{
    "info": {
        "nct_id": "NCT03802773",
        "official_title": "Cord Blood Transplantation With Myeloablative Conditioning and Post-transplant Cyclophosphamide in Patients With Hematological Malignancies (The COmPACt Study)",
        "inclusion_criteria": "* Age: ≥ 18 ≤ 75 years old\n* CB unit transplantation (TNC> 2,0 x10^7/kg and > 4/6 loci HLA matched)\n* Myeloablative conditioning regimen consisting of either Thiotepa/ Busulfan/ Fludarabine or TBI/ Fludarabine\n* GVHD prophylaxis including PT-Cy (30 mg/kg or more on days + 3and +5) CSA and MMF\n* Diagnosis of 1 of the following hematological malignancies: Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome, high risk Acute Lymphoblastic Leukemia (ALL), Bi phenotypic/undifferentiated leukemia, Chronic Myeloid Leukemia resistant to TK inhibitors, Ph-neg Myeloproliferative Neoplasms, resistant/relapsing Non-Hodgkin's lymphoma ineligible for an autologous transplant.\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 75 Years",
        "exclusion_criteria": "* Positive serologic markers for human immunodeficiency virus (HIV)\n* Acute hepatitis B virus (HBV) or acute hepatitis C virus (HCV) infection",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Age: ≥ 18 ≤ 75 years old",
            "criterions": [
                {
                    "exact_snippets": "Age: ≥ 18 ≤ 75 years old",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "N/A",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 75,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* CB unit transplantation (TNC> 2,0 x10^7/kg and > 4/6 loci HLA matched)",
            "criterions": [
                {
                    "exact_snippets": "CB unit transplantation",
                    "criterion": "CB unit transplantation",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "TNC> 2,0 x10^7/kg",
                    "criterion": "TNC",
                    "requirements": [
                        {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 2.0,
                                "unit": "x10^7/kg"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "> 4/6 loci HLA matched",
                    "criterion": "HLA loci match",
                    "requirements": [
                        {
                            "requirement_type": "match level",
                            "expected_value": {
                                "operator": ">",
                                "value": 4,
                                "unit": "loci"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Myeloablative conditioning regimen consisting of either Thiotepa/ Busulfan/ Fludarabine or TBI/ Fludarabine",
            "criterions": [
                {
                    "exact_snippets": "Myeloablative conditioning regimen consisting of either Thiotepa/ Busulfan/ Fludarabine or TBI/ Fludarabine",
                    "criterion": "myeloablative conditioning regimen",
                    "requirements": [
                        {
                            "requirement_type": "components",
                            "expected_value": [
                                "Thiotepa",
                                "Busulfan",
                                "Fludarabine",
                                "TBI"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* GVHD prophylaxis including PT-Cy (30 mg/kg or more on days + 3and +5) CSA and MMF",
            "criterions": [
                {
                    "exact_snippets": "GVHD prophylaxis including PT-Cy (30 mg/kg or more on days + 3and +5)",
                    "criterion": "GVHD prophylaxis",
                    "requirements": [
                        {
                            "requirement_type": "inclusion",
                            "expected_value": [
                                "PT-Cy (30 mg/kg or more on days + 3and +5)",
                                "CSA",
                                "MMF"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Diagnosis of 1 of the following hematological malignancies: Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome, high risk Acute Lymphoblastic Leukemia (ALL), Bi phenotypic/undifferentiated leukemia, Chronic Myeloid Leukemia resistant to TK inhibitors, Ph-neg Myeloproliferative Neoplasms, resistant/relapsing Non-Hodgkin's lymphoma ineligible for an autologous transplant.",
            "criterions": [
                {
                    "exact_snippets": "Diagnosis of 1 of the following hematological malignancies: Acute Myeloid Leukemia (AML)",
                    "criterion": "hematological malignancy",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": "Acute Myeloid Leukemia (AML)"
                        }
                    ]
                },
                {
                    "exact_snippets": "Diagnosis of 1 of the following hematological malignancies: ... Myelodysplastic Syndrome",
                    "criterion": "hematological malignancy",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": "Myelodysplastic Syndrome"
                        }
                    ]
                },
                {
                    "exact_snippets": "Diagnosis of 1 of the following hematological malignancies: ... high risk Acute Lymphoblastic Leukemia (ALL)",
                    "criterion": "hematological malignancy",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": "high risk Acute Lymphoblastic Leukemia (ALL)"
                        }
                    ]
                },
                {
                    "exact_snippets": "Diagnosis of 1 of the following hematological malignancies: ... Bi phenotypic/undifferentiated leukemia",
                    "criterion": "hematological malignancy",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": "Bi phenotypic/undifferentiated leukemia"
                        }
                    ]
                },
                {
                    "exact_snippets": "Diagnosis of 1 of the following hematological malignancies: ... Chronic Myeloid Leukemia resistant to TK inhibitors",
                    "criterion": "hematological malignancy",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": "Chronic Myeloid Leukemia resistant to TK inhibitors"
                        }
                    ]
                },
                {
                    "exact_snippets": "Diagnosis of 1 of the following hematological malignancies: ... Ph-neg Myeloproliferative Neoplasms",
                    "criterion": "hematological malignancy",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": "Ph-neg Myeloproliferative Neoplasms"
                        }
                    ]
                },
                {
                    "exact_snippets": "Diagnosis of 1 of the following hematological malignancies: ... resistant/relapsing Non-Hodgkin's lymphoma ineligible for an autologous transplant",
                    "criterion": "hematological malignancy",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": "resistant/relapsing Non-Hodgkin's lymphoma ineligible for an autologous transplant"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 75 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 75 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 75,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Positive serologic markers for human immunodeficiency virus (HIV)",
            "criterions": [
                {
                    "exact_snippets": "Positive serologic markers for human immunodeficiency virus (HIV)",
                    "criterion": "HIV serologic markers",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": "positive"
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [
        {
            "line": "* Acute hepatitis B virus (HBV) or acute hepatitis C virus (HCV) infection",
            "criterions": [
                {
                    "exact_snippets": "Acute hepatitis B virus (HBV) infection",
                    "criterion": "acute hepatitis B virus infection",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "Acute hepatitis C virus (HCV) infection",
                    "criterion": "acute hepatitis C virus infection",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "failed_miscellaneous": []
}