{
    "info": {
        "nct_id": "NCT04252560",
        "official_title": "The Impact of Gut Microbiota in Anastomoses Insufficiency After Resection and Direct Anastomosis for Colorectal Cancer.",
        "inclusion_criteria": "Healthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Ongoing antibiotics treatment\n* antibiotics treatment in the last 6 months\n* acute surgery\n* palliative surgery\n* Ulcerös colitis or Crohns disease\n* Prior colectomy\n* Small intestine stoma before the operation\n* neoadjuvant treatment\n* Colon preparation",
        "miscellaneous_criteria": "Inclusion Criteria Colorectal group\n\n* adenocarcinom in colon or rektum\n* curative operation planed\n* direct anastomose plan\n* elective surgery\n\nInclusion Criteria HIPEC group :\n\n* All patients with appendix, colon or rectal cancer accepted for CRS+HIPEC"
    },
    "inclusion_lines": [
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Ongoing antibiotics treatment",
            "criterions": [
                {
                    "exact_snippets": "Ongoing antibiotics treatment",
                    "criterion": "antibiotics treatment",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "ongoing"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* antibiotics treatment in the last 6 months",
            "criterions": [
                {
                    "exact_snippets": "antibiotics treatment in the last 6 months",
                    "criterion": "antibiotics treatment",
                    "requirements": [
                        {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 6,
                                        "unit": "months"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* acute surgery",
            "criterions": [
                {
                    "exact_snippets": "acute surgery",
                    "criterion": "acute surgery",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* palliative surgery",
            "criterions": [
                {
                    "exact_snippets": "palliative surgery",
                    "criterion": "palliative surgery",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Ulcerös colitis or Crohns disease",
            "criterions": [
                {
                    "exact_snippets": "Ulcerös colitis",
                    "criterion": "Ulcerös colitis",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "Crohns disease",
                    "criterion": "Crohns disease",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Prior colectomy",
            "criterions": [
                {
                    "exact_snippets": "Prior colectomy",
                    "criterion": "colectomy",
                    "requirements": [
                        {
                            "requirement_type": "prior occurrence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Small intestine stoma before the operation",
            "criterions": [
                {
                    "exact_snippets": "Small intestine stoma before the operation",
                    "criterion": "small intestine stoma",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* neoadjuvant treatment",
            "criterions": [
                {
                    "exact_snippets": "neoadjuvant treatment",
                    "criterion": "neoadjuvant treatment",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Colon preparation",
            "criterions": [
                {
                    "exact_snippets": "Colon preparation",
                    "criterion": "colon preparation",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [
        {
            "line": "Inclusion Criteria Colorectal group",
            "criterions": [
                {
                    "exact_snippets": "Colorectal group",
                    "criterion": "cancer type",
                    "requirements": [
                        {
                            "requirement_type": "specificity",
                            "expected_value": "colorectal"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* adenocarcinom in colon or rektum",
            "criterions": [
                {
                    "exact_snippets": "adenocarcinom in colon",
                    "criterion": "adenocarcinoma in colon",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "adenocarcinom in ... rektum",
                    "criterion": "adenocarcinoma in rectum",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* curative operation planed",
            "criterions": [
                {
                    "exact_snippets": "curative operation planed",
                    "criterion": "operation plan",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": "curative"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* direct anastomose plan",
            "criterions": [
                {
                    "exact_snippets": "direct anastomose plan",
                    "criterion": "anastomosis plan",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": "direct"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* elective surgery",
            "criterions": [
                {
                    "exact_snippets": "elective surgery",
                    "criterion": "elective surgery",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* All patients with appendix, colon or rectal cancer accepted for CRS+HIPEC",
            "criterions": [
                {
                    "exact_snippets": "appendix, colon or rectal cancer",
                    "criterion": "cancer type",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": [
                                "appendix",
                                "colon",
                                "rectal"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "accepted for CRS+HIPEC",
                    "criterion": "CRS+HIPEC acceptance",
                    "requirements": [
                        {
                            "requirement_type": "acceptance",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": [
        {
            "line": "Inclusion Criteria HIPEC group :",
            "criterions": []
        }
    ]
}