{
    "info": {
        "nct_id": "NCT03837782",
        "official_title": "Minimally Invasive Versus Abdominal Radical Resection for Colorectal Cancer",
        "inclusion_criteria": "(i) tumor without distant metastasis; (ii) classified as stage I, II or III by TNM staging system; (iii) Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1; (iv) a minimum of 12 lymph nodes resected to accurately identify stage; (v) solitary malignant lesion after thorough colonoscopy; (vi) complete resection (R0) with no positive nodes left behind; (vii) histological diagnosis of adenocarcinoma.\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 90 Years",
        "exclusion_criteria": "(i) <18 years or >90 years; (ii) serious concurrent illness; (iii) clinically suspicious distant metastasis detected by positron emission tomography-computed tomography (PET-CT); (iv) familial adenomatous polyposis syndrome (FAP), hereditary non-polyposis colorectal cancer (HNPCC) and other hereditary CRC; (v) postoperative pathological close, indeterminate, or positive margins; (vi) circumferential resection margin < 1mm in rectal cancer; (vii) short anticipated life expectancy due to postoperative comorbidities on account of cardiopulmonary insufficiency.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "(i) tumor without distant metastasis; (ii) classified as stage I, II or III by TNM staging system; (iii) Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1; (iv) a minimum of 12 lymph nodes resected to accurately identify stage; (v) solitary malignant lesion after thorough colonoscopy; (vi) complete resection (R0) with no positive nodes left behind; (vii) histological diagnosis of adenocarcinoma.",
            "criterions": [
                {
                    "exact_snippets": "tumor without distant metastasis",
                    "criterion": "distant metastasis",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "classified as stage I, II or III by TNM staging system",
                    "criterion": "TNM stage",
                    "requirements": [
                        {
                            "requirement_type": "classification",
                            "expected_value": [
                                "I",
                                "II",
                                "III"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1",
                    "criterion": "ECOG Performance Status",
                    "requirements": [
                        {
                            "requirement_type": "value",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "=",
                                        "value": 1,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "a minimum of 12 lymph nodes resected",
                    "criterion": "lymph nodes resected",
                    "requirements": [
                        {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 12,
                                "unit": "N/A"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "solitary malignant lesion after thorough colonoscopy",
                    "criterion": "solitary malignant lesion",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "complete resection (R0) with no positive nodes left behind",
                    "criterion": "complete resection (R0)",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "R0"
                        }
                    ]
                },
                {
                    "exact_snippets": "histological diagnosis of adenocarcinoma",
                    "criterion": "histological diagnosis",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": "adenocarcinoma"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 90 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 90 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 90,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "(i) <18 years or >90 years; (ii) serious concurrent illness; (iii) clinically suspicious distant metastasis detected by positron emission tomography-computed tomography (PET-CT); (iv) familial adenomatous polyposis syndrome (FAP), hereditary non-polyposis colorectal cancer (HNPCC) and other hereditary CRC; (v) postoperative pathological close, indeterminate, or positive margins; (vi) circumferential resection margin < 1mm in rectal cancer; (vii) short anticipated life expectancy due to postoperative comorbidities on account of cardiopulmonary insufficiency.",
            "criterions": [
                {
                    "exact_snippets": "<18 years or >90 years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<",
                                        "value": 18,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": ">",
                                        "value": 90,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "serious concurrent illness",
                    "criterion": "concurrent illness",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": "serious"
                        }
                    ]
                },
                {
                    "exact_snippets": "clinically suspicious distant metastasis detected by positron emission tomography-computed tomography (PET-CT)",
                    "criterion": "distant metastasis",
                    "requirements": [
                        {
                            "requirement_type": "detection method",
                            "expected_value": "PET-CT"
                        },
                        {
                            "requirement_type": "clinical suspicion",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "familial adenomatous polyposis syndrome (FAP), hereditary non-polyposis colorectal cancer (HNPCC) and other hereditary CRC",
                    "criterion": "hereditary colorectal cancer syndromes",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": [
                                "familial adenomatous polyposis syndrome (FAP)",
                                "hereditary non-polyposis colorectal cancer (HNPCC)",
                                "other hereditary CRC"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "postoperative pathological close, indeterminate, or positive margins",
                    "criterion": "postoperative pathological margins",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": [
                                "close",
                                "indeterminate",
                                "positive"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "circumferential resection margin < 1mm in rectal cancer",
                    "criterion": "circumferential resection margin",
                    "requirements": [
                        {
                            "requirement_type": "size",
                            "expected_value": {
                                "operator": "<",
                                "value": 1,
                                "unit": "mm"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "short anticipated life expectancy due to postoperative comorbidities on account of cardiopulmonary insufficiency",
                    "criterion": "life expectancy",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": "short"
                        },
                        {
                            "requirement_type": "cause",
                            "expected_value": "postoperative comorbidities due to cardiopulmonary insufficiency"
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}