{
    "info": {
        "nct_id": "NCT02080962",
        "official_title": "Hypofractionated Radiotherapy for Nonmelanoma Skin Cancer: Study Phase II Clinical Trial",
        "inclusion_criteria": "* Cosmesis not important\n* Basal cell carcinoma (BCC) or squamous cell carcinoma (SCC) of any differentiation\n* Clinical stage I and II\n* Location on the thorax, abdomen, pelvis (except perineum), arm, thigh, cheek\n* Patient with up to 3 injuries eligible for the study\n* Karnofsky Performance Status (KPS) ≥ 70%\n* Age > 18 years\n* Informed Consent signed by the patient consenting to undergo the study\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Indian Race\n* Prior treatment for their skin cancer\n* More than three synchronous lesions to treatment with RT\n* Basal syndrome, xeroderma, vitiligo and albinism\n* Immunosuppression\n* Prior burn at the tumor site\n* Tumor > 5 cm\n* Age <18 years\n* Carrier mental incapacity\n* People in a relationship of dependence as prisoners, soldiers, students, staff, etc..",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Cosmesis not important",
            "criterions": [
                {
                    "exact_snippets": "Cosmesis not important",
                    "criterion": "cosmesis",
                    "requirements": [
                        {
                            "requirement_type": "importance",
                            "expected_value": "not important"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Basal cell carcinoma (BCC) or squamous cell carcinoma (SCC) of any differentiation",
            "criterions": [
                {
                    "exact_snippets": "Basal cell carcinoma (BCC)",
                    "criterion": "Basal cell carcinoma",
                    "requirements": [
                        {
                            "requirement_type": "differentiation",
                            "expected_value": "any"
                        }
                    ]
                },
                {
                    "exact_snippets": "squamous cell carcinoma (SCC)",
                    "criterion": "squamous cell carcinoma",
                    "requirements": [
                        {
                            "requirement_type": "differentiation",
                            "expected_value": "any"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Clinical stage I and II",
            "criterions": [
                {
                    "exact_snippets": "Clinical stage I and II",
                    "criterion": "clinical stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": [
                                "I",
                                "II"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Patient with up to 3 injuries eligible for the study",
            "criterions": [
                {
                    "exact_snippets": "up to 3 injuries",
                    "criterion": "number of injuries",
                    "requirements": [
                        {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 3,
                                "unit": "N/A"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Karnofsky Performance Status (KPS) ≥ 70%",
            "criterions": [
                {
                    "exact_snippets": "Karnofsky Performance Status (KPS) ≥ 70%",
                    "criterion": "Karnofsky Performance Status (KPS)",
                    "requirements": [
                        {
                            "requirement_type": "score",
                            "expected_value": {
                                "operator": ">=",
                                "value": 70,
                                "unit": "%"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Age > 18 years",
            "criterions": [
                {
                    "exact_snippets": "Age > 18 years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Informed Consent signed by the patient consenting to undergo the study",
            "criterions": [
                {
                    "exact_snippets": "Informed Consent signed by the patient",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "signed",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Indian Race",
            "criterions": [
                {
                    "exact_snippets": "Indian Race",
                    "criterion": "race",
                    "requirements": [
                        {
                            "requirement_type": "specificity",
                            "expected_value": "Indian"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Prior treatment for their skin cancer",
            "criterions": [
                {
                    "exact_snippets": "Prior treatment for their skin cancer",
                    "criterion": "skin cancer treatment",
                    "requirements": [
                        {
                            "requirement_type": "prior treatment",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* More than three synchronous lesions to treatment with RT",
            "criterions": [
                {
                    "exact_snippets": "More than three synchronous lesions",
                    "criterion": "synchronous lesions",
                    "requirements": [
                        {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 3,
                                "unit": "N/A"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Basal syndrome, xeroderma, vitiligo and albinism",
            "criterions": [
                {
                    "exact_snippets": "Basal syndrome",
                    "criterion": "Basal syndrome",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "xeroderma",
                    "criterion": "xeroderma",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "vitiligo",
                    "criterion": "vitiligo",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "albinism",
                    "criterion": "albinism",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Immunosuppression",
            "criterions": [
                {
                    "exact_snippets": "Immunosuppression",
                    "criterion": "immunosuppression",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Prior burn at the tumor site",
            "criterions": [
                {
                    "exact_snippets": "Prior burn at the tumor site",
                    "criterion": "burn at the tumor site",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Tumor > 5 cm",
            "criterions": [
                {
                    "exact_snippets": "Tumor > 5 cm",
                    "criterion": "tumor size",
                    "requirements": [
                        {
                            "requirement_type": "size",
                            "expected_value": {
                                "operator": ">",
                                "value": 5,
                                "unit": "cm"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Age <18 years",
            "criterions": [
                {
                    "exact_snippets": "Age <18 years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": "<",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Carrier mental incapacity",
            "criterions": [
                {
                    "exact_snippets": "Carrier mental incapacity",
                    "criterion": "mental capacity",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* People in a relationship of dependence as prisoners, soldiers, students, staff, etc..",
            "criterions": [
                {
                    "exact_snippets": "People in a relationship of dependence as prisoners",
                    "criterion": "relationship of dependence",
                    "requirements": [
                        {
                            "requirement_type": "examples",
                            "expected_value": [
                                "prisoners"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "People in a relationship of dependence as ... soldiers",
                    "criterion": "relationship of dependence",
                    "requirements": [
                        {
                            "requirement_type": "examples",
                            "expected_value": [
                                "soldiers"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "People in a relationship of dependence as ... students",
                    "criterion": "relationship of dependence",
                    "requirements": [
                        {
                            "requirement_type": "examples",
                            "expected_value": [
                                "students"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "People in a relationship of dependence as ... staff",
                    "criterion": "relationship of dependence",
                    "requirements": [
                        {
                            "requirement_type": "examples",
                            "expected_value": [
                                "staff"
                            ]
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "line": "* Location on the thorax, abdomen, pelvis (except perineum), arm, thigh, cheek",
            "criterions": [
                {
                    "exact_snippets": "Location on the thorax",
                    "criterion": "location",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": "thorax"
                        }
                    ]
                },
                {
                    "exact_snippets": "Location on the abdomen",
                    "criterion": "location",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": "abdomen"
                        }
                    ]
                },
                {
                    "exact_snippets": "Location on the pelvis (except perineum)",
                    "criterion": "location",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": "pelvis"
                        },
                        {
                            "requirement_type": "exclusion",
                            "expected_value": "perineum"
                        }
                    ]
                },
                {
                    "exact_snippets": "Location on the arm",
                    "criterion": "location",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": "arm"
                        }
                    ]
                },
                {
                    "exact_snippets": "Location on the thigh",
                    "criterion": "location",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": "thigh"
                        }
                    ]
                },
                {
                    "exact_snippets": "Location on the cheek",
                    "criterion": "location",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": "cheek"
                        }
                    ]
                }
            ]
        }
    ],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}