{
    "info": {
        "nct_id": "NCT03144648",
        "official_title": "Molecular Subtypes of Premenopausal Breast Cancer in Latin American Women (PRECAMA): a Multicenter Population-based Case-control Study",
        "inclusion_criteria": "* woman between 20 and 45 years old\n* woman less than 3 years older or younger than the case\n* living in the area that the study is taking place during the past 3 years\n* woman menstruated at least once in the past 12 months\n* woman diagnosed with a primary breast cancer by histopathological examination (only for cases)\nHealthy volunteers allowed\nMust be FEMALE\nMust have minimum age of 20 Years\nMust have maximum age of 45 Years",
        "exclusion_criteria": "* woman receiving tumor treatment, such as radiotherapy, chemotherapy or anti-estrogens (for example, tamoxifen) (except treatment for non-melanoma skin cancers)\n* woman taking (or has previously taken) any of the following medications in the past 6 months: tamoxifen, Evista (raloxifene), Fareston (toremifene), Aromasin (exemestane), Femara (letrozole), Arimidez (anastrozole) or Megace (megestrol)\n* woman suffering from chronic kidney failure\n* woman having a pathology that will hinder adequate communication\n* woman who is pregnant or nursing\n* woman who has been previously diagnosed with a cancer(except for non-melanoma skin cancers)\n* any other reason to exclude",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* woman between 20 and 45 years old",
            "criterions": [
                {
                    "exact_snippets": "woman",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "value",
                            "expected_value": "female"
                        }
                    ]
                },
                {
                    "exact_snippets": "between 20 and 45 years old",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 20,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 45,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* woman less than 3 years older or younger than the case",
            "criterions": [
                {
                    "exact_snippets": "woman",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "value",
                            "expected_value": "female"
                        }
                    ]
                },
                {
                    "exact_snippets": "less than 3 years older or younger than the case",
                    "criterion": "age difference from case",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": -3,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 3,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* living in the area that the study is taking place during the past 3 years",
            "criterions": [
                {
                    "exact_snippets": "living in the area that the study is taking place",
                    "criterion": "residency",
                    "requirements": [
                        {
                            "requirement_type": "location",
                            "expected_value": "area that the study is taking place"
                        }
                    ]
                },
                {
                    "exact_snippets": "during the past 3 years",
                    "criterion": "residency duration",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* woman menstruated at least once in the past 12 months",
            "criterions": [
                {
                    "exact_snippets": "woman menstruated at least once in the past 12 months",
                    "criterion": "menstruation",
                    "requirements": [
                        {
                            "requirement_type": "frequency",
                            "expected_value": "at least once in the past 12 months"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* woman diagnosed with a primary breast cancer by histopathological examination (only for cases)",
            "criterions": [
                {
                    "exact_snippets": "woman",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "expected gender",
                            "expected_value": "female"
                        }
                    ]
                },
                {
                    "exact_snippets": "diagnosed with a primary breast cancer",
                    "criterion": "primary breast cancer diagnosis",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "by histopathological examination",
                    "criterion": "diagnosis method",
                    "requirements": [
                        {
                            "requirement_type": "method",
                            "expected_value": "histopathological examination"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must be FEMALE",
            "criterions": [
                {
                    "exact_snippets": "Must be FEMALE",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 20 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 20 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 20,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 45 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 45 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 45,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* woman receiving tumor treatment, such as radiotherapy, chemotherapy or anti-estrogens (for example, tamoxifen) (except treatment for non-melanoma skin cancers)",
            "criterions": [
                {
                    "exact_snippets": "woman",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "value",
                            "expected_value": "female"
                        }
                    ]
                },
                {
                    "exact_snippets": "receiving tumor treatment, such as radiotherapy, chemotherapy or anti-estrogens (for example, tamoxifen)",
                    "criterion": "tumor treatment",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "except treatment for non-melanoma skin cancers",
                    "criterion": "treatment for non-melanoma skin cancers",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* woman taking (or has previously taken) any of the following medications in the past 6 months: tamoxifen, Evista (raloxifene), Fareston (toremifene), Aromasin (exemestane), Femara (letrozole), Arimidez (anastrozole) or Megace (megestrol)",
            "criterions": [
                {
                    "exact_snippets": "woman taking (or has previously taken) any of the following medications in the past 6 months: tamoxifen, Evista (raloxifene), Fareston (toremifene), Aromasin (exemestane), Femara (letrozole), Arimidez (anastrozole) or Megace (megestrol)",
                    "criterion": "medication usage",
                    "requirements": [
                        {
                            "requirement_type": "medications",
                            "expected_value": [
                                "tamoxifen",
                                "Evista (raloxifene)",
                                "Fareston (toremifene)",
                                "Aromasin (exemestane)",
                                "Femara (letrozole)",
                                "Arimidez (anastrozole)",
                                "Megace (megestrol)"
                            ]
                        },
                        {
                            "requirement_type": "time frame",
                            "expected_value": "past 6 months"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* woman suffering from chronic kidney failure",
            "criterions": [
                {
                    "exact_snippets": "woman",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "value",
                            "expected_value": "female"
                        }
                    ]
                },
                {
                    "exact_snippets": "chronic kidney failure",
                    "criterion": "chronic kidney failure",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* woman having a pathology that will hinder adequate communication",
            "criterions": [
                {
                    "exact_snippets": "woman",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "value",
                            "expected_value": "female"
                        }
                    ]
                },
                {
                    "exact_snippets": "having a pathology that will hinder adequate communication",
                    "criterion": "communication ability",
                    "requirements": [
                        {
                            "requirement_type": "hindrance",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* woman who is pregnant or nursing",
            "criterions": [
                {
                    "exact_snippets": "woman who is pregnant",
                    "criterion": "pregnancy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "woman who is ... nursing",
                    "criterion": "nursing",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* woman who has been previously diagnosed with a cancer(except for non-melanoma skin cancers)",
            "criterions": [
                {
                    "exact_snippets": "woman",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "value",
                            "expected_value": "female"
                        }
                    ]
                },
                {
                    "exact_snippets": "previously diagnosed with a cancer",
                    "criterion": "cancer diagnosis",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "except for non-melanoma skin cancers",
                    "criterion": "cancer type",
                    "requirements": [
                        {
                            "requirement_type": "exclusion",
                            "expected_value": "non-melanoma skin cancers"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* any other reason to exclude",
            "criterions": [
                {
                    "exact_snippets": "any other reason to exclude",
                    "criterion": "exclusion reason",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}