{
    "info": {
        "nct_id": "NCT00522262",
        "official_title": "Alberta Physical Activity and Breast Cancer Prevention (ALPHA) Trial",
        "inclusion_criteria": "* Female\n* Age 50-74 at baseline\n* Postmenopausal\n* Moderately sedentary lifestyle\n* Live in Calgary or Edmonton, Alberta, Canada\n* English-speaking\n* Willing to be randomized\n* Body-mass index 22.0-40.0\n* Breast tissue density >=0%\nHealthy volunteers allowed\nMust be FEMALE\nMust have minimum age of 50 Years\nMust have maximum age of 74 Years",
        "exclusion_criteria": "* Previous invasive cancer in last 5 years\n* Major co-morbidities\n* Unable to participate in exercise program\n* Current smoker\n* Current excessive drinker\n* Hormone replacement therapy use in previous 2 years\n* Drugs that may influence one or more study outcomes",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Female",
            "criterions": [
                {
                    "exact_snippets": "Female",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Age 50-74 at baseline",
            "criterions": [
                {
                    "exact_snippets": "Age 50-74",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 50,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 74,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Postmenopausal",
            "criterions": [
                {
                    "exact_snippets": "Postmenopausal",
                    "criterion": "menopausal status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "postmenopausal"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Moderately sedentary lifestyle",
            "criterions": [
                {
                    "exact_snippets": "Moderately sedentary lifestyle",
                    "criterion": "lifestyle",
                    "requirements": [
                        {
                            "requirement_type": "activity level",
                            "expected_value": "moderately sedentary"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Live in Calgary or Edmonton, Alberta, Canada",
            "criterions": [
                {
                    "exact_snippets": "Live in Calgary or Edmonton, Alberta, Canada",
                    "criterion": "residence location",
                    "requirements": [
                        {
                            "requirement_type": "location",
                            "expected_value": [
                                "Calgary",
                                "Edmonton"
                            ]
                        },
                        {
                            "requirement_type": "region",
                            "expected_value": "Alberta, Canada"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* English-speaking",
            "criterions": [
                {
                    "exact_snippets": "English-speaking",
                    "criterion": "language",
                    "requirements": [
                        {
                            "requirement_type": "proficiency",
                            "expected_value": "English"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Willing to be randomized",
            "criterions": [
                {
                    "exact_snippets": "Willing to be randomized",
                    "criterion": "willingness to be randomized",
                    "requirements": [
                        {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Body-mass index 22.0-40.0",
            "criterions": [
                {
                    "exact_snippets": "Body-mass index 22.0-40.0",
                    "criterion": "body-mass index",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 22.0,
                                        "unit": ""
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 40.0,
                                        "unit": ""
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Breast tissue density >=0%",
            "criterions": [
                {
                    "exact_snippets": "Breast tissue density >=0%",
                    "criterion": "breast tissue density",
                    "requirements": [
                        {
                            "requirement_type": "density",
                            "expected_value": {
                                "operator": ">=",
                                "value": 0,
                                "unit": "%"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must be FEMALE",
            "criterions": [
                {
                    "exact_snippets": "Must be FEMALE",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 50 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 50 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 50,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 74 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 74 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 74,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Previous invasive cancer in last 5 years",
            "criterions": [
                {
                    "exact_snippets": "Previous invasive cancer in last 5 years",
                    "criterion": "previous invasive cancer",
                    "requirements": [
                        {
                            "requirement_type": "time since last occurrence",
                            "expected_value": {
                                "operator": "<=",
                                "value": 5,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Major co-morbidities",
            "criterions": [
                {
                    "exact_snippets": "Major co-morbidities",
                    "criterion": "co-morbidities",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": "major"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Unable to participate in exercise program",
            "criterions": [
                {
                    "exact_snippets": "Unable to participate in exercise program",
                    "criterion": "exercise program participation",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Current smoker",
            "criterions": [
                {
                    "exact_snippets": "Current smoker",
                    "criterion": "smoking status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "current smoker"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Current excessive drinker",
            "criterions": [
                {
                    "exact_snippets": "Current excessive drinker",
                    "criterion": "alcohol consumption",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "excessive"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Hormone replacement therapy use in previous 2 years",
            "criterions": [
                {
                    "exact_snippets": "Hormone replacement therapy use in previous 2 years",
                    "criterion": "hormone replacement therapy use",
                    "requirements": [
                        {
                            "requirement_type": "time frame",
                            "expected_value": "previous 2 years"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Drugs that may influence one or more study outcomes",
            "criterions": [
                {
                    "exact_snippets": "Drugs that may influence one or more study outcomes",
                    "criterion": "drugs",
                    "requirements": [
                        {
                            "requirement_type": "influence on study outcomes",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}