{
    "info": {
        "nct_id": "NCT03724591",
        "official_title": "A Randomized Controlled Clinical Trial to Investigate the Effects of Total Mesorectum Excision With Left Colic Artery Preservation for the Treatment of Rectal Cancer",
        "inclusion_criteria": "* Patients suitable for curative surgery over 18 years old;\n* American Society of Anesthesiologists(ASA) grade I-III;\n* Pathological diagnosis of rectal adenocarcinoma;\n* Patients suitable for abdominalperineal resection\n* Informed consent;\n* No history of familial adenomatous polyposis, ulcerative colitis or Crohn's disease.\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 85 Years",
        "exclusion_criteria": "* Pregnant patient;\n* History of psychiatric disease;\n* Use of systemic steroids;\n* Simultaneous multiple primary colorectal cancer;\n* Preoperative imaging examination results show:1. Tumor involves the surrounding organs and combined organ resection need to be done;2. distant metastasis;3. unable to perform R0 resection;\n* History of any other malignant tumor in recent 5 years;\n* Patients need emergency operation: mechanic ileus, perforation.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Patients suitable for curative surgery over 18 years old;",
            "criterions": [
                {
                    "exact_snippets": "Patients suitable for curative surgery",
                    "criterion": "suitability for curative surgery",
                    "requirements": [
                        {
                            "requirement_type": "suitability",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "over 18 years old",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum age",
                            "expected_value": {
                                "operator": ">",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* American Society of Anesthesiologists(ASA) grade I-III;",
            "criterions": [
                {
                    "exact_snippets": "American Society of Anesthesiologists(ASA) grade I-III",
                    "criterion": "ASA grade",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 1,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 3,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Pathological diagnosis of rectal adenocarcinoma;",
            "criterions": [
                {
                    "exact_snippets": "Pathological diagnosis of rectal adenocarcinoma",
                    "criterion": "rectal adenocarcinoma",
                    "requirements": [
                        {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Patients suitable for abdominalperineal resection",
            "criterions": [
                {
                    "exact_snippets": "Patients suitable for abdominalperineal resection",
                    "criterion": "suitability for abdominalperineal resection",
                    "requirements": [
                        {
                            "requirement_type": "suitability",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Informed consent;",
            "criterions": [
                {
                    "exact_snippets": "Informed consent",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* No history of familial adenomatous polyposis, ulcerative colitis or Crohn's disease.",
            "criterions": [
                {
                    "exact_snippets": "No history of familial adenomatous polyposis",
                    "criterion": "familial adenomatous polyposis",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "No history of ... ulcerative colitis",
                    "criterion": "ulcerative colitis",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "No history of ... Crohn's disease",
                    "criterion": "Crohn's disease",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 85 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 85 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 85,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Pregnant patient;",
            "criterions": [
                {
                    "exact_snippets": "Pregnant patient",
                    "criterion": "pregnancy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* History of psychiatric disease;",
            "criterions": [
                {
                    "exact_snippets": "History of psychiatric disease",
                    "criterion": "psychiatric disease",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Use of systemic steroids;",
            "criterions": [
                {
                    "exact_snippets": "Use of systemic steroids",
                    "criterion": "systemic steroid use",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Simultaneous multiple primary colorectal cancer;",
            "criterions": [
                {
                    "exact_snippets": "Simultaneous multiple primary colorectal cancer",
                    "criterion": "multiple primary colorectal cancer",
                    "requirements": [
                        {
                            "requirement_type": "simultaneity",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Preoperative imaging examination results show:1. Tumor involves the surrounding organs and combined organ resection need to be done;2. distant metastasis;3. unable to perform R0 resection;",
            "criterions": [
                {
                    "exact_snippets": "Tumor involves the surrounding organs",
                    "criterion": "tumor involvement",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": "surrounding organs"
                        }
                    ]
                },
                {
                    "exact_snippets": "distant metastasis",
                    "criterion": "distant metastasis",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "unable to perform R0 resection",
                    "criterion": "R0 resection",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* History of any other malignant tumor in recent 5 years;",
            "criterions": [
                {
                    "exact_snippets": "History of any other malignant tumor in recent 5 years",
                    "criterion": "malignant tumor",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 5,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Patients need emergency operation: mechanic ileus, perforation.",
            "criterions": [
                {
                    "exact_snippets": "emergency operation: mechanic ileus",
                    "criterion": "emergency operation",
                    "requirements": [
                        {
                            "requirement_type": "condition",
                            "expected_value": "mechanic ileus"
                        }
                    ]
                },
                {
                    "exact_snippets": "emergency operation: ... perforation",
                    "criterion": "emergency operation",
                    "requirements": [
                        {
                            "requirement_type": "condition",
                            "expected_value": "perforation"
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}