{
    "info": {
        "nct_id": "NCT02543762",
        "official_title": "Usefulness of Chromoendoscopy for the Early Detection of Colorectal Cancer Associated With Inflammatory Bowel Disease",
        "inclusion_criteria": "* Diagnosis of UC or colitis EC corroborated by clinical and histology\n* involvement of at least one third of the colon in patients with CD\n* involvement proximal to the rectum in patients with UC\n* Duration of disease > 10 years\n* No clinical activity:\n* May Score <6\n* CDEIS <3.5\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Personal history of CRC\n* colectomy\n* coagulopathy\n* refusal to participate in the study\n* known allergy to indigo carmine\n* colonoscopy in the last 6 months",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Diagnosis of UC or colitis EC corroborated by clinical and histology",
            "criterions": [
                {
                    "exact_snippets": "Diagnosis of UC",
                    "criterion": "ulcerative colitis (UC)",
                    "requirements": [
                        {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "colitis EC corroborated by clinical and histology",
                    "criterion": "colitis EC",
                    "requirements": [
                        {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "corroboration",
                            "expected_value": [
                                "clinical",
                                "histology"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* involvement of at least one third of the colon in patients with CD",
            "criterions": [
                {
                    "exact_snippets": "involvement of at least one third of the colon",
                    "criterion": "colon involvement",
                    "requirements": [
                        {
                            "requirement_type": "extent",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "third"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* involvement proximal to the rectum in patients with UC",
            "criterions": [
                {
                    "exact_snippets": "involvement proximal to the rectum",
                    "criterion": "involvement proximal to the rectum",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Duration of disease > 10 years",
            "criterions": [
                {
                    "exact_snippets": "Duration of disease > 10 years",
                    "criterion": "duration of disease",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">",
                                "value": 10,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* No clinical activity:",
            "criterions": [
                {
                    "exact_snippets": "No clinical activity",
                    "criterion": "clinical activity",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* May Score <6",
            "criterions": [
                {
                    "exact_snippets": "May Score <6",
                    "criterion": "May Score",
                    "requirements": [
                        {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": "<",
                                "value": 6,
                                "unit": "N/A"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* CDEIS <3.5",
            "criterions": [
                {
                    "exact_snippets": "CDEIS <3.5",
                    "criterion": "CDEIS",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": "<",
                                "value": 3.5,
                                "unit": "N/A"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Personal history of CRC",
            "criterions": [
                {
                    "exact_snippets": "Personal history of CRC",
                    "criterion": "personal history of CRC",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* colectomy",
            "criterions": [
                {
                    "exact_snippets": "colectomy",
                    "criterion": "colectomy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* coagulopathy",
            "criterions": [
                {
                    "exact_snippets": "coagulopathy",
                    "criterion": "coagulopathy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* refusal to participate in the study",
            "criterions": [
                {
                    "exact_snippets": "refusal to participate in the study",
                    "criterion": "participation in the study",
                    "requirements": [
                        {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* known allergy to indigo carmine",
            "criterions": [
                {
                    "exact_snippets": "known allergy to indigo carmine",
                    "criterion": "allergy",
                    "requirements": [
                        {
                            "requirement_type": "substance",
                            "expected_value": "indigo carmine"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* colonoscopy in the last 6 months",
            "criterions": [
                {
                    "exact_snippets": "colonoscopy in the last 6 months",
                    "criterion": "colonoscopy",
                    "requirements": [
                        {
                            "requirement_type": "recency",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 6,
                                        "unit": "months"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}