{
    "info": {
        "nct_id": "NCT00467220",
        "official_title": "Effect of Daily Calorie Restriction or Alternate-day Reductions in Calorie Intake on Risk for Cardiovascular Disease and Cancer",
        "inclusion_criteria": "* Male and female; body mass index (BMI) between 20-30 kg/m2;\n* Age between 35-65 years; sedentary (light exercise less than 1h per week) or moderately active (1 to 2h per week);\n* Weight stable for >3 months prior to the beginning of the study;\n* Able to give written informed consent;\n* Female subjects must be post-menopausal for at least 2 years and can not be on hormone replacement therapy (HRT).\nHealthy volunteers allowed\nMust have minimum age of 35 Years\nMust have maximum age of 65 Years",
        "exclusion_criteria": "* Diabetic;\n* History of cardiovascular disease, i.e. myocardial infarction or stroke;\n* History of cancer;\n* Taking glucose lowering medication;\n* Taking weight loss medication",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Male and female; body mass index (BMI) between 20-30 kg/m2;",
            "criterions": [
                {
                    "exact_snippets": "Male and female",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "allowed_values",
                            "expected_value": [
                                "male",
                                "female"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "body mass index (BMI) between 20-30 kg/m2",
                    "criterion": "body mass index (BMI)",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 20,
                                        "unit": "kg/m2"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 30,
                                        "unit": "kg/m2"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Age between 35-65 years; sedentary (light exercise less than 1h per week) or moderately active (1 to 2h per week);",
            "criterions": [
                {
                    "exact_snippets": "Age between 35-65 years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 35,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 65,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "sedentary (light exercise less than 1h per week)",
                    "criterion": "physical activity level",
                    "requirements": [
                        {
                            "requirement_type": "activity level",
                            "expected_value": "sedentary"
                        }
                    ]
                },
                {
                    "exact_snippets": "moderately active (1 to 2h per week)",
                    "criterion": "physical activity level",
                    "requirements": [
                        {
                            "requirement_type": "activity level",
                            "expected_value": "moderately active"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Weight stable for >3 months prior to the beginning of the study;",
            "criterions": [
                {
                    "exact_snippets": "Weight stable for >3 months",
                    "criterion": "weight stability",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Able to give written informed consent;",
            "criterions": [
                {
                    "exact_snippets": "Able to give written informed consent",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Female subjects must be post-menopausal for at least 2 years and can not be on hormone replacement therapy (HRT).",
            "criterions": [
                {
                    "exact_snippets": "Female subjects must be post-menopausal for at least 2 years",
                    "criterion": "menopausal status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "post-menopausal"
                        },
                        {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2,
                                "unit": "years"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "can not be on hormone replacement therapy (HRT)",
                    "criterion": "hormone replacement therapy",
                    "requirements": [
                        {
                            "requirement_type": "usage",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 35 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 35 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 35,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 65 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 65 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 65,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Diabetic;",
            "criterions": [
                {
                    "exact_snippets": "Diabetic",
                    "criterion": "diabetes",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* History of cardiovascular disease, i.e. myocardial infarction or stroke;",
            "criterions": [
                {
                    "exact_snippets": "History of cardiovascular disease, i.e. myocardial infarction",
                    "criterion": "myocardial infarction",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "History of cardiovascular disease, i.e. ... stroke",
                    "criterion": "stroke",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* History of cancer;",
            "criterions": [
                {
                    "exact_snippets": "History of cancer",
                    "criterion": "cancer history",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Taking glucose lowering medication;",
            "criterions": [
                {
                    "exact_snippets": "Taking glucose lowering medication",
                    "criterion": "glucose lowering medication",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Taking weight loss medication",
            "criterions": [
                {
                    "exact_snippets": "Taking weight loss medication",
                    "criterion": "weight loss medication",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}