{
    "info": {
        "nct_id": "NCT01015131",
        "official_title": "A Pilot Study to Evaluate the Correlation Between 18F-FLT-PET Uptake, Ki-67 Immunohistochemistry, and Proliferation Signature in Response to Neo-Adjuvant Chemotherapy in Breast Cancer",
        "inclusion_criteria": "* Has newly-diagnosed stage IIB/IIIA/IIIB locally advanced breast cancer\n* Is eligible for pre-operative (neo-adjuvant) chemotherapy\nHealthy volunteers allowed\nMust be FEMALE\nMust have minimum age of 35 Years\nMust have maximum age of 75 Years",
        "exclusion_criteria": "* Has a contraindication to magnetic resonance imaging (MRI)\n* Any condition that would limit ability to undergo MRI or PET scans\n* Is a nursing mother\n* Has moderate to end-stage renal disease and is not on dialysis or has renal failure on chronic dialysis",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Has newly-diagnosed stage IIB/IIIA/IIIB locally advanced breast cancer",
            "criterions": [
                {
                    "exact_snippets": "newly-diagnosed",
                    "criterion": "diagnosis status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "newly-diagnosed"
                        }
                    ]
                },
                {
                    "exact_snippets": "stage IIB/IIIA/IIIB",
                    "criterion": "cancer stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": [
                                "IIB",
                                "IIIA",
                                "IIIB"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "locally advanced breast cancer",
                    "criterion": "cancer type",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": "locally advanced breast cancer"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Is eligible for pre-operative (neo-adjuvant) chemotherapy",
            "criterions": [
                {
                    "exact_snippets": "eligible for pre-operative (neo-adjuvant) chemotherapy",
                    "criterion": "pre-operative (neo-adjuvant) chemotherapy eligibility",
                    "requirements": [
                        {
                            "requirement_type": "eligibility",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must be FEMALE",
            "criterions": [
                {
                    "exact_snippets": "Must be FEMALE",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 35 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 35 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 35,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 75 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 75 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 75,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Has a contraindication to magnetic resonance imaging (MRI)",
            "criterions": [
                {
                    "exact_snippets": "contraindication to magnetic resonance imaging (MRI)",
                    "criterion": "contraindication to MRI",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Any condition that would limit ability to undergo MRI or PET scans",
            "criterions": [
                {
                    "exact_snippets": "condition that would limit ability to undergo MRI",
                    "criterion": "ability to undergo MRI",
                    "requirements": [
                        {
                            "requirement_type": "limitation",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "condition that would limit ability to undergo ... PET scans",
                    "criterion": "ability to undergo PET scans",
                    "requirements": [
                        {
                            "requirement_type": "limitation",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Is a nursing mother",
            "criterions": [
                {
                    "exact_snippets": "Is a nursing mother",
                    "criterion": "nursing mother",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Has moderate to end-stage renal disease and is not on dialysis or has renal failure on chronic dialysis",
            "criterions": [
                {
                    "exact_snippets": "moderate to end-stage renal disease",
                    "criterion": "renal disease",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": "moderate to end-stage"
                        }
                    ]
                },
                {
                    "exact_snippets": "not on dialysis",
                    "criterion": "dialysis status",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "renal failure on chronic dialysis",
                    "criterion": "renal failure",
                    "requirements": [
                        {
                            "requirement_type": "dialysis status",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}