{
    "info": {
        "nct_id": "NCT00007982",
        "official_title": "CAMP 004A - Phase 2 Study Of Intensive Chemotherapy (BET) For Selected Categories Of Malignant Central Nervous System Tumor",
        "inclusion_criteria": "Healthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "",
        "miscellaneous_criteria": "DISEASE CHARACTERISTICS:\n\n* Histologically confirmed malignant tumors\n\n  * Anaplastic astrocytoma\n  * Oligodendroglioma\n  * Germ cell tumor\n  * Medulloblastoma\n  * Primary neuroectodermal tumor\n  * Esthesioneuroblastoma\n  * CNS lymphoma (primary or systemic disease)\n* Multifocal intracranial disease allowed\n* No extraneural metastases (except controlled systemic lymphoma)\n* Pretreatment considerations based on tumor type\n\n  * Anaplastic astrocytoma:\n\n    * Recurrent disease\n    * Any treatment at diagnosis allowed (carmustine dose limited to 480 mg/m2)\n    * Chemotherapy not required at recurrence\n  * Oligodendroglioma:\n\n    * Disease response (at least minor) to conventional chemotherapy OR\n    * Recurrent disease\n  * Esthesioneuroblastoma:\n\n    * Attempted complete surgical resection\n    * Disease progression after radiotherapy\n    * Response to chemotherapy regimen comprising cyclophosphamide, etoposide, and cisplatin\n  * CNS lymphoma:\n\n    * Disease refractory to methotrexate OR\n    * Failure after initial treatment with methotrexate OR\n    * Considered at high risk for disease relapse despite initial response\n* Radiographic or pathological confirmation of recurrent disease required\n* Not eligible for other high priority national or institutional clinical studies\n\nPATIENT CHARACTERISTICS:\n\nAge:\n\n* 18 and over\n\nPerformance status:\n\n* ECOG or Zubrod 0-1\n\nLife expectancy:\n\n* Not specified\n\nHematopoietic:\n\n* Not specified\n\nHepatic:\n\n* Not specified\n\nRenal:\n\n* Creatinine less than 1.5 times normal\n\nCardiovascular:\n\n* LVEF at least 45%\n\nPulmonary:\n\n* DLCO at least 60% predicted OR\n* Approval of pulmonologist\n\nOther:\n\n* Not pregnant or nursing\n* HIV negative\n\nPRIOR CONCURRENT THERAPY:\n\nBiologic therapy:\n\n* Not specified\n\nChemotherapy:\n\n* See Disease Characteristics\n* No other concurrent chemotherapy\n\nEndocrine therapy:\n\n* No concurrent anticancer hormonal therapy\n* No concurrent steroids as antiemetics\n\nRadiotherapy:\n\n* See Disease Characteristics\n\nSurgery:\n\n* See Disease Characteristics\n\nOther:\n\n* No concurrent barbiturates or acetaminophen\n* Participation in other concurrent supportive care or gene therapy trials allowed"
    },
    "inclusion_lines": [
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [],
    "miscellaneous_lines": [
        {
            "line": "DISEASE CHARACTERISTICS:",
            "criterions": [
                {
                    "exact_snippets": "DISEASE CHARACTERISTICS",
                    "criterion": "disease characteristics",
                    "requirements": [
                        {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Histologically confirmed malignant tumors",
            "criterions": [
                {
                    "exact_snippets": "Histologically confirmed malignant tumors",
                    "criterion": "malignant tumors",
                    "requirements": [
                        {
                            "requirement_type": "confirmation method",
                            "expected_value": "histologically confirmed"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Anaplastic astrocytoma",
            "criterions": [
                {
                    "exact_snippets": "Anaplastic astrocytoma",
                    "criterion": "anaplastic astrocytoma",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Oligodendroglioma",
            "criterions": [
                {
                    "exact_snippets": "Oligodendroglioma",
                    "criterion": "oligodendroglioma",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Germ cell tumor",
            "criterions": [
                {
                    "exact_snippets": "Germ cell tumor",
                    "criterion": "germ cell tumor",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Medulloblastoma",
            "criterions": [
                {
                    "exact_snippets": "Medulloblastoma",
                    "criterion": "medulloblastoma",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Primary neuroectodermal tumor",
            "criterions": [
                {
                    "exact_snippets": "Primary neuroectodermal tumor",
                    "criterion": "neuroectodermal tumor",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": "primary"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Esthesioneuroblastoma",
            "criterions": [
                {
                    "exact_snippets": "Esthesioneuroblastoma",
                    "criterion": "esthesioneuroblastoma",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* CNS lymphoma (primary or systemic disease)",
            "criterions": [
                {
                    "exact_snippets": "CNS lymphoma (primary or systemic disease)",
                    "criterion": "CNS lymphoma",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": [
                                "primary",
                                "systemic"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Multifocal intracranial disease allowed",
            "criterions": [
                {
                    "exact_snippets": "Multifocal intracranial disease allowed",
                    "criterion": "multifocal intracranial disease",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* No extraneural metastases (except controlled systemic lymphoma)",
            "criterions": [
                {
                    "exact_snippets": "No extraneural metastases",
                    "criterion": "extraneural metastases",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "controlled systemic lymphoma",
                    "criterion": "systemic lymphoma",
                    "requirements": [
                        {
                            "requirement_type": "control status",
                            "expected_value": "controlled"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Pretreatment considerations based on tumor type",
            "criterions": [
                {
                    "exact_snippets": "Pretreatment considerations based on tumor type",
                    "criterion": "tumor type",
                    "requirements": [
                        {
                            "requirement_type": "considerations",
                            "expected_value": "pretreatment"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Anaplastic astrocytoma:",
            "criterions": [
                {
                    "exact_snippets": "Anaplastic astrocytoma",
                    "criterion": "anaplastic astrocytoma",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Recurrent disease",
            "criterions": [
                {
                    "exact_snippets": "Recurrent disease",
                    "criterion": "disease recurrence",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Any treatment at diagnosis allowed (carmustine dose limited to 480 mg/m2)",
            "criterions": [
                {
                    "exact_snippets": "Any treatment at diagnosis allowed",
                    "criterion": "treatment at diagnosis",
                    "requirements": [
                        {
                            "requirement_type": "allowance",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "carmustine dose limited to 480 mg/m2",
                    "criterion": "carmustine dose",
                    "requirements": [
                        {
                            "requirement_type": "limit",
                            "expected_value": {
                                "operator": "<=",
                                "value": 480,
                                "unit": "mg/m2"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Chemotherapy not required at recurrence",
            "criterions": [
                {
                    "exact_snippets": "Chemotherapy not required at recurrence",
                    "criterion": "chemotherapy",
                    "requirements": [
                        {
                            "requirement_type": "necessity at recurrence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Oligodendroglioma:",
            "criterions": [
                {
                    "exact_snippets": "Oligodendroglioma",
                    "criterion": "oligodendroglioma",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Disease response (at least minor) to conventional chemotherapy OR",
            "criterions": [
                {
                    "exact_snippets": "Disease response (at least minor) to conventional chemotherapy",
                    "criterion": "disease response to conventional chemotherapy",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": "at least minor"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Recurrent disease",
            "criterions": [
                {
                    "exact_snippets": "Recurrent disease",
                    "criterion": "disease recurrence",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Esthesioneuroblastoma:",
            "criterions": [
                {
                    "exact_snippets": "Esthesioneuroblastoma",
                    "criterion": "esthesioneuroblastoma",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Attempted complete surgical resection",
            "criterions": [
                {
                    "exact_snippets": "Attempted complete surgical resection",
                    "criterion": "surgical resection",
                    "requirements": [
                        {
                            "requirement_type": "attempted",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "completeness",
                            "expected_value": "complete"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Disease progression after radiotherapy",
            "criterions": [
                {
                    "exact_snippets": "Disease progression after radiotherapy",
                    "criterion": "disease progression",
                    "requirements": [
                        {
                            "requirement_type": "timing",
                            "expected_value": "after radiotherapy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Response to chemotherapy regimen comprising cyclophosphamide, etoposide, and cisplatin",
            "criterions": [
                {
                    "exact_snippets": "Response to chemotherapy regimen comprising cyclophosphamide, etoposide, and cisplatin",
                    "criterion": "response to chemotherapy regimen",
                    "requirements": [
                        {
                            "requirement_type": "drugs involved",
                            "expected_value": [
                                "cyclophosphamide",
                                "etoposide",
                                "cisplatin"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* CNS lymphoma:",
            "criterions": [
                {
                    "exact_snippets": "CNS lymphoma",
                    "criterion": "CNS lymphoma",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Disease refractory to methotrexate OR",
            "criterions": [
                {
                    "exact_snippets": "Disease refractory to methotrexate",
                    "criterion": "disease",
                    "requirements": [
                        {
                            "requirement_type": "refractory to",
                            "expected_value": "methotrexate"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Failure after initial treatment with methotrexate OR",
            "criterions": [
                {
                    "exact_snippets": "Failure after initial treatment with methotrexate",
                    "criterion": "treatment with methotrexate",
                    "requirements": [
                        {
                            "requirement_type": "outcome",
                            "expected_value": "failure after initial treatment"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Considered at high risk for disease relapse despite initial response",
            "criterions": [
                {
                    "exact_snippets": "Considered at high risk for disease relapse",
                    "criterion": "risk for disease relapse",
                    "requirements": [
                        {
                            "requirement_type": "risk level",
                            "expected_value": "high"
                        }
                    ]
                },
                {
                    "exact_snippets": "despite initial response",
                    "criterion": "initial response",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Radiographic or pathological confirmation of recurrent disease required",
            "criterions": [
                {
                    "exact_snippets": "Radiographic or pathological confirmation of recurrent disease required",
                    "criterion": "recurrent disease",
                    "requirements": [
                        {
                            "requirement_type": "confirmation",
                            "expected_value": [
                                "radiographic",
                                "pathological"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Not eligible for other high priority national or institutional clinical studies",
            "criterions": [
                {
                    "exact_snippets": "Not eligible for other high priority national or institutional clinical studies",
                    "criterion": "eligibility for other high priority clinical studies",
                    "requirements": [
                        {
                            "requirement_type": "eligibility",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "Age:",
            "criterions": [
                {
                    "exact_snippets": "Age:",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* 18 and over",
            "criterions": [
                {
                    "exact_snippets": "18 and over",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Performance status:",
            "criterions": [
                {
                    "exact_snippets": "Performance status:",
                    "criterion": "performance status",
                    "requirements": [
                        {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* ECOG or Zubrod 0-1",
            "criterions": [
                {
                    "exact_snippets": "ECOG or Zubrod 0-1",
                    "criterion": "ECOG or Zubrod performance status",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 1,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Life expectancy:",
            "criterions": [
                {
                    "exact_snippets": "Life expectancy",
                    "criterion": "life expectancy",
                    "requirements": [
                        {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Hematopoietic:",
            "criterions": [
                {
                    "exact_snippets": "Hematopoietic:",
                    "criterion": "hematopoietic system",
                    "requirements": [
                        {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Hepatic:",
            "criterions": [
                {
                    "exact_snippets": "Hepatic:",
                    "criterion": "hepatic function",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Renal:",
            "criterions": [
                {
                    "exact_snippets": "Renal:",
                    "criterion": "renal function",
                    "requirements": [
                        {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Creatinine less than 1.5 times normal",
            "criterions": [
                {
                    "exact_snippets": "Creatinine less than 1.5 times normal",
                    "criterion": "creatinine",
                    "requirements": [
                        {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 1.5,
                                "unit": "times normal"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Cardiovascular:",
            "criterions": [
                {
                    "exact_snippets": "Cardiovascular:",
                    "criterion": "cardiovascular condition",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* LVEF at least 45%",
            "criterions": [
                {
                    "exact_snippets": "LVEF at least 45%",
                    "criterion": "LVEF",
                    "requirements": [
                        {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">=",
                                "value": 45,
                                "unit": "%"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Pulmonary:",
            "criterions": [
                {
                    "exact_snippets": "Pulmonary:",
                    "criterion": "pulmonary",
                    "requirements": [
                        {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* DLCO at least 60% predicted OR",
            "criterions": [
                {
                    "exact_snippets": "DLCO at least 60% predicted",
                    "criterion": "DLCO",
                    "requirements": [
                        {
                            "requirement_type": "predicted percentage",
                            "expected_value": {
                                "operator": ">=",
                                "value": 60,
                                "unit": "%"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Approval of pulmonologist",
            "criterions": [
                {
                    "exact_snippets": "Approval of pulmonologist",
                    "criterion": "pulmonologist approval",
                    "requirements": [
                        {
                            "requirement_type": "approval",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* HIV negative",
            "criterions": [
                {
                    "exact_snippets": "HIV negative",
                    "criterion": "HIV status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "negative"
                        }
                    ]
                }
            ]
        },
        {
            "line": "PRIOR CONCURRENT THERAPY:",
            "criterions": [
                {
                    "exact_snippets": "PRIOR CONCURRENT THERAPY",
                    "criterion": "prior concurrent therapy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Biologic therapy:",
            "criterions": [
                {
                    "exact_snippets": "Biologic therapy",
                    "criterion": "biologic therapy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Chemotherapy:",
            "criterions": [
                {
                    "exact_snippets": "Chemotherapy",
                    "criterion": "chemotherapy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* See Disease Characteristics",
            "criterions": [
                {
                    "exact_snippets": "Disease Characteristics",
                    "criterion": "disease characteristics",
                    "requirements": [
                        {
                            "requirement_type": "N/A",
                            "expected_value": "see details"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* No other concurrent chemotherapy",
            "criterions": [
                {
                    "exact_snippets": "No other concurrent chemotherapy",
                    "criterion": "concurrent chemotherapy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "Endocrine therapy:",
            "criterions": [
                {
                    "exact_snippets": "Endocrine therapy",
                    "criterion": "endocrine therapy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* No concurrent anticancer hormonal therapy",
            "criterions": [
                {
                    "exact_snippets": "No concurrent anticancer hormonal therapy",
                    "criterion": "anticancer hormonal therapy",
                    "requirements": [
                        {
                            "requirement_type": "concurrency",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* No concurrent steroids as antiemetics",
            "criterions": [
                {
                    "exact_snippets": "No concurrent steroids as antiemetics",
                    "criterion": "steroids",
                    "requirements": [
                        {
                            "requirement_type": "usage",
                            "expected_value": "not concurrent as antiemetics"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Radiotherapy:",
            "criterions": [
                {
                    "exact_snippets": "Radiotherapy",
                    "criterion": "radiotherapy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* See Disease Characteristics",
            "criterions": [
                {
                    "exact_snippets": "Disease Characteristics",
                    "criterion": "disease characteristics",
                    "requirements": [
                        {
                            "requirement_type": "N/A",
                            "expected_value": "See Disease Characteristics"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Surgery:",
            "criterions": [
                {
                    "exact_snippets": "Surgery",
                    "criterion": "surgery",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* See Disease Characteristics",
            "criterions": [
                {
                    "exact_snippets": "Disease Characteristics",
                    "criterion": "disease characteristics",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* No concurrent barbiturates or acetaminophen",
            "criterions": [
                {
                    "exact_snippets": "No concurrent barbiturates",
                    "criterion": "barbiturates",
                    "requirements": [
                        {
                            "requirement_type": "concurrent use",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "No concurrent ... acetaminophen",
                    "criterion": "acetaminophen",
                    "requirements": [
                        {
                            "requirement_type": "concurrent use",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Participation in other concurrent supportive care or gene therapy trials allowed",
            "criterions": [
                {
                    "exact_snippets": "Participation in other concurrent supportive care or gene therapy trials allowed",
                    "criterion": "participation in other trials",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": [
                                "supportive care",
                                "gene therapy"
                            ]
                        },
                        {
                            "requirement_type": "concurrency",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": [
        {
            "line": "PATIENT CHARACTERISTICS:",
            "criterions": []
        },
        {
            "line": "* Not specified",
            "criterions": []
        },
        {
            "line": "* Not specified",
            "criterions": []
        },
        {
            "line": "* Not specified",
            "criterions": []
        },
        {
            "line": "Other:",
            "criterions": []
        },
        {
            "line": "* Not pregnant or nursing",
            "criterions": [
                {
                    "exact_snippets": "Not pregnant",
                    "criterion": "pregnancy status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "not ... nursing",
                    "criterion": "nursing status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Not specified",
            "criterions": []
        },
        {
            "line": "Other:",
            "criterions": []
        }
    ]
}