{
    "info": {
        "nct_id": "NCT04528420",
        "official_title": "Evaluation of Optimised Early Management in the Context of Radiochemotherapy for Curatively Treated Squamous Cell Carcinoma of the Head and Neck",
        "inclusion_criteria": "* Male or female, over 18 and under 75 years of age,\n* Worl Health Organisation score < 2,\n* Treatment for a localized squamous cell carcinoma of the head and neck for which a curative treatment by concomitant post-operative radiochemotherapy based on cisplatin is retained,\n* Having signed the informed consent,\n* Affiliate or beneficiary of a social protection scheme.\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 75 Years",
        "exclusion_criteria": "* History of other neoplastic disease less than 2 years old or progressive,\n* History of radiotherapy for head and neck cancer,\n* Contraindications to cisplatin,\n* Pregnant or breastfeeding woman,\n* Protected major (under guardianship or curatorship),\n* Patient participating in a therapeutic study\n* Patient unable to understand the study for any reason or to comply with the constraints of the trial",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Male or female, over 18 and under 75 years of age,",
            "criterions": [
                {
                    "exact_snippets": "Male or female",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "over 18 and under 75 years of age",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">",
                                        "value": 18,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<",
                                        "value": 75,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Worl Health Organisation score < 2,",
            "criterions": [
                {
                    "exact_snippets": "Worl Health Organisation score < 2",
                    "criterion": "World Health Organisation score",
                    "requirements": [
                        {
                            "requirement_type": "score",
                            "expected_value": {
                                "operator": "<",
                                "value": 2,
                                "unit": "N/A"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Treatment for a localized squamous cell carcinoma of the head and neck for which a curative treatment by concomitant post-operative radiochemotherapy based on cisplatin is retained,",
            "criterions": [
                {
                    "exact_snippets": "localized squamous cell carcinoma of the head and neck",
                    "criterion": "squamous cell carcinoma of the head and neck",
                    "requirements": [
                        {
                            "requirement_type": "localization",
                            "expected_value": "localized"
                        }
                    ]
                },
                {
                    "exact_snippets": "curative treatment by concomitant post-operative radiochemotherapy based on cisplatin is retained",
                    "criterion": "treatment plan",
                    "requirements": [
                        {
                            "requirement_type": "treatment type",
                            "expected_value": "curative"
                        },
                        {
                            "requirement_type": "treatment method",
                            "expected_value": [
                                "concomitant",
                                "post-operative",
                                "radiochemotherapy",
                                "cisplatin"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Having signed the informed consent,",
            "criterions": [
                {
                    "exact_snippets": "Having signed the informed consent",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "signed",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Affiliate or beneficiary of a social protection scheme.",
            "criterions": [
                {
                    "exact_snippets": "Affiliate or beneficiary of a social protection scheme.",
                    "criterion": "social protection scheme",
                    "requirements": [
                        {
                            "requirement_type": "affiliation or beneficiary status",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 75 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 75 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 75,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* History of other neoplastic disease less than 2 years old or progressive,",
            "criterions": [
                {
                    "exact_snippets": "History of other neoplastic disease less than 2 years old",
                    "criterion": "history of other neoplastic disease",
                    "requirements": [
                        {
                            "requirement_type": "age",
                            "expected_value": {
                                "operator": "<",
                                "value": 2,
                                "unit": "years"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "progressive",
                    "criterion": "progressive neoplastic disease",
                    "requirements": [
                        {
                            "requirement_type": "progression",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* History of radiotherapy for head and neck cancer,",
            "criterions": [
                {
                    "exact_snippets": "History of radiotherapy for head and neck cancer",
                    "criterion": "radiotherapy history",
                    "requirements": [
                        {
                            "requirement_type": "condition",
                            "expected_value": "head and neck cancer"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Contraindications to cisplatin,",
            "criterions": [
                {
                    "exact_snippets": "Contraindications to cisplatin",
                    "criterion": "cisplatin",
                    "requirements": [
                        {
                            "requirement_type": "contraindications",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Pregnant or breastfeeding woman,",
            "criterions": [
                {
                    "exact_snippets": "Pregnant",
                    "criterion": "pregnancy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "breastfeeding",
                    "criterion": "breastfeeding",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Protected major (under guardianship or curatorship),",
            "criterions": [
                {
                    "exact_snippets": "Protected major (under guardianship or curatorship)",
                    "criterion": "legal status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "protected major"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Patient participating in a therapeutic study",
            "criterions": [
                {
                    "exact_snippets": "Patient participating in a therapeutic study",
                    "criterion": "participation in a therapeutic study",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Patient unable to understand the study for any reason or to comply with the constraints of the trial",
            "criterions": [
                {
                    "exact_snippets": "Patient unable to understand the study",
                    "criterion": "understanding of the study",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "unable ... to comply with the constraints of the trial",
                    "criterion": "compliance with trial constraints",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}