{
    "info": {
        "nct_id": "NCT00815620",
        "official_title": "Best Therapy for Patients With Neuroendocrine Tumors",
        "inclusion_criteria": "* Biopsy-proven neuroendocrine tumor (WHO class I-II, TNM grading 1-2)\n* Advanced disease with lymph node or distant metastases (N1, M1) undergoing cytoreduction by surgery/local ablative therapy or peptide receptor radiotherapy\n* curative intent of all therapies possible\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 90 Years",
        "exclusion_criteria": "* Undifferentiated neuroendocrine carcinoma (WHO class III, TNM grading 3)\n* secondary tumor\n* advanced carcinoid heart disease requiring surgery",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Biopsy-proven neuroendocrine tumor (WHO class I-II, TNM grading 1-2)",
            "criterions": [
                {
                    "exact_snippets": "Biopsy-proven neuroendocrine tumor",
                    "criterion": "neuroendocrine tumor",
                    "requirements": [
                        {
                            "requirement_type": "confirmation",
                            "expected_value": "biopsy-proven"
                        }
                    ]
                },
                {
                    "exact_snippets": "WHO class I-II",
                    "criterion": "WHO class",
                    "requirements": [
                        {
                            "requirement_type": "classification",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 1,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "TNM grading 1-2",
                    "criterion": "TNM grading",
                    "requirements": [
                        {
                            "requirement_type": "grading",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 1,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Advanced disease with lymph node or distant metastases (N1, M1) undergoing cytoreduction by surgery/local ablative therapy or peptide receptor radiotherapy",
            "criterions": [
                {
                    "exact_snippets": "Advanced disease with lymph node or distant metastases (N1, M1)",
                    "criterion": "disease stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": [
                                "N1",
                                "M1"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "undergoing cytoreduction by surgery/local ablative therapy",
                    "criterion": "cytoreduction treatment",
                    "requirements": [
                        {
                            "requirement_type": "treatment type",
                            "expected_value": [
                                "surgery",
                                "local ablative therapy"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "undergoing ... peptide receptor radiotherapy",
                    "criterion": "peptide receptor radiotherapy",
                    "requirements": [
                        {
                            "requirement_type": "treatment",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* curative intent of all therapies possible",
            "criterions": [
                {
                    "exact_snippets": "curative intent of all therapies possible",
                    "criterion": "therapies",
                    "requirements": [
                        {
                            "requirement_type": "intent",
                            "expected_value": "curative"
                        },
                        {
                            "requirement_type": "possibility",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 90 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 90 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 90,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Undifferentiated neuroendocrine carcinoma (WHO class III, TNM grading 3)",
            "criterions": [
                {
                    "exact_snippets": "Undifferentiated neuroendocrine carcinoma",
                    "criterion": "neuroendocrine carcinoma",
                    "requirements": [
                        {
                            "requirement_type": "differentiation",
                            "expected_value": "undifferentiated"
                        }
                    ]
                },
                {
                    "exact_snippets": "WHO class III",
                    "criterion": "WHO classification",
                    "requirements": [
                        {
                            "requirement_type": "classification",
                            "expected_value": "III"
                        }
                    ]
                },
                {
                    "exact_snippets": "TNM grading 3",
                    "criterion": "TNM grading",
                    "requirements": [
                        {
                            "requirement_type": "grading",
                            "expected_value": {
                                "operator": "=",
                                "value": 3,
                                "unit": "N/A"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* secondary tumor",
            "criterions": [
                {
                    "exact_snippets": "secondary tumor",
                    "criterion": "secondary tumor",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* advanced carcinoid heart disease requiring surgery",
            "criterions": [
                {
                    "exact_snippets": "advanced carcinoid heart disease",
                    "criterion": "carcinoid heart disease",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": "advanced"
                        }
                    ]
                },
                {
                    "exact_snippets": "requiring surgery",
                    "criterion": "surgery requirement",
                    "requirements": [
                        {
                            "requirement_type": "necessity",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}