{
    "info": {
        "nct_id": "NCT03787966",
        "official_title": "Attenuating Cancer Treatment-related Toxicity in Oncology Patients With a Tailored Physical Exercise Program: Study Protocol of the ATOPE Trial in Women Recently Diagnosed With Breast Cancer",
        "inclusion_criteria": "* 18 years or older\n* Breast cancer diagnosis I-III stage\n* On the waiting list to anticancer medical treatment (at least surgery, chemotherapy and radiotherapy.\n* If they meet other criteria which predisposes to higher toxicity.\n* Have signed informed consent.\n* Have medical clearance for participation.\nHealthy volunteers allowed\nMust be FEMALE\nMust have minimum age of 18 Years\nMust have maximum age of 70 Years",
        "exclusion_criteria": "* Patient underwent previous cancer treatments.\n* Patients were previously diagnosed with cancer.\n* Pregnant patients.\n* Patients performing other type of therapeutic exercise at diagnosis time with an intake >or = to 150 moderate-intensity or 75 min of vigorous-intensity a day.\n* Therapeutic exercise practice not recommended because psychiatric or cognitive disorders or cute or chronic condition that prevents exercise (advanced lung disease, oxygen requirement, stenosis >70%, metastasis etc.).",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* 18 years or older",
            "criterions": [
                {
                    "exact_snippets": "18 years or older",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum age",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Breast cancer diagnosis I-III stage",
            "criterions": [
                {
                    "exact_snippets": "Breast cancer diagnosis",
                    "criterion": "breast cancer",
                    "requirements": [
                        {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "I-III stage",
                    "criterion": "cancer stage",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 1,
                                        "unit": "stage"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 3,
                                        "unit": "stage"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* On the waiting list to anticancer medical treatment (at least surgery, chemotherapy and radiotherapy.",
            "criterions": [
                {
                    "exact_snippets": "On the waiting list to anticancer medical treatment",
                    "criterion": "anticancer medical treatment waiting list",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "at least surgery, chemotherapy and radiotherapy",
                    "criterion": "anticancer medical treatment types",
                    "requirements": [
                        {
                            "requirement_type": "types",
                            "expected_value": [
                                "surgery",
                                "chemotherapy",
                                "radiotherapy"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* If they meet other criteria which predisposes to higher toxicity.",
            "criterions": [
                {
                    "exact_snippets": "predisposes to higher toxicity",
                    "criterion": "predisposition to higher toxicity",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Have signed informed consent.",
            "criterions": [
                {
                    "exact_snippets": "signed informed consent",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "signed",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Have medical clearance for participation.",
            "criterions": [
                {
                    "exact_snippets": "medical clearance",
                    "criterion": "medical clearance",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must be FEMALE",
            "criterions": [
                {
                    "exact_snippets": "Must be FEMALE",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 70 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 70 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 70,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Patient underwent previous cancer treatments.",
            "criterions": [
                {
                    "exact_snippets": "Patient underwent previous cancer treatments.",
                    "criterion": "previous cancer treatments",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Patients were previously diagnosed with cancer.",
            "criterions": [
                {
                    "exact_snippets": "previously diagnosed with cancer",
                    "criterion": "cancer diagnosis",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Pregnant patients.",
            "criterions": [
                {
                    "exact_snippets": "Pregnant patients",
                    "criterion": "pregnancy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Patients performing other type of therapeutic exercise at diagnosis time with an intake >or = to 150 moderate-intensity or 75 min of vigorous-intensity a day.",
            "criterions": [
                {
                    "exact_snippets": "Patients performing other type of therapeutic exercise at diagnosis time",
                    "criterion": "therapeutic exercise",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "intake >or = to 150 moderate-intensity or 75 min of vigorous-intensity a day",
                    "criterion": "exercise intensity and duration",
                    "requirements": [
                        {
                            "requirement_type": "intensity and duration",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 150,
                                        "unit": "min"
                                    },
                                    {
                                        "operator": ">=",
                                        "value": 75,
                                        "unit": "min"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [
        {
            "line": "* Therapeutic exercise practice not recommended because psychiatric or cognitive disorders or cute or chronic condition that prevents exercise (advanced lung disease, oxygen requirement, stenosis >70%, metastasis etc.).",
            "criterions": [
                {
                    "exact_snippets": "psychiatric or cognitive disorders",
                    "criterion": "psychiatric or cognitive disorders",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "acute or chronic condition that prevents exercise",
                    "criterion": "acute or chronic condition that prevents exercise",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "advanced lung disease",
                    "criterion": "advanced lung disease",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "oxygen requirement",
                    "criterion": "oxygen requirement",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "stenosis >70%",
                    "criterion": "stenosis",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": ">",
                                "value": 70,
                                "unit": "%"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "metastasis",
                    "criterion": "metastasis",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        }
    ],
    "failed_miscellaneous": []
}