{
    "info": {
        "nct_id": "NCT04536220",
        "official_title": "Establish a Diagnostic Model Based on Multiple Molecule Profiling and Certain Established Markers for Identification of Pancreatic Cancer",
        "inclusion_criteria": "1. age 18-75 years,male or female\n2. diagnosis or suspection of solid pancreatic mass based on previous imaging examination (ultrasonography, CT or MRI)\n3. lesion diameter larger than 1 cm\n4. signed informed consent letter\nMust have minimum age of 18 Years\nMust have maximum age of 80 Years",
        "exclusion_criteria": "1. pregnant female\n2. Pancreatic cystic lesions\n3. Anticoagulant/antiplatelet therapy cannot be suspended\n4. unable or refuse to provide informed consent\n5. Coagulopathy (platelet count < 50× 103/μL,international normalized ratio > 1.5)\n6. Severe cardiopulmonary dysfunction that cannot tolerate intravenous anesthesia\n7. with history of mental disease\n8. other medical conditions that are not suitable for EUS-FNA",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "1. age 18-75 years,male or female",
            "criterions": [
                {
                    "exact_snippets": "age 18-75 years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 75,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "male or female",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "allowed_values",
                            "expected_value": [
                                "male",
                                "female"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. diagnosis or suspection of solid pancreatic mass based on previous imaging examination (ultrasonography, CT or MRI)",
            "criterions": [
                {
                    "exact_snippets": "diagnosis or suspection of solid pancreatic mass",
                    "criterion": "solid pancreatic mass",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "based on previous imaging examination (ultrasonography, CT or MRI)",
                    "criterion": "previous imaging examination",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": [
                                "ultrasonography",
                                "CT",
                                "MRI"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "3. lesion diameter larger than 1 cm",
            "criterions": [
                {
                    "exact_snippets": "lesion diameter larger than 1 cm",
                    "criterion": "lesion diameter",
                    "requirements": [
                        {
                            "requirement_type": "size",
                            "expected_value": {
                                "operator": ">",
                                "value": 1,
                                "unit": "cm"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "4. signed informed consent letter",
            "criterions": [
                {
                    "exact_snippets": "signed informed consent letter",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "signed",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 80 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 80 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 80,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "1. pregnant female",
            "criterions": [
                {
                    "exact_snippets": "pregnant female",
                    "criterion": "pregnancy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. Pancreatic cystic lesions",
            "criterions": [
                {
                    "exact_snippets": "Pancreatic cystic lesions",
                    "criterion": "pancreatic cystic lesions",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "3. Anticoagulant/antiplatelet therapy cannot be suspended",
            "criterions": [
                {
                    "exact_snippets": "Anticoagulant/antiplatelet therapy cannot be suspended",
                    "criterion": "anticoagulant/antiplatelet therapy",
                    "requirements": [
                        {
                            "requirement_type": "suspendability",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "4. unable or refuse to provide informed consent",
            "criterions": [
                {
                    "exact_snippets": "unable or refuse to provide informed consent",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "ability to provide",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "5. Coagulopathy (platelet count < 50× 103/μL,international normalized ratio > 1.5)",
            "criterions": [
                {
                    "exact_snippets": "Coagulopathy (platelet count < 50× 103/μL",
                    "criterion": "platelet count",
                    "requirements": [
                        {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<",
                                "value": 50,
                                "unit": "× 103/μL"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "Coagulopathy ... international normalized ratio > 1.5",
                    "criterion": "international normalized ratio",
                    "requirements": [
                        {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 1.5,
                                "unit": "N/A"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "6. Severe cardiopulmonary dysfunction that cannot tolerate intravenous anesthesia",
            "criterions": [
                {
                    "exact_snippets": "Severe cardiopulmonary dysfunction",
                    "criterion": "cardiopulmonary dysfunction",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": "severe"
                        }
                    ]
                },
                {
                    "exact_snippets": "cannot tolerate intravenous anesthesia",
                    "criterion": "tolerance to intravenous anesthesia",
                    "requirements": [
                        {
                            "requirement_type": "tolerance",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "7. with history of mental disease",
            "criterions": [
                {
                    "exact_snippets": "history of mental disease",
                    "criterion": "mental disease",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "8. other medical conditions that are not suitable for EUS-FNA",
            "criterions": [
                {
                    "exact_snippets": "other medical conditions that are not suitable for EUS-FNA",
                    "criterion": "medical conditions",
                    "requirements": [
                        {
                            "requirement_type": "suitability for EUS-FNA",
                            "expected_value": false
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}