{
    "info": {
        "nct_id": "NCT02894645",
        "official_title": "Ma-Spore ALL 2010 Study",
        "inclusion_criteria": "1. Confirmed diagnosis of non-Burkitt B-lineage ALL\n2. 1 to 17 years of age (before 18th birthday)\n3. Renal function within normal range for age\n4. Liver function within normal range for age\n5. Able to participate in the full 2 years of treatment\nHealthy volunteers allowed\nMust have minimum age of 1 Year\nMust have maximum age of 17 Years",
        "exclusion_criteria": "1. Age less than one year or age greater than/equals to 18 years\n2. Previous treatment with cytotoxic agents or high-dose steroids\n3. Mixed phenotype acute leukemia (MPAL)\n4. ALL as secondary malignancy\n5. Abnormal renal or liver function\n6. Doubtful compliance or unable to afford full course of therapy",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "1. Confirmed diagnosis of non-Burkitt B-lineage ALL",
            "criterions": [
                {
                    "exact_snippets": "Confirmed diagnosis of non-Burkitt B-lineage ALL",
                    "criterion": "non-Burkitt B-lineage ALL",
                    "requirements": [
                        {
                            "requirement_type": "diagnosis",
                            "expected_value": "confirmed"
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. 1 to 17 years of age (before 18th birthday)",
            "criterions": [
                {
                    "exact_snippets": "1 to 17 years of age (before 18th birthday)",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "N/A",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 1,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<",
                                        "value": 18,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "3. Renal function within normal range for age",
            "criterions": [
                {
                    "exact_snippets": "Renal function within normal range for age",
                    "criterion": "renal function",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": "within normal range for age"
                        }
                    ]
                }
            ]
        },
        {
            "line": "4. Liver function within normal range for age",
            "criterions": [
                {
                    "exact_snippets": "Liver function within normal range for age",
                    "criterion": "liver function",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": "normal range for age"
                        }
                    ]
                }
            ]
        },
        {
            "line": "5. Able to participate in the full 2 years of treatment",
            "criterions": [
                {
                    "exact_snippets": "Able to participate in the full 2 years of treatment",
                    "criterion": "participation duration",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": "=",
                                "value": 2,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 1 Year",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 1 Year",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "Year"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 17 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 17 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 17,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "1. Age less than one year or age greater than/equals to 18 years",
            "criterions": [
                {
                    "exact_snippets": "Age less than one year",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "N/A",
                            "expected_value": {
                                "operator": "<",
                                "value": 1,
                                "unit": "year"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "age greater than/equals to 18 years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "N/A",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. Previous treatment with cytotoxic agents or high-dose steroids",
            "criterions": [
                {
                    "exact_snippets": "Previous treatment with cytotoxic agents",
                    "criterion": "previous treatment",
                    "requirements": [
                        {
                            "requirement_type": "treatment type",
                            "expected_value": "cytotoxic agents"
                        }
                    ]
                },
                {
                    "exact_snippets": "Previous treatment with ... high-dose steroids",
                    "criterion": "previous treatment",
                    "requirements": [
                        {
                            "requirement_type": "treatment type",
                            "expected_value": "high-dose steroids"
                        }
                    ]
                }
            ]
        },
        {
            "line": "3. Mixed phenotype acute leukemia (MPAL)",
            "criterions": [
                {
                    "exact_snippets": "Mixed phenotype acute leukemia (MPAL)",
                    "criterion": "mixed phenotype acute leukemia",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "4. ALL as secondary malignancy",
            "criterions": [
                {
                    "exact_snippets": "ALL as secondary malignancy",
                    "criterion": "secondary malignancy",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": "ALL"
                        }
                    ]
                }
            ]
        },
        {
            "line": "5. Abnormal renal or liver function",
            "criterions": [
                {
                    "exact_snippets": "Abnormal renal ... function",
                    "criterion": "renal function",
                    "requirements": [
                        {
                            "requirement_type": "functionality",
                            "expected_value": "abnormal"
                        }
                    ]
                },
                {
                    "exact_snippets": "Abnormal ... liver function",
                    "criterion": "liver function",
                    "requirements": [
                        {
                            "requirement_type": "functionality",
                            "expected_value": "abnormal"
                        }
                    ]
                }
            ]
        },
        {
            "line": "6. Doubtful compliance or unable to afford full course of therapy",
            "criterions": [
                {
                    "exact_snippets": "Doubtful compliance",
                    "criterion": "compliance",
                    "requirements": [
                        {
                            "requirement_type": "certainty",
                            "expected_value": "doubtful"
                        }
                    ]
                },
                {
                    "exact_snippets": "unable to afford full course of therapy",
                    "criterion": "affordability of therapy",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": false
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}