{
    "info": {
        "nct_id": "NCT00956280",
        "official_title": "Epidemiologic Study of KRAS Mutation in Brazilian Patients With Advanced or Metastatic Non Small Cell Lung Cancer",
        "inclusion_criteria": "* Histological or cytological confirmation of locally advanced or metastatic Non Small Cell Lung Cancer (IIIB-IV)\n* Tumour sample (block of slides) available for KRAS analysis\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Confirmation of locally advanced or metastatic NSCLC (IIIB-IV) exclusively by cytology, with no tumour sample access.\n* Previous treatment using a MEK inhibitor or any other regimen containing docetaxel (previous treatment with paclitaxel is accepted)",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Histological or cytological confirmation of locally advanced or metastatic Non Small Cell Lung Cancer (IIIB-IV)",
            "criterions": [
                {
                    "exact_snippets": "Histological or cytological confirmation",
                    "criterion": "confirmation method",
                    "requirements": [
                        {
                            "requirement_type": "method",
                            "expected_value": [
                                "histological",
                                "cytological"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "locally advanced or metastatic Non Small Cell Lung Cancer",
                    "criterion": "Non Small Cell Lung Cancer stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": [
                                "locally advanced",
                                "metastatic"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "Non Small Cell Lung Cancer (IIIB-IV)",
                    "criterion": "Non Small Cell Lung Cancer stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": "IIIB-IV"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Tumour sample (block of slides) available for KRAS analysis",
            "criterions": [
                {
                    "exact_snippets": "Tumour sample (block of slides) available",
                    "criterion": "tumour sample",
                    "requirements": [
                        {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "KRAS analysis",
                    "criterion": "KRAS analysis",
                    "requirements": [
                        {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Confirmation of locally advanced or metastatic NSCLC (IIIB-IV) exclusively by cytology, with no tumour sample access.",
            "criterions": [
                {
                    "exact_snippets": "locally advanced or metastatic NSCLC (IIIB-IV)",
                    "criterion": "NSCLC stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": [
                                "IIIB",
                                "IV"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "exclusively by cytology",
                    "criterion": "diagnosis method",
                    "requirements": [
                        {
                            "requirement_type": "method",
                            "expected_value": "cytology"
                        }
                    ]
                },
                {
                    "exact_snippets": "no tumour sample access",
                    "criterion": "tumour sample access",
                    "requirements": [
                        {
                            "requirement_type": "access",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Previous treatment using a MEK inhibitor or any other regimen containing docetaxel (previous treatment with paclitaxel is accepted)",
            "criterions": [
                {
                    "exact_snippets": "Previous treatment using a MEK inhibitor",
                    "criterion": "previous treatment with MEK inhibitor",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "any other regimen containing docetaxel",
                    "criterion": "previous treatment with docetaxel",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "previous treatment with paclitaxel is accepted",
                    "criterion": "previous treatment with paclitaxel",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}