{
    "info": {
        "nct_id": "NCT03178929",
        "official_title": "A Randomized Controlled Study on the Effect of S-Adenosyl Methionine Treatment on Anti-tumor Recurrence After Radical Treatment of Primary Hepatic Carcinoma",
        "inclusion_criteria": "* Patient must sign the informed consent prior to the beginning of any study-related procedures;\n* Patients diagnosed of Primary liver cancer;\n* BCLC Stage：Stage 0、Stage A;\n* Accept radical treatment;\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* With any other anti-cancer treatment before or after the surgery;\n* Patients with extrahepatic metastasis;\n* Patients with apparent cardiac, pulmonary, cerebral and renal dysfunction;\n* Subjects accepting other trial drugs or participating in other clinical trials;\n* Female with pregnancy or during the lactation period.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Patient must sign the informed consent prior to the beginning of any study-related procedures;",
            "criterions": [
                {
                    "exact_snippets": "Patient must sign the informed consent",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "signed",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Patients diagnosed of Primary liver cancer;",
            "criterions": [
                {
                    "exact_snippets": "diagnosed of Primary liver cancer",
                    "criterion": "Primary liver cancer",
                    "requirements": [
                        {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* BCLC Stage：Stage 0、Stage A;",
            "criterions": [
                {
                    "exact_snippets": "BCLC Stage：Stage 0、Stage A",
                    "criterion": "BCLC Stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": [
                                "Stage 0",
                                "Stage A"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Accept radical treatment;",
            "criterions": [
                {
                    "exact_snippets": "Accept radical treatment",
                    "criterion": "radical treatment",
                    "requirements": [
                        {
                            "requirement_type": "acceptance",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* With any other anti-cancer treatment before or after the surgery;",
            "criterions": [
                {
                    "exact_snippets": "With any other anti-cancer treatment before or after the surgery",
                    "criterion": "anti-cancer treatment",
                    "requirements": [
                        {
                            "requirement_type": "timing",
                            "expected_value": [
                                "before surgery",
                                "after surgery"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Patients with extrahepatic metastasis;",
            "criterions": [
                {
                    "exact_snippets": "Patients with extrahepatic metastasis",
                    "criterion": "extrahepatic metastasis",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Patients with apparent cardiac, pulmonary, cerebral and renal dysfunction;",
            "criterions": [
                {
                    "exact_snippets": "apparent cardiac ... dysfunction",
                    "criterion": "cardiac dysfunction",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "apparent ... pulmonary ... dysfunction",
                    "criterion": "pulmonary dysfunction",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "apparent ... cerebral ... dysfunction",
                    "criterion": "cerebral dysfunction",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "apparent ... renal dysfunction",
                    "criterion": "renal dysfunction",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Subjects accepting other trial drugs or participating in other clinical trials;",
            "criterions": [
                {
                    "exact_snippets": "Subjects accepting other trial drugs",
                    "criterion": "acceptance of other trial drugs",
                    "requirements": [
                        {
                            "requirement_type": "participation",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "participating in other clinical trials",
                    "criterion": "participation in other clinical trials",
                    "requirements": [
                        {
                            "requirement_type": "participation",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Female with pregnancy or during the lactation period.",
            "criterions": [
                {
                    "exact_snippets": "Female with pregnancy",
                    "criterion": "pregnancy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "during the lactation period",
                    "criterion": "lactation period",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}