{
    "info": {
        "nct_id": "NCT01929148",
        "official_title": "Is Prophylactic Bilateral Salpingectomy Added to Laparoscopic Myomectomy as New Preventive Strategy for Ovarian Cancer a Safe Procedure?",
        "inclusion_criteria": "* Indication to laparoscopic myomectomy\n* Accomplished reproductive desire\nHealthy volunteers allowed\nMust be FEMALE\nMust have minimum age of 18 Years\nMust have maximum age of 50 Years",
        "exclusion_criteria": "* Age older than 50 years\n* family history of ovarian cancer, BRCA positive\n* basal FSH value of >20 IU/mL and/or E2 levels >60 pg/mL\n* presence of menopausal symptoms,irregular (cycle-to-cycle variation over 12 months >20 days orpresence of any breakthrough bleeding) menstrual cycles, hormonereplacement treatment and/or hormonal contraception for the last 3 months, history of previous uterine or ovarian surgeries, and imaging suggestive of ovarian cyst or tubal pathology at transvaginal ultrasound.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Indication to laparoscopic myomectomy",
            "criterions": [
                {
                    "exact_snippets": "Indication to laparoscopic myomectomy",
                    "criterion": "indication for laparoscopic myomectomy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Accomplished reproductive desire",
            "criterions": [
                {
                    "exact_snippets": "Accomplished reproductive desire",
                    "criterion": "reproductive desire",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "accomplished"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must be FEMALE",
            "criterions": [
                {
                    "exact_snippets": "Must be FEMALE",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 50 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 50 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 50,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Age older than 50 years",
            "criterions": [
                {
                    "exact_snippets": "Age older than 50 years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 50,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* family history of ovarian cancer, BRCA positive",
            "criterions": [
                {
                    "exact_snippets": "family history of ovarian cancer",
                    "criterion": "family history of ovarian cancer",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "BRCA positive",
                    "criterion": "BRCA status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "positive"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* basal FSH value of >20 IU/mL and/or E2 levels >60 pg/mL",
            "criterions": [
                {
                    "exact_snippets": "basal FSH value of >20 IU/mL",
                    "criterion": "basal FSH value",
                    "requirements": [
                        {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 20,
                                "unit": "IU/mL"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "E2 levels >60 pg/mL",
                    "criterion": "E2 levels",
                    "requirements": [
                        {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 60,
                                "unit": "pg/mL"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [
        {
            "line": "* presence of menopausal symptoms,irregular (cycle-to-cycle variation over 12 months >20 days orpresence of any breakthrough bleeding) menstrual cycles, hormonereplacement treatment and/or hormonal contraception for the last 3 months, history of previous uterine or ovarian surgeries, and imaging suggestive of ovarian cyst or tubal pathology at transvaginal ultrasound.",
            "criterions": [
                {
                    "exact_snippets": "presence of menopausal symptoms",
                    "criterion": "menopausal symptoms",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "irregular (cycle-to-cycle variation over 12 months >20 days",
                    "criterion": "menstrual cycles",
                    "requirements": [
                        {
                            "requirement_type": "irregularity",
                            "expected_value": {
                                "operator": ">",
                                "value": 20,
                                "unit": "days"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "presence of any breakthrough bleeding",
                    "criterion": "breakthrough bleeding",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "hormone replacement treatment",
                    "criterion": "hormone replacement treatment",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "hormonal contraception for the last 3 months",
                    "criterion": "hormonal contraception",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "history of previous uterine or ovarian surgeries",
                    "criterion": "uterine or ovarian surgeries",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "imaging suggestive of ovarian cyst or tubal pathology at transvaginal ultrasound",
                    "criterion": "ovarian cyst or tubal pathology",
                    "requirements": [
                        {
                            "requirement_type": "imaging evidence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "failed_miscellaneous": []
}