{
    "info": {
        "nct_id": "NCT01190566",
        "official_title": "PET-MR Fusion Imaging and Surrogate Marker for Prediction and Monitoring of Response to Neoadjuvant Chemotherapy in Breast Cancer Patients",
        "inclusion_criteria": "* Pathologically confirmed breast cancer\n* Clinical stage IIb, IIIa, IIIb, IIIc\n* Must have measurable disease\n* Performance status of ECOG 0-2\n* Adequate, bone marrow, liver, heart, and renal function\n* Who did not receive chemotherapy for breast cancer\n* Must agree with and signed informed consent\nHealthy volunteers allowed\nMust be FEMALE\nMust have minimum age of 18 Years\nMust have maximum age of 70 Years",
        "exclusion_criteria": "* Prior history of cancer besides breast cancer\n* Active bacterial infection\n* Pregnant or lactating women\n* Psychological disease or seizure\n* History of arrhythmia, congestive heart failure, myocardial infarct, or unstable angina\n* Male breast cancer\n* Who had a pacemaker or history of open heart surgery",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Pathologically confirmed breast cancer",
            "criterions": [
                {
                    "exact_snippets": "Pathologically confirmed breast cancer",
                    "criterion": "breast cancer",
                    "requirements": [
                        {
                            "requirement_type": "confirmation method",
                            "expected_value": "pathologically confirmed"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Clinical stage IIb, IIIa, IIIb, IIIc",
            "criterions": [
                {
                    "exact_snippets": "Clinical stage IIb, IIIa, IIIb, IIIc",
                    "criterion": "clinical stage",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": [
                                "IIb",
                                "IIIa",
                                "IIIb",
                                "IIIc"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Must have measurable disease",
            "criterions": [
                {
                    "exact_snippets": "Must have measurable disease",
                    "criterion": "measurable disease",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Performance status of ECOG 0-2",
            "criterions": [
                {
                    "exact_snippets": "Performance status of ECOG 0-2",
                    "criterion": "ECOG performance status",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Adequate, bone marrow, liver, heart, and renal function",
            "criterions": [
                {
                    "exact_snippets": "Adequate, bone marrow",
                    "criterion": "bone marrow function",
                    "requirements": [
                        {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "Adequate, ... liver",
                    "criterion": "liver function",
                    "requirements": [
                        {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "Adequate, ... heart",
                    "criterion": "heart function",
                    "requirements": [
                        {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "Adequate, ... renal function",
                    "criterion": "renal function",
                    "requirements": [
                        {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Who did not receive chemotherapy for breast cancer",
            "criterions": [
                {
                    "exact_snippets": "did not receive chemotherapy for breast cancer",
                    "criterion": "chemotherapy for breast cancer",
                    "requirements": [
                        {
                            "requirement_type": "receipt",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Must agree with and signed informed consent",
            "criterions": [
                {
                    "exact_snippets": "Must agree with and signed informed consent",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "agreement",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "signature",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must be FEMALE",
            "criterions": [
                {
                    "exact_snippets": "Must be FEMALE",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 70 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 70 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 70,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Prior history of cancer besides breast cancer",
            "criterions": [
                {
                    "exact_snippets": "Prior history of cancer besides breast cancer",
                    "criterion": "prior history of cancer",
                    "requirements": [
                        {
                            "requirement_type": "exclusion",
                            "expected_value": "breast cancer"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Active bacterial infection",
            "criterions": [
                {
                    "exact_snippets": "Active bacterial infection",
                    "criterion": "bacterial infection",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Pregnant or lactating women",
            "criterions": [
                {
                    "exact_snippets": "Pregnant",
                    "criterion": "pregnancy status",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "lactating women",
                    "criterion": "lactation status",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Psychological disease or seizure",
            "criterions": [
                {
                    "exact_snippets": "Psychological disease",
                    "criterion": "psychological disease",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "seizure",
                    "criterion": "seizure",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* History of arrhythmia, congestive heart failure, myocardial infarct, or unstable angina",
            "criterions": [
                {
                    "exact_snippets": "History of arrhythmia",
                    "criterion": "arrhythmia",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "History of ... congestive heart failure",
                    "criterion": "congestive heart failure",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "History of ... myocardial infarct",
                    "criterion": "myocardial infarct",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "History of ... unstable angina",
                    "criterion": "unstable angina",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Male breast cancer",
            "criterions": [
                {
                    "exact_snippets": "Male breast cancer",
                    "criterion": "breast cancer",
                    "requirements": [
                        {
                            "requirement_type": "gender",
                            "expected_value": "male"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Who had a pacemaker or history of open heart surgery",
            "criterions": [
                {
                    "exact_snippets": "Who had a pacemaker",
                    "criterion": "pacemaker",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "history of open heart surgery",
                    "criterion": "open heart surgery",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}