1 |
0 |
NCI-2009-00817 |
NCT00001337 |
Dose-Adjusted EPOCH Chemotherapy and Rituximab (Cd20+) in Adults and Children with Previously Untreated Aggressive Non-Hodgkin's Lymphoma |
Inclusion |
Human immunodeficiency virus (HIV) negative |
HIV excluded OR HIV UNKNOWN |
C15175 = NO OR C15175=C17998 |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998')], 'operators': ['OR']} |
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2 |
1 |
NCI-2011-00312 |
NCT01012817 |
A Phase 1/2 Trial of ABT-888, an Inhibitor of Poly(ADP-ribose) Polymerase (PARP), and Topotecan (TPT) in Patients with Solid Tumors (Phase 1) and Relapsed Ovarian Cancer or Primary Peritoneal Cancer (Phase 2) after Prior Platinum Containing First-Line Chemotherapy |
Exclusion |
Immunocompromised patients (other than that related to the use of corticosteroids) including patients known to be human immunodeficiency virus (HIV) positive |
HIV negative included: Immunocompromised excluded (unless due to corticosteroid usage) |
C14139 = NO OR (C14139=NO AND C211=YES) AND (C15175 = NO OR C15175=C17998) |
{'triples': [('C14139', '=', 'NO'), ('C14139', '=', 'NO'), ('C211', '=', 'YES'), ('C15175', '=', 'NO'), ('C15175', '=', 'C17998')], 'operators': ['OR', 'AND', 'AND', 'OR']} |
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3 |
2 |
NCI-2011-00878 |
NCT00956007 |
A Phase III Study of Postoperative Radiation Therapy (IMRT) +/- Cetuximab for Locally-Advanced Resected Head and Neck Cancer |
Exclusion |
Severe, active co-morbidity, defined as follows: * Acquired immune deficiency syndrome (AIDS) based upon current Centers for Disease Control and Prevention (CDC) definition; note: human immunodeficiency virus (HIV) testing is not required for entry into this protocol; protocol-specific requirements may also exclude immuno-compromised patients |
AIDS excluded; immunocompromised excluded |
(C2851=NO) AND (C14139 = NO) |
{'triples': [('C2851', '=', 'NO'), ('C14139', '=', 'NO')], 'operators': ['AND']} |
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4 |
3 |
NCI-2011-01915 |
NCT00887146 |
N0577 (CODEL): Phase III Intergroup Study of Radiotherapy with Concomitant and Adjuvant Temozolomide versus Radiotherapy with Adjuvant PCV Chemotherapy in Patients with 1p/19q Co-deleted Anaplastic Glioma or Low Grade Glioma |
Exclusion |
Patients known to be human immunodeficiency virus (HIV) positive and currently receiving retroviral therapy are not eligible; note: patients known to be HIV positive, but without clinical evidence of an immunocompromised state, are eligible for the study |
HIV positive and receiving antiretroviral therapy excluded; HIV positive and no immunopromised eligible. |
(C15175=NO) OR (C15175=C17998) OR (C15175 = YES AND C94631 = NO) OR (C15175 = YES AND C14139 = NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C94631', '=', 'NO'), ('C15175', '=', 'YES'), ('C14139', '=', 'NO')], 'operators': ['OR', 'OR', 'AND', 'OR', 'AND']} |
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5 |
4 |
NCI-2011-01973 |
NCT00980954 |
Phase III Randomized Study of Concurrent Chemotherapy and Pelvic Radiation Therapy with or without Adjuvant Chemotherapy in High-Risk Patients with Early-Stage Cervical Carcinoma following Radical Hysterectomy |
Inclusion |
Patients with known human immunodeficiency virus (HIV) positive must have a cluster of differentiation (CD)4 cell count be >= 350 cells/mm^3 within 14 days prior to study entry (note, however, that HIV testing is not required for entry into this protocol) |
HIV Negative or HIV positive and CD4>= 350 |
(C15175 = NO) OR (C15175 = C17998) OR (C15175 = YES AND C103810 >= 350 {cells}/mm3) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C103810', '>=', '350 {cells}/mm3')], 'operators': ['OR', 'OR', 'AND']} |
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6 |
5 |
NCI-2011-01974 |
NCT00981656 |
A Phase II Protocol for Patients with Stage T1 Bladder Cancer to Evaluate Selective Bladder Preserving Treatment by Radiation Therapy Concurrent with Radiosensitizing Chemotherapy following a Thorough Transurethral Surgical Re-staging |
Exclusion |
Severe, active co-morbidity, defined as follows: * Acquired immune deficiency syndrome (AIDS) based upon the current Centers for Disease Control and Prevention (CDC) definition; note, however, that human immunodeficiency virus (HIV) testing is not required for entry into this protocol; protocol-specific requirements may also exclude immuno-compromised patients |
AIDS excluded; immunocompromised excluded |
(C2851 = NO) AND (C14139 = NO) |
{'triples': [('C2851', '=', 'NO'), ('C14139', '=', 'NO')], 'operators': ['AND']} |
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7 |
6 |
NCI-2011-01987 |
NCT01013649 |
A Phase II-R and a Phase III Trial Evaluating Both Erlotinib (Ph II-R) and Chemoradiation (Ph III) as Adjuvant Treatment for Patients with Resected Head of Pancreas Adenocarcinoma |
Inclusion |
Patients with active human immunodeficiency virus (HIV) infection are eligible if their cluster of differentiation (CD)4 count is > 499/cu mm and their viral load is < 50 copies/ml; use of highly active antiretroviral treatment (HAART) is allowed |
HIV negative or HIV eligible if CD4 > 499 cell/mm3 and viral load < 50 copies/ml and HAART yes or no. |
(C15175 = NO) OR (C15175=C17998) OR (C15175 = YES AND C103810 > 499 {cells}/mm3 AND C92544 < 50 {copies}/ml) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C103810', '>', '499 {cells}/mm3'), ('C92544', '<', '50 {copies}/ml')], 'operators': ['OR', 'OR', 'AND', 'AND']} |
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8 |
7 |
NCI-2011-01992 |
NCT02085408 |
Phase III Randomized Trial of Clofarabine as Induction and Post-Remission Therapy vs. Standard Daunorubicin & Cytarabine Induction and Intermediate Dose Cytarabine Post-Remission Therapy, Followed by Decitabine Maintenance vs. Observation in Newly-Diagnosed Acute Myeloid Leukemia in Older Adults (Age >/= 60 Years) |
Inclusion |
*B21Patients with known human immunodeficiency virus (HIV) infection are excluded *No human immunodeficiency virus (HIV) infection; patients with immune dysfunction are at a significantly higher risk of toxicities from intensive immunosuppressive therapies |
HIV positive excluded |
C15175 = NO OR C15175=C17998 |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998')], 'operators': ['OR']} |
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9 |
8 |
NCI-2011-02034 |
NCT01118026 |
Phase II Trial of Response-Adapted Therapy Based on Positron Emission Tomography (PET) for Bulky Stage I and Stage II Classical Hodgkin Lymphoma (HL) |
Inclusion |
Patients with known human immunodeficiency virus (HIV) must have a CD4 count > 350 and be on concurrent antiretrovirals; patients with a history of intravenous drug abuse or any behavior associated with an increased risk of HIV infection should be tested for exposure to the HIV virus; an HIV test is not required for entry on this protocol, but is required if the patient is perceived to be at risk |
HIV positive if CD4 > 350 and on retrovirals. |
(C15175 = NO) OR (C15175=C17998) OR (C15175 = YES AND C103810 > 350 {cells}/mm3) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C103810', '>', '350 {cells}/mm3')], 'operators': ['OR', 'OR', 'AND']} |
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10 |
9 |
NCI-2011-02500 |
NCT01366144 |
An Early Phase 1 Study of ABT-888 in Combination with Carboplatin and Paclitaxel in Patients with Hepatic or Renal Dysfunction and Solid Tumors |
Exclusion |
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; however, HIV-positive patients without an acquired immune deficiency syndrome (AIDS)-defining diagnosis who are not receiving agents with the potential for pharmacokinetic (PK) interactions with ABT-888 may be eligible |
HIV positive and antiretrovirals excluded; HIV positive without AIDS defining diagnosis included |
(C15175 = NO) OR (C15175=C17998) OR C15175 = YES AND C94631 = NO) OR (C15175 = YES AND C2851 =NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C94631', '=', 'NO'), ('C15175', '=', 'YES'), ('C2851', '=', 'NO')], 'operators': ['OR', 'OR', 'AND', 'OR', 'AND']} |
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11 |
10 |
NCI-2011-02515 |
NCT01051635 |
A Phase I Study of Indenoisoquinolines LMP400 and LMP776 in Adults with Relapsed Solid Tumors and Lymphomas |
Exclusion |
Patients with clinically significant illnesses which could compromise participation in the study, including, but not limited to, active or uncontrolled infection, immune deficiencies, known human immunodeficiency virus (HIV) infection requiring antiretroviral therapy, |
HIV positive with antiretroviral therapy excluded |
(C15175 = NO) OR (C15175=C17998) OR (C15175 = YES AND C94631 = NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C94631', '=', 'NO')], 'operators': ['OR', 'OR', 'AND']} |
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12 |
11 |
NCI-2011-02539 |
NCT01226940 |
A Phase I Trial of Lenalidomide and Radiotherapy in Children with Diffuse Intrinsic Pontine Gliomas and High-Grade Gliomas |
Exclusion |
Known human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible |
HIV positive with antiretroviral therapy excluded |
(C15175 = NO) OR (C15175=C17998) OR (C15175 = YES AND C94631 = NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C94631', '=', 'NO')], 'operators': ['OR', 'OR', 'AND']} |
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13 |
12 |
NCI-2011-02592 |
NCT01386385 |
A Dose Finding Study Followed by Phase II Randomized, Placebo-Controlled Study of Veliparib (ABT-888) Added to Chemoradiotherapy with Carboplatin and Paclitaxel for Unresectable Stage III Non-small Cell Lung Cancer (NSCLC), (NCI Study Number 8811) |
Inclusion |
Patients must not have any known immune deficiencies; patients with immune deficiency are at increased risk of lethal infections when treated with marrow-suppressive therapy; therefore, known human immunodeficiency virus (HIV) positive patients receiving combination anti-retroviral therapy are excluded from the study |
HIV positive with antiretroviral therapy excluded |
(C15175 = NO) OR (C15175=C17998) OR (C14139=C17998) OR (C15175 = YES AND C94631 = NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C14139', '=', 'C17998'), ('C15175', '=', 'YES'), ('C94631', '=', 'NO')], 'operators': ['OR', 'OR', 'OR', 'AND']} |
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14 |
13 |
NCI-2011-02673 |
NCT01359592 |
A Phase II Trial of PET-Directed Therapy for Limited Stage Diffuse Large B-Cell Lymphoma (DLBCL) |
Inclusion |
Patients must not be known to be human immunodeficiency virus (HIV)-positive |
|
(C15175 = NO) OR (C15175=C17998) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998')], 'operators': ['OR']} |
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15 |
14 |
NCI-2011-02674 |
NCT01368588 |
Androgen Deprivation Therapy and High Dose Radiotherapy with or without Whole-Pelvic Radiotherapy in Unfavorable Intermediate or Favorable High Risk Prostate Cancer: A Phase III Randomized Trial |
Exclusion |
Severe, active co-morbidity, defined as follows: * Acquired immune deficiency syndrome (AIDS) based upon current Centers for Disease Control and Prevention (CDC) definition; note, however, that human immunodeficiency virus (HIV) testing is not required for entry into this protocol; protocol-specific requirements may also exclude immuno-compromised patients |
AIDS excluded; immunocompromised excluded |
(C2851 = NO) OR (C15175=C17998) AND (C14139 = NO) |
{'triples': [('C2851', '=', 'NO'), ('C15175', '=', 'C17998'), ('C14139', '=', 'NO')], 'operators': ['OR', 'AND']} |
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16 |
15 |
NCI-2012-00680 |
NCT01333046 |
Administration of Tumor-Associated Antigen (TAA)-Specific Cytotoxic T-Lymphocytes to Patients with Active or Relapsed Hodgkin or Non-Hodgkin Lymphoma |
Exclusion |
PROCUREMENT: Patients with active human immunodeficiency virus (HIV) positive at time of procurement (can be pending at the time of blood draw) |
HIV positive excluded |
(C15175 = NO) OR (C15175=C17998) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998')], 'operators': ['OR']} |
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17 |
16 |
NCI-2012-00860 |
NCT01587352 |
A Phase 2 Study of Vorinostat (NSC 701852) in Metastatic Uveal Melanoma |
Exclusion |
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy will be eligible unless the cluster of differentiation (CD)4 count is < 200 cells/mm^3 within one month of study enrollment |
HIV positive on antiretrovirals included if CD4 >= 200 |
(C15175 = NO) OR (C15175=C17998) OR (C15175 = YES AND C103810 > 200 {cells}/mm3) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C103810', '>', '200 {cells}/mm3')], 'operators': ['OR', 'OR', 'AND']} |
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18 |
17 |
NCI-2012-00864 |
NCT01585805 |
A Randomized Phase II Study of Gemcitabine, Cisplatin +/- Veliparib in Patients with Pancreas Adenocarcinoma and a Known BRCA/ PALB2 Mutation (Part I) and a Phase II Single Arm Study of Single-Agent Veliparib in Previously Treated Pancreas Adenocarcinoma (Part II) |
Exclusion |
Patients with a known active infection, e.g., hepatitis B virus or hepatitis C virus; human immunodeficiency virus (HIV)-positive patients who are otherwise well and who do not have evidence of significant immune compromise are eligible |
HIV positive and healthy and not immunocompromised included |
(C15175 = NO) OR (C15175=C17998) OR (C15175 = YES AND C115935 = YES AND C14139 = NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C115935', '=', 'YES'), ('C14139', '=', 'NO')], 'operators': ['OR', 'OR', 'AND', 'AND']} |
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19 |
18 |
NCI-2012-01040 |
NCT01638533 |
A Phase 1 and Pharmacokinetic Single Agent Study of Romidepsin in Patients with, Lymphomas, Chronic Lymphocytic Leukemia and Select Solid Tumors and Varying Degrees of Liver Dysfunction |
Inclusion |
Human immunodeficiency virus (HIV)-positive patients who are not receiving: agents with the potential for PK interactions with romidepsin or hepatotoxic antiretrovirals (nucleoside reverse-transcriptase inhibitors [NRTIs]: abacavir, didanosine, emtricitabine, lamivudine, stavudine, and zidovudine), dual protease inhibitor (PI)-based regimens except low-dose boosting with ritonavir, atazanavir, indinavir, maraviroc, and nevirapine may be eligible; additionally, the HIV-positive patients should have a cluster of differentiation (CD)4 count > 250/mm^3; if the specific cause of hepatic dysfunction is unknown, the patient should be worked up for other viral causes of hepatitis and their eligibility determined after consultation with the principal investigator |
HIV positive eligible if CD4 > 250 |
(C15175 = NO) AND (C15175 = C17998) AND (C15175 = YES AND C103810 > 250 {cells}/mm3) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C103810', '>', '250 {cells}/mm3')], 'operators': ['AND', 'AND', 'AND']} |
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20 |
19 |
NCI-2012-01695 |
NCT01775475 |
Randomized, Phase II Trial of CHOP vs. Oral Chemotherapy with Concomitant Antiretroviral Therapy in Patients with HIV-Associated Lymphoma in Sub-Saharan Africa |
Inclusion |
All participants must be prescribed combination antiretroviral therapy with the goal of virological suppression using an acceptable regimen that adheres to national guidelines for treatment of HIV infection; non-suppressed, treatment experienced patients, defined as patients with a viral load > 400 copies/mL who have been on antiretroviral therapy for more than 4 months can be enrolled if an alternative antiretroviral therapy (ART) regimen is available that includes at least two ART drugs that, in the opinion of the site investigator, are expected to have activity based on genotypic testing (if available) and treatment history; patients are not allowed to receive zidovudine (azidothymidine [AZT]) as part of concurrent chemotherapy and ART regimen, since it is myelosuppressive; zidovudine may be discontinued and substituted as clinically indicated prior to or at the time of enrollment *HIV-1 infection, documented by any licensed rapid HIV test or HIV enzyme or chemiluminescence immunoassay (E/CIA) test kit at any time prior to study entry and confirmed by a licensed Western blot or a second antibody test by a method other than the initial rapid HIV and/or E/CIA, or confirmed by HIV-1 antigen or plasma HIV-1 ribonucleic acid (RNA) viral load > 1,000 copies/mL * WHO (World Health Organization) and CDC (Centers for Disease Control and Prevention) guidelines mandate that confirmation of the initial test result must use a test that is different from the one used for the initial assessment; a reactive initial rapid test should be confirmed by either another type of rapid assay or an E/CIA that is based on a different antigen preparation and/or different test principle (e.g., indirect versus competitive), or a Western blot or a plasma HIV-1 RNA viral load |
antiviral therapy = Y and virological suppression =Y and immunocompromised =NO and viarl load > 400 copies/ML and antiretroviral therapy > 4 months and zidovudivine = NO |
HIV=YES AND C94631=YES AND C14139=NO AND C947=NO |
{'triples': [('HIV', '=', 'YES'), ('C94631', '=', 'YES'), ('C14139', '=', 'NO'), ('C947', '=', 'NO')], 'operators': ['AND', 'AND', 'AND']} |
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21 |
20 |
NCI-2012-01712 |
NCT01695941 |
A Phase I Study of MLN8237 in Combination with Bortezomib and Rituximab in Relapsed and Refractory Mantle Cell and Low Grade Non-Hodgkin Lymphoma |
Exclusion/Inclusion |
Exclusion: HIV-positive patients on combination antiretroviral therapy which include cytochrome p450 inhibitors are ineligible; patients with CD4 counts less than 300 CD4+ cells/mm^3 and or a high viral load are ineligible Inclusion: Patients with human immunodeficiency virus (HIV) who are not receiving cytochrome p450 inhibitors, and who have a minimum of 300+ cluster of differentiation 4 (CD4)+ cells/mm^3, an undetectable viral load, and no history of acquired immune deficiency syndrome (AIDS) indicator conditions |
(HIV =NO) OR (HIV =UNKNOWN) OR (HIV =YES and HAART=No) or (HIV=YES and HAART=YES AND Cytochrome P450 3A4 Inhibitor=NO AND CD4>= 300 {cells}/mm3 AND Viral Load=undetectable AND AIDS=NO) |
(C15175 =NO) OR (C15175 =C17998) OR (C15175 =YES and C94631=No) or (C15175 =YES and C94631=YES AND C111373=NO AND C103810>= 300 {cells}/mm3 AND C92544=C111568 AND C2851=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES and C94631=No or C15175 =YES and C94631=YES'), ('C111373', '=', 'NO'), ('C103810', '>=', '300 {cells}/mm3'), ('C92544', '=', 'C111568'), ('C2851', '=', 'NO')], 'operators': ['OR', 'OR', 'AND', 'AND', 'AND', 'AND']} |
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22 |
21 |
NCI-2012-01995 |
NCT01674140 |
Phase III Randomized, Placebo-Controlled Clinical Trial Evaluating the Use of Adjuvant Endocrine Therapy +/- One Year of Everolimus in Patients with High-Risk, Hormone Receptor-Positive and HER2/Neu Negative Breast Cancer. e^3 Breast Cancer Study-Evaluating Everolimus with Endocrine Therapy. |
Inclusion |
Patients known to be human immunodeficiency virus (HIV) positive may be enrolled if baseline cluster of differentiation (CD)4 count is > 500 cells/mm^3 AND not taking anti-retroviral therapy; patients with known hepatitis are not eligible unless there is a known negative hepatitis panel; (exception: previous history of hepatitis A infection that is not currently active is allowed); patients must not have any known uncontrolled underlying pulmonary disease |
(HIV =NO) OR (HIV =UNKNOWN) OR (HIV =YES AND CD4>500 {cells}/mm3 AND HAART=NO) OR (C3096=NO) OR (C3096=Y AND Viral Load=0 {copies}/mm3 OR (C141405=NO) OR (C129452C=NO) |
(C15175 =NO) OR (C15175 =C17998) OR (C15175 =YES AND C103810>500 {cells}/mm3 AND C94631=NO) OR (C3096=NO) OR (C3096=Y AND C92544=C111568 {copies}/mm3 OR (C141405=NO) OR (C129452C=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C103810', '>', '500 {cells}/mm3'), ('C94631', '=', 'NO'), ('C3096', '=', 'NO'), ('C3096', '=', 'Y'), ('C92544', '=', 'C111568 {copies}/mm3'), ('C141405', '=', 'NO'), ('C129452C', '=', 'NO')], 'operators': ['OR', 'OR', 'AND', 'AND', 'OR', 'OR', 'AND', 'OR', 'OR']} |
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23 |
22 |
NCI-2012-01998 |
NCT01668719 |
A Randomized Phase I/II Study of Optimal Induction Therapy of Bortezomib, Dexamethasone and Lenalidomide with or without Elotuzumab (NSC-764479) for Newly Diagnosed High Risk Multiple Myeloma (HRMM) |
Inclusion |
Patients who are known to be human immunodeficiency virus positive (HIV+) are eligible providing they meet all of the following additional criteria within 28 days prior to registration: * Cluster of differentiation (CD)4 cells >= 500/mm^3 * Viral load of < 50 copies HIV messenger ribonucleic acid (mRNA)/mm^3 if on combination antiretroviral therapy (cART) or < 25,000 copies HIV mRNA if not on cART * No zidovudine or stavudine as part of cART * Patients who are HIV+ and do not meet all of these criteria are not eligible for this study |
(HIV =NO) OR (HIV =UNKNOWN) OR (HIV =YES AND CD4>=500 {cells}/mm3) AND ((HIV=YES AND cART=YES AND Viral Load<50 {copies}/mm3) OR (HIV =YES AND cART=NO AND Viral Load<25000 {copies}/mm3)) AND (Zidovudine=NO) AND (Stavudine=NO) |
(C15175 =NO) OR (C15175 =C17998) OR (C15175 =YES AND C103810>=500 {cells}/mm3) AND ((C15175 =YES AND C94631=YES AND C92544<50 {copies}/mm3) OR (C15175 =YES AND C94631=NO AND C92544<25000 {copies}/mm3)) AND (C947=NO) AND (C1428=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C103810', '>=', '500 {cells}/mm3'), ('C15175', '=', 'YES'), ('C94631', '=', 'YES'), ('C92544', '<', '50 {copies}/mm3'), ('C15175', '=', 'YES'), ('C94631', '=', 'NO'), ('C92544', '<', '25000 {copies}/mm3'), ('C947', '=', 'NO'), ('C1428', '=', 'NO')], 'operators': ['OR', 'OR', 'AND', 'AND', 'AND', 'AND', 'OR', 'AND', 'AND', 'AND', 'AND']} |
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24 |
23 |
NCI-2012-02009 |
NCT01711541 |
Carboplatin-Paclitaxel Induction Chemotherapy and ABT-888 (Veliparib) - a Phase 1/Randomized Phase 2 Study in Patients with Locoregionally Advanced Squamous Cell Carcinoma of the Head and Neck |
Inclusion |
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are not eligible |
HIV = NO or HIV = Y and HAART = NO |
(C15175 = NO) OR (C15175 =C17998) or (C15175 = YES and C94631 = NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998 or C15175 = YES and C94631 = NO')], 'operators': ['OR']} |
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25 |
24 |
NCI-2012-02057 |
NCT01730937 |
Randomized Phase III Study of Sorafenib Versus Stereotactic Body Radiation Therapy Followed by Sorafenib in Hepatocellular Carcinoma |
Exclusion |
Use of combination anti-retroviral therapy for human immunodeficiency virus (HIV) |
HIV = NO or HIV = Y and HAART = NO |
(C15175 = NO) OR (C15175 =C17998) or (C15175 = YES and C94631 = NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998 or C15175 = YES and C94631 = NO')], 'operators': ['OR']} |
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26 |
25 |
NCI-2012-02608 |
NCT01863550 |
Randomized Phase III Trial of Bortezomib, LENalidomide and Dexamethasone (VRd) versus Carfilzomib, Lenalidomide, Dexamethasone (CRd) Followed by Limited or Indefinite DURation Lenalidomide MaintenANCE in Patients with Newly Diagnosed Symptomatic Multiple Myeloma (ENDURANCE) |
Inclusion |
STEP I: Human immunodeficiency virus (HIV) infection is not excluded; known HIV positive patients must meet the following criteria: * Cluster of differentiation (CD)4 cell count >= 350/mm^3 * No history of acquired immune deficiency syndrome (AIDS)-related illness * Not currently prescribed zidovudine or stavudine |
STEP I: HIV=NO OR HIV=UNKNOWN OR (HIV=YES AND CD4>=350{cells}/mm3 AND AIDS=NO AND Zidovudine=NO AND Stavudine=NO) |
STEP I: C15175=NO OR C15175=C17998 OR (C15175=YES AND C103810>=350{cells}/mm3 AND C2851=NO AND C947=NO AND C1428=NO) |
{'triples': [('STEP I: C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C103810', '>=', '350{cells}/mm3'), ('C2851', '=', 'NO'), ('C947', '=', 'NO'), ('C1428', '=', 'NO')], 'operators': ['OR', 'OR', 'AND', 'AND', 'AND', 'AND']} |
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27 |
26 |
NCI-2012-02767 |
NCT01749397 |
A Phase I Trial of the Combination of the PARP Inhibitor ABT-888 with Intraperitoneal Floxuridine (FUDR) in Epithelial Ovarian, Primary Peritoneal and Fallopian Tube Cancers |
Exclusion |
Immunocompromised patients (other than that related to the use of corticosteroids) with the exception of patients known to be human immunodeficiency virus (HIV) positive and have a cluster of differentiation 4 (CD4) count > 400 and do not require antiretroviral therapy |
(Immunocompromised=NO) OR (HIV=NO) OR (HIV =UNKNOWN) OR (HIV =Y AND CD4>400 {cells}/mm3 AND HAART=NO) |
(C14139=NO) OR (C15175=NO) OR (C15175 =C17998) OR (C15175 =Y AND C103810>400 {cells}/mm3 AND C94631=NO) |
{'triples': [('C14139', '=', 'NO'), ('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'Y'), ('C103810', '>', '400 {cells}/mm3'), ('C94631', '=', 'NO')], 'operators': ['OR', 'OR', 'OR', 'AND', 'AND']} |
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28 |
27 |
NCI-2012-02875 |
NCT01586403 |
Transfer of Genetically Engineered Lymphocytes in Melanoma Patients: A Phase 1 Dose Escalation Study |
Exclusion |
Known infection with human immunodeficiency virus (HIV), hepatitis B virus (HBV), or hepatitis C virus (HCV) |
HIV = NO or HIV = Y or HBV = Y or HCV =Y |
C15175 = NO OR C15175 =C17998 |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998')], 'operators': ['OR']} |
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29 |
28 |
NCI-2012-03124 |
NCT01755195 |
A Phase 2 Study of Cabozantinib (XL184), a Dual Inhibitor of MET and VEGFR, in Patients with Metastatic Refractory Soft Tissue Sarcoma |
Exclusion |
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible |
(HIV =NO) OR (HIV =UNKNOWN) OR (HIV=YES AND HAART=NO) |
(C15175 =NO) OR (C15175 =C17998) OR (C15175=YES AND C94631=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C94631', '=', 'NO')], 'operators': ['OR', 'OR', 'AND']} |
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30 |
29 |
NCI-2013-00046 |
NCT01771107 |
A Pilot Trial of AVD and Brentuximab Vedotin (SGN-35) in the Treatment of Stage II-IV HIV-Associated Hodgkin Lymphoma |
Inclusion |
Participants must have previously untreated HIV-classical HL (cHL), with the exception of up to 14 consecutive days of steroids, emergency radiation, or 1 prior cycle of cyclophosphamide to reduce tumor burden and improve hyperbilirubinemia in the setting of lymphoma related liver involvement Participants must discontinue use of the following agents within 7 days prior to therapy * Strong CYP3A4 inhibitors that treat HIV * If patients are taking any of these excluded medications, they must be discontinued at least 7 days (1 week) prior to the initiation of chemotherapy HIV positive; documentation of HIV-1 infection by means of any one of the following: * Documentation of HIV diagnosis in the medical record by a licensed health care provider; * Documentation of receipt of antiretroviral therapy (ART) by a licensed health care provider; * HIV-1 RNA detection by a licensed HIV-1 RNA assay demonstrating > 1000 RNA copies/mL; * Any licensed HIV screening antibody and/or HIV antibody/antigen combination assay confirmed by a second licensed HIV assay such as a HIV-1 western blot confirmation or HIV rapid multispot antibody differentiation assay Patients already receiving erythropoietin or granulocyte colony stimulating factor (GCSF) for treatment of HIV-related cytopenia are eligible * NOTE: A “licensed†assay refers to a United States (US) Food and Drug Administration (FDA)-approved assay, which is required for all investigational new drug (IND) studies Patients already receiving erythropoietin or granulocyte colony stimulating factor (GCSF) for treatment of HIV-related cytopenia are eligible |
HIV=YES AND Cytochrome P450 3A4 Inhibitor=NO AND (Erythropoietin=YES OR Erythropoietin=NO) AND (Granulocyte Colony-Stimulating Factor=YES OR Granulocyte Colony-Stimulating Factor=NO) |
C15175=YES AND C111373=NO AND (C20429=YES OR C20429=NO) AND (C26078=YES OR C26078=NO) |
{'triples': [('C15175', '=', 'YES'), ('C111373', '=', 'NO'), ('C20429', '=', 'YES'), ('C20429', '=', 'NO'), ('C26078', '=', 'YES'), ('C26078', '=', 'NO')], 'operators': ['AND', 'AND', 'OR', 'AND', 'OR']} |
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31 |
30 |
NCI-2013-00370 |
NCT01220583 |
A Randomized Phase II / Phase III Study of Adjuvant Concurrent Radiation and Chemotherapy Versus Radiation Alone in Resected High-Risk Malignant Salivary Gland Tumors |
Exclusion |
Severe, active co-morbidity, defined as follows: * Acquired immune deficiency syndrome (AIDS) based upon current Centers for Disease Control (CDC) definition; note, however, that human immunodeficiency virus (HIV) testing is not required for entry into this protocol |
(HIV=NO OR HIV =UNKNOWN) AND AIDS=NO) |
(C15175=NO OR C15175 =C17998) AND C2851=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C2851', '=', 'NO')], 'operators': ['OR', 'AND']} |
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32 |
31 |
NCI-2013-00500 |
NCT01810913 |
Randomized Phase II/III Trial of Surgery and Postoperative Radiation Delivered with Concurrent Cisplatin versus Docetaxel versus Docetaxel and Cetuximab for High-Risk Squamous Cell Cancer of the Head and Neck |
Exclusion |
Severe, active co-morbidity, defined as follows: * Acquired immune deficiency syndrome (AIDS) based upon current Centers for Disease and Control and Prevention (CDC) definition; note: human immunodeficiency virus (HIV) testing is not required for entry into this protocol; protocol-specific requirements may also exclude immuno-compromised patients |
(HIV =NO) OR (HIV =UNKNOWN) (AIDS=NO) OR (Immunocompromised=NO) I believe this can be changed to AIDS=NO |
C15175 =NO OR C15175 =C17998 AND (C2851=NO AND C14139=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C2851', '=', 'NO'), ('C14139', '=', 'NO')], 'operators': ['OR', 'AND', 'AND']} |
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33 |
32 |
NCI-2013-00716 |
NCT00978250 |
Multi-Histology Phase II Study of 5-Fluoro-2'-Deoxycytidine with Tetrahydrouridine (FdCyd + THU) |
Exclusion |
Patients with clinically significant illnesses which would compromise participation in the study, including, but not limited to: active or uncontrolled infection, immune deficiencies or confirmed diagnosis of human immunodeficiency virus (HIV) infection, ... that would limit compliance with study requirements |
(HIV=NO OR HIV =UNKNOWN OR Immunocompromised=NO) AND (Healthy=YES)? |
C15175=NO OR C15175 =C17998 OR (C14139=NO AND C115935=YES) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C14139', '=', 'NO'), ('C115935', '=', 'YES')], 'operators': ['OR', 'OR', 'AND']} |
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34 |
33 |
NCI-2013-00737 |
NCT01822496 |
A Randomized Phase II Study of Individualized Combined Modality Therapy for Stage III Non-small Cell Lung Cancer (NSCLC) |
Exclusion |
Severe, active co-morbidity, defined as follows: * Acquired immune deficiency syndrome (AIDS) based upon current Centers for Disease Control and Prevention (CDC) definition; note, however, that human immunodeficiency virus (HIV) testing is not required for entry into this protocol; protocol-specific requirements may also exclude immuno-compromised patients |
(HIV =NO) OR (HIV =UNKNOWN) OR (AIDS=NO) OR (Immunocompromised=NO) |
(C15175 =NO) OR (C15175 =C17998) OR (C2851=NO) OR (C14139=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C2851', '=', 'NO'), ('C14139', '=', 'NO')], 'operators': ['OR', 'OR', 'OR']} |
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35 |
34 |
NCI-2013-00739 |
NCT01822509 |
A Phase I/Ib Study of Ipilimumab or Nivolumab in Patients with Relapsed Hematologic Malignancies after Allogeneic Hematopoietic Cell Transplantation |
Exclusion |
Patients with known chronic human immunodeficiency virus (HIV), hepatitis B or hepatitis C infections should be excluded |
(HIV =NO) OR (HIV =UNKNOWN) |
(C15175 =NO) OR (C15175 =C17998) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998')], 'operators': ['OR']} |
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36 |
35 |
NCI-2013-00740 |
NCT01822522 |
Phase I Trial of Cabozantinib (XL184) for Advanced Solid Tumors in Persons with HIV Infection |
Inclusion/Exclusion |
Inclusion: *Participants must have known HIV infection and histologically confirmed solid malignancy that is metastatic or unresectable and for which standard curative or palliative measures do not exist or are no longer effective; any number of prior cancer therapies will be permitted; at least 4 weeks must have elapsed since prior chemotherapy or biological therapy, 6 weeks if the regimen included carmustine (BCNU) or mitomycin C; prior radiation therapy to the thoracic cavity, abdomen, or pelvis must be completed at least 3 months prior to registration; radiotherapy to any other site (including bone or brain metastases) must be completed at least 28 days prior to registration *Serologic documentation of HIV infection at any time prior to study entry, as evidenced by positive enzyme-linked immunosorbent assay (ELISA), positive western blot, or any other federally approved licensed HIV test; alternatively, this documentation may include a record that another physician has documented that the participant has HIV infection based on prior ELISA and western blot, or other approved diagnostic tests * Participating participants MUST receive appropriate care and treatment for HIV infection, including antiretroviral medications, when clinically indicated and should be under the care of a physician experienced in HIV management; participants will be eligible regardless of antiretroviral medication (including no antiretroviral medication) provided there is no intention to initiate therapy or the regimen has been stable for at least 4 weeks with no intention to change the regimen within 8 weeks following study entry; as study-specific (antiretroviral-based) strata fill, however, only participants who are receiving the therapies eligible for the remaining open strata will be accrued Exclusion: Other clinically significant disorders such as: * Active infection requiring systemic treatment within 28 days before the first dose of study treatment; participants with HIV infection will be eligible provided they meet the criteria; |
HIV = Y |
C15175 =YES |
{'triples': [('C15175', '=', 'YES')], 'operators': []} |
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37 |
36 |
NCI-2013-00826 |
NCT01841723 |
A Multicenter Phase 2 Study of the Bruton's Tyrosine Kinase Inhibitor PCI-32765 (Ibrutinib) for Treatment of Relapsed Hairy Cell Leukemia |
Exclusion |
Human immunodeficiency virus (HIV)-positive patients will be eligible unless they have been previously diagnosed with an acquired immune deficiency syndrome (AIDS)-defining illness |
HIV |
(C15175 =NO) OR (C15175 =C17998) OR (C15175=YES AND C2851=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C2851', '=', 'NO')], 'operators': ['OR', 'OR', 'AND']} |
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38 |
37 |
NCI-2013-00858 |
NCT01849146 |
Phase I Study of AZD1775 (MK-1775) with Radiation and Temozolomide in Patients with Newly Diagnosed Glioblastoma and Evaluation of Intratumoral Drug Distribution in Patients with Recurrent Glioblastoma |
Exclusion |
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible |
(HIV =NO) OR (HIV =UNKNOWN) OR (HIV =YES AND HAART=NO) |
(C15175 =NO) OR (C15175 =C17998) OR (C15175 =YES AND C94631=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C94631', '=', 'NO')], 'operators': ['OR', 'OR', 'AND']} |
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39 |
38 |
NCI-2013-00877 |
NCT01851369 |
A Phase I/II Trial of TRC102 (Methoxyamine HCl) in Combination with Temozolomide in Patients with Relapsed Solid Tumors and Lymphomas |
Exclusion |
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible |
(HIV =NO) OR (HIV =UNKNOWN) OR (HIV =YES AND HAART=NO) |
(C15175 =NO) OR (C15175 =C17998) OR (C15175 =YES AND C94631=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C94631', '=', 'NO')], 'operators': ['OR', 'OR', 'AND']} |
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40 |
39 |
NCI-2013-00890 |
NCT01935934 |
A Phase 2 Study of XL184 (Cabozantinib) in Recurrent or Metastatic Endometrial Cancer |
Exclusion |
Known human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible |
(HIV =NO) OR (HIV =UNKNOWN) OR (HIV =YES AND HAART=NO) |
(C15175 =NO) OR (C15175 =C17998) OR (C15175 =YES AND C94631=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C94631', '=', 'NO')], 'operators': ['OR', 'OR', 'AND']} |
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41 |
40 |
NCI-2013-00998 |
NCT01881867 |
A Phase 2 Study of Recombinant Glycosylated Human Interleukin-7 (CYT107) after Completion of Standard FDA Approved Therapy with Sipuleucel-T (Provenge®) for Patients with Asymptomatic or Minimally Symptomatic Metastatic Castration-Resistant Prostate Cancer (mCRPC) |
Exclusion |
Known human immunodeficiency virus (HIV) or other history of immunodeficiency disorder; HIV-positive patients on combination antiretroviral therapy are ineligible |
(HIV =NO) OR (HIV =UNKNOWN) OR (Immunocompromised=NO) OR (HIV =YES AND HAART=NO) |
(C15175 =NO) OR (C15175 =C17998) OR (C14139=NO) OR (C15175 =YES AND C94631=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C14139', '=', 'NO'), ('C15175', '=', 'YES'), ('C94631', '=', 'NO')], 'operators': ['OR', 'OR', 'OR', 'AND']} |
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42 |
41 |
NCI-2013-01132 |
NCT01534598 |
Phase I Trial of Oral 5-Fluoro-2'-Deoxycytidine with Oral Tetrahydrouridine in Patients with Advanced Solid Tumors |
Exclusion |
Patients with clinically significant illnesses which would compromise participation in the study, including, but not limited to active or uncontrolled infection, immune deficiencies, known human immunodeficiency virus (HIV) infection requiring protease inhibitor therapy, ... that would limit compliance with study requirements |
(HIV =NO) OR (HIV =UNKNOWN) OR (Immunocompromised=NO) OR (HIV =YES AND HIV Protease Inhibitor=NO) |
(C15175 =NO) OR (C15175 =C17998) OR (C14139=NO) OR (C15175 =YES AND C97366=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C14139', '=', 'NO'), ('C15175', '=', 'YES'), ('C97366', '=', 'NO')], 'operators': ['OR', 'OR', 'OR', 'AND']} |
0.0 |
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5.0 |
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43 |
42 |
NCI-2013-01275 |
NCT01896999 |
A Phase I Study with an Expansion Cohort/Randomized Phase II Study of the Combinations of Ipilimumab, Nivolumab, and Brentuximab Vedotin in Patients with Relapsed/Refractory Hodgkin Lymphoma |
Inclusion |
PHASE I: Human immunodeficiency virus (HIV) positive patients are allowed on this study if they have a cluster of differentiation 4 (CD4) count > 400, and are on a stable antiviral regimen; patients with poorly controlled HIV or other chronic active viral infections will be excluded PHASE II: HIV positive patients are allowed on this study if they have a CD4 count > 400, and are on a stable antiviral regimen; patients with poorly controlled HIV or other chronic active viral infections will be excluded |
(HIV =NO) OR (HIV =UNKNOWN) OR (HIV =YES AND CD4>400 {cells}/mm3 AND HAART=YES) |
(C15175 =NO) OR (C15175 =C17998) OR (C15175 =YES AND C103810>400 {cells}/mm3 AND C94631=YES) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C103810', '>', '400 {cells}/mm3'), ('C94631', '=', 'YES')], 'operators': ['OR', 'OR', 'AND', 'AND']} |
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44 |
43 |
NCI-2013-01320 |
NCT01902173 |
Phase I/II Study of the Safety and Efficacy of the AKT Inhibitor GSK2141795 in Combination with Dabrafenib and Trametinib in Patients with BRAF Mutant Cancer |
Inclusion |
Patients with human immunodeficiency virus (HIV) are eligible if they are not on antiviral agents and have adequate cluster of differentiation (CD)4 counts (>= 500 mm^3) |
(HIV =NO) OR (HIV =UNKNOWN) OR (HIV =YES AND HAART=NO AND CD4>=500 {cells}/mm3)} |
(C15175 =NO) OR (C15175 =C17998) OR (C15175 =YES AND C94631=NO AND C103810>=500 {cells}/mm3)} |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C94631', '=', 'NO'), ('C103810', '>=', '500 {cells}/mm3}')], 'operators': ['OR', 'OR', 'AND', 'AND']} |
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45 |
44 |
NCI-2013-01357 |
NCT01912625 |
A Phase 1 Study of Trametinib in Combination with Chemoradiation for KRAS Mutant Non-small Cell Lung Cancer |
Exclusion |
Known hepatitis B virus (HBV), or hepatitis C virus (HCV) infection (patients with chronic or cleared HBV and HCV infection are eligible); patients with human immunodeficiency virus (HIV) are not eligible if on anti-retroviral medications HIV-positive patients on combination antiretroviral therapy are ineligible |
(HIV =NO) OR (HIV =UNKNOWN) OR (HIV =YES AND HAART=NO) |
(C15175 =NO) OR (C15175 =C17998) OR (C15175 =YES AND C94631=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C94631', '=', 'NO')], 'operators': ['OR', 'OR', 'AND']} |
0.0 |
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4.0 |
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46 |
45 |
NCI-2013-01368 |
NCT01925131 |
A Phase I Study of Inotuzumab Ozogamicin (NSC-772518) in Combination with CVP (Cyclophosphamide, Vincristine, Prednisone) for Patients with Relapsed/Refractory CD22-Positive Acute Leukemia (including B-ALL, Mixed Phenotypic Leukemia and Burkitt's Leukemia) |
Inclusion |
Patients who are known to be human immunodeficiency virus positive (HIV+) are eligible providing they meet all of the following additional criteria within 28 days prior to registration: * CD4+ cells >= 350/mm^3 (nadir) * Viral load of < 50 copies HIV messenger ribonucleic acid (mRNA)/mm^3 if on combination antiretroviral therapy (cART) or < 25,000 copies HIV mRNA if not on cART * No zidovudine or stavudine as part of cART Patients who are HIV+ and do not meet all of these criteria are not eligible for this study |
(HIV =NO) OR (HIV =UNKNOWN) OR (HIV =YES AND CD4>=350 {cells}/mm3 AND Viral Load<50 {copies}/mm3 AND HAART=YES) OR (HIV=YES AND CD4>=350 {cells}/mm3 AND Viral Load<25000 {copies}/mm3 AND HAART=NO) AND (Zidovudine=NO) AND (Stavudine=NO) |
(C15175 =NO) OR (C15175 =C17998) OR (C15175 =YES AND C103810>=350 {cells}/mm3 AND C92544<50 {copies}/mm3 AND C94631=YES) OR (C15175=YES AND C103810>=350 {cells}/mm3 AND C92544<25000 {copies}/mm3 AND C94631=NO) AND (C947=NO) AND (C1428=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C103810', '>=', '350 {cells}/mm3'), ('C92544', '<', '50 {copies}/mm3'), ('C94631', '=', 'YES'), ('C15175', '=', 'YES'), ('C103810', '>=', '350 {cells}/mm3'), ('C92544', '<', '25000 {copies}/mm3'), ('C94631', '=', 'NO'), ('C947', '=', 'NO'), ('C1428', '=', 'NO')], 'operators': ['OR', 'OR', 'AND', 'AND', 'AND', 'OR', 'AND', 'AND', 'AND', 'AND', 'AND']} |
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47 |
46 |
NCI-2013-01452 |
NCT00942877 |
Phase II Study of Cediranib (AZD2171) in Patients with Alveolar Soft Part Sarcoma |
Exclusion |
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible |
(HIV=NO) OR (HIV =UNKNOWN) OR (HIV=YES AND HAART=NO) |
(C15175=NO) OR (C15175 =C17998) OR (C15175=YES AND C94631=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C94631', '=', 'NO')], 'operators': ['OR', 'OR', 'AND']} |
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48 |
47 |
NCI-2013-01474 |
NCT01273155 |
Phase I Pharmacokinetic Study of Belinostat for Solid Tumors and Lymphomas in Patients with Varying Degrees of Hepatic Dysfunction |
Exclusion |
Human immunodeficiency virus (HIV) positive patients who are not on retroviral therapy will not be excluded from cohort 1, the normal liver function cohort * HIV positive patients who are not on retroviral therapy will be excluded from cohorts 2-4 HIV-positive patients on combination antiretroviral therapy are ineligible |
(HIV=NO) OR (HIV =UNKNOWN) OR (HIV=YES AND HAART=NO AND (Abnormal Liver Function Test=NO OR Abnormal Liver Function Test=YES)) |
(C15175=NO) OR (C15175 =C17998) OR (C15175=YES AND C94631=NO AND (C122516=NO OR C122516=YES)) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C94631', '=', 'NO'), ('C122516', '=', 'NO'), ('C122516', '=', 'YES')], 'operators': ['OR', 'OR', 'AND', 'AND', 'OR']} |
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49 |
48 |
NCI-2013-01491 |
NCT01362803 |
A Phase I/II Study of the Mitogen Activated Protein Kinase Kinase (MEK) 1 Inhibitor Selumetinib (AZD6244; HYD Sulfate) in Children with Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas (PN) |
Exclusion |
Any evidence of severe or uncontrolled systemic disease, active infection, active bleeding diatheses or renal transplant, including any patient known to have hepatitis B, hepatitis C or human immunodeficiency virus (HIV) will be excluded; patients with HIV who have adequate cluster of differentiation (CD)4 count, not requiring antiretroviral medication will not be excluded |
(HIV=NO) OR (HIV =UNKNOWN) OR (HIV=YES AND CD4=Sufficient {cells}/mm3 AND HAART=NO) |
(C15175=NO) OR (C15175 =C17998) OR (C15175=YES AND C103810=C63351 {cells}/mm3 AND C94631=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C103810', '=', 'C63351 {cells}/mm3'), ('C94631', '=', 'NO')], 'operators': ['OR', 'OR', 'AND', 'AND']} |
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50 |
49 |
NCI-2013-01496 |
NCT01391962 |
A Phase II Trial in Which Patients with Metastatic Alveolar Soft Part Sarcoma Are Randomized to Either Sunitinib or Cediranib Monotherapy, with Cross-Over at Disease Progression |
Exclusion |
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible |
(HIV=NO) OR (HIV =UNKNOWN) OR (HIV=YES AND HAART=NO) |
(C15175=NO) OR (C15175 =C17998) OR (C15175=YES AND C94631=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C94631', '=', 'NO')], 'operators': ['OR', 'OR', 'AND']} |
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51 |
50 |
NCI-2013-01520 |
NCT01572493 |
A Phase I Study of a Continuous Intravenous Infusion of Recombinant Human IL-15 (rhIL-15) in Adults with Metastatic Cancers |
Exclusion |
Documented human immunodeficiency virus (HIV), active bacterial infections, active or chronic hepatitis B, or hepatitis C infection |
HIV=NO OR HIV =UNKNOWN |
C15175=NO OR C15175 =C17998 |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998')], 'operators': ['OR']} |
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52 |
51 |
NCI-2013-01568 |
NCT01748825 |
A Phase I Study of Single-Agent AZD1775 (MK-1775), a Wee1 Inhibitor, in Patients with Advanced Refractory Solid Tumors |
Exclusion |
Human immunodeficiency virus (HIV) positive patients on antiretroviral therapy are ineligible |
(HIV=NO) OR (HIV =UNKNOWN) OR (HIV=YES AND HAART=NO) |
(C15175=NO) OR (C15175 =C17998) OR (C15175=YES AND C94631=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C94631', '=', 'NO')], 'operators': ['OR', 'OR', 'AND']} |
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53 |
52 |
NCI-2013-01588 |
NCT01827384 |
Molecular Profiling-Based Assignment of Cancer Therapy for Patients with Advanced Solid Tumors |
Exclusion |
TUMOR BIOPSY SEQUENCING: Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible TREATMENT: HIV-positive patients on combination antiretroviral therapy are ineligible |
(HIV=NO) OR (HIV =UNKNOWN) OR (HIV=YES AND HAART=NO) |
(C15175=NO) OR (C15175 =C17998) OR (C15175=YES AND C94631=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C94631', '=', 'NO')], 'operators': ['OR', 'OR', 'AND']} |
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54 |
53 |
NCI-2013-01702 |
NCT02004275 |
A Phase I/II Study of Pomalidomide, Dexamethasone, and Ixazomib vs.Pomalidomide and Dexamethasone for Patients with Multiple Myeloma Refractory to Lenalidomide and Proteasome Inhibitor-Based Therapy |
Inclusion |
Patients with human immunodeficiency virus (HIV) infection are eligible, provided they meet the following: * No history of acquired immunodeficiency syndrome (AIDS)-defining conditions or other HIV related illness * Cluster of differentiation (CD)4+ cells nadirs > 350/mm^3 * Treatment sensitive HIV and, if on anti-HIV therapy, HIV viral load < 50 copies/mm^3 * Please note: HIV+ patients who enroll on this study and are assigned to treatment with ixazomib may need to modify their anti-retroviral therapy prior to receiving protocol therapy if they are on strong inducers or potent inhibitors of cytochrome P450 3A4 |
(HIV=NO) OR (HIV =UNKNOWN) OR (HIV=YES AND AIDS=NO AND AIDS-Related Disorder =NO AND CD4> 350 {cells}/mm3 AND Treatment-sensitive HIV=YES AND HAART=NO) OR (HIV=YES AND AIDS=NO AND AIDS-Related Disorder =NO AND CD4> 350 {cells}/mm3 AND Treatment-sensitive HIV=YES AND HAART=YES AND Viral Load< 50 {copies}/mm3) |
(C15175=NO) OR (C15175 =C17998) OR (C15175=YES AND C2851=NO AND C4991=NO AND C103810> 350 {cells}/mm3 AND Treatment-sensitive HIV=YES AND C94631=NO) OR (C15175=YES AND C2851=NO AND C4991=NO AND C103810> 350 {cells}/mm3 AND Treatment-sensitive HIV=YES AND C94631=YES AND C92544< 50 {copies}/mm3) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C2851', '=', 'NO'), ('C4991', '=', 'NO'), ('C103810', '>', '350 {cells}/mm3'), ('Treatment-sensitive HIV', '=', 'YES'), ('C94631', '=', 'NO'), ('C15175', '=', 'YES'), ('C2851', '=', 'NO'), ('C4991', '=', 'NO'), ('C103810', '>', '350 {cells}/mm3'), ('Treatment-sensitive HIV', '=', 'YES'), ('C94631', '=', 'YES'), ('C92544', '<', '50 {copies}/mm3')], 'operators': ['OR', 'OR', 'AND', 'AND', 'AND', 'AND', 'AND', 'OR', 'AND', 'AND', 'AND', 'AND', 'AND', 'AND']} |
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55 |
54 |
NCI-2013-01703 |
NCT01940809 |
A Sequential Safety and Biomarker Study of BRAF-MEK Inhibition on the Immune Response in the Context of Combined CTLA-4 Blockade and PD-1 Blockade for BRAF Mutant Melanoma |
Exclusion |
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible |
(HIV=NO) OR (HIV =UNKNOWN) OR (HIV=YES AND HAART=NO)} |
(C15175=NO) OR (C15175 =C17998) OR (C15175=YES AND C94631=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C94631', '=', 'NO')], 'operators': ['OR', 'OR', 'AND']} |
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56 |
55 |
NCI-2013-01748 |
NCT01947023 |
A Phase 1 Study of Dabrafenib in Combination with Lapatinib in BRAF Mutant Thyroid Cancer |
Exclusion |
Human immunodeficiency virus (HIV)-positive patients on antiviral drugs and/or cluster of differentiation (CD)4 count is inadequate (< 500); if neither condition exists, HIV-positive patients are eligible |
(HIV=NO) OR HIV=UNKNOWN OR (HIV=Y AND HAART=NO AND CD4>500 cells/mm3) |
(C15175=NO) OR (C15175=C17998) OR (C15175=YES AND C94631=NO AND C103810>500 {cells}/mm3) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C94631', '=', 'NO'), ('C103810', '>', '500 {cells}/mm3')], 'operators': ['OR', 'OR', 'AND', 'AND']} |
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57 |
56 |
NCI-2013-01850 |
NCT01993810 |
Phase III Randomized Trial Comparing Overall Survival after Photon versus Proton Chemoradiotherapy for Inoperable Stage II-IIIB NSCLC |
Exclusion |
Severe, active co-morbidity, defined as follows: * Acquired immune deficiency syndrome (AIDS) based upon current Centers for Disease Control and Prevention (CDC) definition; note, however, that human immunodeficiency virus (HIV) testing is not required for entry into this protocol |
(HIV=NO OR HIV =UNKNOWN) AND AIDS=NO |
(C15175=NO OR C15175 =C17998) AND C2851=NO |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C2851', '=', 'NO')], 'operators': ['OR', 'AND']} |
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58 |
57 |
NCI-2013-01999 |
NCT01946789 |
A Phase 1 Study of the Clinical and Immunologic Effects of ALT-803, a Novel Recombinant IL-15 Complex in Patients with Advanced Solid Tumors: Melanoma, Renal Cell, Sarcoma, Colon, Non-Hodgkin Lymphoma, Non-small Cell Lung, Squamous Cell Head and Neck Cancer and Cutaneous Squamous Cell Cancer |
Exclusion |
Human immunodeficiency virus (HIV)-positive patients |
(HIV=NO OR HIV =UNKNOWN) |
(C15175=NO OR C15175 =C17998) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998')], 'operators': ['OR']} |
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59 |
58 |
NCI-2013-02103 |
NCT01989585 |
Phase I/II Study of Dabrafenib, Trametinib, and Navitoclax in BRAF Mutant Melanoma and Other Solid Tumors |
Exclusion |
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible |
HIV=NO OR HIV =UNKNOWN OR (HIV=YES AND HAART=NO) |
C15175=NO OR C15175 =C17998 OR (C15175=YES AND C94631=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C94631', '=', 'NO')], 'operators': ['OR', 'OR', 'AND']} |
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60 |
59 |
NCI-2013-02167 |
NCT01979536 |
A Randomized Phase 2 Trial of Brentuximab Vedotin (SGN35, NSC# 749710), or Crizotinib (NSC#749005, Commercially Labeled) in Combination with Chemotherapy for Newly Diagnosed Patients with Anaplastic Large Cell Lymphoma (ALCL) |
Exclusion |
Patients that are known to be positive for human immunodeficiency virus (HIV) are not eligible; note: inclusion of HIV positive patients will be considered at a later date |
(HIV=NO OR HIV =UNKNOWN) |
(C15175=NO OR C15175 =C17998) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998')], 'operators': ['OR']} |
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61 |
60 |
NCI-2013-02229 |
NCT02003222 |
A Phase III Randomized Trial of Blinatumomab for Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia in Adults |
Inclusion |
Patients with known human immunodeficiency virus (HIV) infection are eligible if they meet all of the following criteria: * No history of acquired immune deficiency syndrome (AIDS)-related complications other than a history of low CD4+ T-cell count (< 200/mm^3) prior to initiation of combination antiretroviral therapy; on study CD4+ T-cell count may not be informative due to leukemia and should not be used as an exclusion criterion if low * Patient must be healthy on the basis of HIV disease with high likelihood of near normal life span were it not for the leukemia * Patient must have serum HIV viral load of < 200 copies/mm^3 * Patient must be on combination antiretroviral therapy with minimal pharmacokinetic interactions with study therapy and minimal overlapping clinical toxicity with protocol therapy * Patient must not be receiving protease inhibitors or once daily formulations containing cobicistat, stavudine, or zidovudine. * It is recommended to utilize a regimen of the integrase inhibitor, dolutegravir, combined with either disoproxil fumarate/emtricitabine or dolutegravir combined with tenofovir alafenamide/emtricitabine |
(HIV=NO) OR (HIV =UNKNOWN) OR (HIV=YES AND AIDS-Related Disorder =NO AND Healthy=YES AND Viral Load>=200 {copies}/mm3 AND HAART=YES AND HIV Protease Inhibitor=NO AND Cobicistat=NO AND Stavudine=NO AND Zidovudine=NO) |
(C15175=NO) OR (C15175 =C17998) OR (C15175=YES AND C4991=NO AND C115935=YES AND C92544>=200 {copies}/mm3 AND C94631=YES AND C97366=NO AND C97360=NO AND C1428=NO AND C947=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C4991', '=', 'NO'), ('C115935', '=', 'YES'), ('C92544', '>=', '200 {copies}/mm3'), ('C94631', '=', 'YES'), ('C97366', '=', 'NO'), ('C97360', '=', 'NO'), ('C1428', '=', 'NO'), ('C947', '=', 'NO')], 'operators': ['OR', 'OR', 'AND', 'AND', 'AND', 'AND', 'AND', 'AND', 'AND', 'AND']} |
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62 |
61 |
NCI-2013-02238 |
NCT01896869 |
A Phase 2, Multicenter Study of FOLFIRINOX Followed by Ipilimumab in Combination with Allogeneic GM-CSF Transfected Pancreatic Tumor Vaccine in the Treatment of Metastatic Pancreatic Cancer |
Exclusion |
Patients with chronic human immunodeficiency virus (HIV), hepatitis B or hepatitis C infections should be excluded |
(HIV=NO) OR (HIV =UNKNOWN) |
(C15175=NO) OR (C15175 =C17998) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998')], 'operators': ['OR']} |
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63 |
62 |
NCI-2013-02288 |
NCT02059499 |
A Randomized, Phase III Study of Intra-anal Imiquimod 2.5 % vs. Topical 5-Fluorouracil 5% vs. Observation for the Treatment of High-Grade Anal Squamous Intraepithelial Lesions in HIV-Positive Men and Women |
Exclusion/Inlusion |
EXCLUSION Participants who received investigational agents, other than investigational antiretroviral agents for HIV, within the 4 weeks before randomization, unless approved by the study chair Inclusion: HIV-positive; documentation of HIV-1 infection by means of any one of the following: * Documentation of HIV diagnosis in the medical record by a licensed health care provider * Documentation of receipt of antiretroviral therapy (ART) (at least two different medications) by a licensed health care provider (documentation may be a record of an ART prescription in the participant’s medical record, a written prescription in the name of the participant for ART, or pill bottles for ART with a label showing the participant’s name) * HIV-1 ribonucleic acid (RNA) detection by a licensed HIV-1 RNA assay demonstrating > 1000 RNA copies/mL * Any licensed HIV screening antibody and/or HIV antibody/antigen combination assay confirmed by a second licensed HIV assay such as a HIV-1 Western blot confirmation or HIV rapid multispot antibody differentiation assay Cluster of differentiation (CD)4 count >= 200 within 120 days prior to enrollment or plasma HIV-1 RNA < 200 copies/mL within 120 days prior to randomization |
HIV=YES AND (CD4>=200 {cells}/mm3 OR Viral Load<200 {copies}/mm3) |
C15175=YES AND (C103810>=200 {cells}/mm3 OR C92544<200 {copies}/mm3) |
{'triples': [('C15175', '=', 'YES'), ('C103810', '>=', '200 {cells}/mm3'), ('C92544', '<', '200 {copies}/mm3')], 'operators': ['AND', 'OR']} |
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64 |
63 |
NCI-2013-02426 |
NCT02029950 |
A Phase I Study of Pomalidomide Given at the Time of Lymphocyte Recovery following Induction Timed Sequential Chemotherapy with Cytarabine, Daunorubicin, and Etoposide (AcDVP16) in Patients with Newly Diagnosed Acute Myeloid Leukemia (AML) and High-Risk MDS |
Inclusion |
Known human immunodeficiency virus (HIV) infected patients (HIV testing will not be performed as a part of screening) on combination antiretroviral therapy are eligible for inclusion; the use of zidovudine is not allowed |
HIV=NO OR HIV=UNKNOWN OR (HIV=YES AND HAART=YES AND Zidovudine=NO) |
C15175=NO OR C15175=C17998 OR (C15175=YES AND C94631=YES AND C947=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C94631', '=', 'YES'), ('C947', '=', 'NO')], 'operators': ['OR', 'OR', 'AND', 'AND']} |
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65 |
64 |
NCI-2014-00115 |
NCT02015104 |
A Randomized, Prospective, Phase II Study to Determine the Efficacy of Bacillus Calmette-Guerin (BCG) Given in Combination with PANVACâ„¢ versus BCG Given Alone in Adults with High Grade Non-muscle Invasive Bladder Cancer (NMIBC) Who Failed at Least 1 Induction Course of BCG |
Exclusion |
Patients unable to avoid close contact or household contact with the following high-risk individuals for three weeks after the day 1 vaccination: (a) children =< 3 years of age, (b) pregnant or nursing women, (c) individuals with prior or concurrent extensive eczema or other eczematoid skin disorders, or (d) immunocompromised individuals, such as those with human immunodeficiency virus (HIV) |
(HIV=NO OR HIV=UNKNOWN) AND (Immunocompromised=NO) |
(C15175=NO OR C15175=C17998) AND (C14139=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C14139', '=', 'NO')], 'operators': ['OR', 'AND']} |
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66 |
65 |
NCI-2014-00416 |
NCT02070549 |
A Phase I Trial of Single Agent Trametinib (GSK1120212) in Advanced Cancer Patients with Hepatic Dysfunction |
Exclusion |
Patients with known human immunodeficiency virus (HIV) infection are eligible if not on antiviral agents and cluster of differentiation (CD)4 counts are adequate (>= 500) HIV-positive patients on combination antiretroviral therapy are ineligible |
HIV =NO OR OR HIV=UNKNOWN OR (HIV =Y AND HAART=NO AND CD4>=500 cells/mm3) |
C15175 =NO OR C15175=C17998 OR (C15175 =YES AND C94631=NO AND C103810>=500 cells/mm3) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C94631', '=', 'NO'), ('C103810', '>=', '500 cells/mm3')], 'operators': ['OR', 'OR', 'AND', 'AND']} |
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67 |
66 |
NCI-2014-00461 |
NCT02079740 |
An Open Label, Two-Part, Phase Ib/II Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of the MEK Inhibitor Trametinib and the BCL2-Family Inhibitor Navitoclax (ABT-263) in Combination in Subjects with KRAS or NRAS Mutation-Positive Advanced Solid Tumors |
Exclusion |
Known hepatitis B virus (HBV), or hepatitis C virus (HCV) infection (patients with chronic or cleared HBV and HCV infection are eligible); patients with human immunodeficiency virus (HIV) are not eligible if on anti-retroviral medications |
HIV=NO OR HIV=UNKNOWN OR (HIV =YES AND HAART=NO) |
C15175=NO OR C15175=C17998 OR (C15175 =YES AND C94631=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C94631', '=', 'NO')], 'operators': ['OR', 'OR', 'AND']} |
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68 |
67 |
NCI-2014-00615 |
NCT02097225 |
Phase I Study of AT13387 in Combination with Dabrafenib and Trametinib in Patients with BRAF-Mutant Melanoma and Other Solid Tumors |
Exclusion |
Patients known to be human immunodeficiency virus (HIV)-positive patients and on combination antiretroviral therapy are ineligible |
HIV=NO OR HIV=UNKNOWN OR (HIV =YES AND HAART=NO) |
C15175=NO OR C15175=C17998 OR (C15175 =YES AND C94631=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C94631', '=', 'NO')], 'operators': ['OR', 'OR', 'AND']} |
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69 |
68 |
NCI-2014-00620 |
NCT02101775 |
A Randomized Placebo-Controlled Phase II Trial Comparing Gemcitabine Monotherapy to Gemcitabine in Combination with AZD 1775 (MK 1775) in Women with Recurrent, Platinum Resistant Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers |
Exclusion |
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible |
HIV=NO OR HIV=UNKNOWN OR (HIV =YES AND HAART=NO) |
C15175=NO OR C15175=C17998 OR (C15175 =YES AND C94631=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C94631', '=', 'NO')], 'operators': ['OR', 'OR', 'AND']} |
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70 |
69 |
NCI-2014-00627 |
NCT02154490 |
A Biomarker-Driven Master Protocol for Previously Treated Squamous Cell Lung Cancer (Lung-Map) |
Inclusion |
Patients with a known history of human immunodeficiency virus (HIV) seropositivity: * Must have undetectable viral load using standard HIV assays in clinical practice * Must have cluster of differentiation (CD)4 count >= 400/mcL * Must not require prophylaxis for any opportunistic infections (i.e., fungal, Mycobacterium avium complex [mAC], or pneumocystis jiroveci pneumonia [PCP] prophylaxis) * Must not be newly diagnosed within 12 months prior to sub-study registration |
HIV=NO OR HIV=UNKNOWN OR (HIV =YES AND VIRAL LOAD=0 {copies}/mm3 AND CD4>=400 {cells}/mm3 AND Prevention and Treatment of Opportunistic Infection =NO AND Diagnosis>12 months) |
C15175=NO OR C15175=C17998 OR (C15175 =YES AND C92544=C111568 {copies}/mm3 AND C103810>=400 {cells}/mm3 AND C15840=NO AND C15220>12 mo) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C92544', '=', 'C111568 {copies}/mm3'), ('C103810', '>=', '400 {cells}/mm3'), ('C15840', '=', 'NO'), ('C15220', '>', '12 mo')], 'operators': ['OR', 'OR', 'AND', 'AND', 'AND', 'AND']} |
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71 |
70 |
NCI-2014-00629 |
NCT02101788 |
A Randomized Phase II/III Study to Assess the Efficacy of Trametinib (GSK 1120212) in Patients with Recurrent or Progressive Low-Grade Serous Ovarian Cancer or Peritoneal Cancer |
Exclusion |
patients with human immunodeficiency virus (HIV) are not eligible if on anti-retroviral medications |
HIV=NO OR HIV=UNKNOWN OR (HIV =Yes AND HAART=NO) |
C15175=NO OR C15175=C17998 OR (C15175 =Yes AND C94631=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'Yes'), ('C94631', '=', 'NO')], 'operators': ['OR', 'OR', 'AND']} |
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72 |
71 |
NCI-2014-00631 |
NCT02101853 |
Risk-Stratified Randomized Phase III Testing of Blinatumomab (NSC#765986) in First Relapse of Childhood B-Lymphoblastic Leukemia (B-ALL) |
Exclusion |
Patients with known human immunodeficiency virus (HIV) infection |
HIV=NO OR HIV=UNKNOWN |
C15175=NO OR C15175=C17998 |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998')], 'operators': ['OR']} |
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73 |
72 |
NCI-2014-00634 |
NCT02101905 |
Drug Distribution and Pharmacodynamic Study of Pulsatile Lapatinib in Surgically Accessible EGFR-Amplified Recurrent High-Grade Glioma |
Exclusion |
Human immunodeficiency virus (HIV)-positive patients on strong cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4) inducers or inhibitors are ineligible |
HIV=NO OR HIV=UNKNOWN OR ((HIV =YES AND (Cytochrome P450 3A4 Inhibitor=NO OR Cytochrome P450 3A4 Inducer =NO)) |
C15175=NO OR C15175=C17998 OR ((C15175 =YES AND (C111373=NO OR C111374=NO)) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C111373', '=', 'NO'), ('C111374', '=', 'NO')], 'operators': ['OR', 'OR', 'AND', 'OR']} |
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74 |
73 |
NCI-2014-00635 |
NCT02135042 |
Randomized Phase II and Phase III Studies of Individualized Treatment for Nasopharyngeal Carcinoma Based on Biomarker Epstein Barr Virus (EBV) Deoxyribonucleic Acid (DNA) |
Exclusion |
Severe, active co-morbidity, defined as follows: * Acquired immune deficiency syndrome (AIDS) based upon current Centers for Disease Control and Prevention (CDC) definition; note, however, that human immunodeficiency virus (HIV) testing is not required for entry into this protocol |
HIV=NO OR HIV=UNKNOWN OR AIDS=NO |
C15175=NO OR C15175=C17998 OR C2851=NO |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C2851', '=', 'NO')], 'operators': ['OR', 'OR']} |
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75 |
74 |
NCI-2014-00636 |
NCT02135419 |
ANCHOR Study: Anal Cancer/HSIL Outcomes Research Study |
Inclusion |
HIV positive; documentation of HIV-1 infection by means of any one of the following: * Documentation of HIV diagnosis in the medical record by a licensed health care provider; * Documentation of receipt of antiretroviral therapy (ART) by a licensed health care provider (documentation may be a record of an ART prescription in the participant’s medical record, a written prescription in the name of the participant for ART, or pill bottles for ART with a label showing the participant’s name; receipt of at least two agents is required; each component agent of a multi-class combination ART regimen will be counted toward the 2-agent requirement, excepting receipt of a pre-exposure prophylaxis [PrEP] regimen alone [e.g., Truvada], which is exclusionary); * HIV-1 ribonucleic acid (RNA) detection by a licensed HIV-1 RNA assay demonstrating > 1000 RNA copies/mL; * Any licensed HIV screening antibody and/or HIV antibody/antigen combination assay confirmed by a second licensed HIV assay such as a HIV-1 western blot confirmation or HIV rapid multispot antibody differentiation assay * NOTE: A “licensed†assay refers to a United States (US) Food and Drug Administration (FDA)-approved assay, which is required for all investigational new drug (IND) studies |
HIV =YES |
C15175 =YES |
{'triples': [('C15175', '=', 'YES')], 'operators': []} |
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76 |
75 |
NCI-2014-00643 |
NCT02101944 |
Pilot Trial Evaluating Viral Protein Production from the Combination of Reolysin and Carfilzomib in Multiple Myeloma |
Inclusion |
Patients must not have known human immunodeficiency virus (HIV) infection or active hepatitis B or C infections |
HIV=NO OR HIV=UNKNOWN |
C15175=NO OR C15175=C17998 |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998')], 'operators': ['OR']} |
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77 |
76 |
NCI-2014-00644 |
NCT02032823 |
A Randomised, Double-Blind, Parallel Group, Placebo-Controlled Multi-centre Phase III Study to Assess the Efficacy and Safety of Olaparib versus Placebo as Adjuvant Treatment in Patients with Germline BRCA1/2 Mutations and High Risk HER2 Negative Primary Breast Cancer Who Have Completed Definitive Local Treatment and Neoadjuvant or Adjuvant Chemotherapy |
Exclusion |
Patients known to be human immunodeficiency virus (HIV) positive with one or more of the following: * Baseline cluster of differentiation (CD)4 count of < 250 cells/mm^3 * History of acquired immune deficiency syndrome (AIDS) indicator conditions * Anti-retroviral therapy with any potent CYP3A4 inhibitor |
HIV=NO OR HIV=UNKNOWN OR (HIV =YES AND CD4>=250 {cells}/mm3 AND AIDS=NO AND Cytochrome P450 3A4 Inhibitor=NO) |
C15175=NO OR C15175=C17998 OR (C15175 =YES AND C103810>=250 {cells}/mm3 AND C2851=NO AND C111373=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C103810', '>=', '250 {cells}/mm3'), ('C2851', '=', 'NO'), ('C111373', '=', 'NO')], 'operators': ['OR', 'OR', 'AND', 'AND', 'AND']} |
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78 |
77 |
NCI-2014-00686 |
NCT02152137 |
A Phase 2 Study of Efatutazone, an Oral PPAR Agonist, In Combination with Paclitaxel in Patients with Advanced Anaplastic Thyroid Cancer |
Inclusion |
Although they will not be considered formal eligibility (exclusion) criteria, physicians should recognize that the following may seriously increase the risk to the patient entering this protocol: * Medical condition such as uncontrolled infection (including human immunodeficiency virus [HIV]), uncontrolled diabetes mellitus or cardiac disease which, in the opinion of the treating physician, would make this protocol unreasonably hazardous for the patient |
|
IGNORE? |
{'triples': [('IGN', '?', '?'), ('E?', '?', '?')], 'operators': []} |
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79 |
78 |
NCI-2014-00688 |
NCT02379416 |
Phase I Trial of the Combination of Nilotinib and Paclitaxel in Adults with Refractory Solid Tumors |
Exclusion |
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible |
HIV =NO OR HIV =UNKNOWN OR (HIV =YES AND HAART=NO) |
C15175 =NO OR C15175 =C17998 OR (C15175 =YES AND C94631=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C94631', '=', 'NO')], 'operators': ['OR', 'OR', 'AND']} |
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80 |
79 |
NCI-2014-00702 |
NCT02206334 |
A Phase 1 Study of Stereotactic Body Radiotherapy (SBRT) for the Treatment of Multiple Metastases |
Exclusion |
Severe, active co-morbidity, defined as follows: * Human immunodeficiency virus (HIV) positive with cluster of differentiation (CD) 4 count < 200 cells/microliter; note that patients who are HIV positive are eligible, provided they are under treatment with highly active antiretroviral therapy (HAART) and have a CD4 count >= 200 cells/microliter within 30 days prior to registration; note also that HIV testing is not required for eligibility for this protocol |
HIV =NO OR HIV =UNKNOWN OR (HIV =YES AND CD4>=200 {cells}/mm3) AND HAART=YES) |
C15175 =NO OR C15175 =C17998 OR (C15175 =YES AND C103810>=200 {cells}/mm3) AND C94631=YES) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C103810', '>=', '200 {cells}/mm3'), ('C94631', '=', 'YES')], 'operators': ['OR', 'OR', 'AND', 'AND']} |
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81 |
80 |
NCI-2014-00746 |
NCT02115282 |
A Randomized Phase III Trial of Endocrine Therapy plus Entinostat/Placebo in Patients with Hormone Receptor-Positive Advanced Breast Cancer |
Inclusion |
Known human immunodeficiency virus (HIV)-positive patients should have a cluster of differentiation (CD)4 count > 250/mm^3 |
HIV =NO OR HIV =UNKNOWN OR (HIV =YES AND CD4>250 {cells}/mm3) |
C15175 =NO OR C15175 =C17998 OR (C15175 =YES AND C103810>250 {cells}/mm3) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C103810', '>', '250 {cells}/mm3')], 'operators': ['OR', 'OR', 'AND']} |
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82 |
81 |
NCI-2014-00816 |
NCT02211755 |
Phase I Trial of the Combination of Bortezomib and Clofarabine in Adults with Refractory Solid Tumors |
Exclusion |
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible |
HIV =NO OR HIV =UNKNOWN OR (HIV =YES AND HAART=NO) |
C15175 =NO OR C15175 =C17998 OR (C15175 =YES AND C94631=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C94631', '=', 'NO')], 'operators': ['OR', 'OR', 'AND']} |
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83 |
82 |
NCI-2014-00849 |
NCT02200042 |
Randomized Phase III Study of Focal Radiation Therapy for Unresectable, Localized Intrahepatic Cholangiocarcinoma |
Exclusion |
Severe, active co-morbidity, defined as follows: * Human immunodeficiency virus (HIV) positive with cluster of differentiation (CD)4 count < 200 cells/microliter; note that patients who are HIV positive are eligible, provided they are under treatment with highly active antiretroviral therapy (HAART) and have a CD4 count >= 200 cells/microliter within 30 days prior to registration; note also that HIV testing is not required for eligibility for this protocol |
HIV=NO OR HIV=Unknown OR (HIV=YES AND CD4>=200 {cells}/mm3) AND HAART=YES) |
C15175=NO OR C15175=C17998 OR (C15175=YES AND C103810>=200 {cells}/mm3) AND C94631=YES) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C103810', '>=', '200 {cells}/mm3'), ('C94631', '=', 'YES')], 'operators': ['OR', 'OR', 'AND', 'AND']} |
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84 |
83 |
NCI-2014-00907 |
NCT02133183 |
Pilot Study of MLN0128 (TAK-228) in Preoperative Recurrent Glioblastoma (GBM) Patients |
Exclusion |
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible |
HIV=NO OR HIV=Unknown OR (HIV=YES AND HAART=NO) |
C15175=NO OR C15175=C17998 OR (C15175=YES AND C94631=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C94631', '=', 'NO')], 'operators': ['OR', 'OR', 'AND']} |
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85 |
84 |
NCI-2014-01043 |
NCT02143401 |
A Phase I Trial of ABT-263 (Navitoclax), a Bcl-2 Inhibitor, and Sorafenib (Nexavar) in Patients with Relapsed or Refractory Solid Organ Tumors |
Exclusion |
Human immunodeficiency virus (HIV)-positive patients on highly active antiretroviral therapy (HAART) are excluded |
HIV=NO OR HIV=Unknown OR (HIV=YES AND HAART=NO) |
C15175=NO OR C15175=C17998 OR (C15175=YES AND C94631=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C94631', '=', 'NO')], 'operators': ['OR', 'OR', 'AND']} |
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86 |
85 |
NCI-2014-01047 |
NCT02143414 |
A Phase II Study of Blinatumomab and POMP (Prednisone, Vincristine, Methotrexate, 6-Mercaptopurine) for Patients >/= 65 Years of Age with Newly Diagnosed Philadelphia-Chromosome Negative (Ph-) Acute Lymphoblastic Leukemia (ALL) and of Dasatinib, Prednisone and Blinatumomab for Patients >/= 65 Years of Age with Newly Diagnosed Philadelphia-Chromosome Positive (Ph+) ALL, Relapsed/Refractory Philadelphia-Chromosome Postive (Ph+) ALL, and Philadelphia-Chromosome-Like Signature (Ph-Like) ALL with Known or Presumed Activating Dastinib-Sensitive Mutations or Kinase Fusions (DSMKF) |
Inclusion |
Patients known to be positive for HIV (the human immunodeficiency virus) may be eligible, providing they meet the following additional criteria within 28 days prior to registration: * No history of acquired immune deficiency syndrome (AIDS)-defining conditions * CD4 cells > 350 cells/mm^3 * If on antiretroviral agents, must not include zidovudine or stavudine * Viral load =< 50 copies HIV messenger ribonucleic acid (mRNA)/mm^3 if on combination antiretroviral therapy (cART) or =< 25,000 copies HIV mRNA/mm^3 if not on cART * Highly active antiretroviral therapy (HAART) regimens are acceptable providing they have only weak P450A4 interactions |
HIV=NO OR HIV=Unknown OR (HIV=YES AND AIDS=NO AND CD4> 350 {cells}/mm3 AND HAART=NO AND Viral Load<=25000 {copies}/mm3) OR (HIV=YES AND AIDS=NO AND CD4> 350 {cells/mm3 AND HAART=YES AND Zidovudine=NO AND Stavudine= NO AND Viral Load<=50 {copies}/mm3) |
C15175=NO OR C15175=C17998 OR (C15175=YES AND C2851=NO AND C103810> 350 {cells}/mm3 AND C94631=NO AND C92544<=25000 {copies}/mm3) OR (C15175=YES AND C2851=NO AND C103810> 350 {cells/mm3 AND C94631=YES AND C947=NO AND C1428= NO AND C92544<=50 {copies}/mm3) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C2851', '=', 'NO'), ('C103810', '>', '350 {cells}/mm3'), ('C94631', '=', 'NO'), ('C92544', '<=', '25000 {copies}/mm3'), ('C15175', '=', 'YES'), ('C2851', '=', 'NO'), ('C103810', '>', '350 {cells/mm3'), ('C94631', '=', 'YES'), ('C947', '=', 'NO'), ('C1428', '=', 'NO'), ('C92544', '<=', '50 {copies}/mm3')], 'operators': ['OR', 'OR', 'AND', 'AND', 'AND', 'AND', 'OR', 'AND', 'AND', 'AND', 'AND', 'AND', 'AND']} |
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87 |
86 |
NCI-2014-01072 |
NCT02179086 |
Randomized Phase II Trial of Hypofractionated Dose-Escalated Photon IMRT or Proton Beam Therapy versus Conventional Photon Irradiation with Concomitant and Adjuvant Temozolomide in Patients with Newly Diagnosed Glioblastoma |
Exclusion |
Severe, active co-morbidity, defined as follows: * Acquired immune deficiency syndrome (AIDS) based upon current Centers for Disease Control and Prevention (CDC) definition; note, however, that human immunodeficiency virus (HIV) testing is not required for entry into this protocol |
(HIV=NO OR HIV=Unknown) AND AIDS=NO |
(C15175=NO OR C15175=C17998) AND C2851=NO |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C2851', '=', 'NO')], 'operators': ['OR', 'AND']} |
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88 |
87 |
NCI-2014-01106 |
NCT02152995 |
A Phase 2 Study of Trametinib in Combination with Radioiodine (RAI) for RAS Mutant or RAS/RAF Wild-Type, RAI-Refractory Recurrent and/or Metastatic Thyroid Cancers |
Exclusion |
Known human immunodeficiency virus (HIV), hepatitis B virus (HBV), or hepatitis C virus (HCV) infection (with the exception of chronic or cleared HBV and HCV infection, which will be allowed); patients with human immunodeficiency virus (HIV) are not eligible if on anti-retroviral medications HIV-positive patients on combination antiretroviral therapy are ineligible |
HIV=NO OR HIV=Unknown OR (HIV=YES AND HAART=NO) |
C15175=NO OR C15175=C17998 OR (C15175=YES AND C94631=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C94631', '=', 'NO')], 'operators': ['OR', 'OR', 'AND']} |
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89 |
88 |
NCI-2014-01107 |
NCT02159989 |
Phase I Study of MLN0128 (TAK-228) (NSC# 768435) in Combination with Ziv-Aflibercept (NSC# 724770) in Patients with Advanced Cancers |
Exclusion |
Patients with human immunodeficiency virus (HIV) will not be denied an opportunity to participate in this clinical trial, if they have adequate cluster of differentiation (CD)4 counts (> 250 CD4+ T lymphocytes/uL) and would be able to be maintained on an antiretroviral combination without pronounced effects on cytochrome (CYP)3A4, 2C9, or 2C19 |
{(HIV=NO) OR (HIV=Y AND HAART=NO AND CD4>250 cells/mm3) AND (HIV=Y AND HAART=Y AND CD4>250 cells/mm3)} |
{(C15175=NO) OR (C15175=Y AND C94631=NO AND C103810>250 cells/mm3) AND (C15175=Y AND C94631=Y AND C103810>250 cells/mm3)} |
{'triples': [('{C15175', '=', 'NO'), ('C15175', '=', 'Y'), ('C94631', '=', 'NO'), ('C103810', '>', '250 cells/mm3'), ('C15175', '=', 'Y'), ('C94631', '=', 'Y'), ('C103810', '>', '250 cells/mm3}')], 'operators': ['OR', 'AND', 'AND', 'AND', 'AND', 'AND']} |
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90 |
89 |
NCI-2014-01118 |
NCT02142803 |
A Phase 1 Study of MLN0128 and Bevacizumab in Patients with Recurrent Glioblastoma and Other Solid Tumors |
Exclusion |
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; if an HIV-positive patient has adequate cluster of differentiation (CD4) counts (CD4 above the lower limit of institutional normal) and is on antiretroviral therapy with newer agents, which are not strong cytochrome (CYP) inhibitors, they will be eligible |
HIV=NO OR HIV=Unknown OR (HIV=YES AND HAART=NO) OR (HIV=YES AND HAART=YES AND CD4>C25555 {cells}/mm3) |
C15175=NO OR C15175=C17998 OR (C15175=YES AND C94631=NO) OR (C15175=YES AND C94631=YES AND C103810>C25555 {cells}/mm3) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C94631', '=', 'NO'), ('C15175', '=', 'YES'), ('C94631', '=', 'YES'), ('C103810', '>', 'C25555 {cells}/mm3')], 'operators': ['OR', 'OR', 'AND', 'OR', 'AND', 'AND']} |
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91 |
90 |
NCI-2014-01222 |
NCT02304458 |
A Phase 1/2 Study of Nivolumab in Children, Adolescents, and Young Adults with Recurrent or Refractory Solid Tumors as a Single Agent and in Combination with Ipilimumab |
Exclusion |
Patients with known human immunodeficiency virus (HIV) or hepatitis B or C are excluded |
HIV=NO OR HIV=Unknown |
C15175=NO OR C15175=C17998 |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998')], 'operators': ['OR']} |
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92 |
91 |
NCI-2014-01223 |
NCT02166463 |
A Randomized Phase 3 Study of Brentuximab Vedotin (SGN-35) for Newly Diagnosed High-Risk Classical Hodgkin Lymphoma (cHL) in Children and Young Adults |
Exclusion |
Patients known to be positive for human immunodeficiency virus (HIV) are not eligible |
HIV=NO OR HIV=Unknown |
C15175=NO OR C15175=C17998 |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998')], 'operators': ['OR']} |
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93 |
92 |
NCI-2014-01340 |
NCT02180867 |
Pazopanib Neoadjuvant Trial in Non-Rhabdomyosarcoma Soft Tissue Sarcomas (PAZNTIS): A Phase II/III Randomized Trial of Preoperative Chemoradiation or Preoperative Radiation plus or minus Pazopanib (NSC# 737754) |
Exclusion |
Human immunodeficiency virus (HIV)-positive subjects on combination antiretroviral therapy are ineligible |
(HIV=NO) OR (HIV=Y AND HAART=NO) |
(C15175=NO) OR (C15175=Y AND C94631=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'Y'), ('C94631', '=', 'NO')], 'operators': ['OR', 'AND']} |
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94 |
93 |
NCI-2014-01470 |
NCT02196181 |
A Randomized Phase II Trial of Intermittent versus Continuous Dosing of Dabrafenib (NSC-763760) and Trametinib (NSC-763093) in BRAF V600E/K Mutant Melanoma |
Inclusion |
Patients with known human immunodeficiency virus (HIV) may be eligible providing they meet the following additional criteria: * Cluster of differentiation (CD)4 cells >= 500/uL * Serum HIV viral load of < 25,000 IU/ml * No current antiretroviral therapy ** Tests must be obtained within 28 days prior to registration; patients who are HIV positive (+) and do not meet all of these criteria are not eligible for this study (HIV/hepatitis testing are not required for patients without known infection) |
HIV=NO OR HIV=Unknown OR (HIV=YES AND CD4>=500 {cells}/mm3 AND Viral Load<25000 {copies}/mm3 AND HAART=NO) |
C15175=NO OR C15175=C17998 OR (C15175=YES AND C103810>=500 {cells}/mm3 AND C92544<25000 {copies}/mm3 AND C94631=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C103810', '>=', '500 {cells}/mm3'), ('C92544', '<', '25000 {copies}/mm3'), ('C94631', '=', 'NO')], 'operators': ['OR', 'OR', 'AND', 'AND', 'AND']} |
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95 |
94 |
NCI-2014-01696 |
NCT02375204 |
A Randomized Phase III Trial Comparing Conventional-Dose Chemotherapy Using Paclitaxel, Ifosfamide, and Cisplatin (TIP) with High-Dose Chemotherapy Using Mobilizing Paclitaxel plus Ifosfamide Followed by High-Dose Carboplatin and Etoposide (TI-CE) as First Salvage Treatment in Relapsed or Refractory Germ Cell Tumors |
Inclusion |
Negative serology (antibody test) for the following infectious diseases: * Human immunodeficiency virus (HIV) type 1 and 2 * Human T-cell leukemia virus (HTLV) type 1 and 2 (mandatory in United States [US] but optional in Canada and Europe) * Hepatitis B surface antigen * Hepatitis C antibody |
HIV=NO OR HIV=Unknown |
C15175=NO OR C15175=C17998 |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998')], 'operators': ['OR']} |
0.0 |
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2.0 |
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96 |
95 |
NCI-2014-01747 |
NCT02224781 |
A Randomized Phase III Trial of Dabrafenib + Trametinib Followed by Ipilimumab + Nivolumab at Progression vs. Ipilimumab + Nivolumab Followed by Dabrafenib + Trametinib at Progression in Patients with Advanced BRAFV600 Mutant Melanoma |
Inclusion |
Individuals who are known to be human immunodeficiency virus (HIV) infected are eligible (note: HIV testing is not required for entry into the study) |
HIV=NO OR HIV=Unknown OR HIV=YES |
C15175=NO OR C15175=C17998 OR C15175=YES |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES')], 'operators': ['OR', 'OR']} |
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97 |
96 |
NCI-2014-01754 |
NCT02203526 |
Phase 1 Study of Ibrutinib and Immuno-Chemotherapy Using Dose-Adjusted-Temozolomide, Etoposide, Doxil, Dexamethasone, Ibrutinib, Rituximab (DA-TEDDI-R) in Primary CNS Lymphoma |
Exclusion |
Human immunodeficiency virus (HIV) positive patients will be excluded with the exception of patients without CD4 depletion (i.e. above the institutional lower limit of normal) and who have no other acquired immune deficiency syndrome (AIDS)-related complications and who have Epstein-Barr virus (EBV) negative tumors; the number of patients in this category is expected to be very low and the principal investigator (PI) will decide their eligibility on a case by case basis |
HIV=NO OR HIV=Unknown OR (HIV=YES AND CD4>C25555 {cells}/mm3 AND AIDS-Related Disorder =NO) |
C15175=NO OR C15175=C17998 OR (C15175=YES AND C103810>C25555 {cells}/mm3 AND C4991=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C103810', '>', 'C25555 {cells}/mm3'), ('C4991', '=', 'NO')], 'operators': ['OR', 'OR', 'AND', 'AND']} |
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98 |
97 |
NCI-2014-01810 |
NCT02364557 |
A Phase IIR/III Trial of Standard of Care Therapy with or without Stereotactic Body Radiotherapy (SBRT) and/or Surgical Ablation for Newly Oligometastatic Breast Cancer |
Exclusion |
Human immunodeficiency virus (HIV) positive with cluster of differentiation (CD)4 count < 200 cells/microliter; note that patients who are HIV positive are eligible, provided they are under treatment with highly active antiretroviral therapy (HAART) and have a CD4 count >= 200 cells/microliter within 30 days prior to registration; note also that HIV testing is not required for eligibility for this protocol |
HIV=NO OR HIV=Unknown OR (HIV=YES AND HAART=YES AND CD4>=200 {cells}/mm3) |
C15175=NO OR C15175=C17998 OR (C15175=YES AND C94631=YES AND C103810>=200 {cells}/mm3) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C94631', '=', 'YES'), ('C103810', '>=', '200 {cells}/mm3')], 'operators': ['OR', 'OR', 'AND', 'AND']} |
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99 |
98 |
NCI-2014-01927 |
NCT02243605 |
A Phase 2 Study of XL184 (Cabozantinib) in Treating Patients with Relapsed Osteosarcomas and Ewing Sarcomas |
Exclusion |
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible |
HIV=NO OR HIV=Unknown OR (HIV=YES AND HAART=NO) |
C15175=NO OR C15175=C17998 OR (C15175=YES AND C94631=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C94631', '=', 'NO')], 'operators': ['OR', 'OR', 'AND']} |
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100 |
99 |
NCI-2014-01984 |
NCT02298959 |
A Phase 1 Trial of MK-3475 plus Ziv-Aflibercept in Patients with Advanced Solid Tumors |
Exclusion |
Patients who are human immunodeficiency virus (HIV) positive may participate if they meet the following eligibility requirements: * They must be stable on their anti-retroviral regimen, and they must be healthy from an HIV perspective * They must have a cluster of differentiation (CD)4 count of greater than 250 cells/mcL * They must not be receiving prophylactic therapy for an opportunistic infection |
HIV=NO OR HIV=Unknown OR (HIV=YES AND HAART=YES AND Healthy=YES AND CD4> 250 {cells}/mm3 AND Prevention and Treatment of Opportunistic Infection =NO) |
C15175=NO OR C15175=C17998 OR (C15175=YES AND C94631=YES AND C115935=YES AND C103810> 250 {cells}/mm3 AND C15840=NO) |
{'triples': [('C15175', '=', 'NO'), ('C15175', '=', 'C17998'), ('C15175', '=', 'YES'), ('C94631', '=', 'YES'), ('C115935', '=', 'YES'), ('C103810', '>', '250 {cells}/mm3'), ('C15840', '=', 'NO')], 'operators': ['OR', 'OR', 'AND', 'AND', 'AND', 'AND']} |
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