{
    "info": {
        "nct_id": "NCT04009148",
        "official_title": "Cascade Testing in Families With Newly Diagnosed Hereditary Breast and Ovarian Cancer Syndrome",
        "inclusion_criteria": "* All subjects must have a diagnosis of epithelial ovarian cancer, Fallopian tube caner or primary peritoneal cancer with a known pathogenic genetic mutation.\n* All subjects must agree to participate.\n* All subjects must have first or second degree relatives who have not been diagnosed with the same genetic mutation.\n* A previous diagnosis of cancer in the subject's first or second degree relative is allowed.\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 99 Years",
        "exclusion_criteria": "* Subjects whose first and/or second degree relatives have already been tested with the subject's known mutations, and no other viable family members are available for testing.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* All subjects must agree to participate.",
            "criterions": [
                {
                    "exact_snippets": "All subjects must agree to participate.",
                    "criterion": "agreement to participate",
                    "requirements": [
                        {
                            "requirement_type": "consent",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* All subjects must have first or second degree relatives who have not been diagnosed with the same genetic mutation.",
            "criterions": [
                {
                    "exact_snippets": "first or second degree relatives who have not been diagnosed with the same genetic mutation",
                    "criterion": "relatives' genetic mutation status",
                    "requirements": [
                        {
                            "requirement_type": "diagnosis",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* A previous diagnosis of cancer in the subject's first or second degree relative is allowed.",
            "criterions": [
                {
                    "exact_snippets": "A previous diagnosis of cancer in the subject's first or second degree relative",
                    "criterion": "family history of cancer",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 99 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 99 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 99,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Subjects whose first and/or second degree relatives have already been tested with the subject's known mutations, and no other viable family members are available for testing.",
            "criterions": [
                {
                    "exact_snippets": "first and/or second degree relatives have already been tested with the subject's known mutations",
                    "criterion": "relatives tested for known mutations",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "no other viable family members are available for testing",
                    "criterion": "availability of viable family members for testing",
                    "requirements": [
                        {
                            "requirement_type": "availability",
                            "expected_value": false
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "line": "* All subjects must have a diagnosis of epithelial ovarian cancer, Fallopian tube caner or primary peritoneal cancer with a known pathogenic genetic mutation.",
            "criterions": [
                {
                    "exact_snippets": "diagnosis of epithelial ovarian cancer",
                    "criterion": "epithelial ovarian cancer",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "diagnosis of ... Fallopian tube cancer",
                    "criterion": "Fallopian tube cancer",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "diagnosis of ... primary peritoneal cancer",
                    "criterion": "primary peritoneal cancer",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "known pathogenic genetic mutation",
                    "criterion": "pathogenic genetic mutation",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}