{
    "info": {
        "nct_id": "NCT00949273",
        "official_title": "A Randomized, Controlled, Multicenter Trial to Evaluate the Safety and Efficacy of Cylindrical Abdominoperineal Resection in the Treatment of Advanced Very Low Rectal Cancer",
        "inclusion_criteria": "* Tumor within 6 cm of the anal verge, or with very narrow pelvis\n* T3-T4 as determined by preoperative MRI or endorectal ultrasonography examination, or a low tumor is fixed or tethered at rectal examination\n* Absence of distant metastases\n* Absence of intestinal obstruction\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 80 Years",
        "exclusion_criteria": "* T1-T2 as determined by preoperative MRI or endorectal ultrasonography examination\n* with distant metastases\n* with intestinal obstruction\n* pregnancy or lactation\n* allergic constitution to heterogeneous protein\n* with operation contraindication\n* with mental disorder",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Tumor within 6 cm of the anal verge, or with very narrow pelvis",
            "criterions": [
                {
                    "exact_snippets": "Tumor within 6 cm of the anal verge",
                    "criterion": "tumor location",
                    "requirements": [
                        {
                            "requirement_type": "distance from anal verge",
                            "expected_value": {
                                "operator": "<=",
                                "value": 6,
                                "unit": "cm"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "very narrow pelvis",
                    "criterion": "pelvis width",
                    "requirements": [
                        {
                            "requirement_type": "width",
                            "expected_value": "very narrow"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* T3-T4 as determined by preoperative MRI or endorectal ultrasonography examination, or a low tumor is fixed or tethered at rectal examination",
            "criterions": [
                {
                    "exact_snippets": "T3-T4 as determined by preoperative MRI or endorectal ultrasonography examination",
                    "criterion": "tumor stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": [
                                "T3",
                                "T4"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "a low tumor is fixed or tethered at rectal examination",
                    "criterion": "tumor fixation",
                    "requirements": [
                        {
                            "requirement_type": "fixation",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Absence of distant metastases",
            "criterions": [
                {
                    "exact_snippets": "Absence of distant metastases",
                    "criterion": "distant metastases",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Absence of intestinal obstruction",
            "criterions": [
                {
                    "exact_snippets": "Absence of intestinal obstruction",
                    "criterion": "intestinal obstruction",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 80 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 80 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 80,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* T1-T2 as determined by preoperative MRI or endorectal ultrasonography examination",
            "criterions": [
                {
                    "exact_snippets": "T1-T2 as determined by preoperative MRI or endorectal ultrasonography examination",
                    "criterion": "tumor stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": [
                                "T1",
                                "T2"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* with distant metastases",
            "criterions": [
                {
                    "exact_snippets": "distant metastases",
                    "criterion": "metastases",
                    "requirements": [
                        {
                            "requirement_type": "location",
                            "expected_value": "distant"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* with intestinal obstruction",
            "criterions": [
                {
                    "exact_snippets": "intestinal obstruction",
                    "criterion": "intestinal obstruction",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* pregnancy or lactation",
            "criterions": [
                {
                    "exact_snippets": "pregnancy",
                    "criterion": "pregnancy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "lactation",
                    "criterion": "lactation",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* allergic constitution to heterogeneous protein",
            "criterions": [
                {
                    "exact_snippets": "allergic constitution to heterogeneous protein",
                    "criterion": "allergic constitution",
                    "requirements": [
                        {
                            "requirement_type": "cause",
                            "expected_value": "heterogeneous protein"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* with operation contraindication",
            "criterions": [
                {
                    "exact_snippets": "operation contraindication",
                    "criterion": "operation contraindication",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* with mental disorder",
            "criterions": [
                {
                    "exact_snippets": "with mental disorder",
                    "criterion": "mental disorder",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}