{
    "info": {
        "nct_id": "NCT02440620",
        "official_title": "Cardiac Toxicity in Medical Treatment of Breast Cancer",
        "inclusion_criteria": "* Diagnosis of HER2 positive breast cancer\n* Adjuvant treatment with trastuzumab\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Left ventricle ejection fraction (LVEF) <50%\n* Chronic or persistent atrial fibrillation\n* History of moderate or severe valvular heart disease.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Diagnosis of HER2 positive breast cancer",
            "criterions": [
                {
                    "exact_snippets": "Diagnosis of HER2 positive breast cancer",
                    "criterion": "HER2 status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "positive"
                        }
                    ]
                },
                {
                    "exact_snippets": "Diagnosis of HER2 positive breast cancer",
                    "criterion": "breast cancer",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Adjuvant treatment with trastuzumab",
            "criterions": [
                {
                    "exact_snippets": "Adjuvant treatment with trastuzumab",
                    "criterion": "adjuvant treatment",
                    "requirements": [
                        {
                            "requirement_type": "medication",
                            "expected_value": "trastuzumab"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Left ventricle ejection fraction (LVEF) <50%",
            "criterions": [
                {
                    "exact_snippets": "Left ventricle ejection fraction (LVEF) <50%",
                    "criterion": "left ventricle ejection fraction (LVEF)",
                    "requirements": [
                        {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": "<",
                                "value": 50,
                                "unit": "%"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Chronic or persistent atrial fibrillation",
            "criterions": [
                {
                    "exact_snippets": "Chronic or persistent atrial fibrillation",
                    "criterion": "atrial fibrillation",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": [
                                "chronic",
                                "persistent"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* History of moderate or severe valvular heart disease.",
            "criterions": [
                {
                    "exact_snippets": "History of moderate or severe valvular heart disease.",
                    "criterion": "valvular heart disease",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": [
                                "moderate",
                                "severe"
                            ]
                        },
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}