{
    "info": {
        "nct_id": "NCT03322020",
        "official_title": "Androgen Deprivation Therapy, External Beam Radiotherapy and Stereotactic Radiosurgery Boost for Men With Intermediate- or High-risk Prostate Cancer",
        "inclusion_criteria": "* Pathologically confirmed intermediate- or high-risk prostate cancer within 6 months after enrollment\n* ECOG performance status 0-1\n* Appropriate values of blood tests within 6 months after enrollment Absolute neutrophil count (ANC) ≥ 1500 cells/mm3 Platelets ≥ 50,000 cells/mm3 Hemoglobin ≥ 8.0 g/dl\n* Appropriate values of kidney function within 6 months after enrollment Creatinine < 2.0 ng/dL\n* Appropriate values of liver function within 6 months after enrollment total bilirubin < 1.5 X maximum normal value alanine aminotransferase or aspartate aminotransferase < 2.5 X maximum normal value\nHealthy volunteers allowed\nMust be MALE\nMust have minimum age of 20 Years",
        "exclusion_criteria": "* Presence of distant metastasis\n* Presence of pelvic LN metastasis\n* History of androgen deprivation therapy within 6 months after enrollment\n* History of definitive treatment for prostate cancer (e.g., radical prostatectomy)\n* History of pelvic irradiation\n* Double primary cancer other than skin/thyroid cancer",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Pathologically confirmed intermediate- or high-risk prostate cancer within 6 months after enrollment",
            "criterions": [
                {
                    "exact_snippets": "Pathologically confirmed intermediate- or high-risk prostate cancer",
                    "criterion": "prostate cancer risk level",
                    "requirements": [
                        {
                            "requirement_type": "confirmation",
                            "expected_value": "pathologically confirmed"
                        },
                        {
                            "requirement_type": "risk level",
                            "expected_value": [
                                "intermediate",
                                "high"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "within 6 months after enrollment",
                    "criterion": "time since enrollment",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 6,
                                        "unit": "months"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* ECOG performance status 0-1",
            "criterions": [
                {
                    "exact_snippets": "ECOG performance status 0-1",
                    "criterion": "ECOG performance status",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 1,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Appropriate values of blood tests within 6 months after enrollment Absolute neutrophil count (ANC) ≥ 1500 cells/mm3 Platelets ≥ 50,000 cells/mm3 Hemoglobin ≥ 8.0 g/dl",
            "criterions": [
                {
                    "exact_snippets": "Absolute neutrophil count (ANC) ≥ 1500 cells/mm3",
                    "criterion": "absolute neutrophil count (ANC)",
                    "requirements": [
                        {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1500,
                                "unit": "cells/mm3"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "Platelets ≥ 50,000 cells/mm3",
                    "criterion": "platelets",
                    "requirements": [
                        {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 50000,
                                "unit": "cells/mm3"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "Hemoglobin ≥ 8.0 g/dl",
                    "criterion": "hemoglobin",
                    "requirements": [
                        {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 8.0,
                                "unit": "g/dl"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Appropriate values of kidney function within 6 months after enrollment Creatinine < 2.0 ng/dL",
            "criterions": [
                {
                    "exact_snippets": "Appropriate values of kidney function",
                    "criterion": "kidney function",
                    "requirements": [
                        {
                            "requirement_type": "timing",
                            "expected_value": "within 6 months after enrollment"
                        }
                    ]
                },
                {
                    "exact_snippets": "Creatinine < 2.0 ng/dL",
                    "criterion": "creatinine level",
                    "requirements": [
                        {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 2.0,
                                "unit": "ng/dL"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Appropriate values of liver function within 6 months after enrollment total bilirubin < 1.5 X maximum normal value alanine aminotransferase or aspartate aminotransferase < 2.5 X maximum normal value",
            "criterions": [
                {
                    "exact_snippets": "liver function within 6 months after enrollment",
                    "criterion": "liver function",
                    "requirements": [
                        {
                            "requirement_type": "time frame",
                            "expected_value": "within 6 months after enrollment"
                        }
                    ]
                },
                {
                    "exact_snippets": "total bilirubin < 1.5 X maximum normal value",
                    "criterion": "total bilirubin",
                    "requirements": [
                        {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 1.5,
                                "unit": "X maximum normal value"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "alanine aminotransferase or aspartate aminotransferase < 2.5 X maximum normal value",
                    "criterion": "alanine aminotransferase or aspartate aminotransferase",
                    "requirements": [
                        {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 2.5,
                                "unit": "X maximum normal value"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must be MALE",
            "criterions": [
                {
                    "exact_snippets": "Must be MALE",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "expected_value",
                            "expected_value": "male"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 20 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 20 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 20,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Presence of distant metastasis",
            "criterions": [
                {
                    "exact_snippets": "Presence of distant metastasis",
                    "criterion": "distant metastasis",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Presence of pelvic LN metastasis",
            "criterions": [
                {
                    "exact_snippets": "Presence of pelvic LN metastasis",
                    "criterion": "pelvic LN metastasis",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* History of androgen deprivation therapy within 6 months after enrollment",
            "criterions": [
                {
                    "exact_snippets": "History of androgen deprivation therapy within 6 months after enrollment",
                    "criterion": "androgen deprivation therapy",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "timeframe",
                            "expected_value": {
                                "operator": "<=",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* History of definitive treatment for prostate cancer (e.g., radical prostatectomy)",
            "criterions": [
                {
                    "exact_snippets": "History of definitive treatment for prostate cancer",
                    "criterion": "definitive treatment for prostate cancer",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "radical prostatectomy",
                    "criterion": "radical prostatectomy",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* History of pelvic irradiation",
            "criterions": [
                {
                    "exact_snippets": "History of pelvic irradiation",
                    "criterion": "pelvic irradiation",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Double primary cancer other than skin/thyroid cancer",
            "criterions": [
                {
                    "exact_snippets": "Double primary cancer",
                    "criterion": "double primary cancer",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "other than skin/thyroid cancer",
                    "criterion": "skin/thyroid cancer",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}