{
    "info": {
        "nct_id": "NCT00254891",
        "official_title": "International, Randomized, Open-Label, Phase 3 Trial of Paclitaxel/Carboplatin Plus PF-3512676 Versus Paclitaxel/Carboplatin Alone as First-Line Treatment of Patients With Advanced Non-Small Cell Lung Cancer",
        "inclusion_criteria": "* Advanced Non-Small-Cell Lung Cancer (NSCLC) stage IIIB with pleural effusion or stage IV\n* No prior systemic treatment for Non-Small-Cell Lung Cancer (NSCLC)with chemotherapy, immunotherapy, biologic response modifiers or other investigational drugs\n* Eastern Cooperative Oncology Performance Status (ECOG PS) 0 or 1\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Small cell or carcinoid lung cancer\n* Known Central Nervous System (CNS) metastasis\n* Pre-existing auto-immune or antibody mediated diseases",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Advanced Non-Small-Cell Lung Cancer (NSCLC) stage IIIB with pleural effusion or stage IV",
            "criterions": [
                {
                    "exact_snippets": "Advanced Non-Small-Cell Lung Cancer (NSCLC)",
                    "criterion": "Non-Small-Cell Lung Cancer (NSCLC)",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": "advanced"
                        }
                    ]
                },
                {
                    "exact_snippets": "stage IIIB with pleural effusion",
                    "criterion": "NSCLC stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": "IIIB"
                        },
                        {
                            "requirement_type": "condition",
                            "expected_value": "pleural effusion"
                        }
                    ]
                },
                {
                    "exact_snippets": "stage IV",
                    "criterion": "NSCLC stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": "IV"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Eastern Cooperative Oncology Performance Status (ECOG PS) 0 or 1",
            "criterions": [
                {
                    "exact_snippets": "Eastern Cooperative Oncology Performance Status (ECOG PS) 0 or 1",
                    "criterion": "Eastern Cooperative Oncology Performance Status (ECOG PS)",
                    "requirements": [
                        {
                            "requirement_type": "value",
                            "expected_value": [
                                "0",
                                "1"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Small cell or carcinoid lung cancer",
            "criterions": [
                {
                    "exact_snippets": "Small cell ... lung cancer",
                    "criterion": "small cell lung cancer",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "carcinoid lung cancer",
                    "criterion": "carcinoid lung cancer",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Known Central Nervous System (CNS) metastasis",
            "criterions": [
                {
                    "exact_snippets": "Known Central Nervous System (CNS) metastasis",
                    "criterion": "Central Nervous System (CNS) metastasis",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Pre-existing auto-immune or antibody mediated diseases",
            "criterions": [
                {
                    "exact_snippets": "Pre-existing auto-immune or antibody mediated diseases",
                    "criterion": "auto-immune diseases",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "Pre-existing auto-immune or antibody mediated diseases",
                    "criterion": "antibody mediated diseases",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "line": "* No prior systemic treatment for Non-Small-Cell Lung Cancer (NSCLC)with chemotherapy, immunotherapy, biologic response modifiers or other investigational drugs",
            "criterions": [
                {
                    "exact_snippets": "No prior systemic treatment for Non-Small-Cell Lung Cancer (NSCLC) with chemotherapy",
                    "criterion": "prior systemic treatment with chemotherapy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "No prior systemic treatment for Non-Small-Cell Lung Cancer (NSCLC) with ... immunotherapy",
                    "criterion": "prior systemic treatment with immunotherapy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "No prior systemic treatment for Non-Small-Cell Lung Cancer (NSCLC) with ... biologic response modifiers",
                    "criterion": "prior systemic treatment with biologic response modifiers",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "No prior systemic treatment for Non-Small-Cell Lung Cancer (NSCLC) with ... other investigational drugs",
                    "criterion": "prior systemic treatment with other investigational drugs",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        }
    ],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}