    "requirements": [
                        {
                            "requirement_type": "time frame",
                            "expected_value": "past year"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Previous history of renal disease with urine protein on urinalysis or clinically significant renal function abnormalities.",
            "criterions": [
                {
                    "exact_snippets": "Previous history of renal disease",
                    "criterion": "renal disease",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "urine protein on urinalysis",
                    "criterion": "urine protein",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "clinically significant renal function abnormalities",
                    "criterion": "renal function abnormalities",
                    "requirements": [
                        {
                            "requirement_type": "clinical significance",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}