{
    "info": {
        "nct_id": "NCT04677673",
        "official_title": "Neoadjuvant Chemotherapy Plus Surgery Versus Surgery First For Elderly Gastric Cancer Patients",
        "inclusion_criteria": "* Histology confirmed non-obstructive adenocarcinoma of the stomach or esophagogastric junction.\n* Clinical stage: cTNM: stage III\n* Performance status: Eastern Cooperative Oncology Group ECOG ≤ 2 (normal to symptomatic but in bed less than half the day)\n* Clinically fit for systemic chemotherapy and gastric cancer surgery, i.e. adequate renal, hepatic, hematologic, and pulmonary function.\n* Written informed consent\nHealthy volunteers allowed\nMust have minimum age of 76 Years",
        "exclusion_criteria": "* Clinically unfit for systemic chemotherapy and gastric cancer surgery, i.e. uncontrolled cardiac disease, or other clinically significant uncontrolled comorbidities, unable to undergo general anesthesia\n* Distant metastases (including retroperitoneal lymph node)\n* Locally advanced inoperable disease (Clinical assessment)\n* Relapse of gastric cancer\n* Malignant secondary disease\n* Prior chemo or radiotherapy\n* Inclusion in another clinical trial\n* Known contraindications or hypersensitivity for planned chemotherapy",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Histology confirmed non-obstructive adenocarcinoma of the stomach or esophagogastric junction.",
            "criterions": [
                {
                    "exact_snippets": "Histology confirmed",
                    "criterion": "histology confirmation",
                    "requirements": [
                        {
                            "requirement_type": "confirmation",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "non-obstructive adenocarcinoma",
                    "criterion": "adenocarcinoma type",
                    "requirements": [
                        {
                            "requirement_type": "obstruction",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "adenocarcinoma of the stomach or esophagogastric junction",
                    "criterion": "adenocarcinoma location",
                    "requirements": [
                        {
                            "requirement_type": "location",
                            "expected_value": [
                                "stomach",
                                "esophagogastric junction"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Clinical stage: cTNM: stage III",
            "criterions": [
                {
                    "exact_snippets": "Clinical stage: cTNM: stage III",
                    "criterion": "clinical stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": "III"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Performance status: Eastern Cooperative Oncology Group ECOG ≤ 2 (normal to symptomatic but in bed less than half the day)",
            "criterions": [
                {
                    "exact_snippets": "Performance status: Eastern Cooperative Oncology Group ECOG ≤ 2",
                    "criterion": "performance status",
                    "requirements": [
                        {
                            "requirement_type": "scale",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2,
                                "unit": "ECOG"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Clinically fit for systemic chemotherapy and gastric cancer surgery, i.e. adequate renal, hepatic, hematologic, and pulmonary function.",
            "criterions": [
                {
                    "exact_snippets": "Clinically fit for systemic chemotherapy",
                    "criterion": "fitness for systemic chemotherapy",
                    "requirements": [
                        {
                            "requirement_type": "fitness",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "Clinically fit for ... gastric cancer surgery",
                    "criterion": "fitness for gastric cancer surgery",
                    "requirements": [
                        {
                            "requirement_type": "fitness",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "adequate renal ... function",
                    "criterion": "renal function",
                    "requirements": [
                        {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "adequate ... hepatic ... function",
                    "criterion": "hepatic function",
                    "requirements": [
                        {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "adequate ... hematologic ... function",
                    "criterion": "hematologic function",
                    "requirements": [
                        {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "adequate ... pulmonary function",
                    "criterion": "pulmonary function",
                    "requirements": [
                        {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Written informed consent",
            "criterions": [
                {
                    "exact_snippets": "Written informed consent",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 76 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 76 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 76,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Clinically unfit for systemic chemotherapy and gastric cancer surgery, i.e. uncontrolled cardiac disease, or other clinically significant uncontrolled comorbidities, unable to undergo general anesthesia",
            "criterions": [
                {
                    "exact_snippets": "Clinically unfit for systemic chemotherapy",
                    "criterion": "fitness for systemic chemotherapy",
                    "requirements": [
                        {
                            "requirement_type": "fitness",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "Clinically unfit for ... gastric cancer surgery",
                    "criterion": "fitness for gastric cancer surgery",
                    "requirements": [
                        {
                            "requirement_type": "fitness",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "uncontrolled cardiac disease",
                    "criterion": "cardiac disease",
                    "requirements": [
                        {
                            "requirement_type": "control",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "other clinically significant uncontrolled comorbidities",
                    "criterion": "clinically significant comorbidities",
                    "requirements": [
                        {
                            "requirement_type": "control",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "unable to undergo general anesthesia",
                    "criterion": "ability to undergo general anesthesia",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Distant metastases (including retroperitoneal lymph node)",
            "criterions": [
                {
                    "exact_snippets": "Distant metastases",
                    "criterion": "distant metastases",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "retroperitoneal lymph node",
                    "criterion": "retroperitoneal lymph node metastases",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Locally advanced inoperable disease (Clinical assessment)",
            "criterions": [
                {
                    "exact_snippets": "Locally advanced inoperable disease",
                    "criterion": "disease operability",
                    "requirements": [
                        {
                            "requirement_type": "operability",
                            "expected_value": "inoperable"
                        }
                    ]
                },
                {
                    "exact_snippets": "Locally advanced inoperable disease",
                    "criterion": "disease stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": "locally advanced"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Relapse of gastric cancer",
            "criterions": [
                {
                    "exact_snippets": "Relapse of gastric cancer",
                    "criterion": "gastric cancer",
                    "requirements": [
                        {
                            "requirement_type": "relapse",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Malignant secondary disease",
            "criterions": [
                {
                    "exact_snippets": "Malignant secondary disease",
                    "criterion": "malignant secondary disease",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Prior chemo or radiotherapy",
            "criterions": [
                {
                    "exact_snippets": "Prior chemo or radiotherapy",
                    "criterion": "prior treatment",
                    "requirements": [
                        {
                            "requirement_type": "types",
                            "expected_value": [
                                "chemo",
                                "radiotherapy"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Inclusion in another clinical trial",
            "criterions": [
                {
                    "exact_snippets": "Inclusion in another clinical trial",
                    "criterion": "inclusion in another clinical trial",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Known contraindications or hypersensitivity for planned chemotherapy",
            "criterions": [
                {
                    "exact_snippets": "Known contraindications ... for planned chemotherapy",
                    "criterion": "contraindications for planned chemotherapy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "hypersensitivity for planned chemotherapy",
                    "criterion": "hypersensitivity for planned chemotherapy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}